Exercise-induced microbial changes in preventing type 2 diabetes

作     者：Ting Yao Hui Wang Kaiqing Lin Ruwen Wang Shanshan Guo Peijie Chen Hao Wu Tiemin Liu Ru Wang 

作者机构：School of Exercise and HealthShanghai Frontiers Science Research Base of Exercise and Metabolic HealthShanghai University of SportShanghai 200438China Department of Physiology and PathophysiologySchool of Basic Medical SciencesXi’an Jiaotong University School of MedicineXi’an 710061China Shanghai Key Laboratory of Metabolic Remodeling and HealthInstitute of Metabolism&Integrative BiologyFudan UniversityShanghai 200433China State Key Laboratory of Genetic EngineeringHuman Phenome InstituteFudan Microbiome Centerand Department of Bariatric and Metabolic SurgeryHuashan HospitalFudan UniversityShanghai 201203China State Key Laboratory of Genetic EngineeringDepartment of Endocrinology and MetabolismHuman Phenome Instituteand School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200032China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2024年第67卷第5期

页      面：892-899页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported in part by the National Key Research and Development Program of China(2020YFA0803800,2019YFA0801900,2018YFA0800300,and 2022YFA0806400) the National Natural Science Foundation of China(31971097,31671242,32150610475,and 31971074) Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202001) Shanghai Frontiers Science Research Base of Exercise and Metabolic Health the Construction Project of High-Level Local Universities in Shanghai Shanghai“Science and Technology Innovation Action Plan”Social Development Science and Technology Reach Project(22dz1204600) Shanghai Municipal Science and Technology Major Project(2017SHZDZX01) 

主　　题：gut microbiota body fat diabetes handgrip maximum oxygen intake 

摘      要：The metabolic benefits associated with long-term physical activity are well appreciated and growing evidence suggests that it involves the gut *** we re-evaluated the link between exercise-induced microbial changes and those associated with prediabetes and *** found that the relative abundances of substantial amounts of diabetes-associated metagenomic species associated negatively with physical fitness in a Chinese athlete students *** additionally showed that those microbial changes correlated more with handgrip strength,a simple but valuable biomarker suggestive of the diabetes states,than maximum oxygen intake,one of the key surrogates for endurance ***,the causal relationships among exercise,risks for diabetes,and gut microbiota were explored based on mediation *** propose that the protective roles of exercise against type 2 diabetes are mediated,at least partly,by the gut microbiota.