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Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi Pradeepkiran Priyanka Rawat Arubala P.Reddy Erika Orlov PHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of Pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of Public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAP-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

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Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing Chen Chao Wu Xiaoling Liu Biao Meng Tao Chen Yu Han Jun Wang Shibo Xi Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

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Effects of In-situ Generated Coinage Nanometals on Crystallization and Microstructure of Fluorophlogopite Mica Containing glass-Ceramics

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Journal of Materials Science & technology 2015年第1期31卷 110-119页

作者： Mrinmoy Garai Nibedita Sasmal Atiar Rahaman Molla Anal Tarafder Basudeb Karmakar glass Science & technology Section Glass DivisionCSIR-Central Glass & Ceramic Research Institute

The effects of in-situ generated coinage nanometals（Cu,Ag and Au） on crystallization behavior,microstructure,thermal and mechanical properties of SiO2-MgO-Al2O3-B2O3-K2O-MgF2（BMAPS） glassceramics were systematically *** addition of coinage nanometai,the glass transition temperature（Tg） is increased by 20-30 ℃,crystallization temperature（Tc） by 30-50 ℃ and dilatometric softening temperature（Td） by 10-25 ℃.It was found that the density of Cu-containing glass was 2.59 g cm-3and for other glasses it was in the range of 2.56-2.57 g *** the non-isothermal differential scanning calorimetry study,the activation energy of crystallization for BMAPS base glass was calculated as 344 kJ/mol,and changed to 406,334 and 274 kJ/mol on addition of Cu,Ag and Au-nanometals,*** evolved in the opaque BMAPS glass-ceramics derived by controlled heat treatment,were identified as fluorophlogopite mica(KMg3(AlSi3O10)F2) by X-ray diffraction（XRD） technique and confirmed by Fourier transformed infrared *** of copper,silver and gold nanometals were also identified by XRD *** is found from field emission scanning electron microscopy that the interlocked grain like microstructure developed in BMAPS glass-ceramics（being heat-treated at 1050 ℃ for 4 h） changed to denser house-of-cards like microstructure（containing smaller sized mica crystals） on addition of coinage *** of BMAPS base glass-ceramic was 2.60 g cm-3and marginally changed to 2.61-2.62 g cm-3on addition of Cu,Ag and *** change in microstructure resulted in the decrease of Vickers micro hardness value from 5.37 to 4.12,4.20 and 4.58 GPa on addition of Cu,Ag and Au,*** nanometai doped mica glass-ceramics containing interlocked microstructure with higher thermal expansion coefficient,hence,is suitable for high temperature sealing application（like solid oxide fuel cell）.

关键词： glass Crystallization X-ray diffraction Microstruc

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Influences of Co-Doping Cation on Properties of PWO∶F- Scintillating Crystal

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Journal of Rare Earths 2006年第Z1期24卷 169-171页

作者： Zhang Mingrong Zhang Chunsheng Fan Yuhong Ge Yuncheng Crystal Laboratory Beijing Glass Research Institute Beijing 100062 China Crystal Laboratory Beijing Glass Research Institute Beijing 100062 China Crystal Laboratory Beijing Glass Research Institute Beijing 100062 China Crystal Laboratory Beijing Glass Research Institute Beijing 100062 China

Whereas the light yield of PWO crystal can be significantly improved by doping with either of F- and Sb3+, effects of heavily co-doping with by F-+Sb3+, F-+Ca2+, and F-+Ca2++Sb3+, respectively, on the properties of PWO scintillation crystals, including optical transmission, luminescence and light yield were studied. The result indicates that co-doping with three dopants, F-+Ca2++Sb3+, is a more effective measure than doping with single dopant F- for the improvement of scintillation properties of PWO crystals, including light yield.

