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D-type neuropeptide decorated AIEgen/RENP hybrid nanoprobes with light-driven ROS generation ability for NIR-Ⅱ fluorescence imaging-guided through-skull photodynamic therapy of gliomas

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Aggregate 2024年第1期5卷 185-195页

作者： Xuelu He Yuan Luo Yanying Li Yuanbo Pan Ryan T.K.Kwok Lulu He Xiaolin Duan Pengfei Zhang Aiguo Wu Ben Zhong Tang Juan Li Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboP.R.China Guangdong Key Laboratory of nanomedicine Shenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS-HK Joint Lab for BiomaterialsResearch Laboratory for Biomedical Optics and Molecular ImagingShenzhen Key Laboratory for Molecular ImagingCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenP.R.China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced StudyThe Hong Kong University of Science and Technology(HKUST)KowloonP.R.China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenP.R.China

Glioma is one of the most common malignant tumors of the central nervous system,leading high mortality rates in ***-induced emission(AIE)photosensitizers-based photodynamic therapy(PDT)has emerged as a promising therapeutic strategy for least-invasive treatment of glioma,which involves local irradiation of the tumor using an external near-infrared(NIR)***,most AIE photosensitizers suffered from poorly penetration of the visible light excitation,bad spatiotemporal resolution in deep tissues and low efficient blood-brain barrier(BBB)crossing ability,which greatly limited the clinical practice of AIE photosensitizers for especially deep-seated brain tumor *** this work,we developed a multifunctional NIR-driven theranostic agent through hybrid of AIE photosensitizers TIND with rare-earth doping nanoparticles(RENPs)NaGdF4:Nd/Yb/Tm with up/down dual-mode conversion *** theranostic agent was further decorated with D-type neuropeptide DNPY for crossing BBB and targeting *** the 808-nm light irradiation,the down-conversion NIR-II luminescence could indicate the position glioma and the upconversion NIR-I luminescence could trigger the AIE photosensitizers producing reactive oxygen species to inhibit orthotopic glioma tumor growth in *** results demonstrate that the integration of Dtype neuropeptide,AIE photosensitizers and RENPs could be promising candidates for in vivo NIR-II fluorescence image-guided through-skull PDT treatments of brain tumors.

关键词： aggregation-induced emission D-type neuropeptide glioma photodynamic therapy rare-earth doping nanoparticles

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Understanding host-graft crosstalk for predicting the outcome of stem cell transplantation

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World Journal of Stem Cells 2024年第3期16卷 232-236页

作者： Luminita Labusca Florin Zugun-Eloae Magnetic Materials and sensors National Institute of Research and Development for Technical PhysicsIasi 700050Romania Orthopedics and Trauma Emergency County Hospital Saint SpiridonIasi 700000Romania Transcend Regional Oncology InstituteIasi 7000000Romania

Mesenchymal stromal cells(MSCs)hold great promise for tissue regeneration in debilitating *** reported improvements,the short-term outcomes of MSC transplantation,which is possibly linked to poor cell survival,demand extensive ***-associated stress microenvironments further complicate *** debate underscores the need for a deeper understanding of the phenotypes of transplanted MSCs and their environment-induced ***,questions arise about how to predict,track,and comprehend cell fate *** vivo cellular imaging has emerged as a critical requirement for both short-and long-term safety and efficacy ***,translating preclinical imaging methods to clinical settings remains *** fate and function of transplanted cells within the host environment present intricate challenges,including MSC engraftment,variability,and inconsistencies between preclinical and clinical *** study explored the impact of high glucose concentrations on MSC survival in diabetic environments,emphasizing mitochondrial *** these factors may enhance MSC survival,suggesting potential strategies involving genetic modification,biomaterials,and *** stressors in diabetic patients is crucial for predicting the effects of MSC-based *** multifaceted challenges call for a holistic approach involving the incorporation of large-scale data,computational disease modeling,and possibly artificial intelligence to enable deterministic insights.

