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Chinese Journal of Structural Chemistry 2019年第11期38卷 1940-1946页

作者： LI Wei LIU Yang LI Chang-Hong YANG Ying-Qun school of Chemistry and Materials Science Hengyang Normal UniversityHengyang 421008China school of Materials and Chemical Engineering Hunan Institute of TechnologyHengyang 421002China Key Laboratory of Functional Metal-organic Compounds of Hunan Province hengyang HengyangHunan 421008China

A new copper(Ⅱ)coordination polymer[Cu5(Hpt)5(H2O)2(2,3-PCA)2]n·12nH2O(1)has been successfully synthesized under hydrothermal conditions with copper hydroxide,3-(pyridin-2-yl)-1,2,4-triazole(Hpt)and 2,3-pyridinedi-carboxylic acid(2,3-PCA).The structure of the title compound was determined by X-ray diffraction analyses,elemental analyses and IR *** architecture of 1 consists of one-dimensional sandwich-like chains which are connected by extensive hydrogen bonding *** solid-state photoluminescence displays an obvious emission band at 384 nm upon excitation at 340 *** addition,electrochemistry property has also been studied.

关键词： copper(Ⅱ)coordination polymer fluorescent electrochemical properties

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Retrospective efficacy analysis of olaparib combined with bevacizumab in the treatment of advanced colorectal cancer

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 906-916页

作者： Yi-Ling Jiang Xue-Yuan Fu Zhi-Hui Yin Department of Oncology The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina Department of Anorectal The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina

BACKGROUND Colorectal cancer(CRC)is a highly prevalent malignancy of the digestive tract worldwide,characterized by a significant morbidity and mortality rate and subtle initial ***,local abdominal pain,and hematochezia occur with the development of cancer,while systemic symptoms such as anemia and weight loss occur in patients with advanced *** timely interventions,the disease can have fatal consequences within a short *** current therapeutic options for colon cancer include olaparib and bevacizumab,which are widely *** study intends to evaluate the clinical efficacy of olaparib combined with bevacizumab in the treatment of advanced CRC,hoping to provide insights into advanced CRC *** To investigate the retrospective efficacy of olaparib combined with bevacizumab in the treatment of advanced *** A retrospective analysis was conducted on a cohort of 82 patients with advanced colon cancer who were admitted to the First Affiliated Hospital of the University of South China between January 2018 and October *** them,43 patients subjected to the classical FOLFOX chemotherapy regimen were selected as the control group,and 39 patients undergoing treatment with olaparib combined with bevacizumab were selected as the observation *** to different treatment regimens,the short-term efficacy,time to progression(TTP),and incidence rate of adverse reactions between the two groups were *** in serum-related indicators[vascular endothelial growth factor(VEGF),matrix metalloprotein-9(MMP-9),cyclooxygenase-2(COX-2)]and tumor markers[human epididymis protein 4(HE4),carbohydrate antigen 125(CA125),carbohydrate antigen 199(CA199)]levels before and after treatment were compared between the two groups at the same *** The objective response rate was discovered to be 82.05%,and the disease control rate was 97.44%in the observation group,which were significantly higher than the respective rates of 5

关键词： Olaparib Bevacizumab Advanced colorectal cancer Efficacy

Solvothermal Synthesis,Crystal Structure and Characterization of a New Binuclear Nickel(Ⅱ)Complex with 2-(4-Methylbenzoyl)benzoic Acid

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Chinese Journal of Structural Chemistry 2021年第7期40卷 878-884,838页

作者： LI Wei LI Chang-Hong LI Yu-Lin KUANG Yun-Fei school of Chemistry and Materials Science Hengyang Normal UniversityHengyang 421008China school of Materials and Chemical Engineering Hunan Institute of TechnologyHengyang 421002China

A new binuclear nickel(Ⅱ)complex[Ni_(2)(MBBA)_(2)(HPT)_(2)(H_(2)O)_(2)]·2H_(2)O(1)was synthesized with nickel hydroxide,2-(4-methylbenzoyl)benzoic acid(HMBBA)and 3-(pyridin-2-yl)-1H-1,2,4-triazole(HPT).It crystallizes in the monoclinic space group P21/n with a=14.5902(13),b=8.8191(6),c=17.6120(14)Å,β=110.830(9)º,V=2118.0(3)Å^(3),M_(r)=958.26,D_(c)=1.503 g/cm^(3),Z=2,μ(MoKa)=0.959,F(000)=992,the final GOOF=1.001,R=0.0353 and wR=*** central Ni(Ⅱ)ion is coordinated by two oxygen and three nitrogen atoms,forming a distorted square pyramidal *** XRD,TG,spectrum analysis and magnetic properties of 1 were studied.

