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Gga-miRNA-181-5p family facilitates chicken myogenesis via targeting TGFBR1 to block TGF-βsignaling

Journal of Integrative Agriculture 2024年第8期23卷 2764-2777页

作者： Xiaoxu Shen Yongtong Tian Wentao He Can He Shunshun Han Yao Han Lu Xia Bo Tan Menggen Ma Houyang Kang Jie Yu Qing Zhu Huadong Yin key laboratory of Livestock and Poultry Multi-omics Ministry of Agriculture and Rural AffairsCollege of Animal Science and TechnologySichuan Agricultural UniversityChengdu 611130China Farm animal genetic Resources Exploration and innovation key laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130China College of Forestry Sichuan Agricultural UniversityChengdu 611130China College of Resources Sichuan Agricultural UniversityChengdu 611130China Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130China key laboratory for animal Disease Resistance nutrition of China Institute of Animal NutritionMinistry of Education/Sichuan Agricultural UniversityChengdu 611130China

MicroRNAs(miRNAs)have been demonstrated to control chicken skeletal muscle growth,however,the potential function of the miR-181-5p family in chicken myogenesis remains largely ***,our study identified the two chicken(Gallus gallus;Gga)miR-181-5p family members widely expressed in various tissues,specifically miR-181a-5p and ***,the breast muscles of fast-growing broilers expressed higher levels of miR-181a-5p and miR-181b-5p than those of slow-growing ***,miR-181a-5p and miR-181b-5p both promote the expression level of myogenic factors including myogenin(MyoG),myogenic differentiation 1(MyoD1),and myosin heavy chain(MyHC),meanwhile accelerating the myotube formation of skeletal muscle satellite cells(SMSCs).Mechanistically,miR-181a-5p and miR-181b-5p directly bind to the 3′untranslated region(UTR)of the transforming growth factor beta receptor 1(TGFBR1)mRNA,further reducing the expression of ***1 is a key Transforming growth factor beta(TGF-β)signaling transduction receptor and had a negative function in muscle cell ***,knockdown of TGFBR1 facilitated the expression of chicken myogenic factors,boosted myotube formation,and decreased the SMAD family member 2/3(SMAD2/3)phosphorylation in chicken ***2/3 are downstream of TGF-βsignaling,and miR-181a-5p and miR-181b-5p could reduce the expression of TGFBR1 to further diminish the SMAD2/3 *** findings revealed that the miR-181-5p family targets TGFBR1 to break the TGF-βsignaling transduction,which resulted in promoting chicken skeletal muscle development.

关键词： miRNA-181-5p family SMSCs differentiation TGFBR1 TGF-βsignaling

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Mechanisms underlying the role of endoplasmic reticulum stress in the placental injury and fetal growth restriction in an ovine gestation model

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Journal of animal Science and Biotechnology 2024年第1期15卷 201-217页

作者： Hao Zhang Xia Zha Yi Zheng Xiaoyun Liu Mabrouk Elsabagh Hongrong Wang Honghua Jiang Mengzhi Wang laboratory of Metabolic manipulation of Herbivorous animal nutrition College of Animal Science and TechnologyYangzhou UniversityYangzhou 225009P.R.China Joint International Research laboratory of Agriculture and Agri‑Product Safety Ministry of Education of ChinaYangzhou UniversityYangzhou 225009P.R.China Department of animal Production and Technology Faculty of Agricultural Sciences and TechnologiesNiğde Omer Halisdemir UniversityNigde 51240Turkey Department of nutrition and Clinical nutrition Faculty of Veterinary MedicineKafrelsheikh UniversityKafrelSheikhEgypt Department of Pediatrics Northern Jiangsu People’s HospitalClinical Medical CollegeYangzhou UniversityYangzhou 225001China State key laboratory of Sheep genetic Improvement and Healthy Production Xinjiang Academy of Agricultural Reclamation ScienceShihezi 832000China

