A histological and biomechanical study of bone stress and bone remodeling around immediately loaded implants

作     者：HAN JingYun HOU JianXia ZHOU Gang WANG Chao FAN YuBo 

作者机构：Key Lab for Biomechanics and Mechanobiology of Ministry of EducationSchool of Biological and Medical EngineeringBeihang University Peking University School and Hospital of Stomatology 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2014年第57卷第6期

页      面：618-626页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1003[医学-口腔医学] 100302[医学-口腔临床医学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(10902010,11120101001) National Science&Technology Pillar Program of China(2012BAI22B02) Research Fund for the Doctoral Program of Higher Education of China(20131102130004) 

主　　题：implant osseointegration bone remodeling immediate loading finite element analysis 

摘      要：Immediate loading(IL)increases the risk of marginal bone *** present study investigated the biomechanical response of peri-implant bone in rabbits after IL,aiming at optimizing load ***-six implants were installed bilaterally into femurs of 48 *** implants on the left side created the maximal initial stress of 6.9 and 13.4 MPa in peri-implant bone and unloaded implants on the contralateral side were *** morphology and bone-implant interface strength were measured with histological examination and push-out testing during a 12-week observation ***,the animal data were incorporated into finite element(FE)models to calculate the bone stress distribution at different levels of *** showed that the stress was concentrated in the bone margin and the bone stress gradually decreased as osseointegration proceeded.A stress of about 2.0 MPa in peri-implant bone had a positive effect on new bone formation,osseointegration and bone-implant interface *** loss was observed in some specimens with stress exceeding 4.0 *** indicate that IL significantly increases bone stress during the early postoperative period,but the load-bearing capacity of peri-implant bone increases rapidly with an increase of bone-implant *** bone responses may be continually promoted when the stress in peri-implant bone is maintained at a definite ***,the progressive loading mode is recommended for IL implants.