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Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang Li Li‑Jiao Wang Xiang‑Biao Qiu Jing‑Wen Li Wei Xu Tao Li Ze‑Bin Lin Chang‑Jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang Sun Jing‑Yu Tang Rong Zhang Han‑Tao Jing Bo Mei Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Zhen Chen Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei‑Hua Jia Hao‑Yu Jiang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang Bo Li Chao Li Gong Li Jia‑Wen Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑Bin Liu Guang‑Yuan Luan Bin‑Bin Qi Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑Cheng Wang Zhao‑Hui Wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Li‑Kun Xie Yi‑Wei Yang Han Yi Yong‑Ji Yu Guo‑Hui Zhang Lin‑Hao Zhang Mo‑Han Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Mao‑Yuan Zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State key laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State key laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State key laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China key laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

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Video-triggered EEG-emotion public databases and current methods: A survey

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神经科学(英文) 2020年第3期6卷 255-287页

作者： Wanrou Hu Gan Huang Linling Li Li Zhang Zhiguo Zhang Zhen Liang School of biomedical Engineering Health Science CenterShenzhen UniversityShenzhen 518060GuangdongChina guangdong Provincial key laboratory of biomedical measurements and ultrasound imaging Shenzhen 518060GuangdongChina Peng Cheng laboratory Shenzhen 518055GuangdongChina

Emotions,formed in the process of perceiving external environment,directly affect human daily life,such as social interaction,work efficiency,physical wellness,and mental *** recent decades,emotion recognition has become a promising research direction with significant application *** the advantages of electroencephalogram(EEG)signals(i.e.,high time resolution)and video-based external emotion evoking(i.e.,rich media information),video-triggered emotion recognition with EEG signals has been proven as a useful tool to conduct emotion-related studies in a laboratory environment,which provides constructive technical supports for establishing real-time emotion interaction *** this paper,we will focus on video-triggered EEG-based emotion recognition and present a systematical introduction of the current available video-triggered EEG-based emotion databases with the corresponding analysis ***,current video-triggered EEG databases for emotion recognition(e.g.,DEAP,MAHNOB-HCI,SEED series databases)will be presented with full ***,the commonly used EEG feature extraction,feature selection,and modeling methods in video-triggered EEG-based emotion recognition will be systematically summarized and a brief review of current situation about video-triggered EEG-based emotion studies will be ***,the limitations and possible prospects of the existing video-triggered EEG-emotion databases will be fully discussed.

关键词： emotion recognition EEG signals video-triggered emotion database

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Three-dimensional tracking of multiple particles in large depth of field using dual-objective bifocal plane imaging

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Chinese Optics Letters 2020年第7期18卷 72-76页

作者： Aiwang Huang Danni Chen Heng Li Dexiang Tang Bin Yu Jia Li Junle Qu key laboratory of Optoelectronic Devices and Systems of Ministry of Education and guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Shenzhen key laboratory of Biomedicine Engineering Shenzhen UniversityShenzhen 518060China key laboratory of Micro-Nano Measuring and imaging in biomedical Optics Shenzhen UniversityShenzhen 518060China

Tracking moving particles in cells by single particle tracking is an important optical approach widely used in biological research. In order to track multiple particles within a whole cell simultaneously, a parallel tracking approach with large depth of field was put forward. It was based on distorted grating and dual-objective bifocal imaging, making use of the distorted grating to expand the depth of field, dual-objective to gather as many photons as possible, and bifocal plane imaging to realize three-dimensional localization. Simulation of parallel tracking of two particles moving along the z axis demonstrated that even when the two are axially separated by10 μm, they can both be localized simultaneously with transversal precision better than 5 nm and axial precision better than 20 nm.

关键词： bifocal imaging dual-objective distorted grating depth of field

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AtMCM10 promotes DNA replication-coupled nucleosome assembly in Arabidopsis

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Journal of Integrative Plant Biology 2023年第1期65卷 203-222页

作者： Xinjie Zhao Jingyi Wang Dan Jin Jinkui Cheng Hui Chen Zhen Li Yu Wang Huiqiang Lou Jian-Kang Zhu Xuan Du Zhizhong Gong State key laboratory of Plant Physiology and Biochemistry College of Biological Sciences China Agricultural UniversityBeijing 100193 China National key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop Sciences The Chinese Academy of Agricultural SciencesBeijing 100081 China State key laboratory of Agro-Biotechnology College of Biological Sciences China Agricultural UniversityBeijing 100193 China key laboratory of Molecular Design for Plant Cell Factory of guangdong Higher Education Institutes Institute of Plant and Food ScienceSchool of Life ScienceDepartment of Biology Southern University of Science and TechnologyShenzhen 518055 China Department of Biochemistry and Molecular Biology International Cancer Center Shenzhen University Medical SchoolShenzhen 518060 China guangdong key laboratory for biomedical measurements and ultrasound imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical Engineering Shenzhen University Medical SchoolShenzhen 518060 China School of Life Science Institute of Life Science and Green Development Hebei UniversityBaoding 071002 China

