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Extraction, identification, and antioxidant property evaluation of limonin from pummelo seeds

Animal Nutrition 2018年第3期4卷 281-287页

作者： Si Qin Chenghao Lv Qingshan Wang Zhibing Zheng Xi Sun Minyi Tang Fangming Deng Key Laboratory for Food Science and Biotechnology of hunan Province College of Food Science and Technology Hunan Agricultural University hunan co-innovation center for utilization of botanical functional ingredients Hunan Agricultural University

Limonin, the main bioactive phytochemical constituent of limonoids with multi-functions, is enriched in citrus fruits and often found at a high concentration in citrus seeds. The present study was attempted to introduce a new and efficient extraction method to isolate limonoids from pummelo seeds, and to evaluate the antioxidant property of the main constituent limonin in Hep G2 cells. Three key single factors were identified for the extraction of limonoids from pummelo seeds using the Box-Behnken experiment design of response surface methodology(RSM), and the optimized extraction parameters were treatment with 89.68 m L of anhydrous acetone for 4.62 h at 78.94C, while the yield of limonoids was 11.52 mg/g. The structure of isolated main constituent of the limonoids was further identified as limonin by Fourier transform infrared(FT-IR) spectrometer and nuclear magnetic resonance(NMR)spectrum. Moreover, the molecular data in Hep G2 cells revealed that limonin exerted its anti-oxidant property mainly by the activation of nuclear factor(erythroid-2)-like 2(Nrf2)/kelch-like ECHassociated protein 1(Keap1)-antioxidant response element(ARE) pathway in the form of transcriptional regulation of Nrf2 m RNA and posttranscriptional regulation of Nrf2/Keap1 system. These results demonstrate that pummelo seeds are an ideal source of limonoids, and limonin is proved to exert its anti-oxidant property by the activation of Nrf2/Keap1 pathway.

关键词： Limonin Extraction Identification Nrf2-ARE pathway Antioxidant

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Inhibitory effect of blue honeysuckle extract on high-fat-diet-induced fatty liver in mice

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Animal Nutrition 2018年第3期4卷 288-293页

作者： Ming Liu Jijun Tan Ziyu He Xi He De-Xing Hou Jianhua He Shusong Wu core Research Program 1515 Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients Hunan Agricultural University The United Graduate School of Agricultural Sciences Kagoshima University

Blue honeysuckle is rich in polyphenols, and recently receiving attention because of its potential antioxidant and anti-inflammatory properties. Nonalcoholic fatty liver disease(NAFLD) is the leading cause of chronic liver disease that develops hepatic inflammation and metabolic syndrome. The present study aims to study the effect of blue honeysuckle extract(BHE) on fat deposition and hepatic lipid peroxidation in a high-fat-diet(HFD)-induced mouse model. Mice were fed a normal diet(ND) or a HFD containing 0.5% or 1% of BHE or not for 45 d. Liver sections were stained by hematoxylin-eosin *** lipids were measured by a clinical analyzer. Insulin was examined by ELISA, and hepatic proteins were detected by Western blotting. Dietary supplementation of BHE dose-dependently suppressed HFD-induced obesity and hepatic fat deposition. Moreover, BHE improved glucose metabolism by increasing insulin sensitivity and attenuated oxidative stress potentially by up-regulating nuclear factor(erythroid-derived 2)-like 2(Nrf2)-mediated pathway.

关键词： Blue honeysuckle Polyphenols Fatty liver Lipid peroxidation Antioxidant

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Hypoglycemic effects of black brick tea with fungal growth in hyperglycemic mice model

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Food Science and Human Wellness 2022年第3期11卷 711-718页

作者： Wei Xu Yang Zhou Ling Lin Dongyin Yuan Yingqi Peng Li Li Wenjun Xiao Zhihua Gong Key Laboratory of Tea Science of Ministry of Education Hunan Agricultural UniversityChangsha 410128China National Research center of Engineering and Technology for utilization of botanical functional ingredients Hunan Agricultural UniversityChangsha 410128China co-innovation center of Education Ministry for utilization of botanical functional ingredients Changsha 410128China hunan Baojiachong Tea Farm co.Ltd. Yiyang 413500China

