检索结果-南通市图书馆

Exploring the utility of organo-polyoxometalate hybrids to inhibit SOX transcription factors

Cell Regeneration 2014年第1期3卷 69-75页

作者： Kamesh Narasimhan Kevin Micoine Emmanuel Lacôte Serge Thorimbert Edwin Cheung Bernold Hasenknopf Ralf Jauch Donnelly Centre for Cellular and Biomolecular Research University of TorontoToronto M5S 3E1Canada Genome Institute of Singapore 60 Biopolis StreetBuona Vista 138672Singapore Sorbonne Universités UPMC Univ Paris 06Institut Parisien de Chimie MoléculaireUMR 82324 Place Jussieu75005 ParisFrance CNRS Institut Parisien de Chimie MoléculaireUMR 82324 Place Jussieu75005 ParisFrance Faculty of Health Sciences University of MacaoAv.Padre Tomas PereiraTaipaMacaoChina Genome Regulation Laboratory Drug Development PipelineGuangzhou Institutes of Biomedicine190 Kai Yuan AvenueScience Park510530 GuangzhouChina

Background:SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer ***,rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical ***(POMs)are inorganic compounds that were previously shown to target the high-mobility group(HMG)of SOX proteins at nanomolar *** continuation of this work,we carried out an assessment of the selectivity of a panel of newly synthesized organo-polyoxometalate hybrids in targeting different transcription factor families to enable the usage of polyoxometalates as specific SOX transcription factor ***:The residual DNA-binding activities of 15 different transcription factors were measured after treatment with a panel of diverse *** belonging to the Dawson structural class were found to be more potent inhibitors than the Keggin ***,organically modified Dawson polyoxometalates were found to be the most potent in inhibiting transcription factor DNA binding *** size of the polyoxometalates and its derivitization were found to be the key determinants of their ***:Polyoxometalates are highly potent,nanomolar range inhibitors of the DNA binding activity of the Sox-HMG ***,binding assays involving a limited subset of structurally diverse polyoxometalates revealed a low selectivity profile against different transcription factor *** progress in achieving selectivity and deciphering structure-activity relationship of POMs require the identification of POM binding sites on transcription factors using elaborate approaches like X-ray crystallography and multidimensional *** summary,our report reaffirms that transcription factors are challenging molecular architec

关键词： architectures attractive rational

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

长期区域化疗在转移性肝癌治疗中的地位

引用

德国医学 2000年第2期17卷 67-68页

作者： M.Lorenz E.Staib-Sebler C.Gog G.Vetter H.Petrowsky H.-H.Mller 吴亚群 Klinik fr Allgemein-und Gefβchirurgie Klinikum der Johann Wolfgang Goethe-UniversittTheodor-Stem-Kai 7D-60590 Frankfurt am MainGermany 同济医科大学附属同济医院

肝转移癌动脉内化疗已有50余年历史,但长期以来仅作为症状治疗。皮下置泵肝动脉插管问题解决后,区域化疗得到重视。氟尿嘧啶脱氧核苷(FUdR)可在肝内维持高浓度,且具良好的溶解性,可经皮下植入泵使用,使病人能在门诊接受2～3周的化疗。... 详细信息

肝转移癌动脉内化疗已有50余年历史,但长期以来仅作为症状治疗。皮下置泵肝动脉插管问题解决后,区域化疗得到重视。氟尿嘧啶脱氧核苷(FUdR)可在肝内维持高浓度,且具良好的溶解性,可经皮下植入泵使用,使病人能在门诊接受2～3周的化疗。其生活质量和有效率(约50％)高于全身化疗组。尽管化学性肝炎、胃十二指肠溃疡、胆管硬化等不良反应只见于动脉内FUdR治疗者,而并不发生于欧洲应用5-氟尿嘧啶(5-Fu)治疗方案者,但肝转移癌的区域治疗还未获公认。

关键词：肝转移瘤药物疗法区域性化疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Head Position of Patients with Right Hemisphere Damage during a Visual Search Task in a Large Field

