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Hypoxia-mediated programmed cell death is involved in the formation of wooden breast in broilers

Journal of animal Science and Biotechnology 2024年第5期15卷 1918-1931页

作者： Xinrui Zhang Tong Xing Lin Zhang Liang Zhao Feng Gao college of animal Science and Technology Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu ProvinceJiangsu Collaborative Innovation Center of Meat Production and ProcessingQuality and Safety ControlNanjing Agricultural UniversityNo.1 WeigangNanjingJiangsu 210095P.R.China

Background Wooden breast(WB)myopathy is a common myopathy found in commercial broiler chickens *** examination has revealed that WB myopathy is accompanied by damage to the pectoralis major(PM)***,the underlying mechanisms responsible for the formation of WB in broilers have not been fully *** study aimed to investigate the potential role of hypoxia-mediated programmed cell death(PCD)in the formation of WB *** Histological examination and biochemical analysis were performed on the PM muscle of the control(coN)and WB groups.A significantly increased thickness of the breast muscle in the top,middle,and bottom portions(Pco_(2) and Tco_(2) in the blood were significantly increased(Pconditions in the PM muscle of the WB *** further evaluated the PCD-related pathways including autophagy,apoptosis,and necroptosis to understand the consequence response to enhanced hypoxic conditions in the PM muscle of birds with *** ratio of LC3 II to LC3 I,and the autophagy-related factors HIF-1α,BNIP3,Beclin1,AMPKα,and ULK1 at the m RNA and protein levels,were all significantly upregulated(P<0.05),showing that autophagy occurred in the PM muscle of the WB *** apoptotic index,as well as the expressions of Bax,Cytc,caspase 9,and caspase 3,were significantly increased(P<0.05),whereas Bcl-2 was significantly decreased(P<0.05)in the WB-affected PM muscle,indicating the occurrence of apoptosis mediated by the mitochondrial ***,the expressions of necroptosis-related factors RIP1,RIP3,and MLKL,as well as NF-κB and the pro-inflammatory cytokines TNF-α,IL-1β,and IL-6,were all significantly enhanced(P<0.05)in the WB-affected PM *** T

关键词： Apoptosis Autophagy Broiler chicken Hypoxia Necroptosis Wooden breast

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Patterns of alteration in boar semen quality from 9 to 37 months old and improvement by protocatechuic acid

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Journal of animal Science and Biotechnology 2024年第5期15卷 1881-1893页

作者： Ruizhi Hu Xizi Yang Jiatai Gong Jing Lv Xupeng Yuan Mingkun Shi Chenxing Fu Bie Tan Zhiyong Fan Liang Chen Hongfu Zhang Jianhua He Shusong Wu hunan collaborative innovation center for Utilization of Botanical Functional Ingredients College of Animal Science and TechnologyHunan Agricultural UniversityChangsha 410128China college of animal Science and Technology Hunan Biological and Electromechanical PolytechnicChangsha 410127China State Key Laboratory of animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Background comprehending the patterns of alteration in boar semen quality and identifying effective nutritional interventions are crucial for enhancing the productivity of commercial pig *** study aimed to examine the alteration in semen quality in boars,and assess the impact of protocatechuic acid(PCA)on semen quality during the phase of declining semen *** In Exp.1,a total of 38 Pig Improvement company(PIC)boars were selected and their semen quality data were recorded from the age of 9 to 37 *** Exp.2,18 PIC boars(28 months old)were randomly assigned into three groups(n=6)and fed a basal diet,a basal diet containing 500 or 1,000 mg/kg PCA,*** experiment lasted for 12 *** The semen volume,concentration,and total number of spermatozoa in boars exhibited an increase from 9 to 19 months old and showed a significant linear decreased trend in 28,24,and 22 months *** motility displayed an upward trajectory,reaching its peak at 20 months of age,and showed a significant linear decreased trend at 20 months *** supplementation of PCA demonstrated an effect to mitigate the decrease in semen volume,concentration of spermatozoa,total number of spermatozoa(P>0.05),and significantly increased the sperm motility(P<0.05).Moreover,supplementation of 1,000 mg/kg PCA significantly increased the sperm viability(P<0.05).Analysis on cellular signaling pathways revealed that PCA restored serum testosterone levels and alleviated oxidative damage by upregulating the expression of HO-1,SOD2,and NQO1 in testicular stromal ***,PCA can enhance phosphorylation by selectively binding to AMP-activated protein kinase(AMPK)protein,thereby improving sperm mitochondrial function and augmenting sperm motility via PGC-1/*** These data elucidated the pattern of semen quality variation in boars within the age range of 9 to 37 months old,and PCA has the potential to be a natural antioxidant to enhance sperm quality throu

