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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan Yang xinxin Yan Shaoli Zhang Yi Teng Qianru Li Changfa xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital center for disease control and prevention of Sheyang County Department of Cancer prevention and control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan center for disease control and prevention Office for Cancer control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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“Mosquito-Free Villages”:Practice,Exploration,and Prospects of Sustainable Mosquito control--Zhejiang,China

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China CDC weekly 2019年第5期1卷 70-74页

作者： Song Guo Wenzhong Huang Jimin Sun Zhenyu Gong Feng Ling Hongzhao Wu Enfu Chen Department of Communicable diseases control and prevention Zhejiang Center for Disease Control and PreventionHangzhouZhejiangChina Pu jiang center for disease control and prevention PujiangZhejiangChina.

Mosquitoes and mosquito-borne diseases have always been a great threat to human *** control based on sustainable vector management strategy is particularly *** Zhejiang Province,exemplary villages of sustainable mosquito control(“mosquito-free villages”)have been successful operated,providing a new model of mosquito control in rural areas based on local *** construction of“mosquito-free village”will apply environmentally-friendly and appropriate technologies to eliminate and transform mosquito breeding sites and to establish mechanisms of cultivating villagers’health literacy of scientific mosquito control and voluntary participation in control activities to keep mosquito density low longterm.

关键词： Sustainable eliminate breeding

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Metagenomic Analysis of Environmental Samples from Wildlife Rescue Station at Poyang Lake, China

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Biomedical and Environmental Sciences 2023年第7期36卷 595-603页

作者： LIU Jia LI xi Yan SONG Wen Tao ZENG xiao Xu LI Hui YANG Lei WANG Da Yan National Institute for Viral disease control and prevention Chinese Center for Disease Control and PreventionBeijing 102206China Nanchang center for disease prevention and control Nanchang 330038JiangxiChina

Objective To improve the understanding of the virome and bacterial microbiome in the wildlife rescue station of Poyang Lake,*** Ten smear samples were collected in March *** sequencing was performed to delineate bacterial and viral *** analysis was performed using the Kraken2 and Bracken methods.A maximum-likelihood tree was constructed based on the RNA-dependent RNA polymerase(RdRp)region of *** We identified 363 bacterial and 6 viral families.A significant difference in microbial and viral abundance was found between samples S01–S09 and *** S01–S09,members of Flavobacteriia and Gammaproteobacteria were the most prevalent,while in S10,the most prevalent bacteria class was *** S01–S09,members of Myoviridae and Herelleviridae were the most prevalent,while the dominant virus family of S10 was *** full genome of the pigeon mesivirus-like virus(NC-BM-233)was recovered from S10 and contained an open reading frame of 8,124 *** showed the best hit to the pigeon mesivirus 2 polyprotein,with 84.10%amino acid *** analysis showed that RdRp clustered into Megrivirus *** This study provides an initial assessment of the bacteria and viruses in the cage-smeared samples,broadens our knowledge of viral and bacterial diversity,and is a way to discover potential pathogens in wild birds .

关键词： Metagenomics Virome Megrivirus B Picornaviridae Poyang Lake Wildlife Rescue Station Wild Bird

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Molecular Characterization of Human Respiratory Adenovirus Infection in Children from November 2016 to October 2017 in xining City, China

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Biomedical and Environmental Sciences 2019年第1期32卷 38-41页

作者： YU Juan LI Hong LU Nan Nan LEI You Ju jiang Shuang Ying ZHAO Sheng Cang RAO Hua xiang center of Hygiene Inspection Qinghai Center for Disease Control and Prevention Institute for Communicable disease control and prevention Qinghai Center for Disease Control and Prevention

Human adenoviruses (HAdVs) belong to the genus Mastadenovirus, family Adenoviridae, and can cause respiratory tract and gastrointestinal tract infections, as well as ocular infections in humans[1]. Till date, a total of 84 unique genotypes of AdVs have been identified and classified as human Mastadenovirus species A to G, and specific types are often associated with certain clinical symptoms, epidemiological settings, and demographic risk groups[2]. Among these species, members of the species HAdV-B (HAdV-3, HAdV-7, HAdV-11, HAdV-16, HAdV-21, HAdV-34, HAdV-35, HAdV-50, etc), HAdV-C (HAdV-1, HAdV-2, HAdV-5, and HAdV-6), and HAdV-E (HAdV-4) have been generally associated with respiratory infections[3]. HAdV infections are mild and self-limited in healthy individuals, whereas they can result in high mortality rates in immunocompetent and immunocompromized patients[4].