关键词： Mesenchymal stem cells Phenotype Transplantation Host Microenvironment Cellular imaging Diabetes mellitus

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Ce6 nanoassemblies:Molecular mechanism and strategies for combinational anticancer therapy Special Collection:Aggregation-Induced Processes and Functions

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Aggregate 2024年第1期5卷 130-147页

作者： Yuwei Liu Shuting Xu Qingyang Lyu Yi Huang Weiping Wang State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Laboratory of Molecular Engineering and nanomedicine Dr.Li Dak-Sum Research CentreThe University of Hong KongHong KongChina

Nowadays,cancer has become the leading cause of death worldwide,driving the need for effective therapeutics to improve patient *** therapy(PDT)has been widely applied as an antitumor modality,owing to its minimal invasiveness,localized tumor damage,and high safety ***,its efficacy is limited by poor stability of photosensitizers,inadequate tumor accumulation,and a complex tumor *** overcome these challenges,extensive endeavors have been made to explore the co-assembly of the widely used photosensitizer chlorin e6(Ce6)with various functional small molecules to enhance pharmacodynamic *** review provides a comprehensive overview of current studies on Ce6-based nanoparticles for effective PDT and precise delivery of functional *** self-assembly mechanism will be discussed in detail,with a focus on potential strategies for combinational therapy with PDT.

关键词： cancer treatment carrier-free chlorin e6(Ce6) light nanomedicine photodynamic therapy(PDT) selfassembly

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Hetero-integrated high-peak-optical-power laser source (940 nm) for time-of-flight sensors

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Chinese Optics Letters 2024年第7期22卷 81-85页

作者： Sergey Olegovich Slipchenko Aleksandr Aleksandrovich Podoskin Ilia Vasil'evich Shushkanov Marina Gennad'evna Rastegaeva Artem Eduardovich Rizaev Matvey Igorevich Kondratov Artem Evgen'evich Grishin Nikita Aleksandrovich Pikhtin Timur Anatol'evich Bagaev Maxim Anatol'evich Ladugin Aleksandr Anatol'evich Marmalyuk Vladimir Aleksandrovich Simakov Ioffe Institut Russian Academy of SciencesSt.Petersburg 194021Russia Open joint-Stock Company M.F.Stel’makh Polyus research Institute Moscow 117342Russia RUDN University Moscow 117198Russia

The generation of high-power laser pulses using a compact hetero-integrated assembly based on a semiconductor laser with a dual-element composite 2μm×100μm aperture and a compact heterothyristor switch is *** achieved peak optical power was 33 W with a pulse duration of 3 ns at a thyristor operating voltage of 55 *** leading edge of the laser pulse turn-on was 50 ps to a power level of 24.7 W,and the turn-on delay between the elements of the composite aperture was 160 ps.

关键词： hetero-integrated assembly semiconductor lasers thyristor switches LIDAR gain-switching mode laser heterostructure

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A Single-Fluorophore Multicolor Molecular Sensor That Visually Identifies Organic Anions Including Phosphates

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CCS Chemistry 2024年第3期6卷 774-782页

作者： Zezhou Zong Qi Zhang Da-Hui Qu Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist joint research Center School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237

Developing fluorescent sensors for small-molecule phosphates offers opportunities in optically detecting biorelevant reactions and ***,it remains elusive how to identify phosphates from other anions,such as carboxylates and sulfates,because current synthetic phosphate receptors lack *** we report the construction of a multicolor fluorescent sensor that can identify phosphates from other analogous *** key design principle is to take advantage of the highly sensitive conformation-dependent emissive wavelength of diphenyl-9,14-dihydrodibenzo[a,c]phenazine fluorophores to sense the minor structural differences between phosphates and other anions,for example,sulfates and *** effect of structural factors such as spacer length and urea versus thiourea has been investigated by comparing the optical properties and binding affinities with the phosphate *** strategy provides a simple and robust fluorescent sensing solution to optically analyze small-molecule phosphates with antiinterference performance.

关键词： fluorescent sensors photoluminescence host-guest chemistry supramolecular chemistry noncovalent bonds

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Synergistic enhancement of chemotherapy for bladder cancer by photothermal dual-sensitive nanosystem with gold nanoparticles and PNIPAM

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Chinese Chemical Letters 2024年第8期35卷 471-474页

作者： Xiangqian Cao Chenkai Yang Xiaodong Zhu Mengxin Zhao Yilin Yan Zhengnan Huang Jinming Cai Jingming Zhuang Shengzhou Li Wei Li Bing Shen Department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of nanomedicine&Shanghai Key Lab of Cell Engineering Naval Medical UniversityShanghai 200433China