关键词： Antioxidants Boars Protocatechuic acid Semen quality Signaling pathway

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Source and level of dietary iron influence semen quality by affecting inflammation, oxidative stress and iron utilization levels in boars

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Journal of animal Science and Biotechnology 2024年第5期15卷 2044-2058页

作者： Yinghui Wu Yamei Li Yueyue Miao Hongkui Wei Hefeng Luo Chunxiao Ren Yawei Zhang Juan Chen Tanghong Wei Jiyan Deng Jian Peng Department of animal Nutrition and Feed Science College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China The cooperative innovation center for Sustainable Pig production Wuhan 400700China Frontiers Science center for animal Breeding and Sustainable production Wuhan 430070China Dekon Food and Agriculture Group Chengdu 610000China Xingjia Bio-Engineering co.Ltd Changsha 410011China

Background Boars fed a mixed form of inorganic and organic iron in excess of the NRC recommended levels still develop anemia,which suggested that the current level and form of iron supplementation in boar diets may be ***,56 healthy Topeka E line boars aged 15–21 months were randomly divided into 5 groups:basal diet supplemented with 96 mg/kg ferrous sulfate(FeSO_(4))and 54 mg/kg glycine chelated iron(Gly-Fe,control);80 mg/kg or 115 mg/kg Gly-Fe;80 mg/kg or 115 mg/kg methionine hydroxyl analogue chelated iron(MHA-Fe,from CalimetFe)for 16 *** effects of dietary iron supplementation with different sources and levels on semen quality in boars were *** 1)Serum Fe and hemoglobin concentrations were not affected by reduced dietary iron levels in the 80 mg/kg or 115 mg/kg Gly-Fe and MHA-Fe groups compared with the control group(P>0.05).2)Serum interleukin-6(IL-6)and sperm malondialdehyde(MDA)levels in the 80 mg/kg or 115 mg/kg MHA-Fe groups were lower than those in the control group(Pconcentrations,and boars in the 115 mg/kg MHA-Fe group had higher seminal plasma Fe concentrations compared with the control group.4)Boars in the 80 mg/kg and 115 mg/kg MHA-Fe groups had lower abnormal sperm rate and in situ oscillating sperm ratio compared to the control group at weeks 12 and/or 16 of the ***,the effect of Gly-Fe on improving semen quality in boars was not evident.5)Serum IL-6 level was positively correlated with hepcidin concentration(Pcorrelated with abnormal sperm rate(Pcorrelations were also found between indicators of iron status and oxidative stress and semen quality ***

关键词： Adult boars Iron level Iron source Iron status Semen quality

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Hi-Tag:a simple and efficient method for identifying protein-mediated long-range chromatin interactions with low cell numbers

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Science China(Life Sciences) 2024年第5期67卷 1027-1034页

作者： Xiaolong Qi Lu Zhang Qiulin Zhao Peng Zhou Sai Xian Zhang Jingjin Li Zhuqing Zheng Yue Xiang Xueting Dai Zhe Jin Yaobang Jian Xinyun Li Liangliang Fu Shuhong Zhao Key Lab of Agricultural animal Genetics Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of AgricultureCollege of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China The cooperative innovation center for Sustainable Pig production Wuhan 430070China Hubei Hongshan Laboratory Frontiers Science Center for Animal Breeding and Sustainable ProductionWuhan 430070China

Protein-mediated chromatin interactions can be revealed by coupling proximity-based ligation with chromatin ***,these techniques require complex experimental procedures and millions of cells per experiment,which limits their widespread application in life science ***,we develop a novel method,Hi-Tag,that identifies high-resolution,long-range chromatin interactions through transposase tagmentation and chromatin proximity ligation(with a phosphorothioate-modified linker).Hi-Tag can be implemented using as few as 100,000 cells,involving simple experimental procedures that can be completed within 1.5 ***,Hi-Tag is capable of using its own data to identify the binding sites of specific proteins,based on which,it can acquire accurate interaction *** results suggest that Hi-Tag has great potential for advancing chromatin interaction studies,particularly in the context of limited cell availability.