引用

World Journal of Neuroscience 2018年第2期8卷 190-202页

作者： Ken Nakatani Shusuke Takahashi Daisuke Kimura Masako Notoya Nobuyuki Sunahara Takashi Fujita Minoru Toyama Shinya Fukunaga Naoe Mori Kiyoe Sakai Shinya Fuwa Department of Rehabilitation Sciences Kansai University of Welfare Sciences Osaka Japan Department of Living and Welfare Faculty of Home Economics Kyoto Women’s University Kyoto Japan Department of Speech and Hearing Sciences and Disorders Kyoto Gakuen University Kyoto Japan School of Health Sciences College of Medical Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan Division of Occupational Therapy Faculty of Care and Rehabilitation Seijoh University Tōkai Japan Department of Sensory Science Faculty of Health Science and Technology Kawasaki University of Medical Welfare Kurashiki Japan

Spatial neglect syndrome with cerebral lesions is characterized by the ina-bility to orient, report, or respond to relevant visual stimuli contralateral to the lesions. In this study, we investigated the pattern of horizontal visual search in a large space;this search was performed by patients with right hemisphere damage caused by cerebrovascular disease. The neck rotation angle and search time in each increment were continuously recorded during the task, and quantitative data of the measurements were collected. Head position during the visual search task in a large space (%) was then calculated. We set angular bands in increments of 5 degrees from the midline on the left and right sides, and calculated the total search time in each angular band. In patients with unilateral spatial neglect (USN), the search time in the angular band of 5 - 9 on the right side was significantly longer (with USN 16.7%, without USN 4.5%, t = 2.52, df = 16, p < 0.05). Furthermore, in patients with neglect in the leftmost end area in a large space, the search time was significantly shorter in the angular band of 1 - 4 degrees to the left (with neglect 13.1%, without neglect 23.7%, t = 2.13, df = 16, p < 0.05), and tended to be long in the angular band of 5 - 9 to the right. The neck rotation angle and pattern during the search task in a large field deviated slightly to the right, and the search time slightly to the left was short. We believe that these results support the rightward deviation of the search pattern and frame of USN patients.

关键词： Head Position Neck Rotation Angle Unilateral Spatial Neglect Visual Exploration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

α-干扰素和病毒唑:慢性丙型肝炎治疗的进展

引用

德国医学 2000年第3期17卷 151-153页

作者： S.Zeuzenm 郝连杰 Medizinische Klinik Ⅱ Zentrum der Inneren Medizin Klinikum der Johann-Wolfagng-Goethe-Universitt Theodora. m.-Stem-Kai 7 D-60590 FrankfurtGermany 同济医科大学附属同济医院

70%～80%的丙型肝炎病毒感染为慢性经过,约30%患者发展成肝硬化,而且发生肝细胞性肝癌的危险性甚高。慢性丙型肝炎病人伴转氨酶升高治疗的适应证是排除其它肝脏疾病,检出丙型肝炎病毒特异性RNA 和组织学证实存在慢性肝炎。慢性丙型肝炎... 详细信息

70%～80%的丙型肝炎病毒感染为慢性经过,约30%患者发展成肝硬化,而且发生肝细胞性肝癌的危险性甚高。慢性丙型肝炎病人伴转氨酶升高治疗的适应证是排除其它肝脏疾病,检出丙型肝炎病毒特异性RNA 和组织学证实存在慢性肝炎。慢性丙型肝炎的首要治疗目的是治疗6个月后。

关键词：丙型肝炎药物疗法 α-干扰素病毒唑

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

斜视手术和遮盖疗法后斜视性弱视的患儿对视物变形的适应——遮盖疗法与视物变形

引用

世界核心医学期刊文摘（眼科学分册） 2006年第6期2卷 31-31页

作者： Fronius M. 王永强(译) Zentrum der Augenheilkunde Theodor-Stern-Kai 7 60590 Frankfurt amMain Germany 不详

