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Utilization of 3D printing technology in hepatopancreatobiliary surgery

Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 123-134页

作者： Wujiang SHI Jiangang WANG Jianjun GAO Xinlei ZOU Qingfu DONG Ziyue HUANG Jialin SHENG Canghai GUAN Yi XU Yunfu CUI Xiangyu ZHONG Department of Hepatopancreatobiliary Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbin150086China Department of General Surgery Tangdu HospitalAir Force Medical UniversityXi’an710032China Key Laboratory of Basic Pharmacology of Ministry of Education Zunyi Medical UniversityZunyi563006China Key Laboratory of Functional and Clinical Translational Medicine Fujian Province UniversityXiamen Medical CollegeXiamen361000China Department of Pathology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Jiangsu Province Engineering Research Center of Tumor Targeted Nano Diagnostic and Therapeutic Materials Yancheng Teachers UniversityYancheng224007China Key Laboratory of Biomarkers and In Vitro Diagnosis Translation of Zhejiang Province Hangzhou310053China Key Laboratory of Gastrointestinal Cancer(Fujian medical university) Ministry of EducationSchool of Basic Medical SciencesFujian Medical UniversityFuzhou350122China Key Laboratory of Myocardial Ischemia Harbin Medical UniversityMinistry of EducationHarbin150086China

The technology of three-dimensional(3D)printing emerged in the late 1970s and has since undergone considerable development to find numerous applications in mechanical engineering,industrial design,and *** biomedical science,several studies have initially found that 3D printing technology can play an important role in the treatment of diseases in hepatopancreatobiliary *** example,3D printing technology has been applied to create detailed anatomical models of disease organs for preoperative personalized surgical strategies,surgical simulation,intraoperative navigation,medical training,and patient ***,cancer models have been created using 3D printing technology for the research and selection of chemotherapy *** the aim to clarify the development and application of 3D printing technology in hepatopancreatobiliary surgery,we introduce seven common types of 3D printing technology and review the status of research and application of 3D printing technology in the field of hepatopancreatobiliary surgery.

关键词： 3D printing Hepatopancreatobiliary surgery Organ model Cancer model

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An Icy Worlds life detection strategy based on Exo-AUV

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Science China Earth sciences 2024年第11期67卷 3515-3535页

作者： Bin WANG Hongde QIN National Key Laboratory of Autonomous Marine Vehicle Technology Harbin Engineering University Shipbuilding Engineering College Harbin Engineering University

In the solar system, Icy Worlds such as Europa and Enceladus hold great potential for extraterrestrial life and may provide humanity an answer, within this century, to the age-old question of life beyond Earth. Exo-AUV technology shows promise in life detection in the icy shell, at the ice-water interface and on the seafloor of exo-ocean. Space agencies, including NASA and DLR, are enthusiastic about deploying Exo-AUVs to explore life in these regions. However, the where and how to find life, the technologies to be utilized and the goals to be achieved are crucial aspects for future Exo-AUV life detection missions on Icy Worlds. This study delves into a hypothetical mission of life detection on Europa, discussing science goals,detectable objects, potential regions and biogenic analysis for Icy Worlds. It proposes a life detection strategy for Icy Worlds based on Exo-AUVs, presents key contextual elements for Exo-AUV operations, outlines technological requirements for hull,payloads and autonomy, introduces the current state of Exo-AUV research and addresses existing challenges. This study also suggests a roadmap for conceptual development of Exo-AUV and a Concept of Operations for Multiple Exo-AUV System(ConOps for MEAS). This system aims to assist planetary scientists and astrobiologists in exploring Icy Worlds, identifying robust biosignatures and potentially discovering extant organisms, even prebiotic chemical systems.

关键词： Icy Worlds Europa Life detection Biological potential Exo-AUV

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Combinational therapy with Myc decoy oligodeoxynucleotides encapsulated in nanocarrier and X-irradiation on breast cancer cells

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Oncology Research 2024年第2期32卷 309-323页

作者： BEHROOZ JOHARI MILAD PARVINZAD LEILAN MAHMOUD GHARBAVI YOUSEF MORTAZAVI ALI SHARAFI HAMED REZAEEJAM Department of medical Biotechnology School of MedicineZanjan University of Medical SciencesZanjanIran Zanjan Pharmaceutical Biotechnology Research Center Zanjan University of Medical SciencesZanjanIran Nanotechnology Research Center Ahvaz Jundishapur University of Medical SciencesAhvazIran Department of Radiology Technology School of Allied Medical SciencesZanjan University of Medical SciencesZanjanIran

