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The new era of cardiovascular research:revolutionizing cardiovascular research with 3D models in a dish

Medical Review 2024年第1期4卷 68-85页

作者： Yuan Yang Hao Yang Fedir N.Kiskin Joe Z.Zhang institute of neurological and psychiatric Disorders Shenzhen Bay LaboratoryShenzhenGuangdong ProvinceChina institute of neurological and psychiatric Disorders Shenzhen Bay LaboratoryShenzhen 518132Guangdong ProvinceChina

Cardiovascular research has heavily relied on studies using patient samples and animal ***,patient studies often miss the data from the crucial early stage of cardiovascular diseases,as obtaining primary tissues at this stage is *** animal models can offer some insights into disease mechanisms,although they usually do not fully recapitulate the phenotype of cardiovascular diseases and their *** recent years,a promising breakthrough has emerged in the form of in vitro three-dimensional(3D)cardiovascular models utilizing human pluripotent stem *** innovative models recreate the intricate 3D structure of the human heart and vessels within a controlled *** advancement is pivotal as it addresses the existing gaps in cardiovascular research,allowing scientists to study different stages of cardiovascular diseases and specific drug responses using human-origin *** this review,we first outline various approaches employed to generate these *** then comprehensively discuss their applications in studying cardiovascular diseases by providing insights into molecular and cellular changes associated with cardiovascular condi***,we highlight the potential of these 3D models serving as a platform for drug testing to assess drug efficacy and *** their immense potential,challenges persist,particularly in maintaining the complex structure of 3D heart and vessel models and ensuring their function is comparable to real ***,overcoming these challenges could revolutionize cardiovascular *** has the potential to offer comprehensive mechanistic insights into human-specific disease processes,ultimately expediting the development of personalized therapies.

关键词： pluripotent stem cells three-dimensional(3D)models cardiac microtissues cardiac organoids vessel organoids organ-on-a-chip

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Endoplasmic reticulum stress,autophagy,neuroinflammation,and sigma 1 receptors as contributors to depression and its treatment

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Neural Regeneration Research 2024年第10期19卷 2202-2211页

作者： Chika Fujii Charles F.Zorumski Yukitoshi Izumi Department of Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor Family institute for Innovative psychiatric Research Washington University School of MedicineSt.LouisMOUSA

The etiological factors contributing to depression and other neuropsychiatric disorders are largely undefined. Endoplasmic reticulum stress pathways and autophagy are well-defined mechanisms that play critical functions in recognizing and resolving cellular stress and are possible targets for the pathophysiology and treatment of psychiatric and neurologic illnesses. An increasing number of studies indicate the involvement of endoplasmic reticulum stress and autophagy in the control of neuroinflammation, a contributing factor to multiple neuropsychiatric illnesses. Initial inflammatory triggers induce endoplasmic reticulum stress, leading to neuroinflammatory responses. Subsequently, induction of autophagy by neurosteroids and other signaling pathways that converge on autophagy induction are thought to participate in resolving neuroinflammation. The aim of this review is to summarize our current understanding of the molecular mechanisms governing the induction of endoplasmic reticulum stress, autophagy, and neuroinflammation in the central nervous system. Studies focused on innate immune factors, including neurosteroids with anti-inflammatory roles will be reviewed. In the context of depression, animal models that led to our current understanding of molecular mechanisms underlying depression will be highlighted, including the roles of sigma 1 receptors and pharmacological agents that dampen endoplasmic reticulum stress and associated neuroinflammation.

关键词： allopregnanolone fluvoxamine ketamine neurosteroids postpartum depression quercetin

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OBSERVATIONS ON TREATMENT OF PEDIATRIC EPILEPSY WITH A HERBAL ANTIEPILEPTIC TABLET

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Journal of Traditional Chinese Medicine 1990年第3期10卷 192-194页

作者：陈德明卢伟孟兰英刘会东李明远王秀国李树春 Depertment of Pediatrics Daqing City 4th Hospital institute of neurologic and psychiatric diseases in children Jiamusi Medical College

In order to assess the effect of aself-made herbal antiepileptic tablet in pre-venting and controlling attacks of epilepsyin children,the authors treated 100 suchcases with the tablet during 1984-1987,while another 40 cases were treated withconventional western medicines to serve *** besides,observations weremade on the effect of the tablet on experi-mental *** following is a report ofthe work.