Minichromosome Maintenance protein 10(MCM10)is essential for DNA replication initiation and DNA elongation in yeasts and *** the functions of MCM10 in DNA replication and repair have been well documented,the detailed mechanisms for MCM10 in these processes are not well ***,we identified AtMCM10 gene through a forward genetic screening for releasing a silenced marker *** plant MCM10 possesses a similar crystal structure as animal MCM10,AtMCM10 is not essential for plant growth or development in ***10 can directly bind to histone H3-H4 and promotes nucleosome assembly in *** nucleosome density is decreased in Atmcm10,and most of the nucleosome density decreased regions in Atmcm10 are also regulated by newly synthesized histone chaperone Chromatin Assembly Factor-1(CAF-1).Loss of both AtMCM10 and CAF-1 is embryo lethal,indicating that AtM CM10 and CAF-1 are indispensable for replication-coupled nucleosome ***10 interacts with both new and parental ***10 mutants have lower H3.1abundance and reduced H3K27me1/3 levels with releasing some silenced *** propose that AtM CM10 deposits new and parental histones during nucleosome assembly,maintaining proper epigenetic modifications and genome stability during DNA replication.

关键词： AtMCM10 H3K27me1 nucleosomes assembly

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A proton birdcage coil integrated with interchangeable single loops for multi-nuclear MRI/MRS

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 168-180页

作者： Yi ZHANG Zhiyan QUAN Feiyang LOU Yujiao FANG Garth J.THOMPSON Gao CHEN Xiaotong ZHANG Department of Neurosurgery the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009China key laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases Hangzhou310009China MOE Frontier Science Center for Brain Science and Brain-machine Integration Zhejiang UniversityHangzhou310058China Interdisciplinary Institute of Neuroscience and Technology College of Biomedical Engineering&Instrument ScienceZhejiang UniversityHangzhou310027China School of Medicine Zhejiang UniversityHangzhou310020China iHuman Institute School of Life Science and TechnologyShanghaiTech UniversityShanghai201210China College of Electrical Engineering Zhejiang UniversityHangzhou310027China

Energy metabolism is fundamental for *** encompasses the utilization of carbohydrates,lipids,and proteins for internal processes,while aberrant energy metabolism is implicated in many *** the present study,using three-dimensional(3D)printing from polycarbonate via fused deposition modeling,we propose a multi-nuclear radiofrequency(RF)coil design with integrated 1H birdcage and interchangeable X-nuclei(^(2)H,^(13)C,^(23)Na,and^(31)P)single-loop coils for magnetic resonance imaging(MRI)/magnetic resonance spectroscopy(MRS).The single-loop coil for each nucleus attaches to an arc bracket that slides unrestrictedly along the birdcage coil inner surface,enabling convenient switching among various nuclei and animal *** to a commercial 1H birdcage coil,the proposed 1H birdcage coil exhibited superior signal-excitation homogeneity and imaging signal-to-noise ratio(SNR).For X-nuclei study,prominent peaks in spectroscopy for phantom solutions showed excellent SNR,and the static and dynamic peaks of in vivo spectroscopy validated the efficacy of the coil design in structural imaging and energy metabolism detection simultaneously.

关键词： Energy metabolism Magnetic resonance imaging(MRI) Magnetic resonance spectroscopy(MRS) Multi-nuclear Radiofrequency coil Three-dimensional(3D)printing

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Synergistic integration of metal nanoclusters and biomolecules as hybrid systems for therapeutic applications

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Acta Pharmaceutica Sinica B 2021年第5期11卷 1175-1199页

作者： Peng Gao Xin Chang Dagan Zhang Yafei Cai Gen Chen Hao Wang Tianfu Wang guangdong key laboratory of biomedical measurements and ultrasound imaging Department of Biomedical EngineeringShenzhen UniversityShenzhen 518060China State key laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China key laboratory of Biomedicine in Gene Diseases and Health of Anhui Higher Education Institutes College of Life SciencesAnhui Normal UniversityWuhu 241000China College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China School of Materials Science and Engineering Central South UniversityChangsha 410083China College of Energy Soochow Institute for Energy and Materials Innovationsand Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou 215006China

Therapeutic nanoparticles are designed to enhance efficacy,real-time monitoring,targeting accuracy,biocompatibility,biodegradability,safety,and the synergy of diagnosis and treatment of diseases by leveraging the unique physicochemical and biological properties of well-developed ***,bio-inspired metal nanoclusters(NCs)consisting of several to roughly dozens of atoms(imaging,and enhanced therapeutic and biocatalytic *** contrast to larger nanoparticles,bio-inspired metal NCs allow rapid renal clearance and better pharmacokinetics in biological ***,advances in nanoscience,interfacial chemistry,and biotechnologies have further spurred researchers to explore bio-inspired metal NCs for therapeutic *** current review presents a comprehensive and timely overview of various metal NCs for various therapeutic applications,with a special emphasis on the design rationale behind the use of biomolecules/cells as the main *** the different hybrid platform,we summarize the current challenges and emerging perspectives,which are expected to offer in-depth insight into the rational design of bio-inspired metal NCs for personalized treatment and clinical translation.

