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Laparoscopic sleeve gastrectomy:More than a restrictive bariatric surgery procedure?

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World Journal of Gastroenterology 2015年第41期21卷 11804-11814页

作者： David Benaiges Antonio Más-Lorenzo Albert Goday José M Ramon Juan J Chillarón Juan Pedro-Botet Juana A Flores-Le Roux department of Endocrinology and Nutrition Hospital del Mar department of Medicine Universitat Autònoma de Barcelona institut Hospital del mar d’Investigacions Mèdiques (IMIM) ciberOBN Instituto de Salud Carlos III department of Gastrointestinal Surgery Hospital del Mar

Sleeve gastrectomy(SG) is a restrictive bariatric surgery technique that was first used as part of restrictive horizontal gastrectomy in the original Scopinaro type biliopancreatic diversion. Its good results as a single technique have led to a rise in its use, and it is currently the second most performed technique worldwide. SG achieves clearly better results than other restrictive techniques and is comparable in some aspects to the Roux-en-Y gastric bypass, the current gold standard in bariatric surgery. These benefits have been associated with different pathophysiologic mechanisms unrelated to weight loss such as increased gastric emptying and intestinal transit, and activation of hormonal mechanisms such as increased GLP-1 hormone and decreased ghrelin. The aim of this review was to highlight the salient aspects of SG regarding its historical evolution, pathophysiologic mechanisms, main results, clinical applications and perioperative complications.

关键词： Bariatric surgery Sleeve gastrectomy Severe obesit

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： maría Norte-Muñoz maría Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz maría Teresa Moreno-Flores marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHciI) neuroprotection olfactory ensheathing glia retinal ganglion cells

Subclinical cardiovascular disease in type 2 diabetes mellitus: To screen or not to screen

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World Journal of Clinical Cases 2014年第9期2卷 415-421页

作者： Juan J Chillarón Juana A Flores-Le Roux David Benaiges Juan Pedro-Botet department of Endocrinology and Nutrition Hospital del Mar Passeig Marítim 25-29 08003 Barcelona Spain institut Municipal d'Investigacions Mèdiques Passeig Marítim 25-29 08003 Barcelona Spain departament de Medicina Universitat Autònoma de Barcelona 08193 Cerdanyola (NOT Sarda?ola) del Vallés Barcelona Spain

The prevalence of type 2 diabetes mellitus(T2DM) has risen in recent decades, and cardiovascular disease remains the leading cause of death in this population. Several clinical trials have demonstrated the benefit of tight control of risk factors on the incidence and mortality of cardiovascular disease. However, in clinical practice, few patients achieve the therapeutic goals. The current diagnostic procedures for subclinical cardiovascular disease in T2 DM patients have not been shown to improve prognosis or mortality, probably because they do not categorize cardiovascular risk. Thus, clinical practice guidelines do not systematically recommend screening for subclinical atherosclerosis in these patients, although it is known that patients with extracoronary atherosclerosis, microangiopathy and poorlycontrolled cardiovascular risk factors are at high risk for cardiovascular disease. Improvements in the reliability of diagnostic tests, with fewer side effects and better cost efficiency, may better help to stratify cardiovascular risk in this group of patients, and further evaluation on this topic should be considered.

关键词： Cardiovascular disease Type 2 diabetes mellitus Cardiovascular risk

Targeting IKKαkinase to prevent tumor progression and therapy resistance

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Cancer Drug Resistance 2020年第3期3卷 482-490页

作者： Carlota Colomer Irene Pecharroman Anna Bigas Lluís Espinosa Cancer Research Program Institut Mar d’Investigacions MèdiquesCIBERONCHospital del MarBarcelona 08003Spain.

Cancer therapy has improved considerably in the last years;however,therapeutic resistance is still a major problem that impedes full response to the treatment and the main cause of patient relapse and *** kinases have been reported to be overactivated in cancer and induce resistance to current *** kinases has proven to be useful for overcoming chemotherapy resistance and thus improving patient *** of kappaB kinase alpha(IKKα)is a serine/threonine kinase that was first described as part of the IKK complex in the nuclear factor-κB(NF-κB)pathway,which regulates several physiological and physiopathological processes such as immunity,inflammation,and ***,the IKKαsubunit has been shown to be dispensable for NF-κB activation and responsible of multiple pro-tumorigenic ***,we identified a nuclear active form of IKKαkinase IKKα(p45)that promotes tumor growth and therapy resistance,independent of canonical NF-κ*** understanding of resistance mechanisms will facilitate drug discovery and provide new effective ***,we review the recent publications on the implications of IKKαin cancer initiation,development,and resistance.

