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Clinical correlations between chronic hepatitis C infection and decreasing bone mass density after treatment with interferon-alpha

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Asian Pacific Journal of tropical Biomedicine 2017年第2期7卷 161-165页

作者： Vahid Babaei Masoud Ghorbani Nastaran Mohseni Hojjat Afraid Yassaman Saghaei Shahram Teimourian Department of Medical Genetics Iran University of Medical SciencesTehranIran Department of research and Development Research and Production ComplexPasteur Institute of IranKarajIran biotechnology research center Biotechnology DepartmentVenom&Biotherapeutics Molecules LaboratoryPasteur Institute of IranTehranIran Iranian Blood Transfusion Organization TehranIran

Objective: To compare the bone mass density in chronic hepatitis patients before and after interferon-a ***: A total of 70 patients with chronic hepatitis C were treated with interferon-a and were evaluated. The treatment dosage was three million IU three times a week for one year. All the patients underwent bone mass density detection at lumbar spine and femoral neck before and after the interferon-a treatment. All the necessary information such as age,sex, and laboratory test, history of occurrence of fractures, lifestyle, and menopause status was collected by interviewers face-to-face from participants at the research visit. Smoking was categorized by whether participants were nonsmokers or smokers. Menopause was designated if there had been complete cessation of menses for more than 12 months. All statistical analyses were performed by SPSS version 14(SPSS, Inc., Chicago, IL, USA).Results: Among 70 patients, 52% were male, 48% were female and the mean age was(57.0 ± 9.6) years(range: 24–79). Twenty-nine percent of the patients had a history of smoking. The mean body mass index was(24.4 ± 3.6) kg/m^2(range: 18.4–35.3). Of the70 cases, 21 had high fibrosis-4. The prevalence of overall fracture history was 2.9%(two patients).Conclusions: Chronic hepatitis C virus infection did increase the risk of development of metabolic bone disease in this cohort. Indeed, greater reduction of bone mass density occurs in advanced liver fibrosis. The bone loss in earlier stages of chronic hepatitis C infection is likely to result from increased bone reduction rather than decreased bone formation. Overall, these observations suggest an important role for chronic hepatitis C virus infection in increased bone turnover in osteodystrophy pathogenesis.

关键词： Hepatitis C Interferon alpha Bone mass density Liver fibrosis Bone mass loss

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Plant Diversity 2020年第5期42卷 362-369页

作者： Jiao Qin Wei Zhang Shi-Bao Zhang Ji-Hua Wang Key Laboratory of Economic Plants and biotechnology Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan650201China Yunnan Key Laboratory for Wild Plant Resources KunmingYunnanChina Key Laboratory of tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnanChina Flower research institute Yunnan Academy of Agricultural SciencesKunmingYunnan650205China

Mycorrhizal fungi are essential for the growth and development of both epiphytic(growing on trees)and lithophytic(growing on rocks)*** studies indicate that in lowland tropical areas,orchid mycorrhizal fungal compositions are correlated with the life form(i.e.,epiphytic,lithophytic,or terrestrial)of their host *** therefore tested if a similar correlation exists in an orchid distributed at higher *** corymbosa is an endangered ornamental orchid species that can be found as a lithophyte and epiphyte in subtropical to subalpine *** on high-throughput sequencing of the fungal internal transcribed spacer 2(ITS2)-rDNA region of mycorrhizae of ***,we detected 73 putative mycorrhizal fungal Operational Taxonomic Units(OTUs).The OTUs of two dominant lineages(Cantharellales and Sebacinales)detected from *** are phylogenetically different from those of other species within the genus Coelogyne,indicating that different orchid species prefer specific mycorrhizal *** also found that the Non-metric multidimensional scaling(NMDS)plots of orchid mycorrhizal fungi were not clustered with life form,the variations among orchid mycorrhizal fungal communities of different life forms were not significant,and most of the OTUs detected from epiphytic individuals were shared by the lithophytic plants,suggesting that orchid mycorrhizal associations of *** were not affected by life *** findings provide novel insights into mycorrhizal associations with endangered ornamental orchids.

