The aryl hydrocarbon receptor and the gut–brain axis

作     者：Andreia Barroso João Vitor Mahler Pedro Henrique Fonseca-Castro Francisco J.Quintana 

作者机构：Ann Romney Center for Neurologic DiseasesBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Faculdade de Medicina FMUSPUniversidade de São PauloSão PauloSPBrazil Broad Institute of MIT and HarvardCambridgeMAUSA 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2021年第18卷第2期

页      面：259-268页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work was supported by grants NS102807 ES02530 ES029136 AI126880 from the NIH and RG-1902-33606 from the NMSS and PA-1604-08459 from the International Progressive MS Alliance.J.V.M.and P.H.F.C.were supported by Santander Universidades and by Fundação Faculdade de Medicina(FFM) São Paulo SP Brazil 

主　　题：Aryl hydrocarbon receptor Autoimmune diseases Infectious diseases cancer 

摘      要：The aryl hydrocarbon receptor(AHR)is a ligand-activated transcription factor initially identified as the receptor for *** half a century after its discovery,AHR is now recognized as a receptor for multiple physiological ligands,with important roles in health and *** this review,we discuss the role of AHR in the gut–brain axis and its potential value as a therapeutic target for immune-mediated diseases.