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Magnesium based degradable biomaterials： A review

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Frontiers of Materials Science 2014年第3期8卷 200-218页

作者： Xue-Nan GU Shuang-Shuang LI Xiao-Ming LI Yu-Bo FAN key laboratory for biomechanics and mechanobiology of ministry of education School of Biological Science and Medical Engineering Beihang University Beijing 100191 China

Magnesium has been suggested as a revolutionary biodegradable metal for biomedical applications. The corrosion of magnesium, however, is too rapid to match the rates of tissue healing and, additionally, exhibits the localized corrosion mechanism. Thus it is necessary to control the corrosion behaviors of magnesium for their practical use. This paper comprehensively reviews the research progress on the development of representative magnesium based alloys, including Mg-Ca, Mg-Sr, Mg-Zn and Mg-REE alloy systems as well as the bulk metallic glass. The influence of alloying element on their microstructures, mechanical properties and corrosion behaviors is summarized. The mechanical and corrosion properties of wrought magnesium alloys are also discussed in comparison with those of cast alloys. Furthermore, this review also covers research carried out in the field of the degradable coatings on magnesium alloys for biomedical applications. Calcium phosphate and biodegradable polymer coatings are discussed based on different preparation techniques used. We also compare the effect of different coatings on the corrosion behaviors of magnesium alloys substrate.

关键词： magnesium alloy degradable biomaterial coating degradation corrosion

Multi-functionalized nanofibers with reactive oxygen species scavenging capability and fibrocartilage inductivity for tendon-bone integration

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Journal of Materials Science & Technology 2021年第11期70卷 91-104页

作者： Peixing Chen Sixiang Wang Zhi Huang Yan Gao Yu Zhang Chunli Wang Tingting Xia Linhao Li Wanqian Liu Li Yang key laboratory of Biorheological Science and Technology Ministry of EducationBioengineering CollegeChongqing UniversityChongqing400044China key laboratory for biomechanics and mechanobiology of ministry of education School of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China

The presence of excessive reactive oxygen species(ROS)after injuries to the enthesis could lead to cellular oxidative damage,high inflammatory response,chronic inflammation,and limited fibrochondral inductivity,making tissue repair and functional recovery ***,a multifunctional silk fibroin nanofiber modified with polydopamine and kartogenin was designed and fabricated to not only effectively reduce inflammation by scavenging ROS in the early stage of the enthesis healing but also enhance fibrocartilage formation with fibrochondrogenic induction in the later *** in vitro results confirmed the antioxidant capability and the fibrochondral inductivity of the functionalized *** vivo studies showed that the multifunctional nanofiber can significantly improve the integration of tendon-bone and accelerate the regeneration of interface tissue,resulting in an excellent biomechanical ***,the incorporation of antioxidant and bio-active molecules into extracellular matrix-like biomaterials in interface tissue engineering provides an integrative approach that facilitates damaged tissue regeneration and functional recovery,thereby improving the clinical outcome of the engineered tissue.

关键词： Polydopamine Kartogenin Tendon-bone interface Reactive oxygen species Scavenging Fibrochondrogenic

Fatigue behavior of cortical bone:a review

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Acta Mechanica Sinica 2021年第3期37卷 516-526,I0004页

作者： Jingwen Li He Gong key laboratory for biomechanics and mechanobiology of ministry of education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China

Fatigue is a common cause of bone *** the main load-bearing tissue,cortical bone carries a considerable share of load in the whole *** cyclic loading condition,microdamage may generates and accumulates in cortical bone,which further triggers the fracture of *** is crucial to explore the fatigue properties of cortical bone and the influential factors for both clinical diagnosis and establishment of models that can predict fatigue failure of human cortical *** this review,the fatigue behavior of cortical bone was *** the complex hierarchical structure and self-repairing process,the risk of catastrophic fracture is *** on these understandings,the multiple influential factors of cortical bone fatigue properties were analyzed,which were considered to be a combination of internal and external *** internal factors include material properties of bone composition(i.e.,mineral,organic material,and water)and bone *** factors refer to loading condition such as frequency,amplitude and direction of ***,age,disease,radiation exposure and other factors affect the fatigue behavior of bone by altering one or more factors mentioned above.

