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Stroke & Vascular Neurology 2023年第2期8卷 119-126页

作者： Shiqi Yuan Xiaxuan Huang Wen Ma Rui Yang Fengshuo Xu Didi Han Tao Huang MIn Peng Anding Xu Jun Lyu Department of Neurology Jinan University First Affiliated HospitalGuangzhouGuangdongChina School of Public Health Xi'an Jiaotong UniversityXi'anShaanxiChina Department of clinical Research Jinan University First Affiliated HospitalGuangzhouGuangdongChina guangdong provincial key laboratory of Traditional Chinese Medicine Informatization GuangzhouGuangdongChina

Objective To explore the correlations of high-density lipoprotein cholesterol(HDL-C)/low-density lipoprotein cholesterol(LDL-C)with myocardial infarction(MI),all-cause mortality,haemorrhagic stroke and ischaemic stroke,as well as the joint association of genetic susceptibility and HDL-C/LDL-C with the MI *** and results This study selected 384093 participants from the UK Biobank(UKB)***,restricted cubic splines indicated non-linear associations of HDL-C/LDL-C with MI,ischaemic stroke and all-cause ***,a Cox proportional-hazards model indicated that compared with HDL-C/LDL-C=0.4-0.6,HDL-C/LDL-C0.6 were correlated with all-cause mortality(HR=0.97 for HDL-C/LDL-C0.6,95%CI=1.16 to 1.26,p0.6 was associated with higher risk haemorrhagic stroke risk after full multivariable adjustment(HR=1.25,95%CI=1.03 to 1.52,pclinical significance and impact of HDL-C/LDL-C need to be further

关键词： infarction haemorrhagic restricted

Decreased b-Cell Function is Associated with Cardiovascular Autonomic Neuropathy in Chinese Patients Newly Diagnosed with Type 2 Diabetes

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Neuroscience Bulletin 2019年第1期35卷 25-33页

作者： Xubin Yang Wen Xu Yanhua Zhu Hongrong Deng Ying Tan Longyi Zeng Jianping Weng Department of Endocrinology and Metabolism Guangdong Provincial Key Laboratory of DiabetologyThird Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

The influence of b-cell function on cardiovascular autonomic neuropathy(CAN), an important diabetesrelated complication, is still unclear. In this study, we aimed to investigate the association between residual b-cell function and CAN in patients newly diagnosed with type 2 diabetes. We enrolled 90 newly-diagnosed type 2 diabetic patients and 37 participants with normal glucose tolerance as controls. The patients were divided into a CAN? group(diabetic patients with CAN, n = 20) and a CAN-group(diabetic patients without CAN, n = 70) according to the standard Ewing battery of tests. Fasting and postprandial plasma glucose, insulin, and C-peptide were *** model assessment-beta cells(HOMA-B) and HOMA-insulin resistance(IR) were calculated. The prevalence of CAN in this population was 22.2%. Compared with the CAN-group, the CAN? group had significantly lower fasting plasma insulin(6.60 ± 4.39 vs 10.45 ± 7.82 l/L, P = 0.029), fasting C-peptide(0.51 ± 0.20 vs0.82 ± 0.51 nmol/L, P = 0.004), and HOMA-B(21.44 ± 17.06 vs 44.17 ± 38.49, P = 0.002). Fasting C-peptide was correlated with the Valsalva ratio(r = 0.24, P = 0.043) and the 30:15 test(r = 0.26,P = 0.023). Further analysis showed that fasting C-peptide(OR: 0.041, 95% CI 0.003–0.501, P = 0.012) and HOMAB(OR: 0.965, 95% CI 0.934–0.996, P = 0.028) were independently associated with cardiovascular autonomic nerve function in this population. The patients with fasting C-peptide values \ 0.67 nmol/L were more likely to have CAN than those with C-peptide levels C0.67 nmol/L(OR:6.00, 95% CI 1.815–19.830, P = 0.003). A high prevalence of CAN was found in patients with newly-diagnosed type 2 diabetes. Decreased b-cell function was closely associated with CAN in this population.

关键词： Cardiovascular autonomic neuropathy b-cell function Type 2 diabetes mellitus

Acceptor-engineering tailored type-Ⅰ photosensitizer with aggregation-induced NIR-II emission for cancer multimodal phototheranostics

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Science China Chemistry 2024年第8期67卷 2647-2660页

