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Luteolin alleviates sorafenib-induced ferroptosis of BRL-3A cells through modulation of the Nrf2/GPX4 signaling pathway

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Traditional Medicine research 2024年第10期9卷 1-9页

作者： Bo-Wen Zhang Di Yang Jin-Tao Li Mei-Hao Peng Jia-Qing Liao Qi Zhao Yi-Xi Yang Qiu-Xia Lu Engineering research Center of Sichuan-Tibet Traditional Medicinal Plant Chengdu UniversityChengdu 610106China School of food and Biological Engineering Chengdu UniversityChengdu 610106China School of Pharmacy Chengdu UniversityChengdu 610106China

Background:Luteolin is a flavonoid chemical that exists in a variety of medicinal and edible plants and holds many biologically active properties in liver protection,anti-cancer,antioxidants,anti-inflammatory,neuroprotective,*** to its hepatoprotective properties,luteolin was selected to co-treat with sorafenib,one of the approved protein kinase inhibitors,to reduce sorafenib-induced normal liver cell ***:The BRL-3A cell line was treated with sorafenib to establish a liver injury model,followed by luteolin *** cell viability was detected,and the mechanism of action was detected by immunofluorescence,western blotting,and real-time quantitative ***:The research findings demonstrated that luteolin could increase cystine/glutamate transporter xCT(SLC7A11)and glutathione peroxidase 4(GPX4)expression and display a chelating effect on iron,which led to increased glutathione and decreased malondialdehyde,Fe^(2+) and lipid reactive oxygen species contents in BRL-3A cells,and the sorafenib-induced mitochondrial membrane potential decrease was also *** addition,when sorafenib caused the accumulation of lipid reactive oxygen species,luteolin could help release this oxidative stress by activating nuclear factor E2-related factor 2(Nrf2)and up-regulating the expression of the associated genes heme oxygenase 1(HO-1)and quinone oxidoreductase 1(NQO1).Conclusion:Therefore,luteolin may ameliorate sorafenib-induced ferroptosis by activating the Nrf2-associated pathway without any impact on sorafenib anti-cancer *** can be used as an adjuvant to sorafenib to reduce liver injury in patients with hepatocellular carcinoma.

关键词： luteolin sorafenib liver injury ferroptosis Nrf2/GPX4

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Can effectoromics and loss-of-susceptibility be exploited for improving Fusarium head blight resistance in wheat?

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The Crop Journal 2021年第1期9卷 1-16页

作者： Andrii Gorash Rita Armonienė Kemal Kazan Institute of agriculture Lithuanian Research Centre for Agriculture and Forestry(LAMMC)Instituto av.1Akademija LT-58344Lithuania Commonwealth Scientific and industrial research Organisation(CSIRO)agriculture and food BrisbaneQLD 4067Australia Queensland Alliance for agriculture and food Innovation(QAAFI) The University of QueenslandBrisbaneQLD 4067Australia

Bread wheat(Triticum aestiuum L.),which provides about 20%of daily calorie intake,is the most widely cultivated crop in the world,in terms of total area devoted to its ***,even small increases in wheat yield can translate into large *** the gap between actual and potential grain yield in wheat is a crucial task to feed the increasing world *** head blight(FHB)caused by the pathogenic fungus Fusaium graminearum and related Fusarium species is one of the most devastating wheat diseases throughout the *** disease reduces not only the yield but also the quality by contaminating the grain with mycotoxins harmful for humans,animals and the *** recent years,remarkable achievements attained in omics"technologies have not only provided new insights into understanding of processes involved in pathogenesis but also helped develop effective new tools for practical plant *** of the genomes of various wheat patho gens,including ***,as well as those of bread and durum wheat and their wild relatives,together with advances made in transcriptomics and bioinformatics,has allowed the identification of candidate pathogen effectors and corresponding host resistance(R)and susceptibility(S)***,so far,FHB effectors and wheat susceptibility genes/factors have been poorly *** this paper,we first briefly highlighted recent examples of improving resistance against pathogens via new techniques in different host *** then propose effective strategies towards developing wheat cultivars with improved resistance to *** hope that the article will spur discussions and interest among researchers about novel approaches with great potential for improving wheat against FHB.

