Study of tree shrew biology and models: A booming and prosperous field for biomedical research

作     者：Yong-Gang Yao Li Lu Rong-Jun Ni Rui Bi Ceshi Chen Jia-Qi Chen Eberhard Fuchs Marina Gorbatyuk Hao Lei Hongli Li Chunyu Liu Long-Bao Lv Kyoko Tsukiyama-Kohara Michinori Kohara Claudia Perez-Cruz Gregor Rainer Bao-Ci Shan Fang Shen An-Zhou Tang Jing Wang Wei Xia Xueshan Xia Ling Xu Dandan Yu Feng Zhang Ping Zheng Yong-Tang Zheng Jumin Zhou Jiang-Ning Zhou 

作者机构：Key Laboratory of Genetic Evolution and Animal ModelsYunnan Key Laboratory of Animal Models and Human Disease MechanismsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)and National Resource Center for Non-Human PrimatesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China Kunming College of Life ScienceUniversity of Chinese Academy of SciencesKunmingYunnan 650204China Mental Health Center and Psychiatric LaboratoryWest China HospitalSichuan UniversityChengduSichuan 610041China Sichuan Clinical Medical Research Center for Mental DisordersChengduSichuan 610044China German Primate CenterLeibniz Institute of Primate ResearchGöttingen 37077Germany Department of Optometry and Vision ScienceSchool of OptometryUniversity of Alabama at BirminghamBirminghamAL 35294USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhanHubei 430074China Soong Ching Ling Institute of Maternity and Child HealthInternational Peace Maternity and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Transboundary Animal Diseases CenterJoint Faculty of Veterinary MedicineKagoshima UniversityKagoshima-cityKagoshima 890-8580Japan Department of Microbiology and Cell BiologyTokyo Metropolitan Institute of Medical ScienceTokyo 156-8506Japan Pharmacology DepartmentCinvestavMexico City 07360Mexico Department of MedicineUniversity of FribourgFribourg CH-1700Switzerland Beijing Engineering Research Center of Radiographic Techniques and EquipmentInstitute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Nuclear Science and TechnologyUniversity of Chinese Academy of SciencesBeijing 100049China CAS Key Laboratory of Mental HealthInstitute of PsychologyChinese Academy of SciencesBeijing 100101China Department of PsychologyUniversity of Chinese Academy of SciencesBeijing 100101China Department of Otorhinolaryngology Head and Neck SurgeryFirst Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530000China Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University)Ministry of EducationNanningGuangxi 530000China Department of NeurobiologySchool of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China School of Public HealthKunming Medical UniversityKunmingYunnan 650500China CAS Key Laboratory of Brain Function and DiseasesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230027China Institute of Brain ScienceFirst Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China 

出 版 物：《Zoological Research》 (动物学研究（英文）)

年 卷 期：2024年第45卷第4期

页      面：877-909页

核心收录：

学科分类：0710[理学-生物学] 08[工学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：supported by the STI2030-Major Projects(2021ZD0200900 to Y.G.Y.) "Light of West China" Program of the Chinese Academy of Sciences(xbzg-zdsys-202302 to Y.G.Y.) 

主　　题：Tree shrew Animal model Neurodegenerative diseases Infectious diseases Neuroscience Phenome 

摘      要：The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with *** recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain ***,the limited availability of tree shrews globally remains a substantial challenge in the ***,determining the key questions best answered using tree shrews constitutes another *** shrew models have historically been used to study hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative *** these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical *** review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this *** emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew *** use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.