Flavonoids from mulberry leaves inhibit fat production and improve fatty acid distribution in adipose tissue in finishing pigs
作者机构：College of Animal Science and TechnologyHunan Agricultural University Hunan Institute of Animal and Veterinary Science Key Laboratory of Conservation and Genetic Analysis of Local Pig Breed Germplasm Resources College of Information and IntelligenceHunan Agricultural University Institute of Subtropical AgricultureChinese Academy of Sciences
出 版 物：《Animal Nutrition》 (动物营养(英文))
年 卷 期：2024年第16卷第1期
页 面：147-157页
核心收录：
学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 0906[农学-兽医学] 09[农学]
基 金：supported by the Hunan Province Key R&D Program Project (2020NK2033) Natural Science Foundation of Hunan Province (2022JJ30317) Innovation Platform and Talent Plan Program of Hunan Province (2022NK4145) National Natural Science Foundation of China (31972600)
主 题：Finishing pig Mulberry leaf Flavonoid Lipid metabolism Fatty acid Lard
摘 要：This study evaluated the effects of flavonoids from mulberry leaves (FML) on plasma biochemical indices,serum activities of lipid metabolism-related enzymes,fat morphology,fatty acid composition,and lipid metabolism in different adipose tissues of finishing *** used 120 Chinese hybrid barrows of Berkshire and Bama mini-pigs with an average initial body weight of 45.11±4.23 *** pigs were randomly assigned to five treatment groups and fed a control diet based on corn,soybean meal,and wheat bran or a control diet supplemented with 0.02%,0.04%,0.08%,or 0.16%*** experimental group had six replicates (pens),with four pigs per *** a 7-d adaptation period,the feeding trial was conducted for 58 *** and adipose tissue samples were collected from 30 pigs (one pig per pen)at the end of the *** results showed that FML supplementation significantly decreased the feed intake to body gain ratio,the plasma concentrations of total cholesterol and free fatty acids,and the serum activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (linear or quadratic effects,P0.05),and decreased the plasma triglyceride concentration (quadratic,P=0.07).Increasing FML supplementation increased the average daily gain and serum activities of lipoprotein lipase (linear and quadratic effects,P0.05) and adipose triglyceride lipase (linear,P0.05).Dietary FML supplementation decreased the adipocyte area in the dorsal subcutaneous adipose (DSA) tissue of finishing pigs (linear,P=0.05) and increased the adipocyte area in the visceral adipose tissue (quadratic,P0.01).Increasing FML supplementation decreased the C20:1 content in DSA,abdominal subcutaneous adipose,and visceral adipose tissues of finishing pigs (P0.05) and increased the C18:3n3 and n-3 PUFA contents(P0.05).The lipid metabolism genes were regulated by the PPARγ-LXRa-ABCA1 signaling pathway,and their expressions differed in different adipose *** findings suggest that FML improved growth performance,reg
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