关键词： Effectoromics Susceptibility genes Fusarium head blight Fusarium graminearum Wheat breeding for resistance

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Impact of High Pressure Homogenization (HPH) Treatment on the Nutritional Quality of Egg/Yogurt, Vegetable and Fruit Based Creams

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food and Nutrition Sciences 2014年第1期5卷 27-34页

作者： Mattia Di Nunzio Lucia Vannini Nadia Tossani Francesca Patrignani Rosalba Lanciotti Alessandra Bordoni Department of agri-food Sciences & Technologies Alma Mater Studiorum-University of Bologna Cesena Italy Dipartimento di Scienze Biomediche e Neuromotorie Alma Mater Studiorum-University of Bologna Bologna Italy. Interdepartmental centre for industrial agri-food research Alma Mater Studiorum-University of Bologna Cesena Italy Interdepartmental centre for industrial agri-food research Alma Mater Studiorum-University of Bologna Cesena Italy Department of agri-food Sciences & Technologies Alma Mater Studiorum-University of Bologna Cesena Italy

The food industry has made large investments in processing facilities relying mostly on conventional thermal processing technologies with well-established reliability and efficacy. These techniques have important disadvantages such as off flavors, destruction of nutrients, and other losses of product quality. Non thermal processing is a key factor for preserving or improving the nutritional value of food, and high pressure homogenization (HPH) processing is now a celebrated option experiencing worldwide commercial growth. Notwithstanding, little is known on the impact of HPH treatments on the nutritional value of food. In this study we have evaluated the possible modification induced by HPH treatment in egg-yogurt, mixed vegetable, and mixed fruit creams. Our results evidence that HPH does not affect the nutritional quality of lipids and does not cause lipolysis, lipid peroxidation and vitamin E loss. In plant food products, HPH preserved or improved the nutritional quality, suggesting its use as valid alternative to thermal pasteurization for obtaining high quality products with preserved nutritional characteristics. Although further investigations are needed, especially at extreme pressure and temperature combinations, our results open new perspectives for the production of ambient stable products with good nutritional value, and contribute to process optimization.

关键词： High Pressure Homogenization Nutritional Quality

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Novel energy recovery from an integrated municipal solid waste and leachate treatment system

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Waste Disposal and Sustainable Energy 2024年第1期6卷 53-61页

作者： Siti Salwa Khamis Hadi Purwanto Hamzah Mohd Salleh Alya Naili Rozhan Mohamed Abdur Rahman Mahammadsalman Warimani Noor Alam Faculty of Engineering International Islamic University MalaysiaJalan Gombak53100Kuala LumpurMalaysia Department of Engineering Management Universitas Internasional Semen IndonesiaGresikIndonesia Halalan Thayyiban research centre Sultan Sharif Ali Islamic UniversityBandar Seri BegawanBrunei Department of Mechanical Engineering P.A.College of EngineeringMangaloreKarnataka574153India Department of Mechanical Engineering Malaysia-Japan International Institute of TechnologyUniversity of Technology Malaysia54100Kuala LumpurMalaysia

Population growth,waste generation,and massive waste mismanagement have led to environmental *** of municipal solid waste(MSW)requires an efficient and sustainable integrated *** integrated thermal processing of MSW is one of the best waste management *** this study,energy analysis of MSW is carried out based on the material and energy balance of 2000 kg wet MSW,which contains 50%*** the leachate is removed,the dry MSW is sent for carbon content enhancement in carbonization to produce MSW-based ***,the combustion of MSW-based char provided high heat and syngas to be used in a hydrothermal process for MSW leachate *** result shows that the char fuel of MSW produces a sufficient amount of energy,13501.29 MJ(84.55%),in the form of synthetic gas by-product,which has a big potential as an energy *** novelty of the proposed integrated thermal system is to produce 84.55%synthetic gas by-product,which is used for electricity production,cooking,food,and heat energy for industrial *** proposed applications of this paper offer insightful information for policymaking regarding novel MSW techniques,which are economical,energy-efficient,and environmentally ***,it increases the effectiveness of MSW utilization.