作者： Jiangao Li Niu Niu Deliang Wang Xue Liu Yi Qin Lei Wang Ben Zhong Tang Dong Wang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China Guangzhou Municipal and guangdong provincial key laboratory of Molecular Target Clinical Pharmacologythe State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Exploration of single molecular species synchronously featured by long excitation/emission wavelength, accurate diagnosis, and effective therapy, remains supremely appealing to implement high-performance cancer phototheranostics. However, those previously established phototheranostic agents are undiversified and stereotyped in terms of structural skeleton, and generally exhibit insufficient phototheranostic outcomes. Herein, we innovatively utilized indanone-condensed thiadiazolo[3,4-g]quinoxaline(ITQ) as electron acceptor to construct novel photosensitizer with second near-infrared(NIR-II) emission. Experimental study and theoretical calculation demonstrated that comparing with the counterparts constituting by widely employed NIR-II building block benzobisthiadiazole(BBTD) and 6,7-diphenylthiadiazoloquinoxaline(DPTQ), ITQ-based photosensitizer(TITQ) showed superior aggregation-induced emission(AIE) characteristics, much stronger type-I reactive oxygen species(ROS) production, and prominent photothermal conversion capacity. Furthermore, TITQ nanoparticles with excellent biocompatibility were capable of effectively accumulating in the tumor site and visualizing tumor through fluorescence-photoacoustic-photothermal trimodal imaging with highly spatiotemporal resolution, and completely eliminating tumor by type-I photodynamic-photothermal therapy.

关键词： phototheranostics aggregation-induced emission NIR-Ⅱfluorescence acceptor engineering photodynamic-photothermal therapy

Nanomedicine-based treatment:An emerging therapeutical strategy for pulmonary hypertension

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Nano Research 2023年第5期16卷 7007-7029页

作者： Shuya Wang Qiaohui Chen Tianjiao Zhao Kelong Ai Changping Hu Department of pharmacology Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha 410078China Hunan provincial key laboratory of Cardiovascular Research Changsha 410078China

Pulmonary hypertension(PH)can cause breathing difficulty,a rapid decline of exercise capacity,heart failure,eventually death of the *** latest epidemiological study demonstrates that PH has a much higher incidence than previously *** is still a highly fatal disease due to the many disadvantages of the current drugs,such as short half-life,lack of targeting,potent side *** PH pathological features offer great opportunities for nanomedicines for ***,emerging nanomedicines demonstrated great advantages in the therapeutic effect of PH by enhancing the accumulation of drugs in PH lesion,optimizing drug efficacy,minimizing drug side ***,this promising field of cross-cutting research is far from being widely explored due to the huge professional *** solve this problem,we provide a comprehensive review for the latest progresses of nanomedicines in the treatment of ***,we systematical summarized the PH pathological features and the current clinical drug treatment of *** advantages of nanomedicines are also deeply discussed in the treatment of ***,we focused on the research progresses of nanomedicines in PH through three aspects:advanced nano-drug delivery system for traditional drugs and new target drugs,gene therapy-based nanomedicines,other nanomedicines for the treatment of ***,we also discussed the prospects and challenges for the clinical application of nanomedicines in PH,provided directions for the research and development of nanomedicines for PH treatment in the future.

关键词： pulmonary hypertension nanomedicines enhanced penetration and retention effects polymer liposome

Advances of biomarkers in nasopharyngeal carcinoma’s early detection

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Science Bulletin 2024年第2期69卷 141-145页

作者： Xiao-Hui Zheng Allan Hildesheim Wei-Hua Jia State key laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Costa Rican Agency for Biomedical Investigation INCIENSA FoundationSan Jose 10108Costa Rica

Nasopharyngeal carcinoma(NPC),a highly invasive and metastatic cancer,is widely prevalent in South China,Southeast Asia,and North *** patients with stages I and II are often ***,NPC patients are usually diagnosed with advanced-stage(stages III and IV)at their first *** of NPC at early stage is the key to improve the survival of ***-Barr virus(EBV)plays an essential role in NPC occurrence in endemic ***-based biomarkers,including EBV antibody in serum and EBV DNA in plasma,have been specifically proposed for NPC early ***,we summarize recent advances in biomarkers for the early detection of NPC.

关键词： patients nasopharyngeal Nasopharyngeal

Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice

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Acta Pharmaceutica Sinica B 2023年第11期13卷 4535-4552页

作者： Wanze Tang Zhen Ding Huanqing Gao Qinnan Yan Jingping Liu Yingying Han Xiaoting Hou Zhengwei Liu Litong Chen Dazhi Yang Guixing Ma Huiling Cao Department of Biochemistry School of MedicineGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchKey University Laboratory of Metabolism and Health of GuangdongSouthern University of Science and TechnologyShenzhen 518055China The First Affiliated Hospital Southern University of Science and TechnologyShenzhen 518055China clinical laboratory of the Third Affiliated Hospital of Southern Medical University Guangzhou 510630China