关键词： Hi-Tag chromatin interactions transposase tagmentation chromatin proximity ligation low cell numbers

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Research progress on cottonseed meal as a protein source in pig nutrition:An updated review

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animal Nutrition 2024年第3期18卷 220-233页

作者： An Tao Jiahao Wang Bin Luo Bowen Liu Zirui Wang Xingping Chen Tiande Zou Jun Chen Jinming You Jiangxi Province Key Laboratory of animal Nutrition Jiangxi Agricultural UniversityNanchang 330045China Jiangxi Province Key innovation center of Integration in production and Education for High-Quality and Safe Livestock and Poultry Jiangxi Agricultural UniversityNanchang 330045China

At a global level,the supply of protein sources is insufficient to support the current magnitude of pig ***,given the exorbitant expense of conventional protein feed options like soybean meal and fish meal,it becomes imperative to promptly explore alternative sources of protein feed for the sustainable advancement of the pig *** meal,a by-product from the extraction of cottonseed oil,exhibits significant potential as a protein source for pig feed owing to its high protein content,high yield,low cost,well-balanced amino acid composition,and sufficient ***,cottonseed meal possesses several anti-nutritional factors,especially gossypol,which adversely affect growth and reproductive performance,resulting in the limited utilization of cottonseed meal in pig *** maximize the benefits of cottonseed meal and promote its application in pig production,it is imperative to acquire comprehensive knowledge regarding its nutritional value and current *** this review,we initially presented a summary of the nutritional values of cottonseed meal,primary anti-nutritional factors,and effective approaches for improving its utilization as a protein source ***,we comprehensively summarized the latest research progress of cottonseed meal application in pig nutrition over the past *** outcome of this review serves as a theoretical foundation and practical guidance for the research and application of cottonseed meal in pig nutrition and promotes the reduction of soybean meal utilization in the pig industry.

关键词： cottonseed meal Nutritional value Protein source Pig nutrition

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Trimethylamine oxide supplementation differentially regulates fat deposition in liver, longissimus dorsi muscle and adipose tissue of growing-finishing pigs

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animal Nutrition 2024年第2期17卷 25-35页

作者： Andong Zha Wanquan Li Jing Wang Ping Bai Ming Qi Peng Liao Bie Tan Yulong Yin Laboratory of animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of Sciences University of Chinese Academy of Sciences college of animal Science and Technology Hunan Agricultural University Yunnan Southwest Agriculture and animal Husbandry Group co. Ltd.

Trimethylamine oxide(TMAO) is a microbiota-derived metabolite, and numerous studies have shown that it could regulate fat metabolism in humans and mice. However, few studies have focused on the effects of TMAO on fat deposition in growing-finishing pigs. This study aimed to investigate the effect of TMAO on fat deposition and intestinal microbiota in growing-finishing pigs. Sixteen growing pigs were randomly divided into 2 groups and fed with a basal diet with 0 or 1 g/kg TMAO for 149 d. The intestinal microbial profiles, fat deposition indexes, and fatty acid profiles were measured. These results showed that TMAO supplementation had a tendency to decrease lean body mass(P concentration, and reduced alkaline phosphatase(ALP) concentration in serum(P community(P colonic microbial community. TMAO supplementation significantly increased acetate content in the ileum, and Proteobacteria and Escherichia-Shigella were significantly enriched in the TMAO group(P content, as well as the ratio of linoleic acid, n-6polyunsaturated fatty acids(PUFA), and PUFA in the liver(P contrary, TMAO increased intramuscular fat content of the longissimus dorsi muscle, whereas the C18:2n6c ratio was increased,and the n-6 PUFA:PUFA ratio was decreased(P composition and acetate production, and regulated fat distribution and fatty acid composition in growing-finishing pigs. These results