Dark tea(containing Eurotium cristatum)and black tea have hypoglycemic *** black brick tea with fungal growth is obtained from black tea by adding ***,followed by steaming,pressing,fungal growth,and ***,the hypoglycemic effects of black brick tea are still ***,we used black brick tea with fungal growth and black tea as raw materials to study their hypoglycemic effects in a hyperglycemic mice *** these types of black tea could lower the content of blood glucose and increase the content of hepatic glycogen by upregulating the proteins and m RNA expression of phosphatidylinositol-4,5-bisphosphate3-kinase,glycogen synthase,protein kinase B and phosphoinositidedependent protein kinase-1 and downregulating the protein and m RNA expression of glycogen synthase kinase 3β.These regulatory steps were followed by high activities of glutathione peroxidase and superoxide dismutase and low content of *** teas can promote blood glucose transport and absorption by upregulating the protein and m RNA expression of insulin receptor substrate-1 and glucose transporter-2 and stimulate glycolysis by upregulating the protein and m RNA expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase *** study suggests that the black brick tea was more effective than the black tea in terms of hypoglycemic.

关键词： Black tea Black brick tea(with fungal growth) High blood glucose Hypoglycemic effect

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Junshanyinzhen tea extract prevents obesity by regulating gut microbiota and metabolic endotoxemia in high-fat diet fed rats

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Food Science and Human Wellness 2024年第4期13卷 2036-2047页

作者： Jian Ouyang Xiuping Li Changwei Liu Danmin Lu Jie Ouyang Fang Zhou Qi Liu Jianan Huang Zhonghua Liu Key Laboratory of Tea Science of Ministry of Education Hunan Agricultural UniversityChangsha 410128China National Research center of Engineering Technology for utilization of functional ingredients from botanicals Hunan Agricultural UniversityChangsha 410128China co-innovation center of Education Ministry for utilization of botanical functional ingredients Hunan Agricultural UniversityChangsha 410128China Key Laboratory for Evaluation and utilization of Gene Resources of Horticultural Crops Ministry of Agriculture and Rural AffairsHunan Agricultural UniversityChangsha 410128China

Obesity is associated with gut dysbiosis and metabolic *** tea extract(JSTE)reduced fat accumulation and body weight in obese ***,the effects and mechanism of JSTE in preventing obesity were ***,we used different doses of JSTE(75,150 and 300 mg/(kg·day))to evaluate the effect on high-fat diet(HFD)-induced rats under 8 weeks of ***,our results showed that JSTE could significantly reduce body weight gain,blood lipid levels and fat accumulation,improve fatty damage in liver tissue(Pcould effectively reverse the microbial diversity and the ratio of Firmicutes to Bacteroidetes to normal levels in HFD-fed *** and Erysipelotrichaceae,which are positively related to obesity,were decreased by JSTE intervention(P<0.05).while Bifidobacteriaceae,Bacteroidaceae,Akkermansia,and Clostridium,which are negatively related to obesity,were ***,these results suggested that JSTE might effectively prevent obesity by modulating gut microbiota dysbiosis,intestinal barrier dysfunction,metabolic endotoxemia and chronic low-grade infl ammation in HFD-induced rats.

关键词： Junshanyinzhen tea Obesity Gut microbiota Gut barrier function Metabolic endotoxemia

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Biochar addition to tea garden soils:effects on tea fluoride uptake and accumulation

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Biochar 2023年第1期5卷 641-656页

作者： Haoyang Wang Teng Hu Minghan Wang Yunshan Liang Chengwen Shen Huaqin Xu Yaoyu Zhou Zhonghua Liu college of Resources and Environment Hunan Agricultural UniversityChangsha 410128HunanChina hunan Provincial Key Laboratory of Rural Ecosystem Health in Dongting Lake Area Changsha 410128HunanChina Key Laboratory of Tea Science of Ministry of Education Hunan Agricultural UniversityChangsha 410128HunanChina National Research center of Engineering and Technology for utilization of functional ingredients From botanicals Collaborative Innovation Center of Utilization of Functional Ingredients From BotanicalsHunan Agricultural UniversityChangsha 410128HunanChina