Bladder cancer is a common malignant tumor of the urinary system with the potential to be treated by nano drug delivery *** current work describes the synthesis and characterization of a novel nanomaterial to construct a nano-carrier based on 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphatecholine(POPC)loaded doxorubicin(DOX)and embedded with gold nanoparticles and poly(N-isopropyl acry-lamide)(PNIPAM)(GNPS@PNIPAM-POPC-DOX,GPPD).The dual-sensitive nanosystem gives simultaneous photothermal treatment and chemotherapy for bladder *** vitro and in vivo properties were as-sessed using bladder cancer cell lines and mice and GPPD system distribution,tumor inhibition,and biocompatibility are *** system had favorable stability,low biological toxicity,controlled re-lease efficiency,photothermal synergistic action,efficient photothermal transition,and favorable tumor suppressive *** a result,GPPD is a potential therapeutic approach for bladder cancer.

关键词： Doxorubicin Gold nanoparticles Thermosensitive polymer Photothermal therapy Bladder cancer

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mRNA medicine:Recent progresses in chemical modification,design,and engineering

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Nano research 2024年第10期17卷 9015-9030页

作者： Xiaowen Hou Jinjun Shi Yuling Xiao Department of Cardiology Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Center for nanomedicine and Department of Anesthesiology Perioperative and Pain MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

Messenger RNA(mRNA)is a type of RNA that carries genetic information from DNA to the ribosome,where it is translated into *** has emerged as a powerful platform for development of new types of medicine,especially after the clinical approval of COVID-19 mRNA *** modification and nanoparticle delivery have contributed to this success significantly by improving mRNA stability,reducing its immunogenicity,protecting it from enzymatic degradation,and enhancing cellular uptake and endosomal ***,substantial progresses have been made in new modification chemistries,sequence design,and structural engineering to generate more stable and efficient next-generation *** innovations could further facilitate the clinical translation of mRNA therapies and *** that numerous review articles have been published on mRNA nanoparticle delivery and biomedical applications over the last few years,we herein focus on overviewing recent advances in mRNA chemical modification,mRNA sequence optimization,and mRNA engineering(e.g.,circular RNA and multitailed mRNA),with the aim of providing new perspectives on the development of more effective and safer mRNA medicines.

关键词： mRNA self-amplifying RNA circular RNA multitailed mRNA chemical modification machine learning

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Inducing mitochondriopathy-like damages by transformable nucleopeptide nanoparticles for targeted therapy of bladder cancer

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National Science Review 2024年第4期11卷 216-227页

作者： Da-Yong Hou Ni-Yuan Zhang Lu Wang Mei-Yu Lv Xiang-Peng Li Peng Zhang Yue-Ze Wang Lei Shen Xiu-Hai Wu Bo Fu Peng-Yu Guo Zi-Qi Wang Dong-Bing Cheng Hao Wang Wanhai Xu NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in Urology Harbin Medical University Department of Urology Harbin Medical University Cancer Hospital CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST) School of Chemistry Chemical Engineering & Life Science Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases Wuhan University of Technology

Mitochondriopathy inspired adenosine triphosphate(ATP) depletions have been recognized as a powerful way for controlling tumor growth. Nevertheless, selective sequestration or exhaustion of ATP under complex biological environments remains a prodigious challenge. Harnessing the advantages of in vivo self-assembled nanomaterials, we designed an Intracellular ATP Sequestration(IAS) system to specifically construct nanofibrous nanostructures on the surface of tumor nuclei with exposed ATP binding sites,leading to highly efficient suppression of bladder cancer by induction of mitochondriopathy-like ***, the reported transformable nucleopeptide(NLS-FF-T) self-assembled into nuclear-targeted nanoparticles with ATP binding sites encapsulated inside under aqueous conditions. By interaction with KPNA2, the NLS-FF-T transformed into a nanofibrous-based ATP trapper on the surface of tumor nuclei,which prevented the production of intracellular energy. As a result, multiple bladder tumor cell lines(T24,EJ and RT-112) revealed that the half-maximal inhibitory concentration(IC50) of NLS-FF-T was reduced by approximately 4-fold when compared to NLS-T. Following intravenous administration, NLS-FF-T was found to be dose-dependently accumulated at the tumor site of T24 xenograft mice. More significantly, this IAS system exhibited an extremely antitumor efficacy according to the deterioration of T24 tumors and simultaneously prolonged the overall survival of T24 orthotopic xenograft mice. Together, our findings clearly demonstrated the therapeutic advantages of intracellular ATP sequestration-induced mitochondriopathy-like damages, which provides a potential treatment strategy for malignancies.

