Biosafety materials:Ushering in a new era of infectious disease diagnosis and treatment with the CRISPR/Cas system

作     者：Yuquan Zhang Ziyue Li Julien Milon Essola Kun Ge Xuyan Dai Huining He Haihua Xiao Yuhua Weng Yuanyu Huang Yuquan Zhang;Ziyue Li;Julien Milon Essola;Kun Ge;Xuyan Dai;Huining He;Haihua Xiao;Yuhua Weng;Yuanyu Huang

作者机构：School of Life ScienceSchool of Medical TechnologyAdvanced Research Institute of Multidisciplinary ScienceKey Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Analytical Science and Technology of Hebei ProvinceCollege of Chemistry and Environmental ScienceKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationHebei UniversityBaoding 071000China Hunan Agricultural UniversityChangsha 410128China Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and DiagnosticsSchool of PharmacyTianjin Medical UniversityTianjin 300070China Beijing National Laboratory for Molecular ScienceState Key Laboratory of Polymer Physical and ChemistryInstitute of ChemistryChinese Academy of ScienceBeijing 100190China School of Materials and the EnvironmentBeijing Institute of TechnologyZhuhai 519085China 

出 版 物：《Biosafety and Health》 (生物安全与健康（英文）)

年 卷 期：2022年第4卷第2期

页      面：70-78页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 

基　　金：supported by the Beijing Municipal Natural Science Foundation(No.7214302) the Natural Science Foundation of Guangdong Province(2019A1515010776) the Beijing-Tianjin-Hebei Basic Research Cooperation Project(19JCZDJC64100) the Beijing Nova Program from Beijing Municipal Science&Technology Commission(Z201100006820005) the National Natural Science Foundation of China(31871003 and 32001008) the National Key R&D Program of China(2021YFE0106900) the Open Fund of Key Laboratory of Medicine Chemistry and Molecular Diagnosis(Hebei University),Ministry of Education of China,and the Young Elite Scientist Sponsorship Program of Beijing Association for Science and Technology(2020-2022). 

主　　题：Biosafety materials CRISPR/Cas SARS-CoV-2 Diagnosis Infectious disease 

摘      要：Despite multiple virus outbreaks over the past decade,including the devastating coronavirus disease 2019(COVID-19)pandemic,the lack of accurate and timely diagnosis and treatment technologies has wreaked havoc on global biosecurity.The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated proteins(Cas)system has the potential to address these critical needs for tackling infectious diseases to detect viral nucleic acids and inhibit viral replication.This review summarizes how the CRISPR/Cas system is being utilized for the treatment and diagnosis of infectious diseases with the help of biosafety materials and highlights the design principle and in vivo and in vitro efficacy of advanced biosafety materials used to deal with virus attacks.