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Aptamer-Anchored Rubrene-Loaded Organic Nanoprobes for Cancer Cell Targeting and Imaging

CCS chemistry 2019年第3期1卷 251-260页

作者： Yuanyuan Li Chuansheng Li Tao Jiang Lihua Zhou Pengfei Zhang Ryan T.K.Kwok Jacky Wing Yip Lam Ping Gong Lintao Cai Ben Zhong Tang Department of chemistry The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyDepartment of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyClear Water BayKowloonChina HKUST Shenzhen Research institute Shenzhen 518057China Guangdong key laboratory of nanomedicine CAS Key Laboratory of Health InformaticsShenzhen Bioactive Materials Engineering Lab for MedicineInstitute of Biomedicine and Biotechnology.Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Pharmaceutical Sciences Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Dongguan key laboratory of Drug Design and Formulation Technology Key Laboratory for NanomedicineGuangdong Medical UniversityDongguan 523808China Center for Aggregation-Induced Emission NSFC Center for Luminescence from Molecular AggregatesSCUT-HKUST Joint Research LaboratoryState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

Fluorescence imaging has become an indispensable technique in cancer research because it can reveal informative molecular,cellular,anatomical,and func-tional *** of advanced fluores-cent probes with superior sensitivity and biological selectivity for fluorescence imaging is thus *** move forward in this direction,we developed an easy self-assembly method for fabricating apta-mer-anchored rubrene-loaded organic fluorescent *** aptamer-modified organic nanop-robes integrated the best features of the organic light-emitting materials and the aptamers,thus endowing them with excellent cell-targeting capabil-ity,high stability,and good *** using this general method,a variety of biocompatible and highly bright organic fluorescent nanoprobes based on novel organic light-emitting materials with specific recognition could be easily constructed for real-time biosensing and long-term biomedical imaging.

关键词： aptamer organic nanoprobes fluores-cence cancer imaging biomedicine

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Defect-induced distinct exciton-exciton interactions in WS2 monolayers

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Science China Materials 2022年第9期65卷 2502-2510页

作者： Weihao Zheng Peng Fan Danliang Zhang Biyuang Zheng Cuihuan Ge Ying Chen Boyi Xu Zilan Tang Jianwu Liu Tian Zhang Ying Jiang Xiao Wang Xiaoli Zhu Shula Chen Quan Yuan Anlian Pan key laboratory for Micro-Nano Physics and Technology of Hunan Province State Key Laboratory of Chemo/Biosensing and Chemometriscs and College of Materials Science and EngineeringHunan UniversityChangsha 410082China School of Physics and Electronics Hunan UniversityChangsha 410082China Wuhan National laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China molecular Science and Biomedicine laboratory(MBL) Institute of Chemical Biology and NanomedicineState Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

The optoelectronic properties of atomically thin transition metal dichalcogenides(TMDs)are largely influenced by defect populations(DPs).In this work,we fabricate WSmonolayers with different DPs by varying the fabrication methods and further reveal their distinct exciton-exciton ***-state photoluminescence(PL)experiments show that the monolayer with the lowest DP shows optimal PL intensity at low excitation power;however,it is overtaken and significantly surpassed by monolayers with higher DPs at high excitation ***-power-dependent experiments demonstrate that these monolayers exhibit distinct PL saturation behaviors with the threshold power differing by four orders of *** with in situ PL imaging and time-resolved PL experiments,we attribute such PL evolution discrepancies to the different DPs within these monolayers,which largely influence the exciton diffusion behavior and subsequently bring about distinct nonradiative exciton-exciton annihilations(EEAs).Valley polarization experiments are further employed to re-examine the DPs of these *** work reveals the distinct PL behaviors and underlying exciton dynamics in TMD monolayers with different DPs,which can largely facilitate the engineering of relevant high-performance devices for practical applications.

