检索结果-南通市图书馆

Increased susceptibility to experimental steatohepatitis induced by methionine-choline deficiency in HBs-Tg mice

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2010年第5期9卷 513-519页

作者： Fu, Miao-Miao Sun, Rui Tian, Zhi-Gang Wei, Hai-Ming Univ Sci & Technol China Inst Immunol Sch Life Sci Hefei Natl Lab Phys Sci Microscale Hefei 230027 Peoples R China

BACKGROUND: Worldwide, about 25% of individuals with chronic hepatitis B have fatty liver disease. Lipogenic diets that are completely devoid of methionine and choline induce nonalcoholic fatty liver disease. However, no animal model of nonalcoholic steatohepatitis associated with HBV infection is available, and the influence of viral infection on nutritional hepatic steatosis is unclear. METHODS: We used HBV surface antigen transgenic mice (HBs-Tg mice), which mimic healthy human carriers with hepatitis B surface antigen. The mice were fed with a high-fat methionine-choline-deficient diet (MCD) to build a reliable rodent nutritional model of nonalcoholic steatohepatitis associated with HBV infection, and the changes in body weight and serum triglycerides were measured. Hepatocyte ballooning changes were determined by hematoxylin and eosin staining. The extent of hepatic fat accumulation was evaluated by oil red O staining. Immunohistochemical assays were performed to detect proliferating cell nuclear antigen as an index of cell proliferation. RESULTS: MCD feeding provoked systemic weight loss and liver injury. MCD feeding caused more macrovesicular fat droplets and fat accumulation in the livers of HBs-Tg mice than in wild-type C57BL/6 mice. In addition, within 30 days of MCD exposure, more PCNA-positive nuclei were found in the livers of HBs-Tg mice. CONCLUSIONS: HBs-Tg mice fed with a lipogenic MCD form more macrovesicular fat droplets earlier, coincident with more hepatocyte proliferation, resulting in the appearance of increased susceptibility to experimental steatohepatitis in these mice.

关键词： high-fat methionine-choline-deficient diet HBV surface antigen transgenic mice steatohepatitis, experimental

Finite element simulation for mechanical response of surface mounted solder joints under different temperature cycling

在线全文

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 2001年第4期11卷 471-474页

作者：马鑫钱乙余 Harbin inst Technol Natl Key Lab Welding Harbin 150001 Peoples R China Elect Prod Reliabil & Environm Testing Res inst Res & Anal Ctr Guangzhou 510610 Peoples R China Hiroshima Univ Dept Mech Engn Higashihiroshima 739 Japan

Nonlinear finite element simulation for mechanical response of surface mounted solder joint under different temperature cycling was carried out. Seven sets of parameters were used in order to evaluate the influence of temperature cycling profile parameters. The results show that temperature cycling history has significant effect on the stress response of the solder joint. Based on the concept of relative damage stress proposed by the authors, it is found that enough high temperature holding time is necessary for designing the temperature cycling profile in accelerated thermal fatigue test.

关键词： finite element simulation surface mounted solder joint thermal cycling mechanical response

Discovery of WTTS candidates in high-galactic latitude translucent molecular clouds

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1999年第23期44卷 2145-2149页

作者： Jinzeng Li Jingyao Hu Wenping Chen Chinese Acad Sci Beijing Astron Observ Beijing 100012 Peoples R China natl Cent Univ Inst Astron Chungli 32054 Taiwan

The results of the survey of low-mass star formation in high-galactic latitude molecular clouds, especially those of the translucent category, based on the ROSAT All-Sky Survey are presented. Six new WTTS candidates have been discovered at high-galactic latitude, a-mong which, two are found to be possibly associated with translucent molecular clouds MBM

关键词： stars formation-stars pre-main sequence-ISM clouds.

Study on the Total Synthesis of 3-Oxo-9β-Acetoxyilicic Acid─The Synthesis of 9β-Acetoxy-3(4),11(13)-Dien-5αH,7αH-12-Eudesmanoic Acid Methyl Ester

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1997年第12期8卷 0-0页

作者： Jiong YANG Zbao Ming XIONG Yong Gang CREN and Yu Lin LI(National Laboratory of Applied Organic Chemistry and institute of Organic Chemistry,ho University, Lanzhou 730000) Lanzhou Univ Natl Lab Appl Organ Chem Lanzhou 730000 Peoples R China Lanzhou Univ Inst Organ Chem Lanzhou 730000 Peoples R China

The synthesis of 99-acetoxy-3(4), 11(13)-dien-5αH 7αH-12-eudesmanoic acid methyl ester (2) was achieved from oxycarvone. The key step is the p-toluenesulfonhydrazide assisted reductiv rearrangement reaction