关键词： Human adenoviruses (HAdVs) mammivirus Eye infection

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Identification of Novel Bartonella washoensis Sequence Type 22 in Marmota himalayana-Jiuquan City,Gansu Province,China,2021–2022

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China CDC weekly 2023年第20期5卷 442-445,I0001页

作者： Ran Duan xiaojin Zheng Qun Duan Asaiti Bukai Peng Zhang Shuai Qin xinmin Lu Dongyue Lyu Haonan Han Dan Zhang Zhaokai He Junrong Liang Deming Tang Jinxiao xi Huaiqi Jing xin Wang State Key Laboratory of Infectious disease prevention and control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Akesai Kazak Autonomous County center for disease control and prevention JiuquanChina Gansu Provincial center for disease control and prevention LanzhouChina

Summary What is already known about this topic?The prevalence of rodent-adapted Bartonella species has been increasing ***,the specific Bartonella species carried by Marmota himalayana(***),a large rodent species,and the potential risk it poses to human populations remain *** is added by this report?Bartonella washoensis(***),associated with human endocarditis,was initially identified in ***,exhibiting a detection rate of approximately one-third and demonstrating a predilection for the heart and *** discovery of the novel Sequence Type 22 has expanded both the isolation source and genetic lineage of *** are the implications for public health practice?Individuals residing within the *** plague focus are at an elevated risk for *** ***,there is a pressing need for public health warnings and efficient clinical case identification in this population.

关键词： Barton expanded initially

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Isolation of Leclercia adecarboxylata Producing Carbapenemases in A Newborn Female

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Biomedical and Environmental Sciences 2023年第9期36卷 874-879页

作者： MENG Shuang MIAO Bei Bei LI Jie YIN Jian Wen LIU Ze Liang jiang Xue Qi GONG xin Yi LI Juan Chinese Field Epidemiology Training Program Chinese Center for Disease Control and PreventionBeijing 102206China State Key Laboratory of Infectious disease prevention and control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Yunnan center for disease control and prevention Kunming 650034YunnanChina

Leclercia adecarboxylata is a Gram-negative bacterium belonging to the Enterobacteriaceae *** our knowledge,this is the first report of a carbapenem-resistant *** strain isolated from a healthy *** *** strain isolated in this study carried four plasmids that may serve as reservoirs for antibiotic resistance *** 2 and 4 did not harbor any antimicrobial resistance *** 3 is a novel plasmid containing three resistance *** bla IMP gene harbored in the strain was most similar to bla IMP-79 at the nucleotide level,with a similarity of 99.4%(737/741).This case highlights the importance of considering *** as a potential cause of infections in children.

关键词： Leclercia adecarboxylata Carbapenem-resistant Newborn

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Relationship Between Climate Change and Marmot Plague of Marmota himalayana Plague Focus—the Altun Mountains of the Qinghai-xizang Plateau,China,2000–2022

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China CDC weekly 2024年第4期6卷 69-74,I0006页

作者： Qun Duan xiaojin Zheng Zhiqiang Gan Dongyue Lyu Hanyu Sha xinmin Lu xiaoling Zhao Asaiti Bukai Ran Duan Shuai Qin Li Wang Jinxiao xi Di Wu Peng Zhang Deming Tang Zhaokai He Huaiqi Jing Biao Kan xin Wang National Institute for Communicable disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina Akesai Kazak Autonomous County center for disease control and prevention Jiuquan CityGansu ProvinceChina Jiuquan center for disease control and prevention Jiuquan CityGansu ProvinceChina Gansu Provincial center for disease control and prevention Lanzhou CityGansu ProvinceChina