关键词： transition metal dichalcogenides monolayers defect population exciton diffusion exciton-exciton annihilation

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In Vivo Activation of Pro-Protein Therapeutics via Chemically Engineered Enzyme Cascade Reaction

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CCS chemistry 2021年第2期3卷 780-790页

作者： Xiaoti Yang Jin Chang Ying Jiang Qiaobing Xu Ming Wang Lanqun Mao Beijing National laboratory for molecular Sciences Key Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of Sciences(ICCAS)Beijing 100190 College of chemistry Beijing Normal UniversityBeijing 100875 University of Chinese Academy of Sciences Beijing 100049 Department of Biomedical Engineering Tufts University4 Colby StreetMedfordMA 02155

Selective and temporal control over protein activity is of great importance for the advancement of the protein of interest into precise molecular *** installing synthetic ligands to proteins for activity regulation,however,is often obscured by either nonspecificity or insufficient *** study reports a chemical approach in which enzymatic cascade reactions were designed for selective activation of pro-protein both in vitro and in ***,the system consisted of aromatic boronic-acid-modified nanoparticles,reactive oxygen species(ROS)-responsive pro-protein(RNase A-NBC),a small molecule drug,β-Lapachone(β-Lap),and strategically screened synthetic lipids,required for the assembly of the *** target-delivered into tumor cells,the reduction ofβ-Lap produces massive H2O2 in response to NAD(P)H quinone oxidoreductase 1(NQO1),a tumor-specific enzyme,which triggers further induction by selective chemical modification of ROS-responsive cytosolic protein ribonuclease A(RNase A)-NBC,thus,switching from“inert”pro-protein to active therapeutics,that ultimately prohibit tumor cell ***,the designed enzymatic cascade activation of the pro-protein was effective in vivo,displaying superior therapeutic efficacy to either the pro-protein alone or theβ-Lap via tumor-targeted delivery and the consequent suppression of the tumor *** both RNase A andβ-Lap have been evaluated clinically as antitumor therapeutics,our chemical multi-step cascade methodology is,therefore,a promising strategy for selective modulation of pro-protein chemistry in the living system for fundamental investigations,favorable toward potential anticancer applications.

关键词： pro-protein activation enzyme cascade reaction protein delivery cancer therapy,nanomedicine

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Nickle-cobalt alloy nanocrystals inhibit activation of inflammasomes

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National Science Review 2023年第8期10卷 211-221页

作者： Jun Lin Liang Dong Yi-Ming Liu Yi Hu Chen Jiang Ke Liu Liu Liu Yong-Hong Song Mei Sun Xing-Cheng Xiang Kun Qu Yang Lu Long-Ping Wen Shu-Hong Yu Department of Neurosurgery The First Affiliated Hospital of USTC School of Basic Medical SciencesDivision of Molecular Medicine Department of Chemistry Institute of Biomimetic Materials&Chemistry Division of Nanomaterials&Chemistry Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) Institute of Basic Medicine and Cancer(IBMC) Chinese Academy of Sciences Anhui Province key laboratory of Advanced Catalytic Materials and Reaction Engineering School of Chemistry and Chemical EngineeringHefei University of Technology The WUT-AMU Franco-Chinese institute Wuhan University of Technology institute of Artificial Intelligence Hefei Comprehensive National Science Center

Activation of inflammasomes—immune system receptor sensor complexes that selectively activate inflammatory responses—has been associated with diverse human diseases, and many nanomedicine studies have reported that structurally and chemically diverse inorganic nanomaterials cause excessive inflammasome activation. Here, in stark contrast to reports of other inorganic nanomaterials, we find that nickel-cobalt alloy magnetic nanocrystals(NiCo NCs) actually inhibit activation of NLRP3, NLRC4 and AIM2 inflammasomes. We show that NiCo NCs disrupt the canonical inflammasome ASC speck formation process by downregulating the lncRNA Neat1, and experimentally confirm that the entry of NiCo NCs into cells is required for the observed inhibition of inflammasome activation. Furthermore, we find that NiCo NCs inhibit neutrophil recruitment in an acute peritonitis mouse model and relieve symptoms in a colitis mouse model, again by inhibiting inflammasome activation. Beyond demonstrating a highly surprising and apparently therapeutic impact for an inorganic nanomaterial on inflammatory responses, our work suggests that nickel-and cobalt-containing nanomaterials may offer an opportunity to design anti-inflammatory nanomedicines for the therapeutics of macrophage-mediated diseases.

