Long non-coding RNAs with essential roles in neurodegenerative disorders
作者机构：Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology the Chinese Academy of Sciences Tsinghua-Peking Center for Life Sciences National Institute on Drug Dependence Peking University PKU/McGovern Institute for Brain Research Peking University Institute of Mental Health National Clinical Research Center for Mental Disorders Key Laboratory of Mental Health and Peking University Sixth Hospital Peking University
出 版 物：《Neural Regeneration Research》 (中国神经再生研究(英文版))
年 卷 期：2024年第19卷第6期
页 面：1212-1220页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学]
基 金：supported by the National Natural Science Foundation of China Nos. 91649119 and 92049105 (both to JL)
主 题：Alzheimer’s disease amyotrophic lateral sclerosis biomarker Huntington’s disease long non-coding RNAs neurodegenerative diseases Parkinson’s disease therapy transcriptional regulation translational regulation
摘 要：Recently, with the advent of high-resolution and high-throughput sequencing technologies, an increasing number of long non-coding RNAs(lncRNAs) have been found to be involved in the regulation of neuronal function in the central nervous system with specific spatiotemporal patterns, across different neurodegenerative diseases. However, the underlying mechanisms of lncRNAs during neurodegeneration remain poorly understood. This review provides an overview of the current knowledge of the biology of lncRNAs and focuses on introducing the latest identified roles, regulatory mechanisms, and research status of lncRNAs in Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. Finally, this review discusses the potential values of lncRNAs as diagnostic biomarkers and therapeutic targets for neurodegenerative diseases, hoping to provide broader implications for developing effective treatments.
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