关键词： Energy Carbonization Hydrothermal Municipal solid waste Integrated system

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Polysaccharide composition during cotton seed fibre development:temporal differences between species and in different seasons

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Journal of Cotton research 2022年第4期5卷 12-24页

作者： PETTOLINO Filomena A. YULIA Dina BACIC Antony LLEWELLYN Danny J. Commonwealth Scientific and industrial research Organisation(CSIRO) Agri-culture and FoodCanberraACT 2601Australia Department of Animal Plant&Soil SciencesLa Trobe Institute for Agriculture and FoodLa Trobe UniversityAgriBio BuildingBundooraVIC 3083Australia

Background:Cotton seed fibres are long single-celled epidermal trichomes that first appear on the surface of the ovule at anthesis and then elongate rapidly over a period of 15-25 days until a secondary cell wall(SCW)begins to develop through a rapid increase in the deposition of microfibrillar cellulose between the plasma membrane and the primary cell wall that eventually terminates *** measurements of the different polysaccharide components in both wall types over time and how they influence fibre quality can direct studies involved in enhanc-ing fibre properties for yarn quality through cell wall manipulation or molecular ***:A detailed chemical analysis of cell wall composition by differential solvent fractionation was used to identify the range of polysaccharides present in mature cotton fibres and used to validate a simpler total cell wall monosaccharide linkage analysis protocol for wall compositional *** of fibres from 5 days post-anthesis through maturity for three cultivated species,Gossypium hirsutum,***,and ***,showed the dynamic nature of cell wall polysaccharide composition through fibre development and that it progressed differently for each *** grown in the glasshouse during either autumn to winter or spring to summer and within each species had fibre qualities and temporal aspects of cell wall development that were different for each ***,the timing of the deposition of the SCW was delayed in winter grown plants and appeared to influence key fibre qual-ity ***:These results suggest that the temporal aspects of cell wall polysaccharide biogenesis during fibre development influence final fibre quality,and this timing is determined by both genetic and environmental *** onset of SCW synthesis appears to be a critical factor coinciding with termination of fibre elongation and specify-ing the duration of wall thickening that then affects fibre le

关键词： Fibre development Gossypium hirsutum Gossypium barbadense Gossypium arboreum

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Changes of protein oxidation,lipid oxidation and lipolysis in Chinese dry sausage with different sodium chloride curing salt content

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food Science and Human Wellness 2020年第4期9卷 328-337页

作者： Bing Zhao Huimin Zhou Shunliang Zhang Xiaoqian Pan Su Li Ning Zhu Qianrong Wu Shouwei Wang Xiaoling Qiao Wenhua Chen China Meat research centre Beijing100068China Beijing Academy of food Sciences Beijing100068China

The effect of sodium chloride(NaCl)curing salt content on protein oxidation,lipid oxidation and lipolysis of Chinese dry sausage was *** groups Chinese dry sausages with 2%and 4%(m/m)salt content were *** degree of protein oxidation increased during the processes in two groups sausages,while the content of phospholipids decreased,neutral lipids and free fatty acids *** degree of protein oxidation,lipid oxidation and lipolysis in 4%NaCl content group was higher than those in 2%NaCl content group,while 4%NaCl content group has higher lipase *** conclusion,4%NaCl may facilitate the protein oxidation,lipid hydrolysis and oxidation in Chinese dry sausage,and the protein oxidation had strong correlation with lipid oxidation and *** results could provide a basis for improving the technology of industrial production.

关键词： Chinese dry sausage sodium chloride Protein oxidation Lipids oxidation Lipolysis

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Effect of diets supplemented with linseed alone or combined with vitamin E and selenium or with plant extracts,on Longissimus thoracis transcriptome in growing-finishing Italian Large White pigs

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Journal of Animal Science and Biotechnology 2019年第1期10卷 159-171页

作者： Rubina Sirri Marika Vitali Paolo Zambonelli Giulia Giannini Martina Zappaterra Domenico Pietro Lo Fiego Dalal Sami Roberta Davoli Interdepartmental centre for industrial agrifood research (CIRI- AGRO) University of Bologna Department of agricultural and food Sciences (DISTAL) University of Bologna Department of Life Sciences University of Modena and Reggio Emilia Interdepartmental research centre for agri-food Biological Resources Improvement and Valorisation (BIOGEST-SITEIA) University of Modena and Reggio Emilia

