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Changing trends of clinicopathologic features and survival duration after surgery for gastric cancer in Northeast China

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1119-1132页

作者： Zhao Zhai Zi-Yu Zhu Xi-Liang Cong Bang-Ling Han Jia-Liang Gao Xin Yin Yu Zhang Sheng-Han Lou Tian-Yi Fang Yi-Min Wang Chun-Feng Li Xue-Feng Yu Yan Ma Ying-Wei Xue Department of gastroenterological Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND Through analyzing the data from a single institution in Northeast China,this study revealed the possible clinicopathologic characteristics that influence the prognosis of patients with gastric cancer(GC).AIM To evaluate the changing trends of clinicopathologic features and survival duration after surgery in patients with GC in Northeast China,which is a highprevalence area of *** The study analyzed the difference in clinicopathologic features and survival duration after surgery of 5887 patients who were histologically diagnosed with GC at the Harbin Medical University Cancer *** study mainly analyzed the data in three periods,2000 to 2004(Phase 1),2005 to 2009(Phase 2),and 2010 to 2014(Phase 3).RESULTS Over time,the postoperative survival rate significantly increased from 2000 to *** the past 15 years,compared with Phases 1 and 2,the tumor size was smaller in Phase 3(P<0.001),but the proportion of high-medium differentiated tumors increased(P<0.001).The proportion of early GC gradually increased from 3.9%to 14.4%(P<0.001).A surprising improvement was observed in the mean number of retrieved lymph nodes,ranging from 11.4 to 27.5(P<0.001).The overall 5-year survival rate increased from 24%in Phase 1 to 43.8%in Phase *** multivariate analysis,it was found that age,tumor size,histologic type,tumor-node-metastasis stage,depth of invasion,lymph node metastasis,surgical approach,local infiltration,radical extent,number of retrieved lymph nodes,and age group were independent risk factors that influenced the prognosis of patients with *** The clinical features of GC in Northeast China changed during the observation *** increasing detection of early GC and more standardized surgical treatment effectively prolonged lifetimes.

关键词： Gastric cancer Clinicopathologic features Survival Time trends Epidemiology Gastrectomy

Epithelial-mesenchymal transition in gastroenterological cancer

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Journal of Cancer Metastasis and Treatment 2015年第1期1卷 183-189页

作者： Hirohisa Okabe Kosuke Mima Seiya Saito Hiromitsu Hayashi Katsunori Imai Hidetoshi Nitta Daisuke Hashimoto Akira Chikamoto Takatoshi Ishiko Toru Beppu Hideo Baba Department of gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamoto 860-8556Japan Department of Multidisciplinary Treatment for gastroenterological Cancer Kumamoto University HospitalKumamoto 860-8556Japan.

Epithelial-mesenchymal transition(EMT)was first reported as an essential process in embryonic cells and later showed that cancer cells,regardless of the context,exhibited a similar phenomenon that was crucial for tumor *** cells lose their adhesive characteristic capacity which is necessary for their functions but gain a mesenchymal *** change from epithelial to the mesenchymal phenotype of cancer cells makes it difficult to understand the mechanism underlying cancer biology and tumor progression.A number of transcription factors involved in tumor cell EMT and microRNA-regulated EMT have been *** review discussed recent findings and new players in EMT in gastrointestinal *** the molecular mechanisms of tumor progression are sometimes context-dependent,the recent findings of EMT have been reviewed in a context-dependent manner.

关键词： Epithelial-mesenchymal transition gastrointestinal cancer microRNA transcription factor

Therapeutic effectiveness of echo-guided percutaneous radiofrequency ablation therapy with a LeVeen needle electrode in hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第7期12卷 1098-1104页

作者： Luigi Solmi Giovanni Nigro Enrico Roda gastroenterological unit Polyclinic Hospital Sant'Orsola-MalpighiUniversity School of MedicineBolognaItaly

瞄准：在在肝脏硬化症的病人获得肝细胞癌(HCC ) 的坏死调查射频脱离(RFA ) 的结果并且在与 HCC 的复发和对待的病人的幸存的关系估计 RFA 的结果。方法：有 63 HCC 的 56 个连续肝脏硬化症的病人与在 2000 年 5 月和 2004 年 5 月之间... 详细信息

瞄准：在在肝脏硬化症的病人获得肝细胞癌(HCC ) 的坏死调查射频脱离(RFA ) 的结果并且在与 HCC 的复发和对待的病人的幸存的关系估计 RFA 的结果。方法：有 63 HCC 的 56 个连续肝脏硬化症的病人与在 2000 年 5 月和 2004 年 5 月之间的 RFA 被对待。HCC 的直径从 1 厘米到 5 厘米(平均数 2.8 厘米) 。在所有情况中， RFA 用可扩充的针电极(LeVeen 针) 在超声指导下面与经皮的途径被执行。治疗功效和复发与双阶段的螺线被评估计算断层摄影术(CT ) 。结果：在单个或多重的治疗以后的完全的坏死在 96.8% 被完成(61/63 ) 肿瘤。我们在 32.3 个月的吝啬的后续期间在 23 个病人(41%) 在完全的坏死以后观察了复发。复发在 2 个病人(8.6%) 并且在在 21 的不同片断是本地的(91.4%) 。主要复杂并发症发生在 3 个病人(4%) 。在后续时期期间， 32 (57.1%) 病人们死了；15 由于 HCC 的前进， 11 从肝失败， 3 从食道的静脉曲张流血并且 3 从不与肝有关的原因疾病。结论：有 LeVeen 针的 RFA 是为在肝脏硬化症的病人的 HCC<5 厘米的有效、安全的治疗。这治疗多远影响病人的幸存率，还得被建立。建立治疗在不同片断阻止复发变得重要，例如干扰素治疗。