关键词： Cortical bone Fatigue Microdamage Influential factor

Biological analysis of woodpecker’s brain after impact experiments

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Science China(Technological Sciences) 2021年第5期64卷 1101-1106页

作者： XU Peng NI YiKun LIU JingLong ZHANG WeiRong LIU SiJian WANG LiZhen FAN YuBo key laboratory for biomechanics and mechanobiology of ministry of education Beijing Advanced Innovation Centre for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China

Woodpeckers can withstand a fierce impact during *** studies have focused on the biomechanical analysis of the pecking process,the properties of the beak and hyoid bone of woodpecker;however,the biological characteristics of the woodpecker brain are also important in resisting impact *** employed impact experiments and biological analysis in normal and injured brains to reveal the impact-resistant biological characteristics of woodpecker brains,as well as the impact energy’s biological effects on the woodpecker *** hoopoe,which has a similar size but only a slight pecking behavior,was selected as the control group to compare brain morphology and neuronal cells differences in normal brains between woodpecker and hoopoe by sectioning and staining.A loading device was designed to conduct a quantifiable impact energy to the woodpeckers’*** groups of woodpeckers were impacted with the same energy on the forehead,beak,tempus and occiput,*** changes in the injured brains were evaluated by Nissl staining and enzyme-linked immunosorbent *** results showed that:(1)woodpeckers had a larger cerebellum and a higher density of Nissl bodies than hoopoe;(2)Nissl apoptosis appeared in the brain samples after the forehead and the occiput impact experiments,but no obvious Nissl body apoptosis was observed after impact on the tempus and the beak;(3)β-amyloid protein accumulated in the normal status woodpecker *** study reveals that:woodpecker brain morphology is well-adapted to impact,woodpecker heads display location-dependent protective performance,with beak and tempus regions having a better protective performance than the forehead and occiput,Nissl apoptosis appears in injured woodpecker brains,and that the accumulation ofβ-amyloid protein does not show a direct relationship with the injury state of woodpecker’s brain tissue in our study.

关键词： woodpecker biomechanics impact experiments impact resistance biological analysis

Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials:Based on the mechanisms of occurrence and development of adhesions

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Bioactive Materials 2023年第8期26卷 387-412页

作者： Jie Liao Xiaoming Li Yubo Fan key laboratory for biomechanics and mechanobiology of ministry of education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China

Postoperative adhesion(POA)widely occurs in soft tissues and usually leads to chronic pain,dysfunction of adjacent organs and some acute complications,seriously reducing patients’quality of life and even being *** for adhesiolysis,there are few effective methods to release existing ***,it requires a second operation and inpatient care and usually triggers recurrent adhesion in a great ***,preventing POA formation has been regarded as the most effective clinical *** have attracted great attention in preventing POA because they can act as both barriers and drug ***,even though much reported research has been demonstrated their efficacy on POA inhibition to a certain extent,thoroughly preventing POA formation is still ***,most biomaterials for POA prevention were designed based on limited experiences,not a solid theoretical basis,showing ***,we aimed to provide guidance for designing anti-adhesion materials applied in different soft tissues based on the mechanisms of POA occurrence and *** first classified the postoperative adhesions into four categories according to the different components of diverse adhesion tissues,and named them as“membranous adhesion”,“vascular adhesion”,“adhesive adhesion”and“scarred adhesion”,***,the process of the occurrence and development of POA were analyzed,and the main influencing factors in different stages were ***,we proposed seven strategies for POA prevention by using biomaterials according to these influencing ***,the relevant practices were summarized according to the corresponding strategies and the future perspectives were analyzed.

关键词： Prevention of postoperative adhesions(POA) Soft tissues Mechanisms of occurrence and development Biomaterials

Recent electroporation-based systems for intracellular molecule delivery

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Nanotechnology and Precision Engineering 2021年第4期4卷 45-52页

作者： Zaizai Dong Lingqian Chang key laboratory for biomechanics and mechanobiology of ministry of education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China

Intracellular delivery of functional molecules,such as DNA probes and plasmids,is an important method for investigating cellular mechanisms and changing cell fates in *** various delivery methods,recent years have seen the emergence of electroporation-based techniques that provide versatile platforms for molecule delivery,with high efficiency and controlled *** this Review,we describe recent electroporation-based systems for intracellular molecule *** principles of electroporation for cell membrane perforation and cargo delivery are briefly *** on various scenarios for the application of electroporation,we review electroporation devices that variously employ structures based on nanochannels,nanostraws,and flow-through microfluidic channels for in vitro intracellular molecule *** also consider in vivo targeted therapies based on delivery of active molecules by electroporation according to the lesion ***,we discuss the current challenges facing electroporation-based techniques,as well as opportunities for their future development,which may lead to innovations in intracellular molecule delivery both for cellular analysis in the laboratory and treatment in the clinic.