Long-term consumption of tea with high fluoride(F)content has a potential threat to human *** application of different amounts of biochar to reduce F accumulation in tea leaves has been little *** this study,a pot experiment was conducted to investigate the effect of biochar amounts(0,0.5%,2.5%,5.0%,8.0%,and 10.0%,w/w)on tea F content during the tea plant *** in tea quality,soil F fraction,and soil properties caused by biochar and the relationship with tea F accumulation were also *** results showed that the application of biochar amendment significantly reduced water-soluble F contents in tea leaves compared to CK(without biochar),especially in the 8.0%treatment(72.55%).Overall,biochar contributed to improving tea polyphenols and caffeine,but had no significant impact on free amino acids and water *** with CK,5.0-10.0%biochar significantly increased soil water-soluble F content due to the substitution of F−with OH−under high ***,biochar applied to tea garden soil was effective in decreasing the soil exchangeable aluminum(Ex-Al)content(46.37-91.90%)and increasing the soil exchangeable calcium(Ca^(2+))content(12.02-129.74%)compared to CK,and correlation analysis showed that this may help reduce F enrichment of tea *** general,the application of 5.0-8.0%biochar can be suggested as an optimal application dose to decrease tea F contents while simultaneously improving tea quality.

关键词： Fluoride Biochar Tea quality Fluoride fractions Fluoride-aluminum complexes

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Anti-inflammatory properties of Fu brick tea water extract contribute to the improvement of diarrhea in mice

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Beverage Plant Research 2022年第1期2卷 19-25页

作者： Xinyue Dai Binggang Ge Mingzhi Zhu Huiwen Wang Tingyu Zeng Zhonghua Liu Donghe Fu Key Laboratory of Tea Science of Ministry of Education Hunan Agricultural UniversityChangshaHunan 410128China National Research center of Engineering Technology for utilization of functional ingredients from botanicals Hunan Agricultural UniversityChangshaHunan 410128China co-innovation center of Education Ministry for utilization of botanical functional ingredients Hunan Agricultural UniversityChangshaHunan 410128China hunan Nutramax Biotechnology co Ltd.ChangshaHunan 410013China

Fu brick tea,a special kind of dark tea fermented dominantly by Eurotium cristatum,is traditionally used for diarrhea therapy in ***,limited reports are available on the anti-diarrhea of Fu brick tea water extract(FTE)and its potential *** the present study,the treatment effects of FTE on the senna-induced diarrhea in mice were *** found that FTE effectively improved diarrhea index and inhibited gut ***,histopathological examination revealed that FTE protected the integrity and reduced inflammatory infiltration of the ileum mucosal ***,FTE significantly decreased the levels of the pro-inflammatory factor 5-hydroxytryptamine(5-HT)and increased the expression of sodium–hydrogen exchanger 3(NHE-3).The association among both intestinal damage and electrolyte balance and inflammation has been reported by many ***,our study showed that FTE had anti-diarrhea activity,which may be associated with anti-inflammatory properties.

关键词： diarrhea inflammatory inhibited

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The Biofunctions of Phytochemicals and Their Applications in Farm Animals： The Nrf2/Keap1 System as a Target

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Engineering 2017年第5期3卷 738-752页

作者： Si Qin De-Xing Hou Key Laboratory for Food Science and Biotechnology of hunan Province College of Food Science and Technology Hunan Agricultural University Changsha 410128 China Hun an co-innovation center for utilization of botanical functional ingredients Hunan Agricultural University Changsha 410128 China The United Graduate School of Agricultural Sdences Faculty of Agriculture Kagoshima University Korimoto Kagoshima 890-0065 Japan