关键词： lead tungstate scintillation crystal light yield doping

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Utilization of iron oxide bearing pellets waste for preparing hard and soft ferromagnetic glass ceramics

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Journal of Advanced Ceramics 2014年第4期3卷 259-268页

作者： Salwa A.M.ABDEL-HAMEED Ibrahim M.HAMED Nehal A.ERFAN glass research Department National Research CenterDokkiCairoEgypt Chemical Engineering Department Faculty of EngineeringMinia UniversityMiniaEgyp

About 8%of the imported iron oxide pellets burdens to Egypt are *** this paper,broken pellets waste(BPW)is used as raw material for the preparation of hard magnetic glass ceramics(HMGC)as well as soft magnetic glass ceramics(SMGC).About 54 wt%and 37 wt%of BPW are used to prepare SMGC and HMGC,*** thermal analysis(DTA)reveals two broad exothermic peaks for HMGC at 591℃and 697℃,whereas one exothermic peak at 820℃is detected for SMGC.X-ray diffraction(XRD)shows the crystallization of hematite as the sol phase in BPW,and meanwhile,Zn-ferrite and Ba-hexaferrite are identified in SMGC and HMGC,*** electron microscopy(TEM)reveals the crystallization of nanosize particles of~20 nm for SMGC and~12 nm for *** scanning magnetometer(VSM)reveals an increase in saturation magnetization from~1 emu/g for BPW to~77 emu/g for SMGC and 21 emu/g for HMGC.

关键词： magnetic materials nanostructure pellets waste

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Mapping of Hd-6-2 for Heading Date Using Two Secondary Segregation Populations in Rice

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Rice science 2018年第3期25卷 161-168页

作者： ZHANG Hua LIU Xu YANG Yongyi XUAN Ning YAO Fangyin Bio-tech research center Shandong Academy of Agricultural Sciences

Heading date is one of the most important traits for rice adaption to different cultivation areas and crop seasons. In this study, two single segment substitution lines(SSSLs), W31-41-61-3-11-3-6-7(W31-SSSL) and W32-59-80-2-11-1-10(W32-SSSL) with substituted intervals derived from the donor parents IR66897 B(W31) and IR66167-27-5-1-6(W32), respectively, with Huajingxian 74(HTX74) were found to comprise a gene for extremely late-heading date, and the gene was tentatively designated as Hd-6-2. Two secondary F2 segregating populations were developed by crossing the two heterozygous SSSLs with HJX74 to map Hd-6-2 gene. According to phenotype analysis of the two mapping populations, the late heading date trait was controlled by a major recessive gene. In the segregation population derived from W31-SSSL, Hd-6-2 was mapped on chromosome 6 between PSM677 and RM204 with the genetic distances of 1.3 and 2.7 c M, respectively. In the population of W32-SSSL, the gene for heading date was mapped to the similar region as Hd-6-2 and co-segregated with PSM672. The sequence alignment of Hd3 a in the coding domains and promoter regions of HJX74 and W31-SSSL are completely consistent, whereas there was a great difference between W32-SSSL and HJX74, suggesting that Hd3 a could hardly be the main cause of the heading date variation in W31-SSSL, but it was probably the main reason for the change of heading stage in W32-SSSL.

关键词： rice single segment substitution line heading date gene mapping Hd3a

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Sol-gel synthesis,properties and protein loading/delivery capacity of hollow bioactive glass nanospheres with large hollow cavity and mesoporous shell

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Frontiers of Materials Science 2022年第3期16卷 145-157页

作者： Ahmed EL-FIQI glass research Department National Research CentreCairo 12622Egypt

Hollow nanospheres exhibit unique properties and find a wide interest in several potential applications such as drug ***,novel hollow bioactive glass nanospheres(HBGn)with large hollow cavity and large mesopores in their outer shells were synthesized by a simple and facile one-pot ultrasound assisted sol-gel method using PEG as the core ***,the produced HBGn exhibited large hollow cavity with ~43 nm in diameter and mesoporous shell of ~37 nm in thickness and 7 nm pore size along with nanosphere size around 117 *** confirmed the presence of Si and Ca elements at the surface of the HBGn outer ***,HBGn showed high protein loading capacity(~570 mg of Cyto c per 1 g of HBGn)in addition to controlled protein release over 5 *** also demonstrated a good in vitro capability of releasing calcium(Ca^(2+):170 ppm)and silicate(SiO_(4)^(4-):78 ppm)ions in an aqueous medium over 2 weeks under physiological-like *** in vitro growth of bone-like hydroxyapatite nanocrystals was exhibited by HBGn during the soaking in SBF.A possible underlying mechanism involving the formation of spherical aggregates(coils)of PEG was proposed for the formation process of HBGn.