Background Exposure to bisphenol A(BPA),an environmental pollutant known for its endocrine-disrupting properties,during gestation has been reported to increase the risk of fetal growth restriction(FGR)in an ovine model of *** hypothesized that the FGR results from the BPA-induced insufficiency and barrier dysfunction of the placenta,oxidative stress,inflammatory responses,autophagy and endoplasmic reticulum stress(ERS).However,precise mechanisms underlying the BPA-induced placental dysfunction,and subsequently,FGR,as well as the potential involvement of placental ERS in these complications,remain to be *** In vivo experiment,16 twin-pregnant(from d 40 to 130 of gestation)Hu ewes were randomly distributed into two groups(8 ewes each).One group served as a control and received corn oil once a day,whereas the other group received BPA(5 mg/kg/d as a subcutaneous injection).In vitro study,ovine trophoblast cells(OTCs)were exposed to 4 treatments,6 replicates *** OTCs were treated with 400μmol/L BPA,400μmol/L BPA+0.5μg/m L tunicamycin(Tm;ERS activator),400μmol/L BPA+1μmol/L 4-phenyl butyric acid(4-PBA;ERS antagonist)and DMEM/F12 complete medium(control),for 24 *** In vivo experiments,pregnant Hu ewes receiving the BPA from 40 to 130 days of pregnancy experienced a decrease in placental efficiency,progesterone(P4)level and fetal weight,and an increase in placental estrogen(E2)level,together with barrier dysfunctions,OS,inflammatory responses,autophagy and ERS in type A *** vitro experiment,the OTCs exposed to BPA for 24 h showed an increase in the E2 level and related protein and gene expressions of autophagy,ERS,pro-apoptosis and inflammatory response,and a decrease in the P4 level and the related protein and gene expressions of antioxidant,anti-apoptosis and barrier ***,treating the OTCs with Tm aggravated BPA-induced dysfunction of barrier and endocrine(the increased E2 level and decreased P4 level),OS,inflamm

关键词： Autophagy Bisphenol A Endoplasmic reticulum stress Fetal growth restriction Inflammatory responses Sheep

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The effects of in ovo feeding of selenized glucose on liver selenium concentration and antioxidant capacity in neonatal broilers

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Chinese Chemical Letters 2024年第6期35卷 312-315页

作者： Jiahui Li Qiao Shi Ying Xue Mingde Zheng Long Liu Tuoyu Geng Daoqing Gong Minmeng Zhao Jiangsu key laboratory of animal genetic Breeding and Molecular Design College of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China Joint International Research laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China Yangzhou UniversityYangzhou 225009China

Selenium is an essential trace element for humans and *** the active center of selenoproteins,the addition of selenium is beneficial to enhance the antioxidant ***,the high cost limits the application of organic Se in agriculture animal *** glucose(SeGlu)is a newly invented organoselenium material with good stability,low toxicity and low *** assay found that SeGlu was able to increase selenium deposition in liver of newborn broilers,and enhance the antioxidant capacity of liver by elevating the activities of antioxidant enzymes such as total superoxide dismutase and glutathione *** paper as the first example clarifying the mechanism of SeGlu to enhance the antioxidant ability of chicks,shows that SeGlu can be used as an organic selenium enrichment additive for early nutrition of *** a cross-discipline study involving chemistry,biology and agriculture animal science,the work may be beneficial for studies in related fields and prompt the development of the selenium science.

关键词： Selenized glucose In ovo feeding Antioxidant capacity Selenium Broiler

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Improve meat production and virus resistance by simultaneously editing multiple genes in livestock using Cas12i^(Max)

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Science China(Life Sciences) 2024年第3期67卷 555-564页

作者： Jilong Ren Tang Hai Yangcan Chen Ke Sun Zhiqiang Han Jing Wang Chongyang Li Qingwei Wang Leyun Wang Huabing Zhu Dawei Yu Wei Li Shanjiang Zhao State key laboratory of animal nutrition Key Laboratory of Animal GeneticsBreeding and Reproduction of Ministry of Agriculture and Rural AffairsInstitute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China State key laboratoryf Stem Cell and Reproductive Biology Instituteof ZooogyChinese Academyof SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Beijing Farm animal Research Center Institute of ZoologyChinese Academy of SciencesBeijing 100101China

The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated gene(Cas) system is continually optimized to achieve the most efficient gene editing effect. The Cas12i^(Max), a Cas12i variant, exhibits powerful DNA editing activity and enriches the gene editing toolbox. However, the application of Cas12i^(Max)in large domestic animals has not yet been reported. To verify the efficiency and feasibility of multiple gene editing in large animals, we generated porcine fibroblasts with simultaneous knockouts of IGF2, ANPEP, CD163,and MSTN via Cas12i^(Max)in one step. Phenotypically stable pigs were created through somatic cell nuclear transfer technology. They exhibited improved growth performance and muscle quality. Furthermore, we simultaneously edited three genes in bovine fibroblasts. A knockout of MSTN and PRNP was created and the amino acid Q-G in CD18 was precisely substituted. Meanwhile, no off-target phenomenon was observed by sum-type analysis or off-target detection. These results verified the effectiveness of Cas12i^(Max)for gene editing in livestock animals and demonstrated the potential application of Cas12i^(Max)in the field of animal trait improvement for agricultural production.

