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Optimization of product characteristics of porous carbon agglomerates using a design of experiments in fluidized bed agglomeration

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Particuology 2024年第6期89卷 258-269页

作者： Martin Oelofse Robert Rack Marcelle Hilden Peter Langguth Department of Pharmaceutical Technology and Biopharmaceutics Johannes Gutenberg UniversityMainzGermany Carbon Advanced Solutions GmbH HeuchelheimGermany

Spraying parameters during particle agglomeration processes can affect the agglomeration kinetics and particle *** study was conducted to better understand the influence of the spraying parameters in a fluidized bed wet agglomeration process,and the influence on the stability characteristics of carbon tablets.A formulation based on fine carbon and peroxide powder,as well as carboxymethyl cellulose as a binder,was used to produce agglomerates in a first production *** in a second production step carbon tablets with a high porosity were molded for the customer goods *** optimization of the compressive strength of these carbon tablets was the goal of the *** agglomerates were produced with a laboratory scale granulator called“ProCell”and were compressed with a five-cavity mechanical *** screening of the agglomeration process parameters and their influence on the agglomerates quality,as well as the performance characteristics of the carbon tablets,were investigated using a multilevel factorial *** experimental runs were done by varying atomized air pressure and feed rate of the *** was determined by the design *** findings of the statistical trials showed that low atomized air pressure and a low feed rate lead to a higher tablet compressive strength.

关键词： Wet agglomeration Fluidized bed Design of experiments Carbon agglomerates and tablets

Aggresome-aggrephagy transition process:geting closer to the functional roles of HDAC6 and BAG3

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Neural Regeneration Research 2024年第6期19卷 1181-1182页

作者： Hagen Körschgen Christian Behl The Autophagy Lab Institute of PathobiochemistryUniversity Medical Center of the Johannes Gutenberg University MainzMainzGermany

Misfolding of proteins as well as their aggregation is a major driver of age-related neurodegenerative ***,cells have evolved sophisticated protein quality control *** the ubiquitin-proteasome-system(UPS)and the autop... 详细信息

关键词： closer system transition

NECAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.E.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

Cellular models of stress resistance may pave ways to fight neurodegenerative diseases

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Neural Regeneration Research 2025年第9期20卷 2579-2580页

作者： Thu Nguyen Minh Pham Christian Behl Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg UniversityMainzGermany

Alzheimer's disease(AD),the most common form of neurodegeneration,is characterized by selective neuronal vulnerability and brain regionselective neuron *** entorhinal cortex and hippoc,ampal CA1 projection neurons are at greater risk in AD whereas other regions display resistance to ***,the cerebellum,a phylogenetically very old region,is affected only very late in the disease progression.

关键词： cortex resistance Alzheimer

Modifying the progression of Parkinson's disease through movement interventions:multimodal quantification of underlying mechanisms

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Neural Regeneration Research 2024年第8期19卷 1651-1652页

作者： Manuel Bange Damian Marc Herz Dumitru Ciolac Gabriel Gonzalez-Escamilla Sergiu Groppa Section of Movement Disorders and Neurostimulation Department of NeurologyFocus Program Translational Neuroscience(FTN)University Medical Center of the Johannes Gutenberg-University MainzMainzGermany

Introduction:Parkinson’s disease(PD)is the most common neurodegenerative movement *** pathological hallmark is the progressive loss of dopaminergic neurons of the substantia nigra pars compacta,which is accompanied by widespread alterations in the structu re and function of distributed brain *** r,these processes cause a variety of motor symptoms such as bradykinesia,rigidity,tremor,gait disorders,or difficulties in fine motor control(Bange et al.,2022).

关键词： alterations movement

Response optimization of a three-axis sensitive SERF magnetometer for closed-loop operation

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Chinese Physics B 2024年第6期33卷 291-297页

作者：周原锐孙永泽汪茜茜秦佳男张雪王言章 Key Laboratory of Geophysical Exploration Equipment(Ministry of Education) Jilin UniversityChangchun 130012China College of Instrumentation and Electrical Engineering Jilin UniversityChangchun 130012China Department of Physics Johannes Gutenberg-Universitat Mainz55128 MainzGermany Helmholtz-Institut GSI Helmholtzzentrum fur Schwerioneforschung55128 MainzGermany

Most triaxial-vectorial magnetic field measurements with spin-exchange relaxation free(SERF)atomic magnetometer(AM)are based on the quasi-steady-state solution of the Bloch ***,the responding speed of these methods is greatly limited because the frequency of the modulation signal should be slow enough to ensure the validity of the quasi-steady-state *** this work,a new model to describe the response of the three-axis sensitive SERF AM with high modulation frequency is presented and *** response of alkali-atomic spin to high-frequency modulation field is further investigated by solving the Bloch equation in a modulation-frequency-dependence *** solution is well verified by our experiments and can offer a reference for selection of modulation *** result shows a potential to achieve a SERF AM operating in a geomagnetic field without heavy aluminum shielding when the modulation frequencies are selected properly.

