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The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

Research 2024年第2期2023卷 373-387页

作者： Di Wu Yi Sun Cancer institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

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Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation

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Zoological Research 2024年第2期45卷 242-252页

作者： Xiu-Sheng Chen Rui Han Yan-Ting Liu Wei Huang Qi Wang Xin Xiong Ying Zhang Jian-Guo Zhao Shi-Hua Li Xiao-Jiang Li Wei-Li Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)GHM Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong 510632China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

PTEN-induced putative kinase 1(PINK1),a mitochondrial kinase that phosphorylates Parkin and other proteins,plays a crucial role in mitophagy and protection against *** in PINK1 and Parkin can lead to loss of function and early onset Parkinson's ***,there is a lack of strong in vivo evidence in rodent models to support the theory that loss of PINK1 affects mitophagy and induces ***,PINK1 knockout pigs(Sus scrofa)do not appear to exhibit *** our recent work involving non-human primates,we found that PINK1 is selectively expressed in primate brains,while absent in rodent *** extend this to other species,we used multiple antibodies to examine the expression of PINK1 in pig *** contrast to tissues from cynomolgus monkeys(Macaca fascicularis),our data did not convincingly demonstrate detectable PINK1expression in pig *** of PINK1 in cultured pig cells did not result in altered Parkin and BAD phosphorylation,as observed in cultured monkey cells.A comparison of monkey and pig striatum revealed more PINK1-phosphorylated substrates in the monkey ***,PINK1 knockout in pigs did not lead to obvious changes in the phosphorylation of Parkin and *** findings provide new evidence that PINK1expression is specific to primates,underscoring the importance of non-human primates in investigating PINK1function and pathology related to PINK1 deficiency.

关键词： PINK1 Parkin Mitochondria Phosphorylation Non-human primates Pigs

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Towards robustness and generalization of point cloud representation:A geometry coding method and a large-scale object-level dataset

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Computational Visual Media 2024年第1期10卷 27-43页

作者： Mingye Xu Zhipeng Zhou Yali Wang Yu Qiao Guangdong-Hong Kong-Macao Joint Laboratory of human-Machine Intelligence-Synergy Systems Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518000China University of Chinese Academy of Sciences Beijing065001China Shanghai AI Laboratory Shanghai200001China SIAT Branch Shenzhen Institute of Artificial Intelligence and Robotics for SocietyShenzhen518000China Alibaba DAMO Academy Hangzhou242332China

Robustness and generalization are two challenging problems for learning point cloud *** tackle these problems,we first design a novel geometry coding model,which can effectively use an invariant eigengraph to group points with similar geometric information,even when such points are far from each *** also introduce a large-scale point cloud dataset,*** consists of 184 categories and 51,915 synthetic objects,which brings new challenges for point cloud classification,and provides a new benchmark to assess point cloud cross-domain ***,we perform extensive experiments on point cloud classification,using ModelNet40,ScanObjectNN,and our PCNet184,and segmentation,using ShapeNetPart and *** method achieves comparable performance to state-of-the-art methods on these datasets,for both supervised and unsupervised *** and our dataset are available at https://***/MingyeXu/PCNet184.

关键词： geometry coding self-supervised learning point cloud classification segmentation 3D analysis

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New findings of Changxingaspis(Xiushuiaspidae,Galeaspida)from the Silurian of Tarim Basin and Zhejiang Province,China

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 531-540页

作者： LI Xutong ZHANG Yumeng LIN Xianghong ZHU Min ZHAO Wenjin TANG Lizhou SHAN Xianren GAI Zhikun Key Laboratory of Vertebrate Evolution and human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China College of Life Sciences Jiangxi Normal UniversityNanchang 330022China Yunnan Key Laboratory for Palaeobiology Institute of PalaeontologyYunnan UniversityKunming 650500China University of Chinese Academy of Sciences Beijing 100044China

