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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao Hongmei Duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina guangdong-HongKong-Macao institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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Near-infrared organic photosensitizers with aggregation-induced emission and switchable fluorescence for fungal infection therapy

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Science China Chemistry 2025年

作者： Xinzhe Yang Zixuan Huang Keke Ding Huili Yang Lirong Wang Qing Xia Rong Hu Guang Shi Bingjia Xu Anjun Qin School of Chemistry South China Normal University State Key Laboratory of Luminescent Materials and devices Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates Center for Aggregation-Induced Emission AIE Institute South China University of Technology Department of Urology The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College) School of Chemistry and Chemical Engineering University of South China

The development of near-infrared (NIR) photosensitizers with aggregation-induced emission (AIE) properties,switchable luminescence colors,and satisfactory photodynamic therapy (PDT) effects on the treatment of fungal infection is of great importance but very ***,two ionic organic luminogens are constructed by employing diphenylamine,diphenylacrylonitrile/1,2-diphenylethene,and methylated quinoline cation as building *** is found that the resulting compounds TCQF and TQF show apparent AIE properties and produce intense fluorescence with high photoluminescence quantum yields of up to 31.2%in the solid *** the meantime,their emission colors can be switched between red and NIR and in the NIR region by mechanical force and solvent vapor,respectively,thereby enabling remarkable and reversible mechanochromism with emission variations of up to 104 *** excitingly,TCQF and TQF can efficiently generate ROS under the illumination of white light and show excellent antimicrobial activities and satisfactory PDT *** by the unique anti-fungus properties,TCQF is employed as a biocompatible NIR photosensitizer for treating wound infection with ***,and apparent PDT effects are *** work provides a new direction for the development of multifunctional NIR materials with AIE properties.

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Micropatterned composite membrane guides oriented cell growth and vascularization for accelerating wound healing

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Regenerative biomaterials 2023年第1期10卷 344-353页

作者： Jiaqi Li Xulong Liu Weiyong Tao Yan Li Yingying Du Shengmin Zhang advanced biomaterials and Tissue Engineering Center Huazhong University of Science and TechnologyWuhan 430074China NMPA Research Base of Regulatory Science for medical devices&institute of Regulatory Science for medical devices Huazhong University of Science and TechnologyWuhan 430074China institute of biomaterials and medical devices Wuhan Institute of Industrial Innovation and DevelopmentWuhan 430074China Department of Biomedical Engineering Huazhong University of Science and TechnologyWuhan 430074China

Skin defect is common in daily life,but repairing large skin defects remains a *** biomaterials to deliver biochemical or physical factors to promote skin tissue regeneration is of great significance for accelerating wound *** surface micropatterns on biomaterials could affect cell behavior and tissue ***,few studies have focused on the construction of wound healing biomaterials with surface micropatterns and their role in skin tissue *** the present study,gelatin-polycaprolactone/silk fibroin composite membranes with different micropatterns were fabricated by photolithography,including line,grid and plane *** vitro cell experiments demonstrated that the line micropattern on the composite membrane could guide cell-oriented growth,and more importantly,promote the expression of angiogenesis-related markers andα-smooth muscle actin(α-SMA)at both gene level and protein *** the rat full-thickness skin defect model,the composite membrane with line micropatterns increasedα-SMA production and neovascularization in wounds,leading to accelerated wound contraction and *** current study not only suggests that composite membranes with specific micropatterns can be promising wound repair materials but also provides new insights into the importance of biomaterial surface topology for tissue regeneration.

关键词： topology cell behavior wound healing gelatin polymer biomaterials

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3D micropattern force triggers YAP nuclear entry by transport across nuclear pores and modulates stem cells paracrine

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National Science Review 2023年第8期10卷 180-193页

作者： Yan Li Zhenyu Zhong Cunjing Xu Xiaodan Wu Jiaqi Li Weiyong Tao Jianglin Wang Yingying Du Shengmin Zhang advanced biomaterials and Tissue Engineering Center Huazhong University of Science and Technology Department of Biomedical Engineering Huazhong University of Science and Technology Research Base of Regulatory Science for medical devices National Medical Products Administration&Institute of Regulatory Science for Medical Devices Huazhong University of Science and Technology

