Whole-genome resequencing of Hu sheep identifies candidate genes associated with agronomic traits
作者机构：State Key Laboratory of Herbage Improvement and Grassland Agro-EcosystemsKey Laboratory of Grassland Livestock Industry InnovationMinistry of Agriculture and Rural AffairsEngineering Research Center of Grassland IndustryMinistry of EducationCollege of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhouGansu 730020China Lanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhouGansu 730046China College of Animal Science and TechnologyGansu Agricultural UniversityLanzhouGansu 730070China
出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)
年 卷 期：2024年第51卷第8期
页 面：866-876页
核心收录：
基 金：supported by the National Key Research and Development Program of China(2021YFD1300901,2022YFD1302000) National Natural Science Foundation of China(32260818,31960653)
主 题：Hu sheep Whole-genome resequencing Selection signature GPR35 NAV1 Single nucleotide polymorphism
摘 要：The phenotypic diversity resulting from artificial or natural selection of sheep has made a significant contribution to human *** sheep are a local sheep breed unique to China with high reproductive rates and rapid *** selection signatures have been widely used to investigate the genetic mechanisms underlying phenotypic variation in ***,we conduct whole-genome sequencing of 207 Hu sheep and compare them with the wild ancestors of domestic sheep(Asiatic mouflon)to investigate the genetic characteristics and selection signatures of Hu *** on six signatures of selection approaches,we detect genomic regions containing genes related to reproduction(BMPR1B,BMP2,PGFS,CYP19,CAMK4,GGT5,and GNAQ),vision(ALDH1A2,SAG,and PDE6B),nervous system(NAV1),and immune response(GPR35,SH2B2,PIK3R3,and HRAS).Association analysis with a population of 1299 Hu sheep reveals that those missense mutations in the GPR35(GPR35 g.952651 AG;GPR35 g.952496 CT)and NAV1(NAV1 g.84216190 CT;NAV1 g.84227412 GA)genes are significantly associated(P0.05)with immune and growth traits in Hu sheep,*** research offers unique insights into the selection characteristics of Hu sheep and facilitates further genetic improvement and molecular investigations.
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