The Myc gene is the essential oncogene in triple-negative breast cancer(TNBC).This study investigates the synergistic effects of combining Myc decoy oligodeoxynucleotides-encapsulated niosomes-selenium hybrid nanocarriers with X-irradiation exposure on the MDA-MB-468 cell *** and scramble ODNs for Myc transcription factor were designed and synthesized based on promoter sequences of the Bcl2 *** nanocarriers were synthesized by loading Myc ODNs and selenium into chitosan(Chi-Se-DEC),which was then encapsulated in niosome-nanocarriers(NISM@Chi-Se-DEC).FT-IR,DLS,FESEM,and hemolysis tests were applied to confirm its characterization and physicochemical ***,cellular uptake,cellular toxicity,apoptosis,cell cycle,and scratch repair assays were performed to evaluate its anticancer effects on cancer *** anticancer assessments were repeated under X-ray irradiation conditions(fractionated 2Gy).Physicochemical characteristics of niosomes containing SeNPs and ODNs showed that it is synthesized *** revealed that the anticancer effect of NISM@Chi-Se-DEC can be significantly improved in combination with X-ray irradiation *** can be concluded that NISM@Chi-Se-DEC nanocarriers have the potential as a therapeutic agent for cancer treatment,particularly in combination with radiation therapy and in-vivo experiments are necessary to confirm the efficacy of this nano-drug.

关键词： Combinational therapy Antisense therapy Myc signaling pathway Niosomes Radiation therapy SeNPs

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Multifunctional high-performance pressure/proximity/temperature sensors enabled by hybrid resistive-supercapacitive response

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Nano Research 2024年第6期17卷 5604-5613页

作者： Huijun Kong Zhongqian Song Meichun Ding Changxiang Shao Jiahui Yu Baolei Wang Weiyan Li Chenwei Li Li Niu School of Chemistry and Pharmaceutical Engineering Shandong First Medical University and Shandong Academy of Medical SciencesJinan 250117China College of Artificial Intelligence and Big Data for medical sciences Shandong First Medical University and Shandong Academy of Medical SciencesJinan 250117China School of Chemical Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China

The issue of sensitivity attenuation in high-pressure region has been a persistent concern for pressure-sensitive electronic *** order to tackle such trade-off between sensitivity and linear range,herein,a hybrid piezoresistive-supercapacitive(HRSC)strategy is proposed via introducing a piezoresistive porous aerogel layer between the charge collecting electrodes and iontronic films of the pressure ***,the HRSC-induced impedance regulation and supercapacitive behavior contribute to significant mitigation in sensitivity attenuation,achieving high sensitivity across wide linear range(44.58 kPa^(−1)from 0 to 3 kPa and 23.6 kPa^(−1)from 3 to 12 kPa).The HRSC pressure sensor exhibits a low detection limit of 1 Pa,fast responsiveness(~130 ms),and excellent cycling stability,allowing to detect tiny pressure of air flow,finger bending,and human ***,the HRSC sensor exhibits exceptional perception capabilities for proximity and temperature,broadening its application scenarios in prosthetic perception and electronic *** proposed HRSC strategy may boost the ongoing research on structural design of high-performance and multimodal electronic sensors.

关键词： multimodal sensor pressure sensor high sensitivity MXene/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)aerogel structural design

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Prevalence of Anemia in Patients with Diabetes Mellitus:A Systematic Review and Meta-Analysis

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Biomedical and Environmental sciences 2024年第1期37卷 96-107页

作者： Monireh Faghir-Ganji Narjes Abdolmohammadi Maryam Nikbina Alireza Amanollahi Alireza Ansari-Moghaddam Rozhan Khezri Hamidreza Baradaran Student Research Committee Iran University of Medical SciencesTehranIran Department of Epidemiology School of Public HealthIran University of Medical SciencesTehranIran Department of Epidemiology School of Public HealthTehran University of Medical SciencesTehranIran Department of Midwifery Shoushtar Faculty of Medical SciencesShoushtarIran Department of Epidemiology School of Public Health and SafetyShahid Beheshti University of Medical SciencesTehranIran Trauma and Injury Research Center Iran University of Medical SciencesTehranIran Health Promotion Research Center Zahedan University of Medical SciencesZahedanIran Endocrine Research Center Institute of Endocrinology and MetabolismIran University of Medical SciencesTehranIran

Objective Anemia is a common public health concern in patients with type 2 diabetes *** study aimed to identify the prevalence of anemia among patients with *** Electronic databases,including PubMed,Scopus,Web of sciences,and Google Scholar,were searched systematically for studies published between 2010 and *** removing duplicates and inappropriate reports,the remaining manuscripts were reviewed and appraised using theNewcastleOttawa Scale(NOS)tool.A random-effects model was used to calculate the pooled estimates of the extracted data using Stata version *** of the studies was assessed using the Q *** A total of 51 articles containing information on 26,485 patients with diabetes were included in this *** articles were mainly from Asia(58.82%)and Africa(35.29%).The overall prevalence of anemia was 35.45%(95%CI:30.30–40.76),with no evidence of heterogeneity by *** the two continents with the highest number of studies,the prevalence of anemia in patients with diabetes was significantly higher in Asia[40.02;95%CI:32.72–47.54]compared to Africa[28.46;95%CI:21.90–35.50](P for heterogeneity=0.029).Moreover,there has been an increasing trend in the prevalence of anemia in patients with diabetes over time,from[15.28;95%CI:9.83–22.21]in 2012 to[40.70;95%CI:10.21–75.93]in *** Globally,approximately 4 in 10 patients with diabetes suffer from ***,routine anemia screening and control programs every 3 months might be useful in improving the quality of life of these patients.