关键词： binuclear nickel(Ⅱ)complex spectrum analysis thermal stability magnetic property

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Expression patterns of cluster of differentiation 147 impact the prognosis of hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2023年第8期15卷 1412-1423页

作者： Yun-Ji Xu Hong-Jie He Peng Wu Wen-Bing Li Department of General Surgery The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)has very low overall *** to global cancer statistics,approximately 905677 new cases were reported in 2020,with at least 830180 of them being *** of differentiation 147(CD147)is a novel,transmembrane glycoprotein that is expressed in a wide variety of tumor cells and plays an important role in various stages of tumor *** on the reports described previously,we theorize that CD147 may be used as a novel biological indicator to predict the prognosis of *** study this possibility,expression profiles of CD147 and corresponding clinical data from The Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)databases were analyzed,and a hazard ratio(HR)was *** To explore the pattern of CD147 expression and its applicability in the prognosis of *** establish HRs and probability points for predicting the prognosis of HCC by correlating CD147 expression with clinical *** determine if CD147 can be a reliable biomarker in HCC *** The CD147 expression profile in HCC and corresponding clinical data were obtained from TCGA *** expression patterns of CD147 were then validated by analyzing data from the GEO *** addition,CD147 immunohistochemistry in HCC was obtained from the Human Protein ***147 expression patterns and clinical characteristics in the prognosis of HCC were analyzed by accessing the UALCAN web ***,sensitivity,and specificity of the CD147 expression profile in predictive prognosis were determined by the time-dependent receiver operating characteristic(ROC)***-Meier curves were plotted to estimate the HR of survival in *** and multivariate Cox regression proportional hazards analyses of CD147 expression levels and clinical characteristics as prognostic factors of HCC were *** were used to establish probability points and predict *** Data from TCGA and GEO databa

关键词： Hepatocellular carcinoma Cluster of differentiation 147 Prognosis Clinical characteristics Hazard ratio

β-Cyclodextrin-modified AuBi metallic aerogels enable efficient peroxidase mimicking for colorimetric sensing of urease-positive pathogenic bacteria

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Nano Research 2023年第7期16卷 9663-9671页

作者： Minghui Wang Peixian Wu Sha Yang Gui-long Wu Na Li Xiaofeng Tan Qinglai Yang Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular PathologyCancer Research InstituteHengyang Medical SchoolUniversity of South ChinaHengyang 421001China

The detection of pathogenic bacteria with improved accessibility,reduced analysis time,and increased sensitivity is of great importance for diagnosing the infected *** have attracted rising attention in the bioassay *** a model nanozyme needs the combined merit of sensible nanostructures and a large specific surface area to guarantee exceptional enzyme-mimic ***,aβ-cyclodextrin modified AuBi aerogel is prepared by a one-pot reduction *** introduction ofβ-cyclodextrin(featured with a hydrophobic cavity and hydrophilic surface)enhances the catalytic activity of AuBi aerogels by engendering host-guest complex and improving dispersity/*** on the specific urea hydrolysis,which could produce NH_(3)to raise pH by urease,the pH up-regulation would inhibit the peroxidase-mimicking performances ofβ-cyclodextrin/AuBi ***,the sensitive colorimetric detection platform for urease activity could be ***,the sensing platform can detect straightforwardly urease-positive Proteus mirabilis in urine circumstances with a wide detection range and a low limit of detection(LOD)of 4 colony-forming unit(CFU)·mL^(-1).The reproducibility,stability,and specificity of this approach are verified to be ***,as an inhibitor of urease activity,the fluoride ion could be detected by the constructed sensing platform sensitively and ***,this work provides a blueprint for designing an ideal nanozyme and paves a new roadway for detecting pathogenic bacteria.