关键词： tablet herbal medicines children besides Qingdao luminal 临床疗效评定 anemia minutes

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Study of tree shrew biology and models: A booming and prosperous field for biomedical research

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Zoological Research 2024年第4期45卷 877-909页

作者： Yong-Gang Yao Li Lu Rong-Jun Ni Rui Bi Ceshi Chen Jia-Qi Chen Eberhard Fuchs Marina Gorbatyuk Hao Lei Hongli Li Chunyu Liu Long-Bao Lv Kyoko Tsukiyama-Kohara Michinori Kohara Claudia Perez-Cruz Gregor Rainer Bao-Ci Shan Fang Shen An-Zhou Tang Jing Wang Wei Xia Xueshan Xia Ling Xu Dandan Yu Feng Zhang Ping Zheng Yong-Tang Zheng Jumin Zhou Jiang-Ning Zhou Key Laboratory of Genetic Evolution and Animal Models Yunnan Key Laboratory of Animal Models and Human Disease MechanismsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) and National Resource Center for Non-Human PrimatesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Mental Health Center and psychiatric Laboratory West China HospitalSichuan UniversityChengduSichuan 610041China Sichuan Clinical Medical Research Center for Mental Disorders ChengduSichuan 610044China German Primate Center Leibniz Institute of Primate ResearchGöttingen 37077Germany Department of Optometry and Vision Science School of OptometryUniversity of Alabama at BirminghamBirminghamAL 35294USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Soong Ching Ling institute of Maternity and Child Health International Peace Maternity and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Transboundary Animal diseases Center Joint Faculty of Veterinary MedicineKagoshima UniversityKagoshima-cityKagoshima 890-8580Japan Department of Microbiology and Cell Biology Tokyo Metropolitan Institute of Medical ScienceTokyo 156-8506Japan Pharmacology Department CinvestavMexico City 07360Mexico Department of Medicine University of FribourgFribourg CH-1700Switzerland Beijing Engineering Research Center of Radiog

The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with *** recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain ***,the limited availability of tree shrews globally remains a substantial challenge in the ***,determining the key questions best answered using tree shrews constitutes another *** shrew models have historically been used to study hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative *** these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical *** review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this *** emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew *** use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.

关键词： Tree shrew Animal model Neurodegenerative diseases Infectious diseases Neuroscience Phenome

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Upregulation of Spinal Voltage-Dependent Anion Channel 1 Contributes to Bone Cancer Pain Hypersensitivity in Rats

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Neuroscience Bulletin 2017年第6期33卷 711-721页

作者： Xiangpeng Kong Jinrong Wei Diyu Wang Xiaoju Zhu Youlang Zhou Shusheng Wang Guang-Yin Xu Guo-Qin Jiang Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-psychiatric diseases and institute of Neuroscience The Second Affiliated Hospital Soochow University Center for Translational Medicine Affiliated Zhangjiagang Hospital of Soochow University

Voltage-dependent anion channel 1（VDAC1） is thought to contribute to the progression of tumor development. However, whether VDAC1 contributes to bone cancer pain remains unknown. In this study, we found that the expression of VDAC1 was upregulated in the L2–5 segments of the spinal dorsal horn at 2 and 3 weeks after injection of tumor cells into the tibial cavity. Intrathecal injection of a VDAC1 inhibitor significantly reversed the pain hypersensitivity and reduced the over-expression of Toll-like receptor 4（TLR4）. Intrathecal injection of minocycline, an inhibitor of microglia, also attenuated the pain hypersensitivity of rat models of bone cancer *** results suggest that VDAC1 plays a significant role in the development of complicated cancer pain, possibly by regulating the expression of TLR4.