关键词： Metal nanoclusters Biomolecule Nanoparticles Hybrid system Synergistic properties Fluorescence Bioprobe Therapy

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Magneto-mechanical effect of magnetic microhydrogel for improvement of magnetic neuro-stimulation

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Nano Research 2023年第5期16卷 7393-7404页

作者： Le Xue Qing Ye Linyuan Wu Dong Li Siyuan Bao Qingbo Lu Sha Liu Dongke Sun Zonghai Sheng Zhijun Zhang Ning Gu Jianfei Sun State key laboratory of Bioelectronics Jiangsu Key Laboratory of Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210009China School of Mechanic Engineering Southeast UniversityNanjing 211189China Department of Neurology Affiliated Zhongda HospitalSchool of MedicineInstitution of NeuropsychiatrySoutheast UniversityNanjing 210009China Paul C.Lauterbur Research Center for biomedical imaging Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong ProvinceShenzhen Key Laboratory of Ultrasound Imaging and TherapyCAS Key Laboratory of Health InformaticsInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Mental Health and Public Health Faculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Medicine Nanjing UniversityNanjing 210008China

Superparamagnetic iron oxide(SPIO)nanoparticles play an important role in mediating precise and effective magnetic neurostimulation and can help overcome limitations related to penetration depth and spatial ***,nanoparticles readily diffuse in vivo,decreasing the spatial resolution and activation *** this study,we employed a microfluidic means to fabricate injectable microhydrogels encapsulated with SPIO nanoparticles,which significantly improved the stability of nanoparticles,increased the magnetic properties,reinforced the stimulation *** fabricated magnetic microhydrogels were highly uniform in size and sphericity,enabling minimally invasive injection into brain *** long-term residency in the cortex up to 22 weeks and the safety of brain tissue were shown using a mouse *** addition,we quantitatively determined the magneto-mechanical force yielded by only one magnetic microhydrogel using a video-based *** force was found to be within 7–8 pN under 10 Hz magnetic stimulation by both theoretical simulation and experimental ***,electrophysiological measurement of brain slices showed that the magnetic microhydrogels offer significant advantages in terms of neural activation relative to dissociative SPIO nanoparticles.A universal strategy is thus offered for performing magnetic neuro-stimulation with an improved prospect for biomedical translation.

关键词： magnetic stimulation superparamagnetic iron oxide(SPIO)nanoparticles magnetic microhydrogel long-term residency magneto-mechanical effect

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New discoveries in the field of metabolism by applying single-cell and spatial omics

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药物分析学报:英文版 2023年第7期13卷 711-725页

作者： Baocai Xie Dengfeng Gao Biqiang Zhou Shi Chen Lianrong Wang Department of Critical Care Medicine Shenzhen Institute of Translational MedicineShenzhen Second People's HospitalThe First Affiliated Hospital of Shenzhen UniversityGuangdong Key Laboratory for Biomedical Measurements and Ultrasound ImagingNational-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringShenzhen University Medical SchoolShenzhenGuangdong518060China Department of Respiratory Diseases The Research and Application Center of Precision MedicineThe Second Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou450014China State key laboratory of Animal Biotech Breeding College of Biological SciencesChina Agricultural UniversityBeijing100193China Department of Geriatric&Spinal Pain Multi-Department Treatment Shenzhen Second People's HospitalThe First Affiliated Hospital of Shenzhen UniversityHealth Science CenterShenzhenGuangdong518035China Department of Gastroenterology Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug DiscoveryZhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan430071China

Single-cell multi-Omics(SCM-Omics)and spatial multi-Omics(SM-Omics)technologies provide state-of-the-art methods for exploring the composition and function of cell types in tissues/*** its emergence in 2009,single-cell RNA sequencing(scRNA-seq)has yielded many groundbreaking new *** combination of this method with the emergence and development of SM-Omics techniques has been a pioneering strategy in neuroscience,developmental biology,and cancer research,especially for assessing tumor heterogeneity and T-cell *** recent years,the application of these methods in the study of metabolic diseases has also *** emerging SCM-Omics and SM-Omics approaches allow the molecular and spatial analysis of cells to explore regulatory states and determine cell fate,and thus provide promising tools for unraveling heterogeneous metabolic processes and making them amenable to ***,we review the evolution of SCM-Omics and SM-Omics technologies,and describe the progress in the application of SCM-Omics and SM-Omics in metabolism-related diseases,including obesity,diabetes,nonalcoholic fatty liver disease(NAFLD)and cardiovascular disease(CVD).We also conclude that the application of SCM-Omics and SM-Omics approaches can help resolve the molecular mechanisms underlying the pathogenesis of metabolic diseases in the body and facilitate therapeutic measures for metabolism-related *** review concludes with an overview of the current status of this emerging field and the outlook for its future.