关键词： Cantharellales Coelogyninae Epiphytic Life form Orchid mycorrhizal fungi Serendipitaceae

Potential use of cucumber (Cucumis sativus L.) endophytic fungi as seed treatment agents against root-knot nematode Meloidogyne incognita

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Journal of Zhejiang University-Science B(Biomedicine & biotechnology) 2011年第3期12卷 219-225页

作者： Xiao-ning YAN Richard A. SIKORA Jing-wu ZHENG institute of biotechnology College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China Soil-Ecosystem Phytopathology and Nematology Institute for Resource Conservation and Plant Science (INRES) Department of Plant Health University of Bonn Bonn 53115 Germany institute of Environment and Plant Protection Chinese Academy of Tropical Agricultural Sciences Danzhou 5 7173 7 China

Seed treatment with endophytic fungi has been regarded as an effective method for plant parasitic nematode *** fungi from cucumber seedlings were isolated and screened for their potential to be used as seed treatment agents against Meloidogyne *** the 294 isolates screened,23 significantly reduced galls formed by *** in greenhouse *** 10 most effective isolates were Fusarium(5),Trichoderma(1),Chaetomium(1),Acremonium(1),Paecilomyces(1),and Phyllosticta(1) .Their control efficacies were repeatedly tested and their colonizations as well as in vitro activity against *** were *** reduced the number of galls by 24.0%-58.4%in the first screening and 15.6%-44.3%in the repeated test,*** Ph511 and Chaetomium Ch1001 had high colonizations on both the roots and the aboveground parts of cucumber *** isolates had colonization preference on the roots,their root colonizations ranging from 20.1%to 47.3%of the total root *** Tr882,Paecilomyces Pa972,and Acremonium Ac985 had low colonizations on both the roots and the aboveground *** Ac985,Chaetomium Ch1001,Paecilomyces Pa972,and Phyllosticta Ph511 produced compounds affecting motility of the second stage juveniles of *** on these results,Chae-tomium Ch1001 was considered to have the highest potential as a seed treatment agent for *** biocontrol.

关键词： Cucumber endophytic fungi Meloidogyne incognita Control efficacy Colonization In vitro activity

Structure-activity Relationship of Sintenin and its Analogues on Six Human Tumor Cell Lines

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Chinese Chemical Letters 2005年第8期16卷 997-1000页

作者： Li Hong HU Bin zou Jing Xu GONG Hai Bo LI Lei Xiang YANG Chang Xin ZHOU Hua BAI Xiu Mei WU Wei CHENG Yu ZHAO Department of Traditional Chinese Medicine and Natural Drug research College of Pharmaceutical Sciences Zhejiang University Hangzhou 310031 Zhejiang Hi sun Naturelite Pharmaceutical R＆D-Co. -Ltd.Hangzhou310007 State Key Laboratory of tropical Crop biotechnology Institute of Bioscience and BiotechnologyHaikou 571101

The synthesis of a cytotoxic natural ester sintenin 1 and thirty-three of its analogues 2-34 were carried out. The cytotoxicities of the synthetic compounds have been screened for human tumor cell lines such as PC-3, Hela, A549, BEL7404, CNE, and KB. The results showed that phenolic derivatives exhibited strongest cytoxicity, and the unsaturated esters were more cytotoxic than their saturated analogues.

关键词： Synthesis natural products sintenin cytotoxicity SAR.

The Roles of acyI-CoA： Diacylglycerol Acyltransferase 2 Genes in the Biosynthesis of Triacylglycerols by the Green Algae Chlamydomonas reinhardtii

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Molecular Plant 2012年第4期5卷 945-947页

作者： Xiao-Dong Deng Bo Gu Ya-Jun Li Xin-Wen Hu Jian-Chun Guo Xiao-Wen Fei Key Laboratory of Biology and Genetic Resources of tropical Crops Ministry of AgricultureInstitute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural ScienceHaikou 571101China Department of Biochemistry Hainan Medical CollegeHaikou571101China College of Agronomy Hainan UniversityHaikou571101China

Dear Editor, Triacylglycerols （triglycerides）（TAGs）, as the major storage forms of energy, mainly are stored in adipocytes, myocytes, enterocytes, hepatocytes, and mammary epithelial cells in mammals, oilseeds in plants, and lipid droplets in microorgan- isms （Yen et al., 2008）. Aside from energy storage, TAGs have essential functions in multiple physiological processes. In plants, TAGs are crucial for seed oil accumulation, germina- tion, and seedling development （Zhang et al., 2005, 2009）. Notably, TAGs derived from plants and microorganisms could serve as the feedstock for biofuels production （Deng et al., 2009）. Therefore, understanding of the molecular basis of TAGs bio- synthesis and storage is of considerable economic importance.