关键词： IKKα cancer therapeutic targets chemoresistance

Quantifying water stress effect on daily light use efficiency in Mediterranean ecosystems using satellite data

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International Journal of Digital Earth 2017年第6期10卷 623-638页

作者： Sergio Sanchez-Ruiz Alvaro Moreno maria Piles Fabio Maselli Arnaud Carrara Steven Running maria Amparo Gilabert departament de Fisica de la Terra i Termodinamica Facultat de FisicaUniversitat de ValenciaBurjassotSpain Numerical Terradynamic Simulation Group University of MontanaMissoulaMTUSA Barcelona Expert Center Institut de Ciencies del MarICM-CSICBarcelonaSpain IBIMET-CNR Sesto FiorentinoItaly Fundacion CEAM PaternaSpain

The capacity of six water stress factors(ε′(i))to track daily light use efficiency(ε)of water-limited ecosystems was *** factors are computed with remote sensing operational products and a limited amount of ground data:ε′1 uses ground precipitation and air temperature,and satellite incoming global solar radiation;ε′(2) uses ground air temperature,and satellite actual evapotranspiration and incoming global solar radiation;ε′_(3) uses satellite actual and potential evapotranspiration;ε′_(4) uses satellite soil moisture;ε′_(5) uses satellite-derived photochemical reflectance index;and ε′_(6) uses ground vapor pressure *** factors were implemented in a production efficiency model based on Monteith’s approach in order to assess their performance for modeling gross primary production(GPP).Estimated GPP was compared to reference GPP from eddy covariance(EC)measurements(GPP EC)in three sites placed in the Iberian Peninsula(two open shrublands and one savanna).ε′_(i) were correlated to ε,which was calculated by dividing GPP EC by ground measured photosynthetically active radiation(PAR)and satellite-derived fraction of absorbed *** results were achieved by ε′(1),ε′(2),ε′(3) and ε′(4) explaining around 40% and 50% of ε variance in open shurblands and savanna,*** terms of GPP,R^(2)≈0.70 were obtained in these cases.

关键词： Light use efficiency water stress GPP Monteith Mediterranean ecosystems

***:A Platform for Mainstreaming citizen Science and Open Science in Europe

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Data Intelligence 2021年第1期3卷 136-149页

作者： Katherin Wagenknecht Tim Woods Francisco García Sanz margaret Gold Anne Bowser Simone Rüfenacht Luigi Ceccaroni Jaume Piera Technische Hochschule Wildau Hochschulring 115745 WildauGermany European citizen Science Association Invalidenstraße 41Berlin 10115Germany Ibercivis Foundation Campus Río EbroC/Mariano Esquillor s/n Edificio I+DZaragoza 50018Spain Leiden University Rapenburg 702311 EZ LeidenThe Netherlands Woodrow Wilson International Center for Scholars 1300 Pennsylvania Ave.WashingtonDCDistrict of Columbia 20004United States Earthwatch Mayfield House256 Banbury RoadOxfordOxfordshire OX27DEUK institut de ciències del mar Consejo Superior de Investigaciones CientíficasPasseig Marítim de la Barceloneta37-49Barcelona 08003Spain

citizen Science(CS)is a prominent field of application for Open Science(OS),and the two have strong synergies,such as:advocating for the data and metadata generated through science to be made publicly available[1];supporting more equitable collaboration between different types of scientists and citizens;and facilitating knowledge transfer to a wider range of audiences[2].While primarily targeted at CS,the *** platform can also support *** of its key functions is to act as a knowledge hub to aggregate,disseminate and promote experience and know-how;for example,by profiling CS projects and collecting tools,resources and training materials relevant to both *** do this,the platform has developed an information architecture that incorporates the public participation in scientific research(PPSR)-Common Conceptual Model.This model consists of the Project Metadata Model,the Dataset Metadata Model and the Observation Data Model,which were specifically developed for CS *** implementing these,the platform will strengthen the interoperating arrangements that exist between other,similar platforms(e.g.,BioCollect and SciStarter)to ensure that CS and OS continue to grow globally in terms of participants,impact and fields of application.

关键词： citizen Science Metadata Open Science Public participation in scientific research(PPSR)

Ku波段旋转扫描扇形波束散射计地面扩展目标在轨定标

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电子与信息学报 2013年第8期35卷 1793-1799页

作者：朱金台董晓龙林文明朱迪中国科学院空间科学与应用研究中心中国科学院微波遥感技术重点实验室中国科学院大学 institut de ciències del mar(ICM-CSIC)Barcelona 08003

旋转扫描扇形波束散射计(Rotating Fan-beam SCATterometer,RFSCAT)是一种新体制的海洋风场测量雷达散射计。RFSCAT对同一观测面元能够提供更多的方位角和入射角观测组合,改善海面风矢量场的反演精度。为了达到设计的风场反演精度,系统... 详细信息

