Diagnostic accuracy of fiberoptic ductoscopy plus in vivo iodine staining for intraductal proliferative lesions

作     者：FENG Xin-zhi SONG Ying-hua ZHANG Feng-xia JIANG Chuan-wu MEI Hong ZHAO Bin 

作者机构：Shandong University Shandong Provincial Medical Imaging Institute Jinan Shandong 250021 China Department of Respiratory Medicine Shandong ProvincialQianfoshan Hospital Jinan Shandong 250014 China Department of Radiology Hiser Hospital of Qingdao QingdaoShandong 266033 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2013年第126卷第16期

页      面：3124-3129页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：carcinoma, ductal breast, endoscopes sensitivity and specificity 

摘      要：Background lodine staining during endoscopy has been successfully used to detect early carcinomatous and precancerous lesions in the esophagus,cervix,and oral *** objective of this study was to determine the diagnostic accuracy of fiberoptic ductoscopy （FDS） plus in vivo iodine staining for intraductal proliferative lesions of the *** We performed periodic acid-Schiff （PAS） and in vitro iodine staining on 52 and 64 specimens of benign mammary hyperplasia,respectively,and 57 and 53 specimens of ductal carcinoma in situ （DCIS）,***,FDS was performed on 177 recurrent nipple discharge patients who were randomly divided into two *** group was iodine-staining group in which 92 patients were randomly selected to undergo iodine staining during FDS,and the remaining 85 were assigned to the control *** specimens of suspicious lesions were obtained and subjected to histopathological *** Following PAS staining,benign mammary hyperplasia lesions were positively stained,while negligible PAS positivity was observed in the DCIS lesions （P 0.05）.Following in vitro iodine staining,benign mammary hyperplasia specimens appeared dark brown,whereas DCIS samples appeared significantly lighter or *** with the pathological examination results,FDS with iodine staining showed an agreement rate in the diagnosis of ductal intraepithelial neoplasia （DIN）,sensitivity,specificity,positive likelihood ratio,negative likelihood ratio,and Youden index of 97.82％,98.83％,83.33％,5.93,0.014,and 0.8216,respectively; the corresponding values for FDS without iodine staining were 88.24％,89.16％,50.00％,1.78,0.217,and 0.3916,*** FDS with iodine staining was superior to conventional FDS for the diagnosis of DIN and is valuable for breast cancer prevention.