关键词： Cas12i^(Max) gene editing livestock multiple trait improvement

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Potential Adverse Outcome Pathways of Chlorinated Organophosphate Flame Retardants

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China CDC weekly 2024年第23期6卷 542-546,I0008-I0011页

作者： Meiyu Zhou Huilin Zhang Qi Xiao Kexin Li Xiaoting Li Haiyan Chu Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineSchool of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of genetic Toxicology The Key Laboratory of Modern Toxicology of Ministry of EducationCenter of Global HealthSchool of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of nutrition and Food Safety School of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina

What is already known about this topic?Chlorinated organophosphate flame retardants(Cl-OPFRs)are frequently detected chemicals in the environment and biological samples,yet there is a lack of systematic evaluation regarding the adverse effects and toxicological mechanisms of *** is added by this report?This study utilizes the adverse outcome pathway(AOP)framework to assess the health implications and mechanisms of Cl-OPFRs,identifying multi-system toxicity,with a particular emphasis on reproductive issues and the possible toxic *** are the implications for public health practice?These results enhance knowledge of the health hazards linked to Cl-OPFRs,supporting the creation of focused risk evaluations and suitable regulatory actions.

关键词： utilize supporting Chlorin

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Utilizing resequencing big data to facilitate Brassica vegetable breeding:tracing introgression pedigree and developing highly specific markers for clubroot resistance

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Horticultural Plant Journal 2024年第3期10卷 771-783页

作者： Zhiyong Ren Jinquan Li Xingyu Zhang Xingxu Li Junhong Zhang Zhibiao Ye Yuyang Zhang Qijun Nie key laboratory of Vegetable Ecological Cultivation on Highland Ministry of Agriculture and Rural AffairsHubei Key Laboratory of Vegetable Germplasm Enhancement and Genetic ImprovementInstitute of Economic CropsHubei Academy of Agricultural SciencesWuhanHubei 430063China National key laboratory for Germplasm innovation and Utilization of Horticultural Crops Huazhong Agricultural UniversityWuhanHubei 430070China Vegetable Research Institute Wuhan Academy of Agricultural SciencesWuhanHubei 430345China Hubei Hongshan laboratory WuhanHubei 430070China Shenzhen Institute of nutrition and Health Huazhong Agricultural UniversityWuhanHubei 430070China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518000China

Clubroot caused by Plasmodiophora brassicae is a devastating disease of Cruciferous *** cultivars with clubroot resistance(CR)is the most effective control *** the two major Brassica vegetable species *** and ***,several commercial cultivars with unclear CR pedigrees have been intensively used as CR donors in ***,the continuous occurrence of CR-breaking makes the CR pedigree underlying these cultivars one of the breeders'most urgent *** complex intraspecific diversity of these two major Brassica vegetables has also limited the applicability of CR markers in different breeding *** we first traced the pedigree underlying two kinds of CR that have been widely applied in breeding by linkage and introgression analyses based on public resequencing *** ***,a major locus CRzi8 underlying the CR of the commercial CR donor‘DegaoCR117’was ***8 was further shown to have been introgressed from turnip(*** ***)and that it carried a potential functional allele of *** turnip introgression carried CRb^(c),sharing the same coding sequence with the CRb that was also identified from chromosome C07 of *** CR cultivars with different *** natural populations,variation analysis of linkage intervals of CRzi8,PbBa8.1,CRb,and CRb^(c)yielded easily resolved InDel markers(>20 bp)for these fundamental CR *** specificity of these markers was tested in diverse cultivars panels,and each exhibited high reliability in *** research demonstrates the value of the practice of applying resequencing big data to solve urgent concerns in breeding programs.

