检索结果-南通市图书馆

Vascular protective effects of aqueous extracts of Tribulus terrestris on hypertensive endothelial injury

Chinese Journal of Natural Medicines 2017年第8期15卷 606-614页

作者： JIANG Yue-Hua GUO Jin-Hao WU Sai YANG Chuan-Hua Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250011China Shandong University of Traditional Chinese Medicine Jinan 250355China Qingdao hiser medical group Qingdao 266034China

Angiotensin Ⅱ(Ang Ⅱ) is involved in endothelium injury during the development of hypertension. Tribulus terrestris(TT) is used to treat hypertension, arteriosclerosis, and post-stroke syndrome in China. The present study aimed to determine the effects of aqueous TT extracts on endothelial injury in spontaneously hypertensive rats(SHRs) and its protective effects against Ang Ⅱ induced injury in human umbilical vein endothelial cells(HUVECs). SHRs were administered intragastrically with TT(17.2 or 8.6 g·kg^(-1)·d^(-1)) for 6 weeks, using valsartan(13.5 mg·kg^(-1)·d^(-1)) as positive control. Blood pressure, heart rate, endothelial morphology of the thoracic aorta, serum levels of Ang Ⅱ, endothelin^(-1)(ET^(-1)), superoxide dismutase(SOD) and malonaldehyde(MDA) were measured. The endothelial injury of HUVECs was induced by 2 × 10–6 mol·L^(-1) Ang Ⅱ. Cell Apoptosisapoptosis, intracellular reactive oxygen species(ROS) was assessed. Endothelial nitric oxide synthase(eN OS), ET^(-1), SOD, and MDA in the cell culture supernatant and cell migration were assayed. The expression of hypertension-linked genes and proteins were analyzed. TT decreased systolic pressure, diastolic pressure, mean arterial pressure and heart rate, improved endothelial integrity of thoracic aorta, and decreased serum leptin, Ang Ⅱ, ET^(-1), NPY, and Hcy, while increased NO in SHRs. TT suppressed Ang Ⅱ-induced HUVEC proliferation and apoptosis and prolonged the survival, and increased cell migration. TT regulated the ROS, and decreased mR NA expression of Akt1, JAK2, PI3Kα, Erk2, FAK, and NF-κB p65 and protein expression of Erk2, FAK, and NF-κB p65. In conclusion, TT demonstrated anti-hypertensive and endothelial protective effects by regulating Erk2, FAK and NF-κB p65.

关键词： Tribulus Terrestris Hypertension Endothelial protection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bilateral traumatic hemorrhage of the basal ganglia

引用

Chinese Journal of Traumatology 2016年第4期19卷 247-248页

作者： Yun-Xu Zhang Shu-Qin Wei Yan-Yun Xing Qi Liu Wen-Jing He hiser medical group Qingdao China

Hemorrhage of the basal ganglia is common in hypertensive patients, and most of the cases are spon- taneous unilateral hemorrhage. Traumatic basal ganglia hemorrhage is uncommon, while bilateral hemorrhage of the basal ganglia after trauma is an extremely rare entity. This report described a rare case of bilateral hemorrhage of the basal ganglia after head trauma. We also analyzed the mechanisms and reviewed relative literatures.

关键词： Bilateral hemorrhage Basal ganglia Craniocerebral trauma Hypertension

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Herbal acupoint sticking combined with electroacupuncture therapy in the treatment of Bell's palsy: a randomized controlled trial

引用

China medical Abstracts(Internal Medicine) 2014年第1期31卷 4-5页

作者：戚其华 Dept Acupunct & Rehabilit Qingdao Hiser Med Center

Objective To observe the clinical efficacy and safety of electroacupuncture(EA)combined with herbal acupoint sticking in the treatment of Bell’s palsy and provide optimizations for the *** One hundred and two cases of Bell’s palsy were randomized into an EA combined with herbal acupoint sticking group(group A,50 cases)and an EA group(group B,52 cases),EA at Cuanzhu(BL 2),Yangbai(GB 14),Taiyang(EX-HN5),Quanliao(SI 18),Xiaguan(ST 7),Yingxiang(LI20),*** applied in both

关键词： acupoint palsy clinic herbal hundred visit facial totally cured

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TGF-β2-induced NEAT1 regulates lens epithelial cell proliferation,migration and EMT by the miR-26a-5p/FANCE axis

引用

International Journal of Ophthalmology(English edition) 2021年第11期14卷 1674-1682页

作者： Xiao-Hui Yu Shao-Yi Liu Cheng-Fang Li Department of Ophthalmology the Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantai 264000Shandong ProvinceChina Department of Ophthalmology Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser Hospital)Qingdao 266033Shandong ProvinceChina