关键词： self-assembly nucleopeptide nanomaterial bladder cancer mitochondriopathy

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Bioinspired Stretchable MXene Deformation-Insensitive Hydrogel Temperature sensors for Plant and Skin Electronics

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research 2024年第1期2023卷 389-401页

作者： Jun Wu Yinghui Li Shengshun Duan Zhehan Wang Xu Jing Yucheng Lin Di Zhu Wei Lei Qiongfeng Shi Li Tao joint International research Laboratory of Information Display and Visualization School of Electronic Science and EngineeringSoutheast UniversityNanjingJiangsu 210096China School of Materials Science and Engineering Southeast UniversityNanjingJiangsu 210096China Center of 2D Materials and Devices Southeast UniversityNanjingJiangsu 210096China

Temperature sensing is of high value in the wearable healthcare,robotics/prosthesis,and noncontact physiological ***,the common mechanic deformation,including pressing,bending,and stretching,usually causes undesirable feature size changes to the inner conductive network distribution of temperature sensors,which seriously influences the ***,inspired by the transient receptor potential mechanism of biological thermoreceptors that could work precisely under various skin contortions,we propose an MXene/Clay/poly(N-isopropylacrylamide)(PNIPAM)(MCP)hydrogel with high stretchability,spike response,and deformation *** dynamic spike response is triggered by the inner conductive network transformation from the 3-dimensional structure to the 2-dimensional surface after water being discharged at the threshold *** water discharge is solely determined by the thermosensitivity of PNIPAM,which is free from mechanical deformation,so the MCP hydrogels can perform precise threshold temperature(32℃)sensing under various deformation conditions,i.e.,pressing and 15%*** a proof of concept,we demonstrated the applications in plant electronics for the real-time surface temperature monitoring and skin electronics for communicating between human and *** research opens venues for the accurate temperature-threshold sensation on the complicated surface and mechanical conditions.

关键词： stretching proof precise

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Enhancing solid-state lithium metal battery performance via indium-based modification of electrolytes and lithium metal surfaces: mechanistic insights and optimization

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Science China Chemistry 2024年

作者： Zhongkai Wu Chen Liu Ziling Jiang Lin Li Siwu Li Chaochao Wei Qiyue Luo Xia Chen Long Zhang Shijie Cheng Chuang Yu State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and Technology School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Interdisciplinary research Center of Smart sensors Academy of Advanced Interdisciplinary Research Xidian University College of Physics and Energy Fujian Normal University

Argyrodite-based solid-state lithium metal batteries exhibit significant potential as next-generation energy storage ***,their practical applications are constrained by the intrinsic poor stability of argyrodite towards Li metal and exposure to air/***,an indium-involved modification strategy is employed to address these *** optimized doping yields a high Li-ion conductivity of 7.5 mS cm-1for Li5.54In0.02PS4.47O0.03Cl1.5electrolyte,accompanied by enhanced endurance against air/moisture and bare Li *** retains 92.0%of its original conductivity after exposure to air at a low dew point of-60°C in dry ***,a composite layer comprising Li–In alloy and LiF phases is generated on the surface of lithium metal anode via the reaction between In F3and molten *** layer effectively mitigates Li dendrite growth by creating a physical barrier from the robust LiF phase,while the Li–In alloy induces uniform Li-ion deposition and accelerates Li transport dynamics across the interphase between the solid electrolyte/Li ***,the In-doped electrolyte facilitates the in-situ generation of Li–In alloy within its voids,reducing local current density and further inhibiting lithium dendrite ***,the combination of the Li5.54In0.02PS4.47O0.03Cl1.5electrolyte and the InF3@Li anode provides exceptional electrochemical performances in both symmetric cells and solid-state lithium metal batteries across different operating ***,the LiNbO3@LiNi0.7Co0.2Mn0.1O2/Li5.54In0.02PS4.47O0.03Cl1.5/InF3@Li cell delivers a high discharge capacity of 167.8 mAh g-1at 0.5 C under 25°C and retains 80.0%of its initial value after 400 *** work offers a viable strategy for designing functional interfaces with enhanced stability for sulfide-based solid-state lithium batteries.

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