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Aggresome-aggrephagy transition process:geting closer to the functional roles of HDAC6 and BAG3

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Neural Regeneration Research 2024年第6期19卷 1181-1182页

作者： Hagen Körschgen Christian Behl The Autophagy Lab Institute of PathobiochemistryUniversity Medical Center of the Johannes Gutenberg University MainzMainzGermany

Misfolding of proteins as well as their aggregation is a major driver of age-related neurodegenerative ***,cells have evolved sophisticated protein quality control *** the ubiquitin-proteasome-system(UPS)and the autop... 详细信息

关键词： closer system transition

Optimization of product characteristics of porous carbon agglomerates using a design of experiments in fluidized bed agglomeration

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Particuology 2024年第6期89卷 258-269页

作者： Martin Oelofse Robert Rack Marcelle Hilden Peter Langguth Department of Pharmaceutical Technology and Biopharmaceutics Johannes Gutenberg UniversityMainzGermany Carbon Advanced Solutions GmbH HeuchelheimGermany

Spraying parameters during particle agglomeration processes can affect the agglomeration kinetics and particle *** study was conducted to better understand the influence of the spraying parameters in a fluidized bed wet agglomeration process,and the influence on the stability characteristics of carbon tablets.A formulation based on fine carbon and peroxide powder,as well as carboxymethyl cellulose as a binder,was used to produce agglomerates in a first production *** in a second production step carbon tablets with a high porosity were molded for the customer goods *** optimization of the compressive strength of these carbon tablets was the goal of the *** agglomerates were produced with a laboratory scale granulator called“ProCell”and were compressed with a five-cavity mechanical *** screening of the agglomeration process parameters and their influence on the agglomerates quality,as well as the performance characteristics of the carbon tablets,were investigated using a multilevel factorial *** experimental runs were done by varying atomized air pressure and feed rate of the *** was determined by the design *** findings of the statistical trials showed that low atomized air pressure and a low feed rate lead to a higher tablet compressive strength.

关键词： Wet agglomeration Fluidized bed Design of experiments Carbon agglomerates and tablets

Evidence of active oviposition avoidance to systemically applied imidacloprid in the Colorado potato beetle

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INSECT SCIENCE 2024年第5期31卷 1543-1554页

作者： Edison, Alitha Michelbach, Anja Sowade, Dominique Kertzel, Hanna Schmidt, Luise Schaefer, Martin Lysander, Maximillian Nauen, Ralf Duchen, Pablo Xu, Shuqing univ Munster Inst Evolut & Biodivers Hufferstr 1 D-48149 Munster Germany johannes gutenberg univ mainz Inst Organism & Mol Evolut iomE Hanns Dieter Husch Weg 15 D-55128 Mainz Germany Dept Cell & Tissue Dynam Munster Germany johannes gutenberg univ mainz Inst Organism & Mol Evolut iomE Mainz Germany Bayer AG Res & Dev Dept Crop Sci Div Monheim Germany

Agricultural pests can develop behavioral resistance to insecticides by choosing to feed or oviposit on insecticide-free hosts. As young larvae have relatively low mobility, oviposition preferences from female adults may play a critical role in shaping the evolutionary trajectory of pest populations. While oviposition avoidance of insecticide-treated hosts was found in different agriculture pests, it remains unclear whether female adults actively choose to occupy insecticide-free hosts. To address this question, we investigated feeding and oviposition preferences between imidacloprid-treated and imidacloprid-free plants in the Colorado potato beetle, Leptinotarsa decemlineata Say, a major potato pest. We performed behavioral choice assays on two strains that differed in both fecundity and insecticide resistance. We found that one strain preferred to feed on the insecticide-free plants and that this preference is not innate. Meanwhile, the other strain chose plants for feeding and oviposition randomly. Further analyses of the moving patterns of the beetles suggested that the oviposition preference in the first strain is likely due to active learning. A strain of L. decemlineata avoided imidacloprid-treated plants for feeding and oviposition in choice assays while another strain chose plants randomly. First feeding is random in both strains. The oviposition avoidance behavior might be an active response due to learning from feeding on both choices of plants. image

关键词： Colorado potato beetle host preferences imidacloprid insecticide resistance oviposition pesticide avoidance LEPTINOTARSA-DECEMLINEATA COLEOPTERA GREEN LEAF VOLATILES INSECTICIDE RESISTANCE FEEDING PREFERENCES LARVAE CHRYSOMELIDAE BEHAVIOR NITROMETHYLENE ORIENTATION DISPERSAL

NECAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.E.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

Modifying the progression of Parkinson's disease through movement interventions:multimodal quantification of underlying mechanisms

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Neural Regeneration Research 2024年第8期19卷 1651-1652页

作者： Manuel Bange Damian Marc Herz Dumitru Ciolac Gabriel Gonzalez-Escamilla Sergiu Groppa Section of Movement Disorders and Neurostimulation Department of NeurologyFocus Program Translational Neuroscience(FTN)University Medical Center of the Johannes Gutenberg-University MainzMainzGermany

Introduction:Parkinson’s disease(PD)is the most common neurodegenerative movement *** pathological hallmark is the progressive loss of dopaminergic neurons of the substantia nigra pars compacta,which is accompanied by widespread alterations in the structu re and function of distributed brain *** r,these processes cause a variety of motor symptoms such as bradykinesia,rigidity,tremor,gait disorders,or difficulties in fine motor control(Bange et al.,2022).

