In Situ Loading and Delivery of Short Single- and Double-Stranded DNA by Supramolecular Organic Frameworks
作者机构：Department of ChemistryShanghai Key Laboratory of Molecular Catalysis and Innovative Materials and Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)Fudan UniversityShanghai 200438China Department of Medicinal ChemistrySchool of PharmacyFudan UniversityShanghai 201203China Children’s Hospital and Institutes of Biomedical SciencesFudan UniversityShanghai 200032China State Key Laboratory of Quality Research in Chinese MedicineInstitute of Chinese Medical SciencesUniversity of MacaoTaipaMacaoChina The Molecular FoundryLawrence Berkeley National LaboratoryBerkeleyCA 94720USA
出 版 物：《CCS Chemistry》 (中国化学会会刊（英文）)
年 卷 期：2019年第1卷第2期
页 面：156-165页
学科分类：07[理学] 0701[理学-数学] 070101[理学-基础数学]
基 金：We thank the National Natural Science Foundation of China(Nos.21432004 and 21529201)for financial sup-port Shanghai Synchrotron Radiation Facility for provid-ing BL16B1 and BL14B1 beamlines for collecting the synchrotron X-ray-scattering and diffraction data and the SIBYLS Beamline 12.3.1 of the Advanced Light Source(ALS) Lawrence Berkeley National Laboratory for collecting solution-phase synchrotron small-angle X-ray-scattering data
主 题：nucleic acid delivery homogeneous car-rier electrostatic interaction self-assembly porous polymer
摘 要：Short DNA represents an important class of bioma-cromolecules that arewidely applied in gene therapy,editing,and ***,the development of simple and reliable methods for their intracellular delivery remains a ***,we describe that seven water-soluble,homogeneous supramole-cular organic frameworks(SOFs)with a well-defined pore size and high stability in water that can accom-plish in situ inclusion of single-stranded(ss)and double-stranded(ds)DNA(21,23,and 58 nt)and effective intracellular delivery(including two non-cancerous and six cancerous cell lines).
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