Biophysical cues of the cellular microenvironment tremendously influence cell behavior by mechanotransduction. However, it is still unclear how cells sense and transduce the mechanical signals from 3D geometry to regulate cell function. Here, the mechanotransduction of human mesenchymal stem cells(MSCs) triggered by 3D micropatterns and its effect on the paracrine of MSCs are systematically investigated. Our findings show that 3D micropattern force could influence the spatial reorganization of the cytoskeleton, leading to different local forces which mediate nucleus alteration such as orientation,morphology, expression of Lamin A/C and chromatin condensation. Specifically, in the triangular prism and cuboid micropatterns, the ordered F-actin fibers are distributed over and fully transmit compressive forces to the nucleus, which results in nuclear flattening and stretching of nuclear pores, thus enhancing the nuclear import of YES-associated protein(YAP). Furthermore, the activation of YAP significantly enhances the paracrine of MSCs and upregulates the secretion of angiogenic growth factors. In contrast, the fewer compressive forces on the nucleus in cylinder and cube micropatterns cause less YAP entering the *** skin repair experiment provides the first in vivo evidence that enhanced MSCs paracrine by 3D geometry significantly promotes tissue regeneration. The current study contributes to understanding the in-depth mechanisms of mechanical signals affecting cell function and provides inspiration for innovative design of biomaterials.

关键词： bioactive materials tissue regeneration 3D micropattern force paracrine mechanotransduction

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Recent advances in surface endothelialization of the magnesium alloy stent materials

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Journal of Magnesium and Alloys 2023年第1期11卷 48-77页

作者： Changjiang Pan Xuhui Liu Qingxiang Hong Jie Chen Yuxin Cheng Qiuyang Zhang Lingjie Meng Juan Dai Zhongmei Yang Lingren Wang Faculty of Mechanical and Material Engineering Jiangsu Provincial Engineering Research Center for Biomaterials and Advanced Medical DevicesHuaiyin Institute of TechnologyHuai’an 223003China The Affiliated Huai’an Hospital of Xuzhou medical University Huai’an 223003China

Magnesium and its alloy have good mechanical properties and biodegradability,and have become the hotspot of the next-generation biodegradable vascular stent ***,their rapid degradation in vivo and poor biocompatibility are still the bottlenecks of clinical applications for the cardiovascular *** particular,how to induce the repair and regeneration of the vascular endothelial with normal physiological functions on the surface of the magnesium alloy stent materials represents the key to its clinical application in the field of cardiovascular *** has been believed that it is an ideal way to completely solve the postoperative complications through constructing the multifunctional anti-corrosive bioactive coating on the magnesium alloy surface to induce the formation of vascular endothelium with normal physiological ***,how to construct a corrosion-resistant multifunctional bioactive coating with the good endothelial regeneration abilities on the magnesium alloy surface still faces a great *** paper mainly focused on highlighting and summarizing the recent advances in the surface endothelialization of the magnesium alloy materials for the vascular stent,including the bio-inert coating,in-situ immobilization of bioactive molecules on the surface,polymer coating loaded with bioactive factors,novel multifunctional polymer coating,bioactive micropatterns,bioactive layer with glycocalyx-like structure,NO-releasing coating and bioactive sol-gel *** advantages and disadvantages of these strategies were discussed and ***,in the senses of future development and clinical application,this paper analyzed and summarized the development direction and prospect of surface endothelialization of the magnesium alloy vascular *** is anticipated that this review can give the new cues to the surface endothelialization of the cardiovascular magnesium alloy stents and promote future advancements in this field.

关键词： Magnesium alloy Stent Endothelialization Surface coating Surface modification

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Magnetofection:Magic magnetic nanoparticles for efficient gene delivery

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Chinese Chemical Letters 2020年第12期31卷 3041-3046页

作者： Qunjie Bi Xu Song Ao Hu Tianying Luo Rongrong Jin Hua Ai Yu Nie National Engineering Research Center for biomaterials Sichuan UniversityChengdu 610064China institute of Regulatory Science for medical devices National Engineering Research Center for BiomaterialsSichuan UniversityChengdu 610064China

Magnetic nanoparticles(MNPs)have become a research hotspot and widely used in the biomedical field in recent decades due to their unique magnetic *** minireview summarizes the specific gene transfection of magnetic particles(magnetofection)during eversy dynamic process of gene delivery(gene binding,cellular uptake,endosomal escape,intracellular trafficking and in vivo targeting).Meanwhile,the synergistic biomedical application of magnetofection and the effects of MNPs have also been discussed,including magnetic resonance imaging(MRI),magnetic mediated hyperthermia(MMH),Fenton reaction and ***,the clinical prospect of magnetofection was briefly expected.