关键词： Electroporation Intracellular delivery Micro/nanodevice Targeted therapy

The study on the mechanical characteristics of articular cartilage in simulated microgravity

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Acta Mechanica Sinica 2012年第5期28卷 1488-1493页

作者： Hai-Jun Niu Qing Wang Yue-Xiang Wang Ang Li Lian-Wen Sun Yan Yan Fan Fan De-Yu Li Yu-Bo Fan key laboratory of the ministry of education for biomechanics and mechanobiology State Key Laboratory of Software Development EnvironmentSchool of Biological Science and Medical EngineeringBeihang University School of Biomedical Engineering Southern Medical University Department of Ultrasound People Liberation Army General Hospital

The microgravity environment of a long-term space flight may induce acute changes in an astronaut＇s musculo-skeletal systems. This study explores the effects of simulated microgravity on the mechanical characteristics of articular cartilage. Six rats underwent tail suspension for 14 days and six additional rats were kept under normal earth gravity as controls. Swelling strains were measured using high-frequency ultrasound in all cartilage samples subject to osmotic loading. Site-specific swelling strain data were used in a triphasic theoretical model of cartilage swelling to determine the uniaxial modulus of the cartilage solid matrix. No severe surface irregularities were found in the cartilage samples obtained from the control or tail-suspended groups. For the tail-suspended group, the thickness of the cartilage at a specified site, as determined by ultrasound echo, showed a minor decrease. The uniaxial modulus of articular cartilage at the specified site decreased significantly, from （6.31 ± 3.37） MPa to （5.05 ± 2.98）MPa （p 〈 0.05）. The histology- stained image of a cartilage sample also showed a reduced number of chondrocytes and decreased degree of matrix staining. These results demonstrated that the 14 d simulated microgravity induced significant effects on the mechanical characteristics of articular cartilage. This study is the first attempt to explore the effects of simulated microgravity on the mechanical characteristics of articular cartilage using an osmotic loading method and a triphasic model. The conclusions may provide reference information for manned space flights and a better understanding of the effects of microgravity on the skeletal system.

关键词： Simulated microgravity Articular cartilage.Triphasic theory High-frequency ultrasound Uniaxialmodulus

A histological and biomechanical study of bone stress and bone remodeling around immediately loaded implants

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Science China(Life Sciences) 2014年第6期57卷 618-626页

作者： HAN JingYun HOU JianXia ZHOU Gang WANG Chao FAN YuBo key Lab for biomechanics and mechanobiology of ministry of education School of Biological and Medical EngineeringBeihang University Peking University School and Hospital of Stomatology

Immediate loading(IL)increases the risk of marginal bone *** present study investigated the biomechanical response of peri-implant bone in rabbits after IL,aiming at optimizing load ***-six implants were installed bilaterally into femurs of 48 *** implants on the left side created the maximal initial stress of 6.9 and 13.4 MPa in peri-implant bone and unloaded implants on the contralateral side were *** morphology and bone-implant interface strength were measured with histological examination and push-out testing during a 12-week observation ***,the animal data were incorporated into finite element(FE)models to calculate the bone stress distribution at different levels of *** showed that the stress was concentrated in the bone margin and the bone stress gradually decreased as osseointegration proceeded.A stress of about 2.0 MPa in peri-implant bone had a positive effect on new bone formation,osseointegration and bone-implant interface *** loss was observed in some specimens with stress exceeding 4.0 *** indicate that IL significantly increases bone stress during the early postoperative period,but the load-bearing capacity of peri-implant bone increases rapidly with an increase of bone-implant *** bone responses may be continually promoted when the stress in peri-implant bone is maintained at a definite ***,the progressive loading mode is recommended for IL implants.

关键词： implant osseointegration bone remodeling immediate loading finite element analysis

Effect of mechanical stresses on degradation behavior of high-purity magnesium in bone environments

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Journal of Materials Science & Technology 2024年第4期171卷 252-261页

作者： Yan Yao Jie Xia Lizhen Wang Yuanming Gao Xili Ding Chao Wang Yubo Fan key laboratory of biomechanics and mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing 100083China

High-purity(HP)magnesium(Mg)has emerged as a promising biomaterial for supporting functional bone *** previous study found that mechanical stresses and the surrounding fibrotic tissue(subcuta-neous)both play crucial roles in the degradation of HP ***,due to challenges in the degradation and regeneration process in vivo,it remains unclear how stress affects HP Mg degradation in bone en-vironments,limiting its further *** this study,novel loading devices were designed and the effects of tensile and compressive stresses on HP Mg degradation in vivo and in vitro bone environments were quantitatively *** addition,bone osteointegration around HP Mg was explored *** stress increases the degradation rate of HP Mg in vivo and in *** Mg degradation in vivo is more sensitive to stress factors than in vitro,but the sensitivity decreases with corrosion *** volume loss rate of HP Mg is multilinear with the applied stress and degradation *** volume of bone tissue surrounding HP Mg is larger in the no-stress group compared to the stressed groups,which is more pronounced with increasing implantation *** results provide valuable insights for optimiz-ing the design of HP Mg-based implants considering load *** will help to achieve a balance between the degradation rate of the implant and the regeneration rate of the surrounding bone.

关键词： High-purity magnesium Quantitative stresses Degradation Bone environments In vivo and in vitro