关键词： biosynthesis TAGGING Lipid Droplets Microbes plants breast epithelium cell Physiological Processes Storage Diacylglycerol O-Acyltransferase Chlamydomonas reinhardtii aluminium Triglycerides Chlorophyceae

Smart breeding driven by big data, artificial intelligence, and integrated genomic-enviromic prediction

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Molecular Plant 2022年第11期15卷 1664-1695页

作者： Yunbi Xu Xingping Zhang Huihui Li Hongjian Zheng Jianan Zhang Michael S.Olsen Rajeev K.Varshney Boddupalli M.Prasanna Qian Qian institute of Crop Sciences CIMMYT-ChinaChinese Academy of Agricultural SciencesBeijing 100081China CIMMYT-China tropical Maize research center School of Food Science and EngineeringFoshan UniversityFoshanGuangdong 528231China Peking University institute of Advanced Agricultural Sciences WeifangShandong 261325China CIMMYT-China Specialty Maize research center Shanghai Academy of Agricultural SciencesShanghai 201400China MolBreeding biotechnology Co. Ltd.ShijiazhuangHebei 050035China National Nanfan research institute(Sanya) Chinese Academy of Agricultural SciencesSanyaHainan 572024China CIMMYT(International Maize and Wheat Improvement center) ICRAF CampusUnited Nations AvenueNairobiKenya State Agricultural biotechnology Centre Centre for Crop and Food InnovationFood Futures InstituteMurdoch UniversityMurdochAustralia

The first paradigm of plant breeding involves direct selection-based phenotypic observation,followed by predictive breeding using statistical models for quantitative traits constructed based on genetic experimental design and,more recently,by incorporation of molecular marker ***,plant performance or phenotype(P)is determined by the combined effects of genotype(G),envirotype(E),and genotype by environment interaction(GEI).Phenotypes can be predicted more precisely by training a model using data collected from multiple sources,including spatiotemporal omics(genomics,phenomics,and enviromics across time and space).Integration of 3D information profiles(G-P-E),each with multidimensionality,provides predictive breeding with both tremendous opportunities and great ***,we first review innovative technologies for predictive *** then evaluate multidimensional information profiles that can be integrated with a predictive breeding strategy,particularly envirotypic data,which have largely been neglected in data collection and are nearly untouched in model *** propose a smart breeding scheme,integrated genomic-enviromic prediction(iGEP),as an extension of genomic prediction,using integrated multiomics information,big data technology,and artificial intelligence(mainly focused on machine and deep learning).We discuss how to implement iGEP,including spatiotemporal models,environmental indices,factorial and spatiotemporal structure of plant breeding data,and cross-species prediction.A strategy is then proposed for prediction-based crop redesign at both the macro(individual,population,and species)and micro(gene,metabolism,and network)***,we provide perspectives on translating smart breeding into genetic gain through integrative breeding platforms and open-source breeding *** call for coordinated efforts in smart breeding through iGEP,institutional partnerships,and innovative technological support.

关键词： smart breeding genomic selection integrated genomic-enviromic selection spatiotemporal omics crop design machine and deep learning big data artificial intelligence

Evaluation of phenolic contents and antioxidant activities of brown seaweeds belonging to Turbinaria spp.(Phaeophyta,Sargassaceae) collected from Gulf of Mannar

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Asian Pacific Journal of tropical Biomedicine 2013年第1期3卷 8-16页

作者： Kajal Chakraborty Nammunayathuputhenkotta Krishnankartha Praveen Kodayan Kizekadath Vijayan Gonugontla Syda Rao Marine biotechnology Division Central Marine Fisheries Research Institute Central Marine Fisheries research institute

Objective:To evaluate the antioxidant activities and total phenolic contents of brown seaweeds belonging to Turbinaria spp.[Turbinaria conoides(***)and Turbinaria ornata(***)collected from Gulf of Mannar of southeastern coast of India in various in vitro ***:The antioxidant activity was evaluated using different in vitro systems,viz.,I,I-diphenyl-2-picrylhydrazyl(DPPH),2,2'-azino-bis-3 ethylbenzothiozoline-6-sulfonic acid diammonium salt(ABTS),H_20_2/H0 radical scavenging,Fe^(2+)ion chelating ability,and reducing ***-Ciocalteu method was used to determine the total phenolic content of the extracts,and the results were expressed as mg of gallic acid equivalents(GE)/g of the seaweed *** acid-reactive substances assay was employed to assess the ability of the seaweed extracts to inhibit lipid ***:Ethyl acetate(EtOAc)fraction of *** registered significantly higher phenolic content(105.97 mg GE/g)than that of ***(69.63 mg GE/g).Significantly higher antioxidant potential as determined by DPPH(64.14%)radical scavenging activity was registered in EtOAc fraction of ***.A higher ABTS(?)radical scavenging(IC_(50)3.16μg/mL),Fe^(2+)chelating(IC_(50)0.46 mg/mL),H_2O_2 scavenging(IC_(50)4.25 mg/mL),lipid peroxidation inhibitory(TBARS,IC_(50)0.21 mg/mL),and reducing abilities(IC_(50)52.67 mg/mL)(P<0.05)were realized in EtOAc fraction of *** than other ***:This study indicated the potential use of *** and *** as candidate species to be used as food supplements/functional foods to increase shelf-life of food items for human consumption,and nutraceuticals to deter deleterious free radical-induced life-threatening diseases.