Reactive oxygen species （ROS） can be caused by mechanical, thermal, infectious, and chemical stimuli, and their negative effects on the health of humans and other animals are of considerable concern. The nuclear factor （erythroid-derived 2）-like 2/Kelch-like ECH-associated protein 1 （Nrf2/Keap1） system plays a major role in maintaining the balance between the production and elimination of ROS via the regulation of a series of detoxifying and antioxidant enzyme gene expressions by means of the antioxidant response element （ARE）. Dietary phytochemicals, which are generally found in vegetables, fruits, grains, and herbs, have been reported to have health benefits and to improve the growth performance and meat quality of farm animals through the regulation of Nrf2-mediated phase II enzymes in a variety of ways. However, the enormous quantity of somewhat chaotic data that is available on the effects of phytochemicals needs to be properly classified according to the functions or mechanisms of phytochemicals, in this review, we first introduce the antioxidant properties of phytochemicals and their relation to the Nrf2/Keap1 system. We then summarize the effects of phytochemicals on the growth performance, meat quality, and intestinal microbiota of farm animals via targeting the Nrf2/Keap1 system. These exhaustive data contribute to better illuminate the underlying biofunctional properties of phytochemicals in farm animals.

关键词： Phytochemical Biofunction Nrf2/Keap1 system Growth performance Meat quality Intestinal microbiota

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Patterns of alteration in boar semen quality from 9 to 37 months old and improvement by protocatechuic acid

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1881-1893页

作者： Ruizhi Hu Xizi Yang Jiatai Gong Jing Lv Xupeng Yuan Mingkun Shi Chenxing Fu Bie Tan Zhiyong Fan Liang Chen Hongfu Zhang Jianhua He Shusong Wu hunan collaborative innovation center for utilization of botanical functional ingredients College of Animal Science and TechnologyHunan Agricultural UniversityChangsha 410128China college of Animal Science and Technology Hunan Biological and Electromechanical PolytechnicChangsha 410127China State Key Laboratory of Animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Background comprehending the patterns of alteration in boar semen quality and identifying effective nutritional interventions are crucial for enhancing the productivity of commercial pig *** study aimed to examine the alteration in semen quality in boars,and assess the impact of protocatechuic acid(PCA)on semen quality during the phase of declining semen *** In Exp.1,a total of 38 Pig Improvement company(PIC)boars were selected and their semen quality data were recorded from the age of 9 to 37 *** Exp.2,18 PIC boars(28 months old)were randomly assigned into three groups(n=6)and fed a basal diet,a basal diet containing 500 or 1,000 mg/kg PCA,*** experiment lasted for 12 *** The semen volume,concentration,and total number of spermatozoa in boars exhibited an increase from 9 to 19 months old and showed a significant linear decreased trend in 28,24,and 22 months *** motility displayed an upward trajectory,reaching its peak at 20 months of age,and showed a significant linear decreased trend at 20 months *** supplementation of PCA demonstrated an effect to mitigate the decrease in semen volume,concentration of spermatozoa,total number of spermatozoa(P>0.05),and significantly increased the sperm motility(P<0.05).Moreover,supplementation of 1,000 mg/kg PCA significantly increased the sperm viability(P<0.05).Analysis on cellular signaling pathways revealed that PCA restored serum testosterone levels and alleviated oxidative damage by upregulating the expression of HO-1,SOD2,and NQO1 in testicular stromal ***,PCA can enhance phosphorylation by selectively binding to AMP-activated protein kinase(AMPK)protein,thereby improving sperm mitochondrial function and augmenting sperm motility via PGC-1/*** These data elucidated the pattern of semen quality variation in boars within the age range of 9 to 37 months old,and PCA has the potential to be a natural antioxidant to enhance sperm quality throu

关键词： Antioxidants Boars Protocatechuic acid Semen quality Signaling pathway

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Developmental changes in intercellular junctions and Kv channels in the intestine of piglets during the suckling and post-weaning periods

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Journal of Animal Science and Biotechnology 2016年第2期7卷 228-237页