Background: Supplementing farm animals diet with functional ingredients may improve the nutritional quality of meat *** composition has been also demonstrated to influence the gene expression with effect on biological processes and ***,the knowledge on the effect of nutrients at the molecular level is *** particular,studies on the effects of antioxidants and polyphenols dietary supplementation have been investigated mainly in rodents,and only scarcely in farm animals so ***-Seq with next-generation sequencing is increasingly the method of choice for studying changes in the transcriptome and it has been recently employed also in pig nutrigenomics studies to identify diet-induced changes in gene *** present study aimed to investigate the effect of diets enriched with functional ingredients(linseed,vitamin E and plant extracts) on the transcriptome of pig Longissimus thoracis to elucidate the role of these compounds in influencing genes involved in muscle physiology and metabolism compared to a standard ***: Eight hundred ninety-three significant differentially expressed genes(DEGs)(FDR adjusted P-value ≤ 0.05)were detected by RNA-Seq analysis in the three diet comparisons(D2-D1,D3-D1,D4-D1).The functional analysis of DEGs showed that the diet enriched with n-3 PUFA from linseed(D2) mostly downregulated genes in pathways and biological processes(BPs) related to muscle development,contraction,and glycogen metabolism compared to the standard *** diet supplemented with linseed and vitamin E/Selenium(D3) showed to mostly downregulate genes linked to oxidative *** few genes involved in extracellular matrix(ECM)organization were upregulated by the ***,the comparison D4-D1 showed that the diet supplemented with linseed and plant extracts(D4) upregulated the majority of genes compared to D1 that were involved in a complex network of pathways and BPs all connected by hub *** particular,IGF2 wa

关键词： Diet supplementation Functional analysis Gene expression Linseed Muscle transcriptome n-3 PUFA Pigs Plant extracts Polyphenols Vitamin E

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Biosurfactants from lactic acid bacteria:A critical review on production,extraction,structural characterization and food application

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food Bioscience 2022年第2期46卷 14-23页

作者： Hippolyte T.Mouafo Alphonse T.Sokamte Augustin Mbawala Robert Ndjouenkeu Somashekar Devappa centre for food and Nutrition research Institute of Medical Research and Medicinal Plants’StudiesPoBox:13033Yaound´eCameroon Department of food Processing and Quality Control University Institute of TechnologyUniversity of Ngaound´er´ePoBox:454 Ngaound´er´eCameroon Department of food Science and Nutrition National School of Agro-Industrial SciencesUniversity of Ngaound´er´ePoBox:454 Ngaound´er´eCameroon Department of Microbiology and Fermentation Technology CSIR-Central Food Technological Research InstituteMysore570020India

Biosurfactants are structurally diverse classes of amphiphilic molecules derived from *** have various properties such as surface,emulsification,antibacterial,anti-adhesive,anti-biofilm,antioxidant activity that can be used in many industrial *** interest in these molecules compared to their synthetic counterparts is due to their biodegradability,low toxicity,structural diversity,and stability over a wide range of pH,temperature,and *** biosurfactants,those derived from lactic acid bacteria(LAB)attracted attention nowadays due to the GRAS(Generally recognized as safe)status of these *** production by LAB strains has been documented in several investigations,and they deal with the functionality and chemical nature of *** biosurfactants were mainly a complex mixture of proteinaceous compounds,glycolipids,glycoproteins,or *** are only a few studies reporting on the elucidation of the structure of LAB ***,biosurfactants’production process includes several unit operations starting from screening methods to the characterization of the biosurfactant *** review highlights the different techniques used in the screening of biosurfactants production by LAB,their extraction and purification processes,and their structural characterization and application in the food industry.