关键词： Magnetic nanoparticles Magentofection Gene therapy Biomedical applications Combined therapy

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Cancer-macrophage hybrid membrane-camouflaged photochlor for enhanced sonodynamic therapy against triple-negative breast cancer

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Nano Research 2022年第5期15卷 4224-4232页

作者： Lishan Zhang Ting Yin Baozhen Zhang Chong Yan Chengyu Lu Lanlan Liu Ze Chen Hui Ran Qingxia Shi Hong Pan Aiqing Ma Lintao Cai guangdong Key Laboratory for Research and Development of Natural Drugs Key Laboratory for NanomedicineGuangdong Medical UniversityDongguan 523808China guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsShenzhen Engineering Laboratory of Nanomedicine and NanoformulationsInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen 518055China

Sonodynamic therapy(SDT)has aroused considerable momentum in cancer therapy due to its abilities of deep penetration,low toxicity,and noninvasion,while insufficient tumor accumulation of sonosensitizers is a major obstacle for SDT ***,we developed a 4T1 cancer cell-macrophage hybrid membrane(HM)-camouflaged sonosensitizer nanoplatform by encapsulating photochlor(HPPH)-loaded albumin nanoparticles(PHNPs).The experimental results proved that the HM-coated biomimetic NPs(PHNPs@HM)could express the characteristic membrane proteins of both cancer cells and macrophages,remarkedly enhancing the effective targeting and endocytosis to 4T1 cells through homologous adhesion recognition and immune ***,as a novel sonosensitizer,HPPH could generate amount of reactive oxygen species(ROS)under ultrasound(US)irradiation and exhibit obvious SDT efficiency to inhibit 4T1 tumor growth through ROS-induced cell *** study provides a novel and multifunctional biomimetic sonosensitizer system to enhance SDT efficiency.

关键词： biomimetic materials sonodynamic therapy hybrid cell membrane photochlor sonosensitizer noninvasive treatment

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3D printed pore morphology mediates bone marrow stem cell behaviors via RhoA/ROCK2 signaling pathway for accelerating bone regeneration

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Bioactive Materials 2023年第8期26卷 413-424页

作者： Qiji Lu Jingjing Diao Yingqu Wang Jianlang Feng Fansen Zeng Yan Yang Yudi Kuang Naru Zhao Yingjun Wang School of Materials Science and Engineering South China University of TechnologyGuangzhou510641PR China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou510006PR China NMPA Key Laboratory for Research and Evaluation of Innovative biomaterials for medical devices.Guangzhou 510006PR China medical devices Research&Testing Center of SCUT Guangzhou510006PR China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou511442PR China guangdong institute of advanced biomaterials and medical devices Guangzhou510535PR China

Bone bionics and structural engineering have sparked a broad interest in optimizing artificial scaffolds for better bone ***,the mechanism behind scaffold pore morphology-regulated bone regeneration remains unclear,making the structure design of scaffolds for bone repair *** address this issue,we have carefully assessed diverse cell behaviors of bone mesenchymal stem cells(BMSCs)on theβ-tricalcium phosphate(β-TCP)scaffolds with three representative pore morphologies(i.e.,cross column,diamond,and gyroid pore unit,respectively).Among the scaffolds,BMSCs on theβ-TCP scaffold with diamond pore unit(designated as D-scaffold)demonstrated enhanced cytoskeletal forces,elongated nucleus,faster cell mobility,and better osteogenic differentiation potential(for example,the alkaline phosphatase expression level in D-scaffold were 1.5-2 times higher than other groups).RNA-sequencing analysis and signaling pathway intervention revealed that Ras homolog gene family A(RhoA)/Rho-associated kinase-2(ROCK2)has in-depth participated in the pore morphology-mediated BMSCs behaviors,indicating an important role of mechanical signaling transduction in scaffold-cell ***,femoral condyle defect repair results showed that D-scaffold could effectively promote endogenous bone regeneration,of which the osteogenesis rate was 1.2-1.8 times higher than the other ***,this work provides insights into pore morphology-mediated bone regeneration mechanisms for developing novel bioadaptive scaffold designs.

