Impact of bariatric surgery on glucose and lipid metabolism and liver and kidney function in food-induced obese diabetic rats
作者机构：Department of Gastrointestinal SurgeryThe First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina
出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)
年 卷 期：2023年第14卷第8期
页 面：1249-1258页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：the Natural Science Foundation of Hunan Province No.2021JJ70119
主 题：Diabetes mellitus Obesity Bariatric surgeries Liver and kidney function
摘 要：BACKGROUND Obesity usually causes diabetes mellitus(DM)and is a serious danger to human *** 2 DM(T2DM)mostly occurs along with *** obesityinduced DM is caused by an excessive long-term diet and surplus *** surgery can improve the symptoms of T2DM in some obese *** different types of bariatric surgery may have different *** To investigate the effect of bariatric surgery on glucose and lipid metabolism and liver and kidney function in *** Male Sprague-Dawley rats aged 6-8 wk underwent Roux-en-Y gastric bypass surgery(RYGB),sleeve gastrectomy(SG),or gastric banding(GB).Glucose and insulin tolerance tests,analyses of biochemical parameters,histological examination,western blot,and quantitative real-time polymerase chain reaction were *** In comparison to the sham operation group,the RYGB,SG,and GB groups had decreased body weight and food intake,reduced glucose intolerance and insulin insensitivity,downregulated biochemical parameters,alleviated morphological changes in the liver and kidneys,and decreased levels of protein kinase Cβ/*** effect in the RYGB group was better than that in the SG and GB *** These results suggest that RYGB,SG and GB may be helpful for the treatment of foodborne obesity-induced DM.
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