关键词： metallic aerogels surface modification urea hydrolysis urease activity fluoride ion proteus mirabilis bacteria detection

Influence of Gut Microbiota and its Metabolites on Progression of Metabolic Associated Fatty Liver Disease

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Chinese medical Sciences Journal 2023年第4期38卷 286-296页

作者： Yuan-Yuan Wang Hai-Lian Lin Ke-Lang Wang Gen-Xiang Que Ting Cao La-Mei Zhu Xia Yang Xue-Feng Yang Hunan Provincial Clinical Research Center for Metabolic Associated Fatty Liver Disease Affiliated Nanhua HospitalHengyang Medical School&University of South ChinaHengyangHunan 421002China Department of Gastroenterology Affiliated Nanhua HospitalHengyang Medical School&University of South ChinaHengyangHunan 421002China Department of Hepatobiliary Surgery Affiliated Nanhua HospitalHengyang Medical School&University of South ChinaHengyangHunan 421002China Department of General Practice Affiliated Nanhua HospitalHengyang Medical School&University of South ChinaHengyangHunan 421002China

Metabolic associated fatty liver disease(MAFLD)has become a prevalent chronic liver disease worldwide because of lifestyle and dietary *** microbiota and its metabolites have been shown to play a critical role in the pathogenesis of *** of the function of gut microbiota and its metabolites in MAFLD may help to elucidate pathological mechanisms,identify diagnostic markers,and develop drugs or probiotics for the treatment of *** we review the pathogenesis of MAFLD by gut microbiota and its metabolites and discuss the feasibility of treating MAFLD from the perspective of gut microbes.

关键词： metabolic associated fatty liver disease intestinal microorganisms non-alcoholic fatty liver disease liver fibrosis hepatocellular carcinoma

Hydrothermal Synthesis, Crystal Structure and Properties of a New Binuclear Cage-like Yttrium(Ⅲ) Complex Y(TMBA)(phen)

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Chinese Journal of Structural Chemistry 2020年第11期39卷 2016-2020页

作者： LI Chang-Hong KUANG Yun-Fei LI Wei LI Yu-Lin school of Materials and Chemical Engineering Hunan Institute of TechnologyHengyang 421002China school of Chemistry and Materials Science Hengyang Normal UniversityHengyang 421008China

A new binuclear cage-like yttrium(Ⅲ) complex Y2(TMBA)6(phen)2(1) with yttrium nitrate, 2,4,6-trimethylbenzoic acid(TMBA) and 1,10-phenanthroline(phen) was synthesized. It crystallizes in the triclinic space group P1 with a = 11.9086(15), b = 12.4843(17), c = 14.2101(18) ?, α = 104.977(4), β = 111.750(4), γ = 95.874(5)o, V = 1848.8(4) ?3, Dc = 1.363 g/cm3, Z = 1, μ(Mo Ka) = 1.627, F(000) = 788, the final GOOF = 1.039, R = 0.0353 and w R = 0.0826. The whole molecule consists of two yttrium ions bridged by four 2,4,6-trimethylbenzoic acid anions. The Y(Ⅲ) ion is coordinated by eight atoms to give a distorted square antiprism coordination geometry. The TG analysis and fluorescent properties of 1 were studied.

关键词： binuclear yttrium(Ⅲ)complex thermal stability fluorescent property

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Impact of bariatric surgery on glucose and lipid metabolism and liver and kidney function in food-induced obese diabetic rats

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World Journal of Diabetes 2023年第8期14卷 1249-1258页

作者： Hong Long Lei Zhao Zhong-Sheng Xiao Shu-Xiang Li Qiu-Lin Huang Shuai Xiao Liang-Liang Wu Department of Gastrointestinal Surgery The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina

BACKGROUND Obesity usually causes diabetes mellitus(DM)and is a serious danger to human *** 2 DM(T2DM)mostly occurs along with *** obesityinduced DM is caused by an excessive long-term diet and surplus *** surgery can improve the symptoms of T2DM in some obese *** different types of bariatric surgery may have different *** To investigate the effect of bariatric surgery on glucose and lipid metabolism and liver and kidney function in *** Male Sprague-Dawley rats aged 6-8 wk underwent Roux-en-Y gastric bypass surgery(RYGB),sleeve gastrectomy(SG),or gastric banding(GB).Glucose and insulin tolerance tests,analyses of biochemical parameters,histological examination,western blot,and quantitative real-time polymerase chain reaction were *** In comparison to the sham operation group,the RYGB,SG,and GB groups had decreased body weight and food intake,reduced glucose intolerance and insulin insensitivity,downregulated biochemical parameters,alleviated morphological changes in the liver and kidneys,and decreased levels of protein kinase Cβ/*** effect in the RYGB group was better than that in the SG and GB *** These results suggest that RYGB,SG and GB may be helpful for the treatment of foodborne obesity-induced DM.