关键词： Bone mesenchymal stem cells 3D-printed scaffold Pore morphology Bone regeneration Structure-osteogenesis relationship

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Chelating ligand-bridged IO-Gd nanoparticles with enhanced contrast performance for dual-mode MRI

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Journal of Materials Science & Technology 2024年第17期184卷 54-63页

作者： Lili Hao Haoyang Ding Xiangchuan Xu Hongli Mao Zhongwei Gu Research institute for biomaterials Tech Institute for Advanced MaterialsBio-inspired Biomedical Materials&Devices CenterCollege of Materials Science and EngineeringJiangsu Collaborative Innovation Center for Advanced Inorganic Function CompositesSuqian Advanced Materials Industry Technology Innovation CenterNanjing Tech UniversityNanjing 211816China NJTech-BARTY Joint Research Center for Innovative medical Technology Nanjing 210000China

Magnetic resonance imaging(MRI)is a non-invasive medical imaging technique that has been widely applied in the clinical diagnosis of diseases across various ***,there is a dearth of high-performance dual-mode contrast agents that provide precise diagnostic information for complex *** this study,iron oxide-gadolinium nanoparticles(IO-Gd NPs)bridged by hydrophilic ligand ethylenedi-amine tetramethylenephosphonic acid(EDTMP)are designed inspired by Solomon-Bloembergen-Morgan(SBM)theory,where T_(1)and T_(2)relaxivity increase with a reduction in Gd *** particular,the NPs with minimum Gd content exhibit excellent dual-mode contrast performance(r_(1)=94.42 mM^(−1)s^(−1),r_(2)=343.62 mM^(−1)s^(−1)).The underlying mechanism is that the bridged EDTMP coordinate limits Gd tum-bling and forces Gd^(3+)to expose itself to the surface of the *** provides more opportunities for water molecules to coordinate with Gd^(3+)and significantly enhances proton ***,the hy-drophilicity of the ligand enhances the water dispersion stability of the NPs and increases the exchange rate of water protons near the NPs,further enhancing the dual-mode contrast ***,the biocom-patibility and in vitro/vivo imaging performances of the IO@EDTMP-Gd NPs are systematically evaluated,and the results demonstrate their potential as dual-mode contrast *** study provides a new strategy for developing dual-mode MRI contrast agents that can further improve the accuracy of MRI in the diagnosis of complex diseases.

关键词： Magnetic resonance imaging Dual-mode contrast agent Chelating ligand Iron oxide Gadolinium

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The morphology of hydroxyapatite nanoparticles regulates clathrinmediated endocytosis in melanoma cells and resultant anti-tumor efficiency

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Nano Research 2022年第7期15卷 6256-6265页

作者： Hongfeng Wu Yuchen Hua Jinjie Wu Qin Zeng Xiao Yang Xiangdong Zhu Xingdong Zhang National Engineering Research Center for biomaterials Sichuan UniversityChengdu 610064China NMPA Key Laboratory for Quality Research and Control of Tissue Regenerative biomaterials&institute of Regulatory Science for medical devices&NMPA Research Base of Regulatory Science for medical devices Sichuan UniversityChengdu 610064China Research Center for Materials Genome Engineering Sichuan UniversityChengdu 610064China

Clathrin-mediated endocytosis plays a critical role for hydroxyapatite nanoparticles(HANPs)to enter tumor cells,induce mitochondrial apoptosis,and inhibit tumor *** study was aimed to investigate how the morphology of HANPs impacts the endocytosis of the particles in melanoma cells,and their anti-tumor effect by using in vitro cell experiments and in vivo tumor animal *** shapes of HANPs,including granular HANPs(G-HANPs),rod-like HANPs(R-HANPs),and needle-like HANPs(N-HANPs),were successfully prepared by wet chemical *** the three HANPs could be internalized into A375 melanoma cells as indicated by cellular transmission electron microscopy *** these HANPs,only G-HANPs induced morphological change of mitochondria and loss of mitochondrial membrane potential(Δψm),and exhibited the greatest intracellular internalization efficiency in the tumor ***,the results of immunofluorescence staining and western blotting indicated that the level of adaptin-2(AP2)protein was up-regulated by all the HANPs,and highest in G-HANPs treated A375 ***,in the tumor-bearing mouse model,we found that tumor growth was delayed by all the three HANPs,of which,G-HANPs delayed tumor growth most efficiently and presented a highest expression level of AP2 protein in tumor ***,this study suggested that the morphology of HANPs regulated their endocytosis efficiency and their effect to inhibit tumor *** work facilitates to direct the rational design of nano-materials for tumor therapy.

关键词： hydroxyapatite nanoparticles adaptin-2 protein morphology endocytosis anti-tumor effect

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