Background: Reduced visual acuity and deficient binocularity are well-known symptoms of amblyopia. Distortions of visual space perception were reportedmore recently in strabismic amblyopia. This study investigated whether strabismus surgery and occlusion therapy have an influence on these deficits in amblyopic children. Materials and Methods: Two aspects of vertical alignment of amblyopic eyes,namely spatial distortion and spatial uncertainty,were investigated prospectively in 13 children (mean age 6 years 9 months) before and after strabismus surgery and in 12 children (mean age 6 years 11 months) during 6 months of occlusion therapy. Results: A different impact of the two types of therapeutic intervention was observed: a slight (statistically not significant) increase of uncertainty was the only change noticed postoperatively after 1 week,spatial distortions were not affected. During occlusion treatment,both clear shifts of alignment and a decrease of uncertainty occurred. Conclusions: The geometry of visual space of amblyopic children showed modifications due to altered visual experience during treatment,most obviously during occlusion therapy. These changes are evidence for unknown features of plasticity of the amblyopic visual system initiated by treatment.

关键词：斜视性弱视遮盖疗法视物变形弱视患儿斜视手术平均年龄治疗方案视觉系统前瞻性研究显著性差异

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells

引用

Cell Regeneration 2013年第1期2卷 42-49页

作者： Jinglei Cai Yanmei Zhang Pengfei Liu Shubin Chen Xuan Wu Yuhua Sun Ang Li Ke Huang Rongping Luo Lihui wang Ying Liu Ting Zhou Shicheng Wei Guangjin Pan Duanqing Pei CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cell Biology and Regenerative Medicine South China Institute for Stem Cell Biology and Regenerative MedicineGuangzhou Institute of Biomedicine and HealthChinese Academy of Sciences190 Kai Yuan AvenueScience ParkGuangzhou 510530P.R.China Department of Regeneration Medicine School of PharmaceuticalJilin UniversityChangchunP.R.China Department of Oral and Maxillofacial Surgery Laboratory of Interdisciplinary StudiesSchool and Hospital of StomatologyPeking UniversityBeijingP.R.China Biodynamic Optical Imaging Center(BIOPIC) Peking UniversityBeijingP.R.China The Shenzhen Key Lab of Gene and Antibody Therapy Center for Biotech&Biomedicine and Division of Life SciencesGraduate School at ShenzhenTsinghua UniversityShenzhenP.R.China Center for Biomedical Materials and Tissue Engineering Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijingP.R.China.

Background:Tooth is vital not only for a good smile,but also good ***,we lose tooth regularly due to accidents or *** ideal solution to this problem is to regenerate tooth with patients’own *** we describe the generation of tooth-like structures from integration-free human urine induced pluripotent stem cells(ifhU-iPSCs).Results:We first differentiated ifhU-iPSCs to epithelial sheets,which were then recombined with E14.5 mouse dental ***-like structures were recovered from these recombinants in 3 weeks with success rate up to 30%for 8 different iPSC lines,comparable to H1 *** further detected that ifhU-iPSC derived epithelial sheets differentiated into enamel-secreting ameloblasts in the tooth-like structures,possessing physical properties such as elastic modulus and hardness found in the regular human ***:Our results demonstrate that ifhU-iPSCs can be used to regenerate patient specific dental tissues or even tooth for further drug screening or regenerative therapies.

关键词： Human urine Integration-free iPSCs Recombinant tooth Bioengineered tooth Dental epithelium

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Tanshinone IIA on LPS-induced inflammatory response in a ROS-NLRP3 inflammasome dependent manner in RAW264.7 cells

引用

TMR Modern Herbal Medicine 2019年第3期2卷 131-139页

作者： Dan Li Shan Gao Sarhene Michael Yu-Ying Guo Hao Deng Shi-Xin Xu Guan-Wei Fan First Teaching Hospital of Tianjin University of Traditional Chinese Medicine 314 An Shan Xi RoadNan Kai District Tianjin300193China Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome Tianjin 300193China