关键词： Cancer-induced pain Spinal dorsal horn Voltage-dependent anion channel 1 Toll-like receptor 4 Microglia

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The aryl hydrocarbon receptor and the gut–brain axis

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Cellular & Molecular Immunology 2021年第2期18卷 259-268页

作者： Andreia Barroso João Vitor Mahler Pedro Henrique Fonseca-Castro Francisco J.Quintana Ann Romney Center for neurologic diseases Brigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Faculdade de Medicina FMUSP Universidade de São PauloSão PauloSPBrazil Broad institute of MIT and Harvard CambridgeMAUSA

The aryl hydrocarbon receptor(AHR)is a ligand-activated transcription factor initially identified as the receptor for *** half a century after its discovery,AHR is now recognized as a receptor for multiple physiological ligands,with important roles in health and *** this review,we discuss the role of AHR in the gut–brain axis and its potential value as a therapeutic target for immune-mediated diseases.

关键词： Aryl hydrocarbon receptor Autoimmune diseases Infectious diseases cancer

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Constructing Artificial Nucleobase Compilation to Enable Precise Molecular Medicine

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Chinese Journal of Chemistry 2023年第11期41卷 1385-1398页

作者： Jingqi Chen Bo Liu Xuan Wang Xueliang Liu Dandan Yang Yu Yang institute of Molecular Medicine (IMM) Shanghai Key Laboratory for Nucleic Acid Chemistry and NanomedicineRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127 China institute of Functional Nano & Soft Materials Laboratory (FUNSOM) Soochow UniversitySuzhouJiangsu215123 China Evergrande Center for Immunologic diseases Ann Romney Center for Neurologic DiseasesHarvard Medical School and Brigham and Women's HospitalBostonMA02115 USA

Nucleic acids are the hereditary information storage medium of life. Due to its high programmability and good biocompatibility, the applications of nucleic acids are not limited to their natural function. However, the efficiency of nucleic acids is often hampered by inherent limitations in numerous practical applications, including limited access to complex functional patterns due to only four building blocks, facile degradation by nucleases, rapid renal clearance, poor pharmacokinetic properties, and so on. To end this, the researchers developed unnatural base pairs (UBPs) and numerous artificial analogues of nucleosides and oligonucleotides in recent decades. The developed UBPs and nucleoside base analogues together constitute artificial nucleobase compilation, which promotes the development of biomedical sciences. Here, we describe the development of artificial nucleobase compilation and summarized its applications in precise molecular medicine, including PCR-based diagnostics, aptamer-based diagnostics, nucleobase analogue drugs construction, ASO modification, aptamer-based therapeutics and biomaterials construction. This review provides an overview of current opportunities and challenges of artificial nucleobase-related precise molecular medicine.

关键词： Nucleobases Oligonucleotides Biological activity Aptamer Drug delivery

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Systems-based approaches to study immunometabolism

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Cellular & Molecular Immunology 2022年第3期19卷 409-420页

作者： Vinee Purohit Allon Wagner Nir Yosef Vijay K.Kuchroo Evergrande Center for Immunologic diseases and Ann Romney Center for neurologic diseases Brigham and Women’s HospitalHarvard Medical SchoolBostonMA02115USA Broad institute of MIT and Harvard CambridgeMA02141USA Department of Electrical Engineering and Computer Science University of CaliforniaBerkeleyCA94720USA Center for Computational Biology University of CaliforniaBerkeleyCA94720USA

Technical advances at the interface of biology and computation,such as single-cell RNA-sequencing(scRNA-seq),reveal new layers of complexity in cellular *** emerging area of investigation using the systems biology approach is the study of the metabolism of immune *** diverse spectra of immune cell phenotypes,sparsity of immune cell numbers in vivo,limitations in the number of metabolites identified,dynamic nature of cellular metabolism and metabolic fluxes,tissue specificity,and high dependence on the local milieu make investigations in immunometabolism challenging,especially at the single-cell *** this review,we define the systemic nature of immunometabolism,summarize cell-and system-based approaches,and introduce mathematical modeling approaches for systems interrogation of metabolic changes in immune *** close the review by discussing the applications and shortcomings of metabolic modeling *** systems-oriented studies of metabolism expected to become a mainstay of immunological research,an understanding of current approaches toward systems immunometabolism will help investigators make the best use of current resources and push the boundaries of the discipline.

