The Biofunctions of Phytochemicals and Their Applications in Farm Animals： The Nrf2/Keap1 System as a Target

作     者：Si Qin De-Xing Hou 

作者机构：Key Laboratory for Food Science and Biotechnology of Hunan Province College of Food Science and Technology Hunan Agricultural University Changsha 410128 China Hun an Co-Innovation Center for Utilization of Botanical Functional Ingredients Hunan Agricultural University Changsha 410128 China The United Graduate School of Agricultural Sdences Faculty of Agriculture Kagoshima University Korimoto Kagoshima 890-0065 Japan 

出 版 物：《Engineering》 (工程（英文）)

年 卷 期：2017年第3卷第5期

页      面：738-752页

核心收录：

学科分类：07[理学] 08[工学] 

基　　金：This work was financially supported by funds from the Core Research Program 1515 of Hunan Agricultural University  the National Natural Science Foundation of China (31101268)  and Scholar Research of Kagoshima University of Japan (for De-Xing Hou) 

主　　题：Phytochemical Biofunction Nrf2/Keap1 system Growth performance Meat quality Intestinal microbiota 

摘      要：Reactive oxygen species （ROS） can be caused by mechanical, thermal, infectious, and chemical stimuli, and their negative effects on the health of humans and other animals are of considerable concern. The nuclear factor （erythroid-derived 2）-like 2/Kelch-like ECH-associated protein 1 （Nrf2/Keap1） system plays a major role in maintaining the balance between the production and elimination of ROS via the regulation of a series of detoxifying and antioxidant enzyme gene expressions by means of the antioxidant response element （ARE）. Dietary phytochemicals, which are generally found in vegetables, fruits, grains, and herbs, have been reported to have health benefits and to improve the growth performance and meat quality of farm animals through the regulation of Nrf2-mediated phase II enzymes in a variety of ways. However, the enormous quantity of somewhat chaotic data that is available on the effects of phytochemicals needs to be properly classified according to the functions or mechanisms of phytochemicals, in this review, we first introduce the antioxidant properties of phytochemicals and their relation to the Nrf2/Keap1 system. We then summarize the effects of phytochemicals on the growth performance, meat quality, and intestinal microbiota of farm animals via targeting the Nrf2/Keap1 system. These exhaustive data contribute to better illuminate the underlying biofunctional properties of phytochemicals in farm animals.