关键词： Biosurfactants Lactic acid bacteria Screening Purification Structural characterization

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Monascus vinegar alleviates high-fat-diet-induced inflammation in rats by regulating the NF-κB and PI3K/AKT/mTOR pathways

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food Science and Human Wellness 2022年第4期11卷 943-953页

作者： Huanmei Meng Jia Song Bingqian Fan Yingqi Li Jiaojiao Zhang Jinping Yu Yu Zheng Min Wang State Key Laboratory of food Nutrition and Safety Key Laboratory of Industrial Fermentation MicrobiologyTianjin Engineering Research Centre of Microbial Metabolism and Fermentation Process ControlCollege of BiotechnologyTianjin University of Science&TechnologyTianjin 300457China Shandong Engineering research centre of Condiment Fermentation Technology Shandong Yutu Co.LtdZibo 255300China

Monascus vinegar(MV) is a typical fermented food with various health-promoting effects. This study aimed to evaluate the role of MV in alleviating high-fat-diet-induced inflammation in rats with hyperlipidemia and elucidate the possible regulatory mechanisms. In the study, serum lipid profiles, liver pathology and liver inflammatory cytokines were analyzed in hyperlipidemia rats with MV(0.5 mL/kg mb, 2 mL/kg mb). Results showed that the administration of MV alleviated dyslipidemia by decreasing the serum and liver levels of triglyceride and total cholesterol. Increase in hepatic lipase and carnitine palmitoyl transferase 1(CPT-1)levels and decrease in hepatocyte steatosis, nephritis, and intestinal tissue injury in the HD group showed that high-dose MV can significantly suppress hepatic lipid accumulation and steatosis. In addition, compared with the model(MOD) group, the HD group showed significantly down-regulated the level of serum or hepatic alanine aminotransferase(ALT), aspartate aminotransferase(AST), CPT-1, interleukin(IL)-2, IL-6, IL-12,and tumor necrosis factor α(TNF-α). Moreover, the HD group showed repressed hepatic nuclear factor κB(NF-κB) pathway and inactivated phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR) pathway mitigated liver inflammation. Similar results were obtained from cell experiments. Collectively, these findings revealed that MV might attenuate high-fat-diet-induced inflammation by inhibiting the NF-κB and PI3K/Akt/mTOR pathways.

关键词： Monascus vinegar Hyperlipidemia Inflammation NF-κB PI3K/AKT/mTOR

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Effects of drinking water supplementation with Lactobacillus reuteri,and a mixture of reuterin and microcin J25 on the growth performance,caecal microbiota and selected metabolites of broiler chickens

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Journal of Animal Science and Biotechnology 2022年第4期13卷 1209-1221页

作者： Liya Zhang Laila Ben Said Nadège Hervé Séverine Zirah Moussa Sory Diarra Ismail Fliss Institute of Nutrition and Functional foods UniversitéLavalQCQuébecCanada Sollio agriculture MontréalQCCanada Molécules de Communication et Adaptation des Microorganismes Muséum National d’Histoire NaturelleParisFrance Guelph research and Development centre Agriculture and Agri-Food CanadaGuelphONCanada.

Background:Since the overuse of antibiotics in animal production has led to a selection of antibiotic-resistant pathogens that affect humans and animals as *** are therefore searching for novel natural alternatives to *** this study Lactobacillus reuteri and a combination of reuterin and microcin J25(RJ)were evaluated as promoters of growth and modulators of the cecal microbiota and metabolite profiles in broiler ***-old Cobb 500 male broilers were distributed to 8 treatments:negative control(without antibiotic),positive control(bacitracin),three concentrations of RJ and three doses of *** plus *** birds(2176,34 per pen,8 pens per treatment)were reared for 35 ***:The body weight of the bacitracin and 5 mmol/L reuterin combined with 0.08μmol/L microcin J25(10RJ)treatment group was significantly higher than that of the negative control group(P<0.05).*** had no significant effect on broiler *** high-throughput sequencing of 16S rRNA showed clustering of cecal microbial operational taxonomic unit diversity according to *** influence of bacitracin and 10RJ on bacterial community overall structure was *** promoted Ruminococcaceae,Lachnospiraceae and Lactobacillaceae,increased the relative abundance of Faecalibacterium and decreased the abundance of Bacteroides and Alistipes,while the negative control condition favored Bacteroidaceae and ***,10RJ increased the concentration of short-chain fatty acid in the cecum and changed the metabolome ***:These overall suggest that 10RJ can promote a host-friendly gut environment by changing the cecal microbiome and *** combination of natural antimicrobial agents in the drinking water had a positive effect on broiler growth and may be suitable as an alternative to antibiotic growth promoters.

关键词： Broiler chicken Lactobacillus reuteri Metabolome Microbiome Microcin J25 Reuterin SCFA

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