Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents

作     者：Chang Qing Shi Zhang Qin Liu Wen Qing Lin Yuan Wei Chen 

作者机构：Key Laboratory of Asymmetric Synthesis ＆ Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China Graduate School of Chinese Academy of Sciences Beijing 100049 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2007年第18卷第8期

页      面：899-901页

核心收录：

学科分类：1002[医学-临床医学] 0703[理学-化学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Chinese Academy of Sciences CAS 

主　　题：Indoles Synthesis Kinesin spindle protein inhibitor Cytotoxicity Cancer treatment 

摘      要：A variety of indole derivatives were designed, synthesized and preliminarily evaluated for their in vitro cytotoxic activity in the A431 and H460 cell lines. All the compounds examined conferred unusual potency in a tumor cell cytotoxicity assay. The findings showed the indole derivatives would be a promising candidate for the development of new anticancer agents.