关键词： inflammasome nickel-cobalt nanoparticle Neat1 colitis NLRP3

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Bioassay development for public health emergency

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The Innovation 2022年第6期3卷 3-4页

作者： Kai Jiao Gang Liu Xiaolei Zuo Jiang Li Chunhai Fan School of chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China key laboratory of Bioanalysis and Metrology for State Market Regulation Shanghai Institute of Measurement&Testing TechnolShanghai 201203China institute of molecular Medicine Shanghai Key Laboratory for Nucleic Acids Chemistry and NanomedicineState Key Laboratory of Oncogenes and Related GenesRenji HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghai 200127China The Interdisciplinary Research Center Shanghai Synchrotron Radiation FacilityZhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

The outbreak of infectious diseases often arouses public health emergencies of international *** the past several decades,we have witnessed the outbreaks of various epidemics and pandemics,such as AIDS,Ebola,SARS,dengue,Zika,bird flu,and particularly the recent coronavirus disease 2019(COVID-19)caused by *** have been generally regarded as the first defense for the prevention and control of infectious *** the representative course of these diseases,bioassays against certain biomarkers are suitable for distinct stages of infection in diverse scenarios(Figure 1).However,the deployed bioassays still possess inherent ***,we briefly summarize the pros and cons of state-of-the-art bioassays for infectious diseases caused by pathogenic viruses and provide an outlook on the advances in the context of public health emergencies.

关键词： prevention Figure limitations

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In Situ Loading and Delivery of Short Single- and Double-Stranded DNA by Supramolecular Organic Frameworks

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CCS chemistry 2019年第2期1卷 156-165页

作者： Bo Yang Xiao-Dan Zhang Jian Li Jia Tian Yi-Peng Wu Fa-Xing Yu Ruibing Wang Hui Wang Dan-Wei Zhang Yi Liu Lu Zhou Zhan-Ting Li Department of chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)Fudan UniversityShanghai 200438China Department of Medicinal chemistry School of PharmacyFudan UniversityShanghai 201203China Children’s Hospital and institutes of Biomedical Sciences Fudan UniversityShanghai 200032China State key laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacaoChina The molecular Foundry Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Short DNA represents an important class of bioma-cromolecules that arewidely applied in gene therapy,editing,and ***,the development of simple and reliable methods for their intracellular delivery remains a ***,we describe that seven water-soluble,homogeneous supramole-cular organic frameworks(SOFs)with a well-defined pore size and high stability in water that can accom-plish in situ inclusion of single-stranded(ss)and double-stranded(ds)DNA(21,23,and 58 nt)and effective intracellular delivery(including two non-cancerous and six cancerous cell lines).

关键词： nucleic acid delivery homogeneous car-rier electrostatic interaction self-assembly porous polymer

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Functional DNA Structures and Their Biomedical Applications

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CCS chemistry 2020年第5期2卷 707-728页

作者： Ziyuan Li Chen Wang Jiang Li Junji Zhang Chunhai Fan Itamar Willner He Tian key laboratory for Advanced Materials and Joint International Research laboratory of Precision chemistry and molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterSchool of Chemistry and Molecular EngineeringEast China University of Science&TechnologyShanghai 200237(China) institute of chemistry The Minerva Center for Biohybrid Complex SystemsThe Hebrew University of JerusalemJerusalem 91904(Israel) Bioimaging Center Shanghai Synchrotron Radiation FacilityZhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210(China) School of chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240(China)

Since the discovery of the double-helix structure in 1953,nucleic acids have been developed from natural genetic codes into functional building blocks in a wide range of biotechnology and materials *** advantage of their design diversity and biocompatibility,functional nucleic acids facilitate the“bottom-up”fabrication of nanomaterials that are highly potential for molecular medicine to treat different diseases,such as *** present perspective article introduces recent advances in the use of these unique properties of nucleic acid biopolymers for biomedical ***,nanomaterial/nucleic acid hybrid structures for sensing,controlled drug release,programmable intracellular imaging,and apoptosis,as well as logic calculation,are ***,the detailed operation for both extracellular and intracellular bioactivity regulation with these new design functional nucleic acid nanostructures are fully illustrated.

关键词： nucleic acid nanomaterial/DNA hybrid DNA nanostructures DNA logic cell regulation

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The influence of physiological environment on the targeting effect of aptamer-guided gold nanoparticles

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Nano Research 2019年第1期12卷 129-135页

作者： Ding Ding Yinling Zhang Edward A.Sykes Long Chen Zhuo Chen Weihong Tan molecular Science and Biomedicine laboratory(MBL) State Key Laboratory of Chemo/Bio-Sensing and ChemometricsCollege of Chemistry and Chemical Engineering and College of Life SciencesHunan UniversityChangsha 410082China School of Medicine Queens University81 Barrie StreetKingstonONK7L 3N6Canada Faculty of Science and Technology University of MacaoAvenida da UniversidadeMacao Taipa 999078China Department of chemistry Departments of Physiology and Functional GenomicsCenter far Research at the Bio/Nano InterfaceUF Health Cancer CenterUF Genetics Institute and McKnight Brain InstituteUniversity of FloridaGainesvilleFlorida 32611USA institute of molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200240China