关键词： Brown seaweeds Turbinaria conoides Turbinaria ornata Antioxidant activity Total phenolic contents

Genome-wide association analysis identified molecular markers associated with important tea flavor-related metabolites

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Horticulture research 2021年第1期8卷 714-730页

作者： Kaixing Fang Zhiqiang Xia Hongjian Li Xiaohui Jiang Dandan Qin Qiushuang Wang Qing Wang Chendong Pan Bo Li Hualing Wu Tea research institute Guangdong Academy of Agricultural SciencesGuangdong Key Laboratory of Tea Plant Resources Innovation&UtilizationGuangzhou 510640China institute of biotechnology Chinese Academy of Tropical Agricultural SciencesHaikou 570100China Hainan University Haikou 570228China

The characteristic secondary metabolites in tea(theanine,caffeine,and catechins)are important factors contributing to unique tea ***,there has been relatively little research on molecular markers related to these ***,we conducted a genome-wide association analysis of the levels of these tea flavor-related metabolites in three *** theanine,caffeine,and catechin levels in Population 1 comprising 191 tea plant germplasms were examined,which revealed that their heritability exceeded 0.5 in the analyzed seasons,with the following rank order(highest to lowest heritabilities):(+)-catechin>(−)-gallocatechin gallate>caffeine=(−)-epicatechin>(−)-epigallocatechin-3-gallate>theanine>(−)-epigallocatechin>(−)-epicatechin-3-gallate>catechin gallate>(+)-*** SNPs detected by amplified-fragment SNP and methylation sequencing divided Population 1 into three groups and seven *** association analysis yielded 307 SNP markers related to theanine,caffeine,and catechins that were common to all three *** of the markers were *** functional annotation of 180 key genes at the SNP loci revealed that FLS,UGT,MYB,and WD40 domain-containing proteins,as well as ATP-binding cassette transporters,may be important for catechin *** and GO analyses indicated that these genes are associated with metabolic pathways and secondary metabolite ***,in Population 2(98 tea plant germplasm resources),30 candidate SNPs were verified,including 17 SNPs that were significantly or extremely significantly associated with specific metabolite *** results will provide a foundation for future research on important flavor-related metabolites and may help accelerate the breeding of new tea varieties.

关键词： analysis breeding Population

Anticancer activity test of ethyl acetate extract of endophytic fungi isolated from soursop leaf(Annona muricata L.)

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Asian Pacific Journal of tropical Medicine 2017年第6期10卷 635-640页

作者： Minarni I Made Artika Heddy Julistiono Nurliani Bermawie Eny Ida Riyanti Hasim Akhmad Endang Zainal Hasan Department of Biochemistry Faculty of Mathematics and SciencesBogor Agricultural UniversityDarmaga CampusBogor 16680Indonesia research center for Biology The Indonesian Institute of Sciences(LIPI)Cibinong-Bogor Indonesia research institute of Medicinal and Aromatic Plants Agricultural Research AgencyBogor-Indonesia center for biotechnology and Genetic Resources of Agriculture Agricultural Research AgencyBogor-Indonesia

Objective: To analyze anticancer activity of an ethyl acetate extract of endophytic fungi isolated from soursop leaf(Annona muricata L.). Methods: Anticancer activity of fungal extracts was determined by observing its toxicity against MCF-7(Michigan Cancer Foundation-7) cells in vitro by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay method. At an extract concentration of 100 μg/m L, 4 isolates out of 12 showed high activity against the cancer cell growth. The four isolates were then selected for further IC50 determination, by measuring the inhibition of cancer cell proliferation at extract concentration of 25 μg/m L, 50 μg/m L, 100 μg/m L, 200 μg/m L and 400 μg/m L. Results: Results showed that isolate Sir-G5 had the highest anticancer activity with an IC50 of 19.20 μg/m L. The best isolates were screened again using a normal cell(Chang cells) to determine its toxicity against normal cells. Results indicated that the extracts do not affect the proliferation of normal cells. Molecular identification showed that the fungal isolate Sir-G5 has a close relationship with Phomopsis sp. Conclusions: The endophytic fungi isolated from soursop leaf has the potential to be used as a source of anticancer agents.

关键词： Annona muricata L Anticancer MCF-7 Endophytic fungi Soursop leaf