关键词： Brassica Clubroot resistance Resequencing Introgression analysis Molecular marker

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Flavonoids from mulberry leaves inhibit fat production and improve fatty acid distribution in adipose tissue in finishing pigs

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animal nutrition 2024年第1期16卷 147-157页

作者： Yingying Liu Yinglin Peng Chen Chen Huibo Ren Ji Zhu Yuan Deng Qingming Cui Xionggui Hu Jianhua He Huali Li Xinghui Zhu Yulong Yin Jun He Yi Xiao College of animal Science and Technology Hunan Agricultural UniversityChangsha410128China Hunan Institute of animal and Veterinary Science Changsha410131China key laboratory of Conservation and genetic Analysis of Local Pig Breed Germplasm Resources Changsha410131China College of Information and Intelligence Hunan Agricultural UniversityChangsha410128China Institute of Subtropical Agriculture Chinese Academy of SciencesChangsha410125China

This study evaluated the effects of flavonoids from mulberry leaves(FML)on plasma biochemical indices,serum activities of lipid metabolism-related enzymes,fat morphology,fatty acid composition,and lipid metabolism in different adipose tissues of finishing *** used 120 Chinese hybrid barrows of Berkshire and Bama mini-pigs with an average initial body weight of 45.11±4.23 *** pigs were randomly assigned to five treatment groups and fed a control diet based on corn,soybean meal,and wheat bran or a control diet supplemented with 0.02%,0.04%,0.08%,or 0.16%*** experimental group had six replicates(pens),with four pigs per *** a 7-d adaptation period,the feeding trial was conducted for 58 *** and adipose tissue samples were collected from 30 pigs(one pig per pen)at the end of the *** results showed that FML supplementation significantly decreased the feed intake to body gain ratio,the plasma concentrations of total cholesterol and free fatty acids,and the serum activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase(linear or quadratic effects,P<0.05),and decreased the plasma triglyceride concentration(quadratic,P=0.07).Increasing FML supplementation increased the average daily gain and serum activities of lipoprotein lipase(linear and quadratic effects,P<0.05)and adipose triglyceride lipase(linear,P<0.05).Dietary FML supplementation decreased the adipocyte area in the dorsal subcutaneous adipose(DSA)tissue of finishing pigs(linear,P=0.05)and increased the adipocyte area in the visceral adipose tissue(quadratic,P<0.01).Increasing FML supplementation decreased the C20:1 content in DSA,abdominal subcutaneous adipose,and visceral adipose tissues of finishing pigs(P<0.05)and increased the C18:3n3 and n-3 PUFA contents(P<0.05).The lipid metabolism genes were regulated by the PPARγ-LXRa-ABCA1 signaling pathway,and their expressions differed in different adipose *** findings suggest that FML improved growth performance,regulated lipid met

关键词： Finishing pig Mulberry leaf Flavonoid Lipid metabolism Fatty acid Lard

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Whole-genome resequencing of Hu sheep identifies candidate genes associated with agronomic traits

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Journal of genetics and Genomics 2024年第8期51卷 866-876页

作者： Liming Zhao Lvfeng Yuan Fadi Li Xiaoxue Zhang Huibin Tian Zongwu Ma Deyin Zhang Yukun Zhang Yuan Zhao Kai Huang Xiaolong Li Jiangbo Cheng Dan Xu Xiaobin Yang Kunchao Han Xiuxiu Weng Weimin Wang State key laboratory of Herbage Improvement and Grassland Agro-Ecosystems Key Laboratory of Grassland Livestock Industry InnovationMinistry of Agriculture and Rural AffairsEngineering Research Center of Grassland IndustryMinistry of EducationCollege of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhouGansu 730020China Lanzhou Veterinary Research Institute Chinese Academy of Agricultural SciencesLanzhouGansu 730046China College of animal Science and Technology Gansu Agricultural UniversityLanzhouGansu 730070China

The phenotypic diversity resulting from artificial or natural selection of sheep has made a significant contribution to human *** sheep are a local sheep breed unique to China with high reproductive rates and rapid *** selection signatures have been widely used to investigate the genetic mechanisms underlying phenotypic variation in ***,we conduct whole-genome sequencing of 207 Hu sheep and compare them with the wild ancestors of domestic sheep(Asiatic mouflon)to investigate the genetic characteristics and selection signatures of Hu *** on six signatures of selection approaches,we detect genomic regions containing genes related to reproduction(BMPR1B,BMP2,PGFS,CYP19,CAMK4,GGT5,and GNAQ),vision(ALDH1A2,SAG,and PDE6B),nervous system(NAV1),and immune response(GPR35,SH2B2,PIK3R3,and HRAS).Association analysis with a population of 1299 Hu sheep reveals that those missense mutations in the GPR35(GPR35 g.952651 A>G;GPR35 g.952496 C>T)and NAV1(NAV1 g.84216190 C>T;NAV1 g.84227412 G>A)genes are significantly associated(Pcharacteristics of Hu sheep and facilitates further genetic improvement and molecular investigations.

