Magneto-mechanical effect of magnetic microhydrogel for improvement of magnetic neuro-stimulation
作者机构：State Key Laboratory of BioelectronicsJiangsu Key Laboratory of Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210009China School of Mechanic EngineeringSoutheast UniversityNanjing 211189China Department of NeurologyAffiliated Zhongda HospitalSchool of MedicineInstitution of NeuropsychiatrySoutheast UniversityNanjing 210009China Paul C.Lauterbur Research Center for Biomedical ImagingKey Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong ProvinceShenzhen Key Laboratory of Ultrasound Imaging and TherapyCAS Key Laboratory of Health InformaticsInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Mental Health and Public HealthFaculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of MedicineNanjing UniversityNanjing 210008China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第5期
页 面：7393-7404页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 081702[工学-化学工艺] 1002[医学-临床医学] 08[工学] 0817[工学-化学工程与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学]
基 金：the National Key Research and Development Program of China(No.2021YFA1201403 to J.F.S.) China Science and Technology Innovation 2030-Major Project(Nos.2022ZD0211701 to Z.J.Z.and 2022ZD0211704 to J.F.S.) the National Natural Science Key Foundation of China(Nos.81830040 and 82130042 to Z.J.Z.) the Science and Technology Program of Guangdong(No.2018B030334001 to Z.J.Z.) the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.SJCX21_0146 to L.X.)
主 题：magnetic stimulation superparamagnetic iron oxide(SPIO)nanoparticles magnetic microhydrogel long-term residency magneto-mechanical effect
摘 要：Superparamagnetic iron oxide(SPIO)nanoparticles play an important role in mediating precise and effective magnetic neurostimulation and can help overcome limitations related to penetration depth and spatial ***,nanoparticles readily diffuse in vivo,decreasing the spatial resolution and activation *** this study,we employed a microfluidic means to fabricate injectable microhydrogels encapsulated with SPIO nanoparticles,which significantly improved the stability of nanoparticles,increased the magnetic properties,reinforced the stimulation *** fabricated magnetic microhydrogels were highly uniform in size and sphericity,enabling minimally invasive injection into brain *** long-term residency in the cortex up to 22 weeks and the safety of brain tissue were shown using a mouse *** addition,we quantitatively determined the magneto-mechanical force yielded by only one magnetic microhydrogel using a video-based *** force was found to be within 7–8 pN under 10 Hz magnetic stimulation by both theoretical simulation and experimental ***,electrophysiological measurement of brain slices showed that the magnetic microhydrogels offer significant advantages in terms of neural activation relative to dissociative SPIO nanoparticles.A universal strategy is thus offered for performing magnetic neuro-stimulation with an improved prospect for biomedical translation.
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