关键词： Prevalence Diabetic foot Anemia Diabetes mellitus

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Identifying and validating MMP family members(MMP2,MMP9,MMP12,and MMP16)as therapeutic targets and biomarkers in kidney renal clear cell carcinoma(KIRC)

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Oncology Research 2024年第4期32卷 737-752页

作者： KUNLUN LI DANDAN LI BARBOD HAFEZ MOUNIR M.SALEM BEKHIT YOUSEF A.BIN JARDAN FARS KAED ALANAZI EHAB I.TAHA SAYED H.AUDA FAIQAH RAMZAN MUHAMMAD JAMIL The Second Affiliated Hospital of harbin medical university Harbin Medical UniversityHarbinChina Department of Pharmaceutical Engineering Jiangsu Ocean UniversityLianyungangChina Department of Biological Engineering University of SalfordSalfordUK Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadhSaudi Arabia Department of Animal and Poultry Production Faculty of Veterinary and Animal SciencesGomal UniversityDera Ismail KhanPakistan Department of Arid Zone Research PARC instituteDera Ismail KhanPakistan

Kidney Renal Clear Cell Carcinoma(KIRC)is a malignant tumor that carries a substantial risk of morbidity and *** MMP family assumes a crucial role in tumor invasion and *** study aimed to uncover the mechanistic relevance of the MMP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma(KIRC)through a comprehensive approach encompassing both computational and molecular ***,Cytoscape,UALCAN,GEPIA,OncoDB,HPA,cBioPortal,GSEA,TIMER,ENCORI,DrugBank,targeted bisulfite sequencing(bisulfite-seq),conventional PCR,Sanger sequencing,and RT-qPCR based analyses were used in the present study to analyze MMP gene family members to accurately determine a few hub genes that can be utilized as both therapeutic targets and diagnostic biomarkers for *** performing STRING and Cytohubba analyses of the 24 MMP gene family members,MMP2(matrix metallopeptidase 2),MMP9(matrix metallopeptidase 9),MMP12(matrix metallopeptidase 12),and MMP16(matrix metallopeptidase 16)genes were denoted as hub genes having highest degree *** analyzing MMP2,MMP9,MMP12,and MMP16 via various TCGA databases and RT-qPCR technique across clinical samples and KIRC cell lines,interestingly,all these hub genes were found significantly overexpressed at mRNA and protein levels in KIRC samples relative to *** notable effect of the up-regulated MMP2,MMP9,MMP12,and MMP16 was also documented on the overall survival(OS)of the KIRC ***,targeted bisulfite-sequencing(bisulfite-seq)analysis revealed that promoter hypomethylation pattern was associated with up-regulation of hub genes(MMP2,MMP9,MMP12,and MMP16).In addition to this,hub genes were involved in various diverse oncogenic *** MMP gene family members(MMP2,MMP9,MMP12,and MMP16)may serve as therapeutic targets and prognostic biomarkers in KIRC.

关键词： KIRC MMP gene family Chemotherapy Overall survival

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A LiDAR Point Clouds Dataset of Ships in a Maritime Environment

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1681-1694页

作者： Qiuyu Zhang Lipeng Wang Hao Meng Wen Zhang Genghua Huang the College of Intelligent Systems Science and Engineering Harbin Engineering UniversityHarbin 150001China Key Laboratory of Space Active Opto-Electronics Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China

For the first time, this article introduces a LiDAR Point Clouds Dataset of Ships composed of both collected and simulated data to address the scarcity of LiDAR data in maritime applications. The collected data are acquired using specialized maritime LiDAR sensors in both inland waterways and wide-open ocean environments. The simulated data is generated by placing a ship in the LiDAR coordinate system and scanning it with a redeveloped Blensor that emulates the operation of a LiDAR sensor equipped with various laser beams. Furthermore,we also render point clouds for foggy and rainy weather conditions. To describe a realistic shipping environment, a dynamic tail wave is modeled by iterating the wave elevation of each point in a time series. Finally, networks serving small objects are migrated to ship applications by feeding our dataset. The positive effect of simulated data is described in object detection experiments, and the negative impact of tail waves as noise is verified in single-object tracking experiments. The Dataset is available at https://***/zqy411470859/ship_dataset.