关键词： SCM-Omics SM-Omics Obesity Diabetes NAFLD CVD

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Centimeter-Deep NIR-II Fluorescence imaging with Nontoxic AIE Probes in Nonhuman Primates

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Research 2020年第1期2020卷 652-665页

作者： Zonghai Sheng Yaxi Li Dehong Hu Tianliang Min Duyang Gao Jen-Shyang Ni Pengfei Zhang Yuenan Wang Xin Liu Kai Li Hairong Zheng Ben Zhong Tang Paul C.Lauterbur Research Center for biomedical imaging Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong ProvinceShenzhen Key Laboratory of Ultrasound Imaging and TherapyCAS Key Laboratory of Health InformaticsInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of biomedical Engineering Southern University of Science and Technology(SUSTech)Shenzhen 518055China Department of Radiation Oncology National Cancer CenterNational Clinical Research Center for CancerCancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518055China Department of Chemistry The Hong Kong University of Science&TechnologyClear Water BayKowloonHong KongChina

Fluorescence probes with aggregation-induced emission(AIE)characteristics are of great importance in biomedical imaging with superior spatial and temporal ***,the lack of toxicity studies and deep tissue imaging in nonhuman primates hinders their clinical ***,we report the blood chemistry and histological analysis in nonhuman primates treated with AIE probes over tenfold of an intravenous dose of clinically used indocyanine green(ICG)during a study period of 36 days to demonstrate AIE probes are ***,through bright and nontoxic AIE probes and fluorescence imaging in the second window(NIR-II,1,000-1,700 nm),we achieve an unprecedented 1.5-centimeter-deep vascular imaging in nonhuman primates,breaking the current limitation of millimeter-deep NIR-II fluorescence *** important findings,i.e.,nontoxic features of AIE probes and centimeter-deep NIR-II vascular imaging in nonhuman primates,may facilitate successful translation of AIE probes in clinical trials.

关键词： Fluorescence Probe breaking

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Effect of persistent high intraocular pressure on microstructure and hydraulic permeability of trabecular meshwork

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Chinese Physics B 2015年第5期24卷 606-613页

作者：梅曦任琳许强郑炜刘志成 School of biomedical Engineering Capital Medical University Beijing key laboratory of Fundamental Research on Biomechanics in Clinical Application Shenzhen key laboratory for Molecular imaging Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences

As the aqueous humor leaves the eye, it first passes through the trabecular meshwork （TM）. Increased flow resistance in this region causes elevation of intraocular pressure （IOP）, which leads to the occurrence of glaucoma. To quantitatively evaluate the effect of high IOP on the configuration and hydraulic permeability of the TM, second harmonic generation （SHG） microscopy was used to image the microstructures of the TM and adjacent tissues in control （normal） and high IOP conditions. Enucleated rabbit eyes were perfused at a pressure of 60 mmHg to achieve the high lOP. Through the anterior chamber of the eye, in situ images were obtained from different depths beneath the surface of the TM. Porosity and specific surface area of the TM in control and high IOP conditions were then calculated to estimate the effect of the high pressure on the permeability of tissue in different depths. We further photographed the histological sections of the TM and compared the in situ images. The following results were obtained in the control condition, where the region of depth was less than 55 μm with crossed branching beams and large pores in the superficial TM. The deeper meshwork is a silk-like tissue with abundant fluorescence separating the small size of pores. The total thickness of pathway tissues composed of TM and juxtacanalicular （JCT） is more than 100 p.m. After putting a high pressure on the inner wall of the eye, the TM region progressively collapses and decreases to be less than 40 μm. Fibers of the TM became dense, and the porosity at 34 μm in the high IOP condition is comparable to that at 105 μm in the control condition. As a consequent result, the permeability of the superficial TM decreases rapidly from 120 μm2 to 49.6 μm2 and that of deeper TM decreases from 1.66 μm2 to 0.57 μm2. Heterogeneity reflected by descent in permeability reduces from 12.4 μm of the control condition to 3.74 μm of the high IOP condition. The persistently high IOP makes the TM region colla

关键词： trabecular meshwork hydraulic permeability intraocular pressure glaucoma

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