AIM:To explore the regulatory mechanism of nuclear paraspeckle assembly transcript 1(NEAT1)in the pathogenesis of posterior capsule opacification(PCO).METHODS:Quantitative reverse transcription polymerase chain reaction(RT-q PCR)was executed to analyze NEAT1 and micro RNA(miR)-26a-5p expression in transforming growth factor-beta 2(TGF-β2)-disposed lens epithelial cells(LECs).The proliferation,cell cycle progression,apoptosis,and migration of TGF-β2-disposed LECs were *** relationship between NEAT1 or fanconi anemia(FA)complementation group E(FANCE)and miR-26a-5p was verified by dual-luciferase reporter ***:TGF-β2 induced NEAT1 expression in ***1 inhibition accelerated apoptosis,cell cycle arrest,decreased proliferation,epithelial-mesenchymal transition(EMT),and migration of TGF-β2-disposed ***1 sponged miR-26a-5p to further regulate FANCE *** experiments presented that miR-26a-5p downregulation overturned NEAT1 silencing-mediated impacts on TGF-β2-disposed LEC biological ***,FANCE overexpression reversed miR-26a-5p mimic-mediated impacts on TGF-β2-disposed LEC biological ***:TGF-β2-induced NEAT1 facilitates LEC proliferation,migration,and EMT by upregulating FANCE via sequestering miR-26a-5p.

关键词： posterior capsule opacification transforming growth factor-beta 2 nuclear paraspeckle assembly transcript 1 miRNA-26a-5p fanconi anemia complementation group E

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Correlation of the changes of blood brain barrier permeability with the activation of apoptosis, inflammatory response and stress response in rats with cerebral hemorrhage

引用

Journal of Hainan medical University 2018年第14期24卷 1-4页

作者： Xi-Yan Zhou Miao Yu Huan-Xin Cui The Affiliated Qingdao hiser Hospital of Qingdao University QingdaoShandong Province266000

Objective:To study the correlation of the changes of blood brain barrier permeability with the activation of apoptosis, inflammatory response and stress response in rats with cerebral ***: SD rats were chosen as experimental animals and divided into the cerebral hemorrhage group and the control group. 24 h after molding, formamide soaking method was referred to determine the levels of blood brain barrier permeability parameters as well as the contents of apoptosis molecules, inflammatory response molecules and oxidative stress molecules in brain tissues around the ***: Blood brain barrier permeability parameter EB level in brain tissues around hematoma of cerebral hemorrhage group was significantly higher than that of control group, and DKK1, PAR-1, Bax, Cyt-C, NF-κB, ICAM1, VCAM1, TNF-α, MMP9, NOX4 and MDA contents were higher than those of control group, andβ-catenin, Bcl-2, Mn-SOD, GSH and T-AOC contents were lower than those of control group;Pearson correlation analysis showed that EB level in brain tissues around hematoma of cerebral hemorrhage group was positively correlated with DKK1, PAR-1, Bax, Cyt-C, NF-κB, ICAM1, VCAM1, TNF-α, MMP9, NOX4 and MDA contents, and negatively correlated withβ-catenin, Bcl-2, Mn-SOD, GSH and T-AOC contents. Conclusion:The increase of blood brain barrier permeability in rats with cerebral hemorrhage is related to the excessive activation of apoptosis, inflammatory response and stress response.

关键词： Cerebral hemorrhage Blood brain barrier Apoptosis Inflammatory response Stress response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gastric signet-ring cell carcinoma with paraneoplastic eosinophilia: A case report and literature review

引用

Oncology and Translational Medicine 2022年第5期8卷 264-266页

作者： Shuguo Wang Haixia Wang Ping Sui Bo Han Clinical Laboratory Qingdao Municipal Hospital(Group)Qingdao 266011China Department of Hematology Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser Hospital)Qingdao 266033China Department of medical Oncology The Affiliated Yuhuangding Hospital of Qingdao UniversityQingdao 264099China

We report the case of a 40-year-old female Chinese patient with gastric signet-ring cell carcinoma that was first diagnosed because of paraneoplastic *** patient’s eosinophil count reduced markedly to normal levels within 24 h after radical gastrectomy and Billroth II *** patient recovered well after the surgery and no abnormalities were found during the regular *** eosinophilia is an unusual manifestation that usually remains asymptomatic;moreover,cases of solid malignant tumors with eosinophilia are *** our knowledge,this is the first reported case of paraneoplastic eosinophilia in a patient with gastric *** considered eosinophilia as a manifestation of a paraneoplastic syndrome,which can be the first clinical manifestation of a malignancy.