New discovery of the early Silurian fossil fish Changxingaspis(Xiushuiaspidae,Galeaspida),Changxingaspis nianzhongi *** ***,are described from the Tataertag Formation in Tarim Basin and the Kangshan Formation in Zhejiang Province,*** mainly differs from *** in the shape of the median dorsal opening that is transverse elliptic with a width/length ratio of about 3.0,the long lateral transverse canals extending to the lateral margin of the headshield,and the second lateral transverse canal with dichotomous *** of *** from the Tataertag Formation and *** from the Kangshan Formation provide direct evidence on the specific level for the correlation between these two formations,which further supports the Silurian fish-bearing red beds in northwest Zhejiang belonging to the Silurian Lower Red Beds(LRBs)rather than the Upper Red Beds(URBs).Additionally,as the first record of the Changxingaspis in Tarim Basin,it extends the paleogeographical distribution of this genus from the South China Block to the Tarim Block,providing new evidence to support faunal exchanges between these two blocks and the hypothesis of a united Tarim-South China Block during the early Silurian.

关键词： vertebrate paleontology Galeaspids Changxingaspis new taxon Tataertag Formation Kangshan Formation Aeronian-Telychian Tarim Zhejiang

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Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a systematic review and meta-analysis

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Neural Regeneration Research 2024年第7期19卷 1584-1592页

作者： Jong Mi Park Masoud Rahmati Sang Chul Lee Jae Il Shin Yong Wook Kim Department and Research institute of Rehabilitation Medicine Yonsei University College of MedicineSeoulSouth Korea Department of Physical Education and Sport Sciences Faculty of Literature and Human SciencesLorestan UniversityKhoramabadIran Department of Pediatrics Yonsei University College of MedicineSeoulSouth Korea

Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease *** cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s *** stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of *** performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal *** searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,*** study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control *** use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the *** with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational *** the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a

关键词： animal animal experimentation mesenchymal stem cells models Parkinson’s disease stem cell transplantation

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Scene text recognition via dual character counting-aware visual and semantic modeling network

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Science China(Information Sciences) 2024年第3期67卷 313-314页

作者： Ke XIAO Anna ZHU Brian Kenji IWANA Cheng-Lin LIU School of Computer Science and Artificial Intelligence Wuhan University of Technology human Interface Laboratory Kyushu University State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of Sciences School of Artificial Intelligence University of Chinese Academy of Sciences

Scene text recognition(STR) is drawing increasing attention nowadays due to its wide application in real life. Character counting information, as auxiliary information, has been shown to be effective in boosting text ... 详细信息

关键词： Decoding

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Exercise-induced microbial changes in preventing type 2 diabetes

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Science China(Life Sciences) 2024年第5期67卷 892-899页

作者： Ting Yao Hui Wang Kaiqing Lin Ruwen Wang Shanshan Guo Peijie Chen Hao Wu Tiemin Liu Ru Wang School of Exercise and Health Shanghai Frontiers Science Research Base of Exercise and Metabolic HealthShanghai University of SportShanghai 200438China Department of Physiology and Pathophysiology School of Basic Medical SciencesXi’an Jiaotong University School of MedicineXi’an 710061China Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism&Integrative BiologyFudan UniversityShanghai 200433China State Key Laboratory of Genetic Engineering Human Phenome InstituteFudan Microbiome Centerand Department of Bariatric and Metabolic SurgeryHuashan HospitalFudan UniversityShanghai 201203China State Key Laboratory of Genetic Engineering Department of Endocrinology and MetabolismHuman Phenome Instituteand School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200032China

The metabolic benefits associated with long-term physical activity are well appreciated and growing evidence suggests that it involves the gut *** we re-evaluated the link between exercise-induced microbial changes and those associated with prediabetes and *** found that the relative abundances of substantial amounts of diabetes-associated metagenomic species associated negatively with physical fitness in a Chinese athlete students *** additionally showed that those microbial changes correlated more with handgrip strength,a simple but valuable biomarker suggestive of the diabetes states,than maximum oxygen intake,one of the key surrogates for endurance ***,the causal relationships among exercise,risks for diabetes,and gut microbiota were explored based on mediation *** propose that the protective roles of exercise against type 2 diabetes are mediated,at least partly,by the gut microbiota.

