Targeting IKKαkinase to prevent tumor progression and therapy resistance
作者机构：Cancer Research ProgramInstitut Mar d’Investigacions MèdiquesCIBERONCHospital del MarBarcelona 08003Spain.
出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)
年 卷 期：2020年第3卷第3期
页 面：482-490页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：IKKα cancer therapeutic targets chemoresistance
摘 要：Cancer therapy has improved considerably in the last years;however,therapeutic resistance is still a major problem that impedes full response to the treatment and the main cause of patient relapse and *** kinases have been reported to be overactivated in cancer and induce resistance to current *** kinases has proven to be useful for overcoming chemotherapy resistance and thus improving patient *** of kappaB kinase alpha(IKKα)is a serine/threonine kinase that was first described as part of the IKK complex in the nuclear factor-κB(NF-κB)pathway,which regulates several physiological and physiopathological processes such as immunity,inflammation,and ***,the IKKαsubunit has been shown to be dispensable for NF-κB activation and responsible of multiple pro-tumorigenic ***,we identified a nuclear active form of IKKαkinase IKKα(p45)that promotes tumor growth and therapy resistance,independent of canonical NF-κ*** understanding of resistance mechanisms will facilitate drug discovery and provide new effective ***,we review the recent publications on the implications of IKKαin cancer initiation,development,and resistance.
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