Osteoporosis(OP)is a systemic skeletal disease that primarily affects the elderly population,which greatly increases the risk of *** we report that Kindlin-2 expression in adipose tissue increases during aging and high-fat diet fed and is accompanied by decreased bone ***-2 specific deletion(K2KO)controlled by Adipoq-Cre mice or adipose tissue-targeting AAV(AAV-Rec2-CasRx-sgK2)significantly increases bone ***,Kindlin-2 promotes peroxisome proliferator-activated receptor gamma(PPARγ)activation and downstream fatty acid binding protein 4(FABP4)expression through stabilizing fatty acid synthase(FAS),and increased FABP4 inhibits insulin expression and decreases bone ***-2 inhibition results in accelerated FAS degradation,decreased PPARγactivation and FABP4 expression,and therefore increased insulin expression and bone ***,we find that FABP4 is increased while insulin is decreased in serum of OP *** FABP4 expression through PPARγactivation by rosiglitazone reverses the high bone mass phenotype of K2KO *** of FAS by C75 phenocopies the high bone mass phenotype of K2KO ***,our study establishes a novel Kindlin-2/FAS/PPARγ/FABP4/insulin axis in adipose tissue modulating bone mass and strongly indicates that FAS and Kindlin-2 are new potential targets and C75 or AAV-Rec2-CasRx-sgK2 treatment are potential strategies for OP treatment.

关键词： Kindlin-2 Adipocyte FAS Bone homeostasis AAV-Rec2-CasRx-sgK2 Osteoporosis C75 mRNA editing

Axial length shortening in myopic children with Stickler syndrome after repeated low-level red-light therapy

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International Journal of Ophthalmology(English edition) 2023年第10期16卷 1712-1717页

作者： Xiang-Hua Tang Meng-Ting Yu Yin Hu Ming-Guang He Xiao Yang State key laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalMelbourneVictoria 3004Australia Ophthalmology Department of SurgeryUniversity of MelbourneMelbourneVictoria 3004Australia

AIM:To report the myopia-controlling effect of repeated low-level red-light(RLRL)therapy in patients with Stickler syndrome(STL),an inherited collagenic disease typically presenting with early onset ***:Three STL children,aged 3,7,and 11y,received RLRL therapy throughout the follow-up period of 17,3,and 6mo,respectively after exclusion of fundus *** on best-corrected visual acuity(BCVA),intraocular pressure,cycloplegic subjective refraction,ocular biometrics,scanning laser ophthalmoscope,optical coherence tomography,genetic testing,systemic disease history,and family history were ***:At the initiation of the RLRL therapy,the spherical equivalent(SE)of 6 eyes from 3 patients ranged from-3.75 to-20.38 D,axial length(AL)were from 23.88 to 30.68 mm,and BCVA were from 0.4 to 1.0(decimal notation).Myopia progression of all six eyes slowed down after RLRL *** in five out of the six eyes shortened-0.07 to-0.63 *** side effects were ***:Three cases of STL whose progression of myopic shift and AL elongation are successfully reduced and even reversed after RLRL therapy.

关键词： Stickler syndrome axial length shortening myopia repeated low-level red-light therapy

Effectiveness and safety of early lens extraction during par plana vitrectomy for proliferative diabetes retinopathy with mild cataract:a randomized clinical trial

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 528-536页

作者： Wei-Bo Feng Lei Zheng Ying-Qi Li Yong-Hao Li Guo-Ming Zhang Xian Wang Bing-Qian Liu Ling Jin Yi-Nuo Huang Yang-Fan Yang Zi-Dong Chen Da-Hui Ma Qing-Shan Chen Chao-Jun Qin Bing-Min Feng Zhu-Min Yang Xing Huang Cheng-Jie Yang Sheng-Hui Liu Ming-Xing Wu State key laboratory of Ophthalmology Guangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesZhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510275Guangdong ProvinceChina Shenzhen Eye Hospital Affiliated to Jinan University Shenzhen 518040Guangdong ProvinceChina The Affiliated Hospital of Guizhou Medical University Guiyang 550004Guizhou ProvinceChina Guangzhou Aier Eye Hospital Guangzhou 510000Guangdong ProvinceChina