关键词： gut microbiota body fat diabetes handgrip maximum oxygen intake

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Waking Up Brain with Electrical Stimulation to Boost Memory in Sleep:A Neuroscience Exploration

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Neuroscience Bulletin 2024年第6期40卷 852-854页

作者： Zhe Zhong Fuling Yan Chunming Xie Department of Neurology School of MedicineAffiliated Zhongda HospitalSoutheast UniversityNanjing210009China institute of Neuropsychiatry Affiliated Zhongda HospitalSoutheast UniversityNanjing210009China The Key Laboratory of Developmental Genes and human Disease Southeast UniversityNanjing210009China

Imagine that,in the future,you could enhance your memory by applying a mild electric current to your brain during *** might sound like science fiction,but it is based on cutting-edge neuroscience *** is widely recognized as a crucial factor for long-term memory consolidation,but the exact mechanisms by which the brain coordinates neural activity across different regions during sleep to reorganize and integrate memories are unknown[1,2].

关键词： Sleep integrate applying

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Long non-coding RNAs with essential roles in neurodegenerative disorders

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Neural Regeneration Research 2024年第6期19卷 1212-1220页

作者： Wandi Xiong Lin Lu Jiali Li Key Laboratory of Animal Models and human Disease Mechanisms of Chinese Academy of Sciences&Yunnan Province Kunming Institute of Zoologythe Chinese Academy of SciencesKunmingYunnan ProvinceChina Tsinghua-Peking Center for Life Sciences BeijingChina National institute on Drug Dependence Peking UniversityBeijingChina PKU/McGovern institute for Brain Research Peking UniversityBeijingChina institute of Mental Health National Clinical Research Center for Mental DisordersKey Laboratory of Mental Health and Peking University Sixth HospitalPeking UniversityBeijingChina

Recently,with the advent of high-resolution and high-throughput sequencing technologies,an increasing number of long non-coding RNAs(lncRNAs)have been found to be involved in the regulation of neuronal function in the central nervous system with specific spatiotemporal patterns,across different neurodegenerative ***,the underlying mechanisms of lncRNAs during neurodegeneration remain poorly *** review provides an overview of the current knowledge of the biology of lncRNAs and focuses on introducing the latest identified roles,regulatory mechanisms,and research status of lncRNAs in Alzheimer's disease,Parkinson's disease,Huntington's disease,and amyotrophic lateral ***,this review discusses the potential values of lncRNAs as diagnostic biomarkers and therapeutic targets for neurodegenerative diseases,hoping to provide broader implications for developing effective treatments.

关键词： Alzheimer's disease amyotrophic lateral sclerosis biomarker Huntington's disease long non-coding RNAs neurodegenerative diseases Parkinson's disease therapy transcriptional regulation translational regulation

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Insights into the provenance implication of leaf wax n-alkanes along the lower Yellow River

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Science China Earth Sciences 2024年第6期67卷 2001-2018页

作者： Liang ZHANG Jinzhao LIU Chong JIANG Fei ZHANG Zhisheng AN School of human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’an 710054China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China National Observation and Research Station of Earth Critical Zone on the Loess Plateau of Shaanxi Xi’an 710061China

Serving as one of the largest rivers in terms of both sediment and organic carbon transport fluxes in the world,the Yellow River plays a crucial role in regional biogeochemical process as well as in the global carbon ***,although a large number of studies have been carried out on the flux,composition,source and seasonal variation of total particulate organic carbon in the Yellow River so far,studies on molecular biomarkers at different spatial and temporal scales are still *** this study,we focus on the molecular and hydrogen isotopic properties of leaf wax n-alkanes among different types of samples which obtained from different seasons(flood ***-flood)along the lower Yellow *** molecular distribution of n-alkanes show that the riparian topsoils are subject to inputs from the overlying vegetation,while the suspended sediments from the flood season are characterized by the mixing of soil materials which originate from various stratigraphy with different ages on the Chinese Loess *** to the contrasting hydrodynamic conditions,the n-alkanes in suspended sediments also show distinct molecular composition between flood and non-flood ***,considering the effect of climatic factors,the proportion of monocots in flood-season suspended sediments is calculated from a semi-quantitative perspective using δ^(2)H_(wax).Our findings may bring to light new considerations for the interpretation of leaf wax proxies in studies of organic matter sources of Yellow River.

关键词： Molecular distribution Hydrogen isotopic composition Leaf wax n-alkanes Suspended sediments Lower Yellow River

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