作者： Jing Wang Liming Zeng Bie Tan Guangran Li Bo Huang Xia Xiong Fengna Li Xiangfeng Kong Gang Liu Yulong Yin hunan Provincial Engineering Research center for Healthy Livestock and Poultry Production Key Laboratory of Agro-ecological Processes in Subtropical Region institute of Subtropical AgricultureChinese Academy of SciencesChangshaHunan 410125China University of the ChineseAcademy of Sciences Beijing 10008China. Science college of Jiangxi Agricultural University NanchangJiangxi 330045China. hunan collaborative innovation center for utilization of botanical functional ingredients Hunan Collaborative Innovation Center of Animal Production SafetyChangshaHunan 410000China.

Background： The intestinal epithelium is an important barrier that depends on a complex mixture of proteins and these proteins comprise different intercellular junctions. The purpose of this study was to investigate the postnatal and developmental changes in morphology, intercellular junctions and voltage-gated potassium（Kv） channels in the intestine of piglets during the suckling and post-weaning ***： Samples of the small intestine were obtained from 1-, 7-, 14-, and 21-d-old suckling piglets and piglets on d 1, 3, 5, and 7 after weaning at 14 d of age. The results showed that the percentage of proliferating cell nuclear antigen（PCNA）-positive cells and alkaline phosphatase（AKP） activity, as well as the abundances of E-cadherin,occludin, and Kv1.5 m RNA and claudin-1, claudin-3, and occludin protein in the jejunum were increased from d 1to d 21 during the suckling period（P 〈 0.05）. Weaning induced decreases in the percentage of PCNA-positive cells,AKP activity and the abundances of E-cadherin, occludin and zonula occludens（ZO）-1 m RNA or protein in the jejunum on d 1, 3 and 5 post-weaning（P 〈 0.05）. There were lower abundances of E-cadherin, occludin and ZO-1m RNA as well as claudin-1, claudin-3 and ZO-1 protein in the jejunum of weanling piglets than in 21-d-old suckling piglets（P 〈 0.05）. The abundances of E-cadherin, occludin, ZO-1 and integrin m RNA were positively related to the percentage of PCNA-positive ***： Weaning at 14 d of age induced damage to the intestinal morphology and barrier. While there was an adaptive restoration on d 7 post-weaning, the measured values did not return to the pre-weaning levels, which reflected the impairment of intercellular junctions and Kv channels.

关键词： Intercellular junctions Kv channels Small intestine Piglets Weaning

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Dietary ferulic acid and vanillic acid on inflammation,gut barrier function and growth performance in lipopolysaccharide-challenged piglets

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Animal Nutrition 2022年第1期8卷 144-152页

作者： Ruizhi Hu Shusong Wu Baizhen Li Jijun Tan Jiahao Yan Ying Wang Zhiyi Tang Ming Liu Chenxing Fu Hongfu Zhang Jianhua He hunan collaborative innovation center for utilization of botanical functional ingredients College of Animal Science and TechnologyHunan Agricultural UniversityChangsha410128China Beijing China-Agri HongKe Bio-Technology co. Ltd.Beijing102206China State Key Laboratory of Animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing100193China

Ferulic acid(FA)and vanillic acid(VA)are considered as major phenolic metabolites of cyanidin 3-glucoside,a polyphenol that widely exists in plants that possess a protective effect against oxidative stress and inflammation in our previous *** study aimed to investigate the effect of FA and VA on inflammation,gut barrier function,and growth performance in a weaned piglet model challenged with lipopolysaccharide(LPS).Thirty-six piglets(PIC 337×C48,28 d of age)were randomly allocated into 3 treatments with 6 replicate pens(2 piglets per pen).They were fed with a basal diet or a diet containing 4,000 mg/kg of FA or *** supplementation of VA significantly increased average daily gain(ADG)(Pcould alleviate inflammation and oxidative stress,but only VA has a significant positive effect on the growth performance of LPS-challenged piglets potentially through modulating gut microbiota.

关键词： Ferulic acid Vanillic acid Inflammation Gut barrier function Growth performance Piglet

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