Associations of HDL-C/LDL-C with myocardial infarction,all-cause mortality,haemorrhagic stroke and ischaemic stroke:a longitudinal study based on 384093 participants from the UK Biobank

作     者：Shiqi Yuan Xiaxuan Huang Wen Ma Rui Yang Fengshuo Xu Didi Han Tao Huang MIn Peng Anding Xu Jun Lyu 

作者机构：Department of NeurologyJinan University First Affiliated HospitalGuangzhouGuangdongChina School of Public HealthXi'an Jiaotong UniversityXi'anShaanxiChina Department of Clinical ResearchJinan University First Affiliated HospitalGuangzhouGuangdongChina Guangdong Provincial Key Laboratory of Traditional Chinese Medicine InformatizationGuangzhouGuangdongChina 

出 版 物：《Stroke & Vascular Neurology》 (卒中与血管神经病学（英文）)

年 卷 期：2023年第8卷第2期

页      面：119-126页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：infarction haemorrhagic restricted 

摘      要：Objective To explore the correlations of high-density lipoprotein cholesterol(HDL-C)/low-density lipoprotein cholesterol(LDL-C)with myocardial infarction(MI),all-cause mortality,haemorrhagic stroke and ischaemic stroke,as well as the joint association of genetic susceptibility and HDL-C/LDL-C with the MI *** and results This study selected 384093 participants from the UK Biobank(UKB)***,restricted cubic splines indicated non-linear associations of HDL-C/LDL-C with MI,ischaemic stroke and all-cause ***,a Cox proportional-hazards model indicated that compared with HDL-C/LDL-C=0.4-0.6,HDL-C/LDL-C0.6 were correlated with all-cause mortality(HR=0.97 for HDL-C/LDL-C0.6,95%CI=1.16 to 1.26,p0.6 was associated with higher risk haemorrhagic stroke risk after full multivariable adjustment(HR=1.25,95%CI=1.03 to 1.52,p0.05).Third,after calculating the coronary heart disease Genetic Risk Score(CHD-GRS)of each participant,the Cox proportional-hazards model indicated that compared with low CHD-GRS and HDL-C/LDL-C=0.4-0.6,participants with a combination of high CHD-GRS and HDL-C/LDL-C0.4 were associated with the highest MI risk(HR=2.45,95%CI=2.15 to 2.8,p0.001).Participants with HDL-C/LDL-C0.4 were correlated with a higher MI risk regardless of whether they had a high,intermediate or low *** In UKB participants,HDL-C/LDL-C ratio of 0.4-0.6 was correlated with lower MI risk,all-cause mortality,haemorrhagic stroke and ischaemic *** with HDL-C/LDL-C0.4 were correlated with a higher MI risk regardless of whether they had a high,intermediate or low *** clinical significance and impact of HDL-C/LDL-C need to be further