旋转扫描扇形波束散射计(Rotating Fan-beam SCATterometer,RFSCAT)是一种新体制的海洋风场测量雷达散射计。RFSCAT对同一观测面元能够提供更多的方位角和入射角观测组合,改善海面风矢量场的反演精度。为了达到设计的风场反演精度,系统要求定标精度为0.5 dB。该文基于中法海洋卫星(Chinese French Oceanography SATellite,CFOSAT)雷达散射计的系统参数,考虑了在轨测量的主要误差源,分析了地面扩展目标在轨外定标的特点,给出了可行的RFSCAT在轨外定标方法,并利用仿真数据对该方法进行验证。利用QuikSCAT散射计的L2A数据和图像重构(SIR)数据,针对地球表面归一化雷达后向散射系数(s 0)稳定的区域,给出了定标地图,为RFSCAT在轨定标提供参考。

关键词：雷达散射计旋转扇形波束散射计 Ku波段在轨定标地面扩展目标

星载散射计再分析风场在海浪模拟中的应用研究

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遥感技术与应用 2016年第6期31卷 1069-1074页

作者：郎姝燕林文明鲍青柳张有广国家卫星海洋应用中心国家海洋局空间海洋遥感与应用研究重点实验室北京100081 institut de ci ncies del mar(ICM-CSIC) Barcelona 08003Spain

基于第三代海浪（谱）模式WAVEWATCHⅢ,采用NCEP/QuikSCAT混合风场作为模式输入,进行了东中国海、太平洋东岸以及太平洋中部夏威夷附近海域的海浪数值模拟。在东中国海,模拟有效波高与浮标的参考值有较高的相关系数,波高的均方根误差约... 详细信息

基于第三代海浪（谱）模式WAVEWATCHⅢ,采用NCEP/QuikSCAT混合风场作为模式输入,进行了东中国海、太平洋东岸以及太平洋中部夏威夷附近海域的海浪数值模拟。在东中国海,模拟有效波高与浮标的参考值有较高的相关系数,波高的均方根误差约为0.5 m;在太平洋东岸和夏威夷附近海域,模拟有效波高比浮标的参考值普遍偏低,不同月份波高的均方根误差在0.4-1.2m之间,但模拟波高与浮标的参考值仍有较强的相关性。结果表明利用WAVEWATCHⅢ结合NCEP/QuikSCAT混合风场模拟东中国海的波高是可行的,但要模拟太平洋中、东部开阔深水海域的波高仍需考虑如涌浪、海流等非风场因素。

关键词： WAVEWATCHⅢ NCEP/QuikSCAT混合风场有效波高浮标

Pancreas sparing duodenectomy in the treatment of primary duodenal neoplasms and other situations with duodenal involvement

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 485-492页

作者： Juli Busquets Josefina Lopez-Dominguez Ana Gonzalez-Castillo marina Vila Nuria Pelaez Lluis Secanella Emilio Ramos Juan Fabregat department of Hepatobiliary and Pancreatic Surgery Hospital Universitari de BellvitgeResearch Group of Hepato-biliary and Pancreatic DiseasesInstitut d'InvestigacióBiomèdica de Bellvitge-IDIBELLBarcelona UniversityL’Hospitalet de LlobregatBarcelona 08907Spain department of General Surgery Hospital del MarBarcelona 08907Spain department of General Surgery Hospital de MataróBarcelona 08907Spain

Background:There are no clearly defined indications for pancreas-preserving *** present study aimed to analyze postoperative morbidity and the outcomes of patients undergoing pancreaspreserving ***:Patients undergoing pancreas-preserving duodenectomy from April 2008 to May 2020 were *** divided the series according to indication:scenario 1,primary duodenal tumors;scenario 2,tumors of another origin with duodenal involvement;and scenario 3,emergency ***:We included 35 *** duodenectomy was performed in 1 patient of adenomatous duodenal polyposis,limited duodenectomy in 7,and third+fourth duodenal portion resection in *** indications for scenario 1 were gastrointestinal stromal tumor(n=13),adenocarcinoma(n=4),neuroendocrine tumor(n=3),duodenal adenoma(n=1),and adenomatous duodenal polyposis(n=1);scenario 2:retroperitoneal desmoid tumor(n=2),recurrence of liposarcoma(n=2),retroperitoneal paraganglioma(n=1),neuroendocrine tumor in pancreatic uncinate process(n=1),and duodenal infiltration due to metastatic adenopathies of a germinal tumor with digestive hemorrhage(n=1);and scenario 3:aortoenteric fistula(n=3),duodenal trauma(n=1),erosive duodenitis(n=1),and biliopancreatic limb ischemia(n=1).Severe complications(Clavien-Dindo≥IIIb)developed in 14%(5/35),and postoperative mortality was 3%(1/35).Conclusions:Pancreas-preserving duodenectomy is useful in the management of primary duodenal tumors,and is a technical option for some tumors with duodenal infiltration or in emergency interventions.

关键词： Duodenectomy Duodenal neoplasms Organ sparing treatments Pancreatic surgery Duodenal diseases