关键词： Growing-finishing pig Trimethylamine oxide Fat deposition Fatty acid composition Intestinal microbiota

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Zinc lactate alleviates oxidative stress by modulating crosstalk between constitutive androstane receptor signaling pathway and gut microbiota profile in weaned piglets

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animal Nutrition 2024年第1期16卷 23-33页

作者： Wenjie Tang Xuan Xiang Houfu Wang Wentao Zhou Liuqin He Yulong Yin Tiejun Li college of animal Science and Technology Hunan Agricultural UniversityChangsha 410128China hunan Provincial Key Laboratory of animal Nutritional Physiology and Metabolic Process CAS Key Laboratory of Agro-Ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China hunan Provincial Key Laboratory of animal Intestinal Function and Regulation Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal UniversityChangsha 410081China college of Advanced Agricultural Science University of Chinese Academy of SciencesBeijing 100049China Sichuan Academy of animal Sciences Animal Breeding and Genetics Key Laboratory of Sichuan ProvinceChengdu 610066China Livestock and Poultry Biological Products Key Laboratory of Sichuan Province Sichuan Animtech Feed Co.LtdChengdu 610000China

This study aimed to determine the regulatory mechanism of dietary zinc lactate(ZL)supplementation on intestinal oxidative stress damage in a paraquat(PQ)-induced piglet ***-eight piglets(mean body weight 9.51±0.23 kg)weaned at 28 d of age were randomly divided into control,ZL,PQ,and ZL+PQ groups(n=7 in each group).The ZL-supplemented diet had little effect on growth performance under normal physiological ***,under PQ challenge,ZL supplementation significantly improved average daily gain(Pconstitutive androstane receptor(CAR)signaling(Pcoccus,Rikenellaceae_RC9_gut_group,Christensenellaceae_R_7_group,Treponema,unclassified_Christensenellaceae,and unclassified_Erysipelotrichaceae(P<0.05).These data reveal that pre-administration of ZL to piglets can suppress intestinal oxidative stress by improving antioxidant and anti-inflammatory capacity and regulating the crosstalk between CAR signaling and gut microbiota.

关键词： Zinc lactate Intestinal barrier Oxidative stress Inflammation constitutive androstane receptor Gut microbiota

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Rumen metagenome reveals the mechanism of mitigation methane emissions by unsaturated fatty acid while maintaining the performance of dairy cows

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animal Nutrition 2024年第3期18卷 296-308页

作者： Zhantao Yang Yuhui Zheng Siyuan Liu Tian Xie Qianqian Wang Zhonghan Wang Shengli Li Wei Wang State Key Laboratory of animal Nutrition and Feeding Beijing Engineering Technology Research Center of Raw Milk Quality and Safety ControlCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Dietary fat content can reduce the methane production of dairy cows;however,the relevance fatty acid(FA)composition has towards this inhibitory effect is ***,in-depth studies elucidating the effects of unsaturated fatty acids(UFA)on rumen function and the mechanism of reducing methane(CH4)production are *** study exposed 10 Holstein cows with the same parity,similar milk yield to two total mixed rations:low unsaturated FA(LUFA)and high unsaturated FA(HUFA)with similar fat *** LUFA group mainly added fat powder(C16:0>90%),and the HUFA group mainly replaced fat powder with extruded *** experiment lasted 26 d,the last 5 d of which,gas exchange in respiratory chambers was conducted to measure gas *** found that an increase in the UFA in diet did not affect milk production(P>0.05)and could align the profile of milk FAs more closely with modern human nutritional ***,we found that increasing the UFA content in the diet lead to a decrease in the abundance of Methanobrevibacter in the rumen(|linear discriminant analysis[LDA]score|>2 and P 2 and Pproduction(Pproduction when fed a UFA diet in dairy *** believe that our study provides new evidence to explore CH4 emission reduction measures for dairy cows.