关键词： triaxial-vectorial magnetic field measurement spin-exchange relaxation free atomic magnetometer

Comparative CFD-DEM study of flow regimes in spout-fluid beds

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Particuology 2024年第2期85卷 323-334页

作者： Hamed Hoorijani Behrad Esgandari Reza Zarghami Rahmat Sotudeh-Gharebagh Navid Mostoufi Multiphase Systems Research Lab School of Chemical EngineeringCollege of EngineeringUniversity of TehranP.O.Box 11155-4563TehranIran Department of Particulate Flow Modelling Johannes Kepler UniversityAltenbergerstr.694040LinzAustria

Spout-fluid beds are unique systems that require thorough study prior to their industrial *** this study,the hydrodynamics of spout-fluid beds were investigated using 3D computational fluid dy-namics coupled with discrete element method(CFD-DEM).Three flow regimes,including jet-in-fluidized bed,spouting-with-aeration,and intermediate/spout-fluidization were studied,and the particle mixing was quantified in these regimes using the Lacey mixing *** results showed that both axial and lateral mixing rates are better in jet-in-fluidized bed and the spouting-with-aeration flow regimes,with the axial mixing being superior to the lateral in all flow *** the diffusivity coefficient revealed that mixing in the jet-in-fluidized bed flow regime is better due to the formation and eruption of bubbles in the ***,the granular temperature was analyzed in all flow regimes,and higher particle velocity fluctuations were observed in the spouting-with-aeration and the jet-in-fluidized bed flow regimes due to the higher spout gas velocity and formation of bubbles in the *** study provides valuable insights into the hydrodynamics of spout-fluid beds in different flow regimes,which can aid in the design and optimization of spout-fluid bed reactors for various industrial applications.

关键词： Flow regime Mixing Diffusivity CFD-DEM Hydrodynamics Spout-fluid bed

Exploring International Media and Information Literacy Initiatives: Insights From DW Akademie’s MIL Model

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Journalism and Mass Communication 2024年第2期14卷 75-89页

作者： Dadakhonov Azamjon Oltmishevich johannes gutenberg university of Mainz Germany

Media and Information Literacy(MIL)is one of the most important topics in today’s mediatized *** the leadership of United Nations Educational,Scientific and Cultural Organization(UNESCO),many international organizations in the world,as foreign donors,annually announce many projects and grants for the promotion and development of the field of MIL in the countries of the *** of the main actors of this movement is DW Akademie with different media and MIL projects several countries of the *** research paper delves into the role of DW Akademie’s MIL model in shaping a media-savvy *** study explores the theoretical underpinnings and practical applications of Deutsche Welle(DW)Akademie’s MIL model,analysing its effectiveness in fostering media literacy *** research employs a multi-faceted approach,incorporating case studies to assess the model’s impact across diverse *** paper also considers the model’s alignment with global educational policies and proposes recommendations for its integration into broader *** investigating DW Akademie’s MIL model,this research contributes to the ongoing discourse on media literacy education,providing valuable insights for educators,policymakers,and *** findings offer a nuanced understanding of the model’s position in cultivating a media-savvy generation poised to navigate the complexities of the information age.

关键词： Media and Information Literacy(MIL) DW Akademie international projects a strategic model MIL personae media literacy skills

On-Surface Synthesis of Anthracene-Fused Zigzag Graphene Nanoribbons from 2,7-Dibromo-9,9′-bianthryl Reveals Unexpected Ring Rearrangements

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Precision Chemistry 2024年第2期2卷 81-87页

作者： Xiushang Xu Amogh Kinikar Marco Di Giovannantonio Carlo A.Pignedoli Pascal Ruffieux Klaus Müllen Roman Fasel Akimitsu Narita Max Planck Institute for Polymer Research 55128 MainzGermany Organic and Carbon Nanomaterials Unit Okinawa Institute of Science and Technology Graduate UniversityKunigami-gunOkinawa 904-0495Japan Empa Swiss Federal Laboratories for Materials Science and Technologynanotech@surfaces Laboratory8600 DübendorfSwitzerland Institute of Structure of Matter-CNR(ISM-CNR) 00133 RomaItaly Institute of Physical Chemistry Johannes Gutenberg University Mainz55128 MainzGermany Department of Chemistry Biochemistry and Pharmaceutical SciencesUniversity of Bern3012 BernSwitzerland

On-surface synthesis has emerged as a powerful strategy to fabricate unprecedented forms of atomically precise graphene nanoribbons(GNRs).However,the on-surface synthesis of zigzag GNRs(ZGNR)has met with only limited ***,we report the synthesis and on-surface reactions of 2,7-dibromo-9,9′-bianthryl as the precursor towardπ-extended *** by scanning tunneling microscopy and high-resolution noncontact atomic force microscopy clearly demonstrated the formation of anthracene-fused *** skeletal rearrangements were also observed,which could be explained by intramolecular Diels-Alder *** calculations of the electronic properties of the anthracene-fused ZGNRs revealed spin-polarized edge-states and a narrow bandgap of 0.20 eV.

关键词： On-surface synthesis Graphene nanoribbon On-surface reaction Rearrangement Edge state