关键词： The Synthesis of 9 H,7 H-12-Eudesmanoic Acid Methyl Ester Dien-5 Study on the Total Synthesis of 3-Oxo-9 Acetoxyilicic Acid Acetoxy-3

A Facile Synthesis of 6β-Hydroxy-7α(H)-eudesma-4-en-3-one

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1998年第9期9卷 817-818页

作者： Gang ZHOU Zhao Ming XIONG Yong Gang CHEN Yu Lin LI (National Laboratory of Applied Organic Chemistry and institute of Organic Chemistry,Lanzhou University, Lanzhou 730000) Lanzhou Univ Inst Organ Chem Lanzhou 730000 Peoples R China Lanzhou Univ Natl Lab Appl Organ Chem Lanzhou 730000 Peoples R China

A stereoselective total synthesis of 6β-hydroxy-7α(H)-eudesma-4-en-3- 1startingfrom (+)-dihydrocarvone 7 has been described.

关键词： synthesis sesquiterpene 6β-Hydroxy-7α(H)-eudesm-4-en-3-one sihydrocarvone

Total Synthesis of (-)-Baimuxifuranic Acid

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1997年第8期8卷 697-700页

作者： Yong Gang CHEN Zhao Ming XIONG Jiong YANG Yu Lin LI(National Laboratory of Applied Organic Chemistry and institute of Organic Chemistry Lanzhou University,Lanzhou 730000) LANZHOU UNIV NATL LAB APPL ORGAN CHEMLANZHOU 730000PEOPLES R CHINA LANZHOU UNIV INST ORGAN CHEMLANZHOU 730000PEOPLES R CHINA

The first total synthesis of (-)-baimuxifuranic acid (1) starting from (-)-carvone has been described. In our studies a surprising allylic oxidation was found in the oxidation of alpha beta-unsaturated aldehyde 5 with... 详细信息

关键词： ppm MHz EIMS Baimuxifuranic Acid Total Synthesis of

The First Total Synthesis of Five Elegan Type Natural Products

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1997年第7期8卷 595-598页

作者： Jing LI Jiong LAN Zuo Sheng LIU Yu Lin LI(National Laboratory of Applied Organic Chemistry and institute of Organic Chemistry,Lanzhou Univerity, Lanzhou 730000) LANZHOU UNIV NATL LAB APPL ORGAN CHEM LANZHOU 730000 PEOPLES R CHINA LANZHOU UNIV INST ORGAN CHEM LANZHOU 730000 PEOPLES R CHINA

The first total synthesis of five linear diterpenes: eleganolone (1), eleganolone acetate (2), elegandiol (3), eleganonal (4) and epoxyeleganolone (5), was achieved from (E,E)-farnesol (6) via 4 to 6 steps. The key st... 详细信息

关键词： ppm HNMR cm IR EIMS The First Total Synthesis of Five Elegan Type Natural Products MHz

On Structure and Thermodynamics of Coherent Nanocrystals

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 1995年第3期11卷 157-164页

作者： LUCK, R LU, K ACAD SINICA INST MET RESNATL KEY LAB RAPIDLY SOLIDIFIED NONEQUILIBRIUM ALSHENYANG 110015PEOPLES R CHINA ACAD SINICA INST MET RESINT CTR MAT PHYSSHENYANG 110015PEOPLES R CHINA MAX PLANCK inst MET RES INST WERKSTOFFWISSENSCHD-70174 STUTTGARTGERMANY

Several classifications for the nanocrystalline morphologies are introduced. It is: demonstrated that coherency and coherence strain are important physical quantities, which influence the stability, the morphology and... 详细信息

关键词： MECHANICAL-PROPERTIES ELECTRON-MICROSCOPY AMORPHOUS NIZR2 STATE TRANSITION CRYSTALLIZATION PARTICLES ALLOYS

First Total Synthesis of (-)-4-O-(6'-hydroxy-7'(9')-dehydro-6',7'-dihydrogeranyl)-coniferyl Alcohol

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1998年第8期9卷 717-720页

作者： Zuo Sheng LIU Chu Sheng HUANG Jiong LAN Yu Lin LI(National Laboratory of Applied Organic Chemistry and institute of Organic Chemistry,Lanzhou University, Lanzhou, 730000) Lanzhou Univ Natl Lab Appl Organ Chem Lanzhou 730000 Peoples R China Lanzhou Univ Inst Organ Chem Lanzhou 730000 Peoples R China

The reduction of 2,3-epoxy alcohol, prepared from the Sharpless asymmetric epoxidation, with the system of Ph3P, iodine, iwhdazole, 2,6-lutidine and water in Et2O/CH3CN,gives a chiral secondary allylic alcohol in 94% yield and 92% e.e.. Using this reaction as the key step, we synthesized (-)-coniferyl alcohol derivative 1 steding from the geraniol through nine steps in an overall yield of 39%.

关键词： coniferyl alcohol synthesis