关键词： alterations movement

Cellular models of stress resistance may pave ways to fight neurodegenerative diseases

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Neural Regeneration Research 2025年第9期20卷 2579-2580页

作者： Thu Nguyen Minh Pham Christian Behl Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg UniversityMainzGermany

Alzheimer's disease(AD),the most common form of neurodegeneration,is characterized by selective neuronal vulnerability and brain regionselective neuron *** entorhinal cortex and hippoc,ampal CA1 projection neurons are at greater risk in AD whereas other regions display resistance to ***,the cerebellum,a phylogenetically very old region,is affected only very late in the disease progression.

关键词： cortex resistance Alzheimer

Response optimization of a three-axis sensitive SERF magnetometer for closed-loop operation

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Chinese Physics B 2024年第6期33卷 291-297页

作者：周原锐孙永泽汪茜茜秦佳男张雪王言章 Key Laboratory of Geophysical Exploration Equipment(Ministry of Education) Jilin UniversityChangchun 130012China College of Instrumentation and Electrical Engineering Jilin UniversityChangchun 130012China Department of Physics Johannes Gutenberg-Universitat Mainz55128 MainzGermany Helmholtz-Institut GSI Helmholtzzentrum fur Schwerioneforschung55128 MainzGermany

Most triaxial-vectorial magnetic field measurements with spin-exchange relaxation free(SERF)atomic magnetometer(AM)are based on the quasi-steady-state solution of the Bloch ***,the responding speed of these methods is greatly limited because the frequency of the modulation signal should be slow enough to ensure the validity of the quasi-steady-state *** this work,a new model to describe the response of the three-axis sensitive SERF AM with high modulation frequency is presented and *** response of alkali-atomic spin to high-frequency modulation field is further investigated by solving the Bloch equation in a modulation-frequency-dependence *** solution is well verified by our experiments and can offer a reference for selection of modulation *** result shows a potential to achieve a SERF AM operating in a geomagnetic field without heavy aluminum shielding when the modulation frequencies are selected properly.

关键词： triaxial-vectorial magnetic field measurement spin-exchange relaxation free atomic magnetometer

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New High-Order Numerical Methods for Hyperbolic Systems of Nonlinear PDEs with Uncertainties

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应用数学与计算数学学报 2024年第3期6卷 2011-2044页

作者： Alina Chertock Michael Herty Arsen S.Iskhakov Safa Janajra Alexander Kurganov Mária Lukáčová-Medvid'ová Department of Mathematics North Carolina State UniversityRaleighNCUSA Department of Mathematics RWTH Aachen UniversityAachenGermany Department of Mathematics Shenzhen International Center for Mathematicsand Guangdong Provincial Key Laboratory of Computational Science and Material DesignSouthern University of Science and TechnologyShenzhen 518055GuangdongChina Institute of Mathematics Johannes Gutenberg University MainzMainzGermany

In this paper,we develop new high-order numerical methods for hyperbolic systems of non-linear partial differential equations(PDEs)with *** new approach is realized in the semi-discrete finite-volume framework and is based on fifth-order weighted essen-tially non-oscillatory(WENO)interpolations in(multidimensional)random space combined with second-order piecewise linear reconstruction in physical *** with spectral approximations in the random space,the presented methods are essentially non-oscillatory as they do not suffer from the Gibbs phenomenon while still achieving high-order *** new methods are tested on a number of numerical examples for both the Euler equations of gas dynamics and the Saint-Venant system of shallow-water *** the latter case,the methods are also proven to be well-balanced and positivity-preserving.

关键词： Hyperbolic conservation and balance laws with uncertainties Finite-volume methods Central-upwind schemes Weighted essentially non-oscillatory(WENO)interpolations

Entropy-Conservative Discontinuous Galerkin Methods for the Shallow Water Equations with Uncertainty

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应用数学与计算数学学报 2024年第3期6卷 1978-2010页

作者： Janina Bender Philipp Öffner Institute of Mathematics University KasselMönchebergstraße 1934127 KasselGermany Institute of Mathematics Johannes Gutenberg UniversityStaudingerweg 955099 MainzGermany Mathematical Institute Technical University ClausthalErzstraße 138678 Clausthal-ZellerfeldGermany

In this paper,we develop an entropy-conservative discontinuous Galerkin(DG)method for the shallow water(SW)equation with random *** of the most popular methods for uncertainty quantification is the generalized Polynomial Chaos(gPC)approach which we consider in the following *** apply the stochastic Galerkin(SG)method to the stochastic SW *** the SG approach in the stochastic hyperbolic SW system yields a purely deterministic system that is not necessarily hyperbolic *** lack of the hyperbolicity leads to ill-posedness and stability issues in numerical *** transforming the system using Roe variables,the hyperbolicity can be ensured and an entropy-entropy flux pair is known from a recent investigation by Gerster and Herty(***.27(3):639-671,2020).We use this pair and determine a cor-responding entropy flux ***,we construct entropy conservative numerical two-point fluxes for this augmented *** applying these new numerical fluxes in a nodal DG spectral element method(DGSEM)with flux differencing ansatz,we obtain a provable entropy conservative(dissipative)*** numerical experiments,we validate our theo-retical findings.

关键词： Shallow water(SW)equations Entropy conservation/dissipation Uncertainty quantification Discontinuous Galerkin(DG) Generalized Polynomial Chaos(gPC)