关键词：治疗效果射频消融肝细胞癌并发症

High HbA1c is a risk factor for complications after hepatectomy and influences for hepatocellular carcinoma without HBV and HCV infection

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 454-463页

作者： Shingo Shimada Toshiya Kamiyama Tatsuya Orimo Akihisa Nagatsu Hirofumi Kamachi Akinobu Taketomi Department of gastroenterological Surgery I Hokkaido University Graduate School of MedicineSapporoJapan

Background:Currently,the population with type 2 diabetes mellitus(DM)is increasing ***,the influence of DM or hyperglycemia on the outcome of resected hepatocellular carcinoma(HCC)is ***:We analyzed 756 patients with HCC who underwent *** patients were assigned to an HbA1c≥7.0%(H-A1c;n=100)or HbA1c<7.0%(L-A1c;n=656)group depending on their HbA1c level at *** investigated prognoses,clinicopathological characteristics and surgical outcomes including morbidities of HCC patients with high HbA1c,prognoses according to the treatment for DM were also ***:Among all patients and those with hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,overall survival(OS)and relapse-free survival(RFS)did not differ significantly between the H-A1c and L-A1c *** contrast,the 5-year OS rate of the H-A1c group was 55%and that of the L-A1c group 71%among patients without HBV and HCV(NBNC patients)(P=0.03).Among NBNC patients,the median RFS of the H-A1c group was 13 months,and that of the L-A1c group was 26 months(P=0.02).In addition,metformin use was an independent favorable factor for both OS and *** H-A1c group had significantly higher rates of hyperbilirubinemia,wound infection,and ***:HCC patients with high HbA1c might have poor prognoses for both survival and recurrence in *** HbA1c may also be a risk factor for morbidities after *** use may constitute a good option for NBNC patients with HCC.

关键词： Hepatocellular carcinoma(HCC) HbA1c diabetes mellitus(DM) hepatectomy metformin

MSH2 is required for cell proliferation,cell cycle control and cell invasiveness in colorectal cancer cells

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Chinese Science Bulletin 2012年第20期57卷 2580-2585页

作者： SHEN Kai YE YingJiang JIANG KeWei LIANG Bin YANG XiaoDong WANG Shan Department of gastroenterological Surgery Surgical Oncology Laboratory Peking UniversityPeople's HospitalBeijing 100044China

We have investigated the role of MSH2,a mismatch repair gene in cell proliferation,cell cycle control and cell invasiveness in the SW480 human colorectal cancer cell ***-mediated inhibition of MSH2 expression was achieved using MSH2 shRNA lentiviral expression *** knockdown of endogenous MSH2 expression was determined by real-time PCR *** most efficient MSH2 knockdown vector was selected for subsequent studies using SW480 *** MSH2 mRNA levels decreased after lentiviral delivery of the MSH2-RNAi,indicating efficient silencing of MSH2 expression in SW480 *** proliferation,cell cycle progression and cell invasiveness were quantified by MTT assays,flow cytometry and transwell assays,***-mediated inhibition of MSH2 expression in SW480 cells resulted in decreased cell proliferation,cell cycle arrest at the G0/G1 phase and decreased cell *** together,these results provide evidence that MSH2 stimulates cell proliferation,promotes cell cycle progression and positively regulates cell invasiveness.

关键词：错配修复基因细胞周期调控细胞增殖侵袭癌细胞大肠细胞周期阻滞 RNAi

Prognostic significance of Borrmann type combined with vessel invasion status in advanced gastric cancer

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World Journal of Gastrointestinal Oncology 2020年第9期12卷 992-1004页

作者： Zhao Zhai Zi-Yu Zhu Yu Zhang Xin Yin Bang-Ling Han Jia-Liang Gao Sheng-Han Lou Tian-Yi Fang Yi-Min Wang Chun-Feng Li Xue-Feng Yu Yan Ma Ying-Wei Xue Department of gastroenterological Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND Borrmann classification(types I-IV)for the detection of advanced gastric cancer has been accepted worldwide,and lymphatic and/or blood vessel invasion(LBVI)status is related to the poor prognosis after gastric *** To evaluate the significance of Borrmann type combined with LBVI status in predicting the prognosis of advanced gastric *** We retrospectively studied the clinicopathological characteristics and long-term survival data of 2604 patients who were diagnosed with advanced gastric adenocarcinoma at Harbin Medical University Cancer Hospital from January 2009 to December *** variables were evaluated by the Pearson’sχ^2 test,the Kaplan-Meier method was used to identify differences in cumulative survival rates,and the Cox proportional hazards model was used for multivariate prognostic *** A total of 2604 patients were included in this *** presence of LVBI[LBVI(+)]and Borrmann type(P=0.001),tumor location(P<0.001),tumor size(P<0.001),histological type(P<0.001),tumor invasion depth(P<0.001),number of metastatic lymph nodes(P<0.001),and surgical method(P<0.001)were significantly correlated with *** analyzing the combination of the Borrmann classification and LBVI status,we found that patients with Borrmann type Ⅲ disease and LBVI(+)had a similar 5-year survival rate to those with Borrmann IV+LBVI(-)(16.4%vs 13.1%,P=0.065)and those with Borrmann IV+LBVI(+)(16.4%vs 11.2%,P=0.112).Subgroup analysis showed that the above results were true for any pT stage and any tumor *** Cox regression analysis showed that Borrmann classification(P=0.023),vascular infiltration(P<0.001),tumor size(P=0.012),pT stage(P<0.001),pN stage(P<0.001),and extent of radical surgery(P<0.001)were independent prognostic factors for *** Since patients with Borrmann Ⅲ disease and LBVI(