关键词： bioactive glass hollow nanosphere hollow cavity mesoporous shell soft-template ultrasound assisted sol-gel synthesis therapeutic protein delivery

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Core Shell Au Ag Nanoparticles in Dielectric Nanocomposites with Plasmon-Enhanced Fluorescence: A New Paradigm in Antimony glasses

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Nano research 2009年第8期2卷 607-616页

作者： Tirtha Som Basudeb Karmakar glass technology Laboratory Glass DivisionCentral Glass and Ceramic Research Institute(Council of Scientifi c and Industrial Research)196Raja S.C.Mullick RoadKolkata 700032India

The nano era demands the synthesis of new nanostructured materials,if possible by simplified techniques,with remarkable properties and versatile ***,we demonstrate a new single-step reproducible melt-quench methodology to fabricate core-shell bimetallic(Au0 Ag0)nanoparticles(2889 nm)embedded glasses(dielectrics)by the use of a new reducing glass matrix,K_(2)O B_(2)O_(3) Sb_(2)O_(3)(KBS)without applying any external reducing agent or multiple processing *** surface plasmon resonance(SPR)band of these nanocomposites embedded in KBS glass is tunable in the range 554-681 *** remarkably,taking advantage of the selective reduction capability of Sb_(2)O_(3),this single-step methodology is used to fabricate inter-metallic:rare-earth ions co-embedded(AuAg:Sm^(3+))dielectric(glass)-based-dnanocomposites and study the effect of enhanced local fi eld on the red upconversion fl uorescence of Sm^(3+)ions at 636 *** enhancement is found to be about 2 *** single-step in-situ selective reduction approach can be used to fabricate a variety of hybrid-nanocomposite devices for laser based applications(see supplementary information).

关键词： Gold-silver nanostructures core-shell morphology surface plasmon resonance antimony glass metal-enhanced rare earth fl uorescence

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Effect of Nd^(3+) on spectroscopic properties of lithium borate glasses

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Journal of Rare Earths 2014年第12期32卷 1148-1153页

作者： D.D.Ramteke K.Annapurna V.K.Deshpande R.S.Gedam Department of Applied Physics Visvesvaraya National Institute of Technology glass Science and technology Section CSIR-Central Glass and Ceramic Research Institute

The spectroscopic properties of lithium borate glasses as a function of Nd3＋ ions concentration were *** absorption spectra of these glasses showed a number of absorption bands in ultra violet and visible *** absorption edge was found to shift towards the longer wavelength（red shift） with increase in *** spectra revealed three major bands at 902, 1063 and 1334 nm which was due to 4F3/2→4I9/2, 11/2 ＆13/2 transitions of Nd3＋ *** intensity was maximum for 1 mol.% Nd2O3 and further increase in Nd2O3 resulted in luminescence *** luminescence quenching behavior at higher concentration of Nd2O3 was attributed to the Nd3＋-Nd3＋ interaction in the glass *** absorption and emission property of these glasses suggested that these glasses could be useful for 1.06 μm infrared laser applications.

关键词： glasses optical properties luminescence laser rare earths

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Development of non-shrinkable ceramic composites for use in high-power microwave tubes

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International Journal of Minerals,Metallurgy and Materials 2019年第4期26卷 516-522页

作者： N.Dandapat S.Ghosh Bioceramics and Coating Division CSIR-Central Glass and Ceramic Research Institute

Al_2O_3–CaO–SiC-based ceramic composites with four different compositions were sintered at 1700℃ for 3 h in an air furnace. The phase analysis, microstructural characterization, and elemental composition determination of the developed composites were performed by X-ray diffraction(XRD), field-emission scanning electron microscopy(FESEM), and energy-dispersive X-ray(EDAX) analysis, respectively. The shrinkage, thermal properties, and electrical resistivity of the composites were also studied. The experimental results showed the effects of adding silicon carbide and calcia to alumina on the thermal, electrical, and shrinkage properties of the resultant composites. Among the four investigated ceramic composites, the one composed of 99 wt% alumina, 0.5 wt% CaO, and 0.5 wt% SiC exhibited the best characteristics for use as a potting material in a dispenser cathode of a microwave tube. The material exhibited slight expansion instead of shrinkage during drying or firing. Other properties of the composite powder, such as its thermal properties and electrical resistivity, were comparable to those of a commercial alumina powder.

关键词： Al2O3-CaO-SiC composite expansion potting material dispenser cathode microwave tube

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