关键词： Hu sheep Whole-genome resequencing Selection signature GPR35 NAV1 Single nucleotide polymorphism

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Structure， properties， bioactivities and structure-activity relationships of polysaccharides from Nostoc flagelliforme grown under three different culture conditions

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Food Science and Human Wellness 2024年

作者： Yanru Li Shigang Shen Longfei Wang Mengyuan Li Yan Zhang Shiru Jia Ruiying Zhu Peipei Han State key laboratory of Food nutrition and Safety， key laboratory of Industrial Fermentation Microbiology， Ministry of Education， College of Biotechnology， Tianjin University of Science and Technology

The physicochemical properties， structural characteristics， antioxidant， radioprotective and lipid-lowering activities， as well as the underlying structure-activity relationships of polysaccharides extracted from Nostoc flagelliforme grown under normal （WL-EPS-1）， salt stress （NaCl-EPS-1） and mixotrophic culture conditions （Glu-EPS-1） were studied. The results demonstrated that WL-EPS-1， NaCl-EPS-1 and Glu-EPS-1 were heteropolysaccharides comprising different proportions of monosaccharides and uronic acid， with different average molecular weights of 0.99 × 103， 1.09 × 103and 1.18 × 103kDa， respectively. Their intrinsic viscosity values were significantly different， at 24.72 dL/g， 29.98 dL/g and 41.06 dL/g， respectively. The functional groups of polysaccharides were not greatly affected， but the chemical composition， triple-helix structure， chain length and surface morphology were significantly influenced by culture conditions. In vitro bioactivity assays showed that the antioxidant activity generally increased in the order of WL-EPS-1 < NaCl-EPS-1 < Glu-EPS-1， while NaCl-EPS-1 had the best radioprotective effect， and Glu-EPS-1 had the best lipid-lowering effect. In addition， the structure-activity relationship of the polysaccharides was analyzed by Partial Least Squares （PLS）， which revealed that the most important factors affecting the antioxidant， radioprotective and lipid-lowering activities of polysaccharides were viscosity and molecular weight. This study provides a strategy for obtaining high-bioactivity polysaccharides by appropriate regulation of culture conditions， as well as opening new directions for the molecular modification of polysaccharides.

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Metabolic profiles and morphological characteristics of leaf tips among different sweet potato(Ipomoea batatas Lam.)varieties

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Journal of Integrative Agriculture 2024年第2期23卷 494-510页

作者： Wenqing Tan Xinbo Guo Zhangying Wang Rong Zhang Chaochen Tang Bingzhi Jiang Ruixue Jia Yuanyuan Deng Shaohai Yang Jingyi Chen Crops Research Institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Crop Genetic Improvement of Guangdong ProvinceGuangzhou 510640China School of Food Science and Engineering South China University of TechnologyGuangzhou 510640China Sericultural&Agri-Food Research Institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional FoodsMinistry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products ProcessingGuangzhou 510610China

Sweet potato leaf tips have high nutritional value,and exploring the differences in the metabolic profiles of leaf tips among different sweet potato varieties can provide information to improve their *** this study,a UPLC-Q-Exactive Orbitrap/MS-based untargeted metabolomics method was used to evaluate the metabolites in leaf tips of 32 sweet potato *** varieties with distinct overall metabolic profiles(A01,A02,and A03),two varieties with distinct profiles of phenolic acids(A20 and A18),and three varieties with distinct profiles of flavonoids(A05,A12,and A16)were *** addition,a total of 163 and 29 differentially expressed metabolites correlated with the color and leaf shape of sweet potato leaf tips,respectively,were identified through morphological *** comparison analysis of the phenotypic traits and a metabolite-phenotypic trait correlation analysis indicated that the color differences of sweet potato leaf tips were markedly associated with ***,the level of polyphenols was correlated with the leaf shape of sweet potato leaf tips,with lobed leaf types having higher levels of polyphenols than the entire leaf *** findings on the metabolic profiles and differentially expressed metabolites associated with the morphology of sweet potato leaf tips can provide useful information for breeding sweet potato varieties with higher nutritional value.

关键词： sweet potato leaf tips phenotypic traits metabolic profile differentially expressed metabolites polyphenols

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