关键词： eosinophilia paraneoplastic syndrome gastric signet-ring cell carcinoma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Diagnostic accuracy of fiberoptic ductoscopy plus in vivo iodine staining for intraductal proliferative lesions

引用

Chinese medical Journal 2013年第16期126卷 3124-3129页

作者： FENG Xin-zhi SONG Ying-hua ZHANG Feng-xia JIANG Chuan-wu MEI Hong ZHAO Bin Shandong University Shandong Provincial Medical Imaging Institute Jinan Shandong 250021 China Department of Respiratory Medicine Shandong ProvincialQianfoshan Hospital Jinan Shandong 250014 China Department of Radiology Hiser Hospital of Qingdao QingdaoShandong 266033 China

Background lodine staining during endoscopy has been successfully used to detect early carcinomatous and precancerous lesions in the esophagus,cervix,and oral *** objective of this study was to determine the diagnostic accuracy of fiberoptic ductoscopy （FDS） plus in vivo iodine staining for intraductal proliferative lesions of the *** We performed periodic acid-Schiff （PAS） and in vitro iodine staining on 52 and 64 specimens of benign mammary hyperplasia,respectively,and 57 and 53 specimens of ductal carcinoma in situ （DCIS）,***,FDS was performed on 177 recurrent nipple discharge patients who were randomly divided into two *** group was iodine-staining group in which 92 patients were randomly selected to undergo iodine staining during FDS,and the remaining 85 were assigned to the control *** specimens of suspicious lesions were obtained and subjected to histopathological *** Following PAS staining,benign mammary hyperplasia lesions were positively stained,while negligible PAS positivity was observed in the DCIS lesions （P ＜0.05）.Following in vitro iodine staining,benign mammary hyperplasia specimens appeared dark brown,whereas DCIS samples appeared significantly lighter or *** with the pathological examination results,FDS with iodine staining showed an agreement rate in the diagnosis of ductal intraepithelial neoplasia （DIN）,sensitivity,specificity,positive likelihood ratio,negative likelihood ratio,and Youden index of 97.82％,98.83％,83.33％,5.93,0.014,and 0.8216,respectively; the corresponding values for FDS without iodine staining were 88.24％,89.16％,50.00％,1.78,0.217,and 0.3916,*** FDS with iodine staining was superior to conventional FDS for the diagnosis of DIN and is valuable for breast cancer prevention.

关键词： carcinoma, ductal breast, endoscopes sensitivity and specificity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacy of laparoscopic low anterior resection for colorectal cancer patients with 3D-vascular reconstruction for left coronary artery preservation

引用

World Journal of Gastrointestinal Surgery 2024年第6期16卷 1548-1557页

作者： Ye Wang Zhi-Sheng Liu Zong-Bao Wang Shawn Liu Feng-Bo Sun Department of General Surgery Qingdao Hiser Hospital Affiliated of Qingdao University(Qingdao Traditional Chinese Medicine Hospital)Qingdao 266033Shandong ProvinceChina Department of Gastrointestinal Surgery National University Hospital of SingaporeSingapore 119228Singapore

BACKGROUND Laparoscopic low anterior resection(LLAR)has become a mainstream surgical method for the treatment of colorectal cancer,which has shown many advantages in the aspects of surgical trauma and postoperative ***,the effect of surgery on patients'left coronary artery and its vascular reconstruction have not been deeply *** the development of medical imaging technology,3D vascular reconstruction has become an effective means to evaluate the curative effect of *** To investigate the clinical value of preoperative 3D vascular reconstruction in LLAR of rectal cancer with the left colic artery(LCA)*** A retrospective cohort study was performed to analyze the clinical data of 146 patients who underwent LLAR for rectal cancer with LCA preservation from January to December 2023 in our *** patients underwent LLAR of rectal cancer with the LCA preserved,and the intraoperative and postoperative data were *** patients were divided into a reconstruction group(72 patients)and a nonreconstruction group(74 patients)according to whether 3D vascular reconstruction was performed before *** clinical features,operation conditions,complications,pathological results and postoperative recovery of the two groups were collected and *** A total of 146 patients with rectal cancer were included in the study,including 72 patients in the reconstruction group and 74 patients in the nonreconstruction *** were 47 males and 25 females in the reconstruction group,aged(59.75±6.2)years,with a body mass index(BMI)(24.1±2.2)kg/m^(2),and 51 males and 23 females in the nonreconstruction group,aged(58.77±6.1)years,with a BMI(23.6±2.7)kg/m^(2).There was no significant difference in the baseline data between the two groups(P>0.05).In the submesenteric artery reconstruction group,35 patients were type Ⅰ,25 patients were type Ⅱ,11 patients were type Ⅲ,and 1 patient was type Ⅳ.There were 37 type Ⅰ patients,24