关键词： Diabetes mellitus Obesity Bariatric surgeries Liver and kidney function

Effect of Apolipoprotein A-I on ATP Binding Cassette Transporter A1 Degradation and Cholesterol Efflux in THP-1 Macrophage-derived Foam Cells

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Acta Biochimica et Biophysica Sinica 2004年第3期36卷 218-226页

作者： Chao-Ke TANG1,2, Guo-Hua TANG1, Guang-Hui YI1, Zuo WANG1, Lu-Shan LIU1, Shuang WAN1, Zhong-Hua YUAN1, Xiu-Sheng HE1, Jun-Hao YANG1, Chang-Geng RUAN1, and Yong-Zong YANG1* 1Institute of Cardiovascular Disease of Nanhua University, hengyang 421001, China 2Xiangya medical school, Central Southern University, Changsha 410078, China Institute of Cardiovascular Disease of Nanhua University hengyang 421001 China Xiangya medical school Central Southern University Changsha 410078 China

Cholesterol-loaded macrophage foam cells are a central componentof atherosclerotic lesions. ATP binding cassette transporter A1 (ABCA1), the defective molecule inTangier disease, mediates the efflux of phospholipid and cholesterolfrom cells to apolipoprotein A-I (apoA-I), reversing foam cell formation. This study investigated the effect of apoA-I on ABCA1 degradation and cholesterol efflux in THP-1 macrophage- derived foam cells. After exposure of the cultured THP-1 macrophage-derived foam cells to apoA-I for different time, cholesterol efflux, ABCA1 mRNA and protein levels were determined by FJ-2107P type liquid scintillator, RT-PCR and Western blot, respectively. The mean ABCA1 fluorescence intensity on THP-1 macrophage-derived foam cells was detected by flow cytometry. Results showed that apoA-I markedly increased ABCA1-mediated cholesterol efflux from THP-1 macrophage-derived foam cells. This was accompanied by an increase in the content of ABCA1. ApoA-I did not alter ABCA1 mRNA abundance. Significantly, thiol protease inhibitors increased the level of ABCA1 protein and slowed its decay in THP-1 macrophage-derived foam cells, whereas none of the proteosome-specific inhibitor lactacystin, other protease inhibitors, or the lysosomal inhibitor NH4Cl showed such effects. The apoA-I-mediated cellular cholesterol efflux was enhanced by thiol protease inhibitors. Our results suggested that thiol protease inhibitors mightprovide an alternative way to upregulate ABCA1 protein. Thisstrategy is especially appealing since it may mimic the stabilizingeffect of the natural ligands apoA-I.

关键词： ATP binding cassette transporter A1 apoA-I flow cytometry cholesterol lipoproteins

Copper homeostasis and cuproptosis in health and disease

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Signal Transduction and Targeted Therapy 2022年第12期7卷 4352-4367页

作者： Liyun Chen Junxia Min Fudi Wang The Fourth Affiliated Hospital The First Affiliated HospitalInstitute of Translational MedicineSchool of Public HealthState Key Laboratory of Experimental HematologyZhejiang University School of MedicineHangzhouChina The First Affiliated Hospital Basic Medical SciencesSchool of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyangChina

all cell *** the accumulation of intracellular copper can induce oxidative stress and perturbing cellular function,copper homeostasis is tightly *** studies identified a novel copper-dependent form of cell death called cuproptosis,which is distinct from all other known pathways underlying cell *** occurs via copper binding to lipoylated enzymes in the tricarboxylic acid(TCA)cycle,which leads to subsequent protein aggregation,proteotoxic stress,and ultimately cell ***,we summarize our current knowledge regarding copper metabolism,copper-related disease,the characteristics of cuproptosis,and the mechanisms that regulate *** addition,we discuss the implications of cuproptosis in the pathogenesis of various disease conditions,including Wilson’s disease,neurodegenerative diseases,and cancer,and we discuss the therapeutic potential of targeting cuproptosis.

关键词： homeostasis metabolism diseases