目的:探讨丹参酮IIA抑制LPS诱导的Raw264.7细胞炎症反应作用机制。方法:LPS刺激RAW264.7细胞构建炎症细胞模型,筛选丹参酮IIA药物适宜浓度,利用DCFH-DA荧光探针检测细胞ROS水平变化,通过实时荧光定量PCR检测NLRP3,IL-1βmRNA水平变化,We... 详细信息

目的:探讨丹参酮IIA抑制LPS诱导的Raw264.7细胞炎症反应作用机制。方法:LPS刺激RAW264.7细胞构建炎症细胞模型,筛选丹参酮IIA药物适宜浓度,利用DCFH-DA荧光探针检测细胞ROS水平变化,通过实时荧光定量PCR检测NLRP3,IL-1βmRNA水平变化,WesternBlot检测p-p65/p65,p-p38/p38,NLRP3,HMGB1蛋白表达。结果:丹参酮IIA能够抑制LPS诱导的RAW264.7细胞炎性反应递质NO及炎症因子TNF-α表达,抑制NLRP3及其下游基因IL-1βmRNA水平表达。丹参酮IIA能够显著抑制LPS+ATP刺激细胞后ROS表达水平,抑制LPS或LPS+ATP刺激RAW264.7细胞NLRP3、NF-κB通路相关蛋白及P38蛋白水平表达,包括IKBα,pp65/p65,pp38/p38蛋白水平表达。LPS或LPS+ATP刺激RAW264.7细胞后,晚期炎症标志因子HMGB1蛋白水平变化没有显著差异。而ROS抑制剂NAC可以抑制LPS+ATP刺激RAW264.7细胞诱导的NLRP3表达增加。结论:丹参酮IIA可以抑制LPS或LPS+ATP刺激RAW264.7细胞诱导的炎症反应,其机制可能涉及丹参酮IIA对ROS-NF-κB/P38-NLRP3通路的调控。

关键词：丹参酮IIA 炎症 NLRP3炎性体 ROS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

使用现代锥形束计算机体层介入套件中的机器人辅助针穿介入术的精确度和速度:一项模型研究

引用

国际医学放射学杂志 2013年第2期 188-188页

作者： B. Schulz K. Eichler P. Siebenhandl T. Gruber-Rouh C. Czerny T.J. Vogl 郭凌飞 Department of Diagnostic and Interventional Radiology Goethe University Hospital Theodor-Stern-Kai 7 60590 Frankfurt Germany

目的分析使用C型臂(C-arm-mounted)锥形束计算机体层装置(CBCT)结合针穿导引软件的机器人辅助介入术在模型研究上的可行性和准确性。材料与方法介入平台可支持小机器人装置并导引穿刺。在获得三维数据后,在CBCT工作站设计出入路径线并... 详细信息

目的分析使用C型臂(C-arm-mounted)锥形束计算机体层装置(CBCT)结合针穿导引软件的机器人辅助介入术在模型研究上的可行性和准确性。材料与方法介入平台可支持小机器人装置并导引穿刺。在获得三维数据后,在CBCT工作站设计出入路径线并在介入监视器上显示,然后机器人可以获得实时的透视图像。分别随机在单倾斜轨道和双倾斜轨道(各20次)多靶位(直径2mm)的模型上进行了40次穿刺。结果所有模型(n=40)介入术均获得成功。到达模型内靶位的入路径为8.5cm(最小4.2cm,最大13.5cm)。针端的偏离值平均为1.1mm(最小0,最大4.5mm),持续时间3min59s(最小2min7s,最大10min37s)。结论在CBCT介入套件中使用推荐的机器人装置,具有较高准确性的针穿介入术可以以合理及时的方式进行单倾斜轨道和双倾斜轨道穿刺。要点①影像导引下的经皮穿刺活检对现代放射学具有重要作用。②简洁机器人装置的发展使得这一操作变得简便。③精确针穿介入术可以及时进行。④复杂的轨迹和较深的入路路径是可行的。