关键词： Laparoscopic low anterior resection 3D vascular reconstruction Coronary artery Colorectal cancer Retrospective cohort study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Feiwei granules in the treatment of idiopathic pulmonary fibrosis:a randomized and placebo-controlled trial

引用

Journal of Traditional Chinese Medicine 2016年第4期36卷 427-433页

作者： Yu Yang Sun Zengtao Shi Liqing Zhang Yanping Zhou Zhaoshan Zhang Shunan Chao Enxiang Graduate School Beijing University of Chinese Medicine Department of Respiratory Medicine the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Respiratory Pyrexia Department Dongfang Hospital Affiliated to Beijing University of Chinese Medicine Department of Respiratory Medicine Xiyuan Hospital of China Academy of Traditional Chinese Medicine Department of Respiratory Medicine Qingdao Hiser Medical Group Department of Respiratory Disease of Traditional Chinese Medicine China-Japan Friendship Hospital

OBJECTIVE： To document the therapeutic effects of Feiwei granules （FGs） for idiopathic pulmonary fi-brosis （IPF）.METHODS： One hundred cases with IPF were ran- domized into the treatment group （80） and control group （20）. Both groups were given basic treat- ment with prednisone. The treatment group was given FGs, and the control group was given Jinshui- bao capsules （JCs）. Treatment lasted for 6 months. The medical Research Council Dyspnea Scale （MRCDS）, the Saint George＇s Hospital Respiratory Questionnaire （SGHRQ）, pulmonary function, the Traditional Chinese Medicine Syndrome Score （TC- MSS）, 6-min walking test （6MWT） and blood gas analyses were recorded before the study as well as 3 months and 6 months after ***： FGs showed greater efficacy than the control in certain parameters between before the study and 6 months, and between 3 months and 6 months, in the MRCDS, some indicators in the SGHRQ, and the TCMSS. There were no significant differences between the treatment group and con- trol group in the remainder of the indices evaluat- ed. In the treatment group, there were significant differences in before and after treatment in the MRCDS, SGHRQ, TCMSS and 6MWT.

关键词： Idiopathic pulmonary fibrosis Dys-pnea Surveys and questionnaires 6-rain walkingtest Feiwei granules Jinshuibao capsules Random-ized controlled trial

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A hippocampal anti-hypertensive mechanism induced by twirling reinforcing-reducing manipulation in rats

引用

Journal of Traditional Chinese medical Sciences 2023年第1期10卷 106-117页

作者： Jiao Sun Liu Yan Yunhong Zhu Jingrong Liang Yingying Zang Tianxiao Zeng Xiaomin Hao Pui Yee Wong Qingguo Liu School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 102488China Department of Rehabilitation Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser Hospital)Qingdao 266033China Department of Acupuncture Mediseed Chinese Medicine Consulting CentrePetaling Jaya 46200Malaysia

Objective:To investigate a hippocampal anti-hypertensive mechanism induced by twirling reinforcingreducing manipulation(TRRM)using proteomics in ***:Forty-two male spontaneously hypertensive rats were randomly divided into 3 groups,and 14 Wistar-Kyoto rats were served as control *** the twirling reinforcing(TRF)group,needles were directly inserted into the Taichong(LR 3)point,then thumbs were moved heavily forward and lightly backward for 3 min,while needles remained inserted for 17 *** the twirling reduction(TRD)group,the same treatment was applied as in the TRF group except that the thumb moved lightly forward and heavily *** the model and control groups,only the corresponding grasping and fixation were *** interventions were conducted for 14 *** blood pressure(BP)of all rats was measured one day before intervention and every other day *** hematoxylin-eosin(H&E)staining,label-free and parallel reaction monitoring proteomic techniques were used to assess hippocampal samples from each ***:Systolic BPs showed a significant decrease in the TRF and TRD groups compared with the model group(Pgroup,H&E staining showed obvious pathological changes in the hippocampus,while in the TRF and TRD groups,the hippocampal morphology was only slightly *** proteomic analysis revealed 1163 differential protein expressions between *** Ontology enrichment analysis confirmed that the differentially expressed proteins were enriched in different biological processes,cellular components,and molecular *** Encyclopedia of Genes and Genomes enrichment analysis showed that TRRM proteins were expressed in the serotonergic synapse pathway,renin-angiotensin system,the mitogen-activated protein kinase signaling pathway,and the peroxisome pathway,which were all also related to BP ***:TRRM can significantly lower the BP of *** mode of action may be through the activation

关键词： Twirling reinforcing-reducing method Blood pressure Hypertension Hippocampus Proteomics Spontaneously hypertension rats Taichong Acupuncture

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：