Introduction:Plague is a zoonotic disease that occurs naturally in specific geographic *** change can influence the populations of the plague host or vector,leading to variations in the occurrence and epidemiology of plague in ***:In this study,we collected meteorological and plague epidemiological data from the Marmota himalayana plague focus in the Altun Mountains of the Qinghai-xizang *** data spanned from 2000 to *** describe the climatic factors and plague epidemic conditions and we describe their analysis by Pearson’s ***:During the period from 2000 to 2022,the isolation rates of Yersinia pestis(***)from marmots and fleas were 9.27%(451/4,864)and 7.17%(118/1,646),***,we observed a positive rate of F1 antibody of 11.25%(443/3,937)in marmots and 18.16%(142/782)in *** regards to climate,there was little variation,and a decreasing trend in blowing-sand days was *** temperature in the previous year showed a negative correlation with the *** isolation rate in marmots(r=−0.555,P=0.011)and the positive rate of F1 antibody in marmots(r=−0.552,P=0.012)in the current *** average annual precipitation in the previous two years showed a positive correlation with marmot density(r=0.514,P=0.024),while blowingsand days showed a negative correlation with marmot density(r=−0.701,P=0.001).Furthermore,the average annual precipitation in the previous three years showed a positive correlation with the isolation rate of *** from marmots(r=0.666,P=0.003),and blowing-sand days showed a negative correlation with marmot density(r=−0.597,P=0.009).Conclusions:The findings of this study indicate that there is a hysteresis effect of climate change on the prevalence of ***,monitoring climate conditions can offer significant insights for implementing timely preventive and control measures to combat plague epidemics.

关键词： Plague epidemiology Plateau

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Epidemic Characteristics and Spatio-Temporal Patterns of HFRS in Qingdao City,China,2010-2022

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Biomedical and Environmental Sciences 2024年第9期37卷 1015-1029页

作者： Ying Li Runze Lu Liyan Dong Litao Sun Zongyi Zhang Yating Zhao Qing Duan Lijie Zhang Fachun jiang Jing Jia Huilai Ma Chinese Field Epidemiology Training Program Chinese Center for Disease Control and PreventionBeijing 100050China National Institute for Viral disease control and prevention Chinese Center for Disease Control and PreventionBeijing 102206China Qingdao Municipal center for disease control and prevention Qingdao 266024ShandongChina Jiaozhou center for disease control and prevention Qingdao 266399ShandongChina Institute for Infectious disease control and prevention Shandong Center for Disease Control and PreventionJinan 250013ShandongChina Office of Epidemiology(Technical Guidance Office for Patriotic Health Work) Chinese Center for Disease Control and PreventionBeijing 102206China

Objective This study investigated the epidemic characteristics and spatio-temporal dynamics of hemorrhagic fever with renal syndrome(HFRS)in Qingdao City,*** Information was collected on HFRS cases in Qingdao City from 2010 to *** epidemiologic,seasonal decomposition,spatial autocorrelation,and spatio-temporal cluster analyses were *** A total of 2,220 patients with HFRS were reported over the study period,with an average annual incidence of 1.89/100,000 and a case fatality rate of 2.52%.The male:female ratio was 2.8:1.75.3%of patients were aged between 16 and 60 years old,75.3%of patients were farmers,and 11.6%had both“three red”and“three pain”*** HFRS epidemic showed two-peak seasonality:the primary fall-winter peak and the minor spring *** HFRS epidemic presented highly spatially heterogeneous,street/township-level hot spots that were mostly distributed in Huangdao,Pingdu,and *** spatio-temporal cluster analysis revealed three cluster areas in Qingdao City that were located in the south of Huangdao District during the fall-winter *** The distribution of HFRS in Qingdao exhibited periodic,seasonal,and regional characteristics,with high spatial clustering *** typical symptoms of“three red”and“three pain”in patients with HFRS were not obvious.