关键词： Methane emission Rumen metagenome Dairy cow Unsaturated fatty acid

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Leucine regulates lipid metabolism in adipose tissue through adipokine-mTOR-SIRT1 signaling pathway and bile acid—microbe axis in a finishing pig model

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animal Nutrition 2024年第1期16卷 158-173页

作者： Yunju Yin Saiming Gong Mengmeng Han Jingzun Wang Hanjing Shi Xianji Jiang Liu Guo Yehui Duan Qiuping Guo Qinghua Chen Fengna Li Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic ProcessHunan Provincial Engineering Research Center for Healthy Livestock and Poultry ProductionChangsha 410125China college of animal Science and Technology Hunan Agricultural UniversityChangsha 410128China college of Modern Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China college of Life Science and Engineering Northwest Minzu UniversityLanzhou 730124China college of Life Sciences Hunan Normal UniversityChangsha 410128China

This study was conducted to explore the regulatory mechanism of leucine(Leu)on lipid metabolism of finishing ***-four Duroc×Landrace×Large cross pigs with an average body weight of68.33±0.97 kg were randomly allocated into 3 treatment groups with 8 replicates per group(1 pig per replicate).The dietary treatments were as follows:control group(coN),0.25%Leu group and 0.50%Leu *** experimental period was 42 *** results showed as follows.(1)compared with the coN,0.25%and 0.50%Leu increased(Pcombinant fatty acid transport protein 1(FATP1),chemerin and peroxisome proliferatoractivated receptorγ(PPARγ)were decreased but the level of fatty acid binding protein 4(FABP4)and fatty acid translocase(FAT/CD36)were increased in backfat *** the 0.25%Leu group,the protein levels of p-Rictor,p-Raptor,p-eIF4E-binding protein 1(p-4EBP1),p-silent mating type information regulator 2homolog 1(p-SIRT1)and acetylation ribosome s6 protein kinase 1(Ac—S6K1)were increased(Pcompared to the coN,the diversity of gut microbiota in the 0.25%Leu group was *** component analysis showed that the relative abundance of Bacteroidetes,Lactobacillus and Desulfovibrio was higher in the 0.25%Leu group than the coN,but the relative abundance of Firmicutes,Treponema and Shigella was lower than in the coN(Pcorrelate to various degrees with the above *** conclusion,Leu could promote adipose tissue lipolysis of finishing pigs through the mTOR-SIRT1 signaling pathway,a

关键词： Leu Lipid metabolism Gut microbiota Bile acid

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A Dietary Source of High Level of Fluoroquinolone Tolerance in mcr-Carrying Gram-Negative Bacteria

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Research 2024年第3期2023卷 105-121页

作者： Tianqi Xu Dan Fang Fulei Li Zhiqiang Wang Yuan Liu Jiangsu co-innovation center for Prevention and control of Important animal Infectious Diseases and Zoonoses College of Veterinary MedicineYangzhou UniversityYangzhou 225009China. Joint International Research Laboratory of Agriculture and Agri-Product safety the Ministry of Education of ChinaYangzhou UniversityYangzhou 225009China. Institute of comparative Medicine Yangzhou UniversityYangzhou 225009China.

The emergence of antibiotic tolerance,characterized by the prolonged survival of bacteria following antibiotic exposure,in natural bacterial populations,especially in pathogens carrying antibiotic resistance genes,has been an increasing threat to public ***,the major causes contributing to the formation of antibiotic tolerance and underlying molecular mechanisms are yet poorly ***,we show that potassium sorbate(PS),a widely used food additive,triggers a high level of fluoroquinolone tolerance in bacteria carrying mobile colistin resistance gene *** studies demonstrate that PS treatment results in the accumulation of intracellular fumarate,which activates bacterial two-component system and decreases the expression level of outer membrane protein OmpF,thereby reducing the uptake of *** addition,the supplementation of PS inhibits aerobic respiration,reduces reactive oxygen species production and alleviates DNA damage caused by bactericidal ***,we demonstrate that succinate,an intermediate product of the tricarboxylic acid cycle,overcomes PS-mediated ciprofloxacin *** multiple animal models,ciprofloxacin treatment displays failure outcomes in PS preadministrated animals,including comparable survival and bacterial loads with the vehicle *** together,our works offer novel mechanistic insights into the development of antibiotic tolerance and uncover potential risks associated with PS use.

关键词： overcome thereby additive

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