●AIM:To evaluate the effectiveness and safety of early lens extraction during pars plana vitrectomy(PPV)for proliferative diabetic retinopathy(PDR)compared to those of PPV with subsequent cataract surgery.●METHODS:This multicenter randomized controlled trial was conducted in three Chinese hospitals on patients with PDR,aged>45y,with mild *** participants were randomly assigned to the combined(PPV combined with simultaneously cataract surgery,i.e.,phacovitrectomy)or subsequent(PPV with subsequent cataract surgery 6mo later)group and followed up for *** primary outcome was the change in best-corrected visual acuity(BCVA)from baseline to 6mo,and the secondary outcomes included complication rates and medical expenses.●RESULTS:In total,129 patients with PDR were recruited and equally randomized(66 and 63 in the combined and subsequent groups respectively).The change in BCVA in the combined group[mean,36.90 letters;95%confidence interval(CI),30.35–43.45]was significantly better(adjusted difference,16.43;95%CI,8.77–24.08;P<0.001)than in the subsequent group(mean,22.40 letters;95%CI,15.55–29.24)6mo after the PPV,with no significant difference between the two groups at *** overall surgical risk of two sequential surgeries was significantly higher than that of the combined surgery for neovascular glaucoma(17.65%vs 3.77%,P=0.005).No significant differences were found in the photocoagulation spots,surgical time,and economic expenses between two *** the subsequent group,the duration of work incapacity(22.54±9.11d)was significantly longer(P<0.001)than that of the combined group(12.44±6.48d).●CONCLUSION:PDR patients aged over 45y with mild cataract can also benefit from early lens extraction during PPV with gratifying effectiveness,safety and convenience,compared to sequential surgeries.

关键词： lens extraction pars plana vitrectomy proliferative diabetic retinopathy cataract simultaneously operations

Evolution and trends of high myopia research from 2002 to 2021: a scientometric analysis

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Annals of Eye Science 2023年第4期8卷 22-35页

作者： Yuan Tan Weining Zhu Yingshi Zou Bowen Zhang Yinglin Yu Wei Li Chaoqun Xu Leyi Hu Guangming Jin Zhenzhen Liu State key laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhouChina Zhongshan Medical School Sun Yat-sen UniversityGuangzhouChina

Background:Research on high myopia has gradually formed a complex network of knowledge,but a panorama of evolutionary trends is *** conducting a scientometric analysis,we can gain a deeper understanding of the development and evolution of this ***:The global literature on high myopia published from 2002 to 2021 was extracted from the Science Citation Index Expanded in the Web of Science Core *** Excel,VOSviewer,and CiteSpace were used to analyse and visualize the bibliometric ***-related information,including countries,journals,authors,citations,subject categories,and its’time trends,was ***:A total of 4,226 included publications showed an annually increasing trend during the past 20 *** high myopia research hotspots were refractive error correction,epidemiology,ocular biometry,drug and laser treatment of myopic fundus lesions,and surgical treatment of myopic fundus *** analysis showed that high myopia genetics and myopic fundus lesion research were the research frontiers.A total of 116 disciplines were involved in high myopia ***(n=3,338)was the most dominant subject ***(betweenness centrality=0.65)was the discipline with the most obvious bridge ***&technology—other topics(burst years:2015–2021;strength=14.88)had the greatest strength as of 2021,which was the hottest subject ***:High myopia genetics and myopic fundus lesion research showed a potential for ***-engineering cross-innovation is a cutting-edge technology trend.

关键词： High myopia theme change evolution research hotspot

Effectiveness and safety of traditional Chinese medical therapy for cancer-related fatigue: a systematic review and Meta-analysis of randomized controlled trials

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Journal of Traditional Chinese Medicine 2020年第5期40卷 738-748页

作者： Zhao Yueyang Wang Sumei Li Jinhua Zhou Yushu Wu Wanyin Swei Sunny Hann Department of Hematology Department of Medical OncologyLaboratory of Tumor BiologyGuangdong Provincial Hospital of Chinese MedicineThe Second Clinical Medical CollegeGuangzhou University of Chinese MedicineGuangzhouGuangdong Province 510120China

OBJECTIVE:To assess the effectiveness and safety of traditional Chinese medical therapy for cancer-related ***:We systematically searched eight electronic databases up to June 2017 for randomized clinical trials of traditional Chinese medical therapy for cancer-related *** authors independently extracted data and assessed the risk bias of the included trials using the Cochrane *** were analyzed by Rev Man 5.2 ***:A total of 23 trials involving 1832 participants identified with cancer-related fatigue were *** trials reported a beneficial effect of traditional Chinese medical therapy on cancer-related *** pooling the data from Chinese herbal medicine therapy and acupuncture or moxibustion therapy,respectively,significant differences were found between experimental groups and control *** improvement rates showed significant differences between traditional Chinese medical therapy and control groups[odds ratio(OR),7.62;95%confidence interval(CI),3.75-15.49;P<0.00001;and OR,3.78;95%CI,2.29-6.23;P<0.00001).Fatigue change scores also showed significant differences between the two groups(mean difference,-0.91;95%CI,-1.16 to-0.65;P<0.00001).Eleven trials demonstrated that traditional Chinese medical therapy improved the quality of life of cancer *** severe adverse effects occurred in traditional Chinese medical therapy ***:Meta-analysis showed that Chinese medical therapy seems to be effective and safe in the treatment of cancer-related fatigue.

关键词： Neoplasms Fatigue Medicine,Chinese Traditional Quality of life Systematic review Randomized clinical trial