关键词： Hemorrhagic fever with renal syndrome Epidemic characteristics Spatio-temporal distribution

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Prevalence and molecular characteristics of Listeria monocytogenes in cooked products and its comparison with isolates from listeriosis cases

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Frontiers of Medicine 2018年第1期12卷 104-112页

作者： Hong Wang Lijuan Luo Zhengdong Zhang Jianping Deng Yan Wang Yimao Miao Ling Zhang xi Chen xiang Liu Songsong Sun Bo xiao Qun Li Changyun Ye Zigong center for disease control and prevention Zigong 643000 China State Key Laboratory of Infectious disease prevention and control National Institute for Communicable Disease Control and Prevention Collaborative Innovation Center for Diagnosis and Treatment of lnfectious Diseases Chinese Center for Disease Control and Prevention Beijing 102206 China

This study aimed to investigate the prevalence and molecular characteristics ofListeria monocytogenes in cooked products in Zigong City, China. The overall occurrence of the L. monocytogenes in the ready-to-eat （RTE） shops and mutton restaurants surveyed was 16.2% （141/873）. An occurrence of 13.5% was observed in RTE pork, 6.5% in RTE vegetables, and more than 24.0% in either cooked mutton or cooked haggis. Serotype 1/2b （45.4%）, 1/2a （33.3%）, and 1/2c （14.2%） were the predominant types. By comparing the clonal complexes （CCs） based on multilocus sequence typing （MLST） of the L. monocytogenes from cooked foods in Zigong City and 33 listeriosis cases from different districts of China, CC87, CC9, CC8, and CC3 were showed to be prevalent in cooked products and CC87 and CC3 were the first two frequent types in the 33 clinic-source strains. All CC87 stains harbored the newly reported Listeria pathogenicity island 4 （LIPI-4） gene fragment ptsA, and all CC3 strains possessed the Listeria pathogenicity island 3 （LIPI-3） gene fragment llsX. These may increase the occurrence of the strains belonging to CC87 and CC3 in listeriosis cases in China and also underline the risk of infection owing to the consumption of the cooked products from Zigong. ST619 （serotype 1/2b） harbored both llsX and ptsA, indicating a potential hypervirulent sequence type in Zigong.

关键词： Listeria monocytogenes MLST LIPI-3 LIPI-4 RTE listeriosis

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Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing

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Biomedical and Environmental Sciences 2024年第3期37卷 294-302页

作者： ZHANG Ya Li SU Wen Zhe WANG Rui Chen LI Yan ZHANG Jun Feng LIU Sheng Hui HU Dan He XU Chong xiao YIN Jia Yu YIN Qi Kai HE Ying LI Fan FU Shi Hong NIE Kai LIANG Guo Dong TAO Yong XU Song Tao MA Chao Feng WANG Huan Yu Shaanxi University of Chinese Medicine Xianyang 712000ShaanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Guangzhou center for disease control and prevention Guangzhou 510000GuangdongChina Shandong center for disease control and prevention Jinan 250000ShandongChina Department of Ophthalmology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China xi'an center for disease control and prevention Xi’an 710054ShaanxiChina

Objective Viral encephalitis is an infectious disease severely affecting human *** is caused by a wide variety of viral pathogens,including herpes viruses,flaviviruses,enteroviruses,and other *** laboratory diagnosis of viral encephalitis is a worldwide ***,high-throughput sequencing technology has provided new tools for diagnosing central nervous system ***,In this study,we established a multipathogen detection platform for viral encephalitis based on amplicon *** We designed nine pairs of specific polymerase chain reaction(PCR)primers for the 12 viruses by reviewing the relevant *** detection ability of the primers was verified by software simulation and the detection of known positive *** sequencing was used to validate the samples,and consistency was compared with Sanger *** The results showed that the target sequences of various pathogens were obtained at a coverage depth level greater than 20×,and the sequence lengths were consistent with the sizes of the predicted *** sequences were verified using the National center for Biotechnology Information BLAST,and all results were consistent with the results of Sanger *** Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral *** is also a useful tool for the high-volume screening of clinical samples.

关键词： Viral encephalitis Amplicon sequencing High-throughput sequencing Multipathogen detection

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