关键词： 3D point clouds dataset dynamic tail wave fog simulation rainy simulation simulated data

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Impact of umbelliprenin-containing niosome nanoparticles on VEGF-A and CTGF genes expression in retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 7-15页

作者： Farzad Dastaviz Akram Vahidi Teymoor Khosravi Ayyoob Khosravi Mehdi Sheikh Arabi Abouzar Bagheri Mohsen Rashidi Morteza Oladnabi Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of medical Genetics School of Advanced Technologies in MedicineGolestan University of Medical SciencesGorgan ***Iran Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Clinical Biochemistry and Genetics Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Department Pharmacology Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell ***:UMB-containing niosomes were created,optimized,and ***-like cells were treated with free UMB and UMB-containing *** IC_(50)values of the treatments were determined using an MTT *** expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA ***’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were *** UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/***:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free ***:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes ***,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual *** findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.

关键词： umbelliprenin niosome age-related macular degeneration vascular endothelial growth factor-A connective tissue growth factor

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Role of Fibrinogen-like Protein 1 in Tumor Recurrence Following Hepatectomy

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 406-415页

作者： Zahra Shafieizadeh Zohreh Shafieizadeh Maryam Davoudi Reza Afrisham Xiaolei Miao Department of medical Laboratory sciences School of Allied Medical SciencesTehran University of Medical SciencesTehranIran School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianningHubeiChina

Partial hepatectomy is a first-line treatment for hepatocellular *** 2 weeks following partial hepatectomy,specific molecular pathways are activated to promote liver ***,residual microtumors may also exploit these pathways to reappear and *** targeting molecules that are differentially regulated between normal cells and malignancies,such as fibrinogen-like protein 1(FGL1),appears to be an effective *** potential functions of FGL1 in both regenerative and malignant cells are discussed within the ambit of this *** FGL1 is normally elevated in regenerative hepatocytes,it is normally downregulated in malignant *** does indeed upregulate FGL1 by increasing the release of transcription factors that promote FGL1,including HNF-1α and STAT3,and inflammatory effectors,such as TGF-β and ***,in turn,stimulates certain proliferative pathways,including EGFR/Src/*** alters the phase transition of highly differentiated hepatocytes from G0 to G1,thereby transforming susceptible cells into cancerous *** of the PI3K/Akt/mTOR pathway by FGL1 allele loss on chromosome 8,a tumor suppressor area,may also cause hepatocellular ***,FGL1 is specifically expressed in the liver via HNF-1α histone acetylase activity,which triggers lipid metabolic reprogramming in ***1 might also be involved in other carcinogenesis processes such as hypoxia,epithelial-mesenchymal transition,immunosuppression,and sorafenib-mediated drug *** study highlights a research gap in these disciplines and the necessity for additional research on FGL1 function in the described processes.

关键词： Fibrinogen-like protein 1 FGL1 Hepatocellular carcinoma Liver regeneration Hepatectomy Lipogenesis Recurrence

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Movement Trend Alterations in the Periaqueductal Gray(PAG)-Employed Ratbot Navigation Are Correlated with Stimulation Parameters

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Journal of Bionic Engineering 2024年第2期21卷 866-876页

作者： Sina Khajei Abed Khorasani Mohammad Reza Afarinesh Vahid Sheibani Neuroscience Research Center Institute of NeuropharmacologyKerman University of Medical SciencesKerman***Iran Cognitive Neuroscience Research Center Institute of NeuropharmacologyKerman University of Medical SciencesKerman***Iran

In previous studies,Periaqueductal Gray(PAG)stimulation was used to stop ratbots from *** to the homology between the PAG and the intercollicular nucleus,which has been used for forward movement in birds,we investigated the possibility of PAG application to induce forward locomotion for the first *** a corridor maze,the traveled distances via PAG electrical stimulation were examined in nine Wistar male rats during three sessions.A custom-designed stimulator was developed to apply the *** results showed reductions in responses to stimulation over ***,the traveled distances had negative slopes during the consecutive trials(in 8 out of the 9 rats),and the slope mean was significantly different from *** was a strong correlation between the stimulation parameters(electric Charge per Phase(CPP)and the Number of Pulses(NP))and the observed *** negative Movement Slopes(MS)were highly correlated with the CPP and the NP,as the Pearson's linear correlation coefficients were−0.87 and−0.79,*** MS-CPP coefficients of determination(R-squared)were also between 0.76 and *** addition,the MS-NP coefficients of determination were between 0.63 and ***,it is concluded that the electrical stimulation parameters influence the behavioral outcomes ***,the PAG area may be considered a suitable candidate for forward locomotion control in the future if the area is harnessed effectively to prevent undesirable chaotic behaviors.

关键词： Periaqueductal Gray(PAG) Navigation Ratbot Animal-robot Forward locomotion Movement slope

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