关键词：平板CT 介入CT 经皮活检机器人机器人装置

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

斜视性弱视儿童空间定位的缺陷

引用

世界核心医学期刊文摘（眼科学分册） 2005年第4期1卷 32-32页

作者： Fronius M. Sireteanu R. Zubcov A. 齐翔云 Dept. of Paediatric Ophthalmology University Eye Hospital Theodor- Stern- Kai 7 60590 Frankfurt Main Germany

Background: Besides loss of visual acuity and binocularity, spatial localization deficits (comprising both increased spatial uncertainty and spatial distortions) are an important feature of strabismic amblyopia. Although they have been extensively investigated in adult amblyopes, there are still many open questions concerning their substrate and relationship to clinical parameters. Our aim was to develop a procedure for assessing vertical alignment, which enabled us to find out whether children with strabismic amblyopia had similar spatial localization deficits, and their relation to the children s clinical condition. Methods: Vertical alignment was assessed in children by comparing the visual direction in space of three loci along the vertical meridian, separated by 5 deg of visual angle. We tested alignment in the amblyopic and dominant eyes of 32 strabismic and in both eyes of 35 control children from 4.5 to 10 years, together with a careful orthoptic examination. Results: In the amblyopic eyes, increased uncertainty and systematic distortions outside the normal range occurred. Large angles of deviation and pathological fixation patterns were necessary, but not sufficient conditions for gross spatial deficits to occur. The fellow dominant eyes showed spatial localization similar to normal eyes. Conclusions: Children with strabismic amblyopia exhibited localization deficits and relationship to clinical data similar to those in adult amblyopes. These data are important for further investigations about the substrate, plasticity and the clinical relevance of perceptual distortions.

关键词：斜视性弱视空间定位弱视眼双眼单视垂直定位临床参数视轴临床资料

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

旋转坐标空间中的双色Einstein-Podolsky-Rosen纠缠实验

引用

Science Bulletin 2020年第4期65卷 280-285页

作者：王锴丁冬生张伟何琼毅郭光灿史保森 Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China School of Instrument Science and Opto-Electronics Engineering Beihang UniversityBeijing 100191China Hefei Innovation Research Institute Beihang UniversityHeifei 230013China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China wang Da-Heng Collaborative Innovation Center for Science of Quantum Manipulation and Control Heilongjiang Province and Harbin University of Science and TechnologyHarbin 150080China State Key Laboratory for Mesoscopic Physics School of PhysicsNano-optoelectronics Frontier Center of the Ministry of Education&Collaborative Innovation Center of Quantum MatterPeking UniversityBeijing 100871China Beijing Academy of Quantum Information Sciences Beijing 100193China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

在量子信息领域,一对粒子在位置和动量上的纠缠称为位置-动量Einstein-Podolsky-Rosen (EPR)纠缠.它是一种重要的纠缠资源,在量子计算和量子通信中有着重要的研究意义. EPR纠缠已经在不同的物理体系中被研究,但这些体系都处在固定的坐... 详细信息

在量子信息领域,一对粒子在位置和动量上的纠缠称为位置-动量Einstein-Podolsky-Rosen (EPR)纠缠.它是一种重要的纠缠资源,在量子计算和量子通信中有着重要的研究意义. EPR纠缠已经在不同的物理体系中被研究,但这些体系都处在固定的坐标空间中.这里纠缠的双光子是利用热原子系综的自发四波混频过程产生的,作者在旋转的位置-动量空间中观察EPR纠缠光子的鬼成像和鬼干涉.通过不同的成像物体,测量到的位置-动量关联展现出有趣的动力学特征,包括关联的逐渐消退和与坐标轴无关的EPR纠缠特性.在旋转坐标空间中操纵EPR纠缠的这些结果展现出它在量子通信和远程量子图像处理中的潜在应用前景.

关键词： Einstein-Podolsky-Rosen entanglement Rotating coordinate space Ghost imaging Ghost interference Quantum communication Distant quantum image processing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：