关键词： Immunometabolism Metabolic techniques GSMM Metabolic modeling Systems biology

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Are there fetal stem cells in the maternal brain?

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Neural Regeneration Research 2013年第7期8卷 593-598页

作者： Osman Demirhan Necmi ekin Deniz Tastemir Erdal Tun Ali rfan Güzel Demet Meral Bülent Demirbek Department of Medical Biology and Genetics Faculty of Medicine University of ukurova Department of Forensic Medicine Faculty of Medicine University of ukurova Vocational School of Health Services Adiyaman University Department of Medical Biology and Genetics Faculty of Medicine Recep Tayyip Erdo an University psychiatric and neurologic Diesease Hospital

Fetal cells can enter maternal blood during pregnancy but whether they can also cross the blood-brain barrier to enter the maternal brain remains poorly understood. Previous results suggest that fetal cells are summoned to repair damage to the mother＇s brain. If this is confirmed, it would open up new and safer avenues of treatment for brain damage caused by strokes and neural diseases. In this study, we aimed to investigate whether a baby＇s stem cells can enter the maternal brain during pregnancy. Deceased patients who had at least one male offspring and no history of abortion and blood transfusion were included in this study. DNA was extracted from brain tissue samples of deceased women using standard phenol-chloroform extraction and ethanol precipitation methods. Genomic DNA was screened by quantitative fluorescent-polymerase chain reaction amplification together with short tandem repeat markers specific to the Y chromosome, and 13, 18, 21 and X. Any foreign DNA residues that could be used to interpret the presence of fetal stem cells in the maternal brain were monitored. Results indicated that fetal stem cells can not cross the blood-brain barrier to enter the maternal brain.

关键词： neural regeneration stem cells neurogenesis fetal stem cells brain tissue hippocampus subventricular zone quantitative fluorescent-PCR pregnancy neural disease DNA Ychromosome grants-supported paper photographs-containing paper neuroregeneration

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Moxibustion for Managing Type 2 Diabetes Mellitus:A Systematic Review

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Chinese Journal of Integrative Medicine 2011年第8期17卷 575-579页

作者： Tae-Hun Kim Tae-Yong Choi Byung-Cheul Shin Myeong Soo Lee Department of Cardiovascular and neurologic diseases College of Oriental MedicineGraduate SchoolKyung Hee University Acupuncture Moxibustion and Meridian Research CenterKorea Institute of Oriental Medicine Brain Disease Research Centre Korea Institute of Oriental Medicine Division of Clinical Medicine School of Korean MedicinePusan National University

Objective：Moxibustion is currently used for treating diabetes mellitus（DM） as a non-drug intervention in East Asian *** systematic review aims to evaluate the effectiveness of moxibustion for managing the symptoms of type 2 DM ***：We searched MEDLINE,AMED,EMBASE,CINAHL, The Cochrane Library,six Korean databases,and four Chinese *** of bias was used for evaluating the quality of the included ***：A total of 5 studies met the inclusion criteria for this *** of the included studies had high risks of *** randomized clinical trial（RCT） compared the effectiveness of one-time moxibustion use with oral administration of glibenclimide and showed the significant effects of moxibustion on glycemic *** RCT tested the effectiveness of moxibustion plus conventional treatment,and the moxibustion group reported significant improvement in fasting and postprandial blood glucose levels compared with the conventional treatment *** RCTs compared the effectiveness of moxibustion versus acupuncture or moxibustion plus acupuncture,and the combined treatment showed the most favorable effects on the control of blood glucose,urine glucose,and glycocylated hemoglobin A_（1C）（HbA_（1C））.One uncontrolled observational study showed favorable effects of moxibustion on the response ***：It is difficult to conclude that moxibustion is an effective intervention for the control of type 2 DM due to the scarcity of trials and the low methodological quality of included *** rigorous RCTs may be necessary to evaluate the effectiveness of moxibustion for type 2 DM.

关键词： moxibustion diabetes mellitus type 2 diabetes mellitus blood glucose systematic review

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