Micropatterned composite membrane guides oriented cell growth and vascularization for accelerating wound healing

作     者：Jiaqi Li Xulong Liu Weiyong Tao Yan Li Yingying Du Shengmin Zhang 

作者机构：Advanced Biomaterials and Tissue Engineering CenterHuazhong University of Science and TechnologyWuhan 430074China NMPA Research Base of Regulatory Science for Medical Devices&Institute of Regulatory Science for Medical DevicesHuazhong University of Science and TechnologyWuhan 430074China Institute of Biomaterials and Medical DevicesWuhan Institute of Industrial Innovation and DevelopmentWuhan 430074China Department of Biomedical EngineeringHuazhong University of Science and TechnologyWuhan 430074China 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2023年第10卷第1期

页      面：344-353页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supported by the National Natural Science Foundation of China(31870960,32171331 and 82130061) the Fundamental Research Funds for the Central Universities,Huazhong University of Science and Technology(2019kfyXMBZ021 and 2020kfyXJJS115) 

主　　题：topology cell behavior wound healing gelatin polymer biomaterials 

摘      要：Skin defect is common in daily life,but repairing large skin defects remains a *** biomaterials to deliver biochemical or physical factors to promote skin tissue regeneration is of great significance for accelerating wound *** surface micropatterns on biomaterials could affect cell behavior and tissue ***,few studies have focused on the construction of wound healing biomaterials with surface micropatterns and their role in skin tissue *** the present study,gelatin-polycaprolactone/silk fibroin composite membranes with different micropatterns were fabricated by photolithography,including line,grid and plane *** vitro cell experiments demonstrated that the line micropattern on the composite membrane could guide cell-oriented growth,and more importantly,promote the expression of angiogenesis-related markers andα-smooth muscle actin(α-SMA)at both gene level and protein *** the rat full-thickness skin defect model,the composite membrane with line micropatterns increasedα-SMA production and neovascularization in wounds,leading to accelerated wound contraction and *** current study not only suggests that composite membranes with specific micropatterns can be promising wound repair materials but also provides new insights into the importance of biomaterial surface topology for tissue regeneration.