Aptamer guided nano medicine shows great promise in targeted cancer *** the loss of targeting capacity duri ng in vivo or clinical trials has largely hindered its popularity and there are no systematic studies to elucidate the ***,we investigated such loss of targeting capacity by examining how the physiological milieu affected targeting *** functionalized gold nanoparticle(AuNP)was chosen as the model and exposed to human blood serum that is used to mimic physiological *** light scattering(DLS),flow cytometry and label-free liquid chromatography tan dem mass spectrometry(LC-MS/MS)were employed to determi ne variations of NPs'surface chemistry and biological identities changes after serum *** showed that the targeting ability loss was caused by protein corona blocking,replacement and enzymatic cleavage of surface aptamer targeting ***,the aggregation issue is critical for the smaller *** of the protein corona profile indicated the accumulation of immune-related proteins on the surface of aptamer-conjugated NPs,which could induce immune response,resulting in rapid clearanee of NPs.

关键词： targeting effect aptamer nanomedicine physiological environment

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Biosafety materials:Ushering in a new era of infectious disease diagnosis and treatment with the CRISPR/Cas system

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Biosafety and Health 2022年第2期4卷 70-78页

作者： Yuquan Zhang Ziyue Li Julien Milon Essola Kun Ge Xuyan Dai Huining He Haihua Xiao Yuhua Weng Yuanyu Huang School of Life Science School of Medical TechnologyAdvanced Research Institute of Multidisciplinary ScienceKey Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China key laboratory of Analytical Science and Technology of Hebei Province College of Chemistry and Environmental ScienceKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationHebei UniversityBaoding 071000China Hunan Agricultural University Changsha 410128China Tianjin key laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of PharmacyTianjin Medical UniversityTianjin 300070China Beijing National laboratory for molecular Science State Key Laboratory of Polymer Physical and ChemistryInstitute of ChemistryChinese Academy of ScienceBeijing 100190China School of Materials and the Environment Beijing Institute of TechnologyZhuhai 519085China

Despite multiple virus outbreaks over the past decade,including the devastating coronavirus disease 2019(COVID-19)pandemic,the lack of accurate and timely diagnosis and treatment technologies has wreaked havoc on global *** clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated proteins(Cas)system has the potential to address these critical needs for tackling infectious diseases to detect viral nucleic acids and inhibit viral *** review summarizes how the CRISPR/Cas system is being utilized for the treatment and diagnosis of infectious diseases with the help of biosafety materials and highlights the design principle and in vivo and in vitro efficacy of advanced biosafety materials used to deal with virus attacks.

关键词： Biosafety materials CRISPR/Cas SARS-CoV-2 Diagnosis Infectious disease

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nucleic Acid Nanoprobes for Biosensor Development in Complex Matrices

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Chemical Research in Chinese Universities 2020年第2期36卷 185-193页

作者： DENG Mengying LI Min MAO Xiuliai LI Fan ZUO Xiaolei Division of Physical Biology CAS Key Laboratory of Interfacial Physics and TechnologyShanghai Synchrotron Radiation Facility(SSRF)Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800P R.China University of Chinese Academy of Science Beijing 100049P.R.China institute of molecular Medicine Renji HospitalSchool of Medicine and School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200127P.R.China

nucleic acid probes in living organisms play an essential role in therapeutics and *** the imaging and sensing of nucleic acid probes in complex biological matrices,a variety of diseases-related biological process,pathogenic process,or pharmacological responses to a therapeutic intervention have been ***,a critical challenge of nucleic acid probes applied in complex matrices lies in enhancing the stability of nucleic acid probes,especially when it suffers from nuclease degradation and protein *** order to enhance the application of nucleic acid nanoprobes in complex matrices,great efforts have been devoted to improving the stability of probes operated in complex media,including construction of nucleic acid nanoprobes with nuclease resistance and protein adsorption resistance,sample pretreatment,anti-biofouling and signal *** this review,we aim to summarize recent advances in the stability of nucleic acid nanoprobes in complex matrices,including the methods of enhancing the stability of probes or signals,and the application of nucleic acid nanoprobes for disease diagnosis.

关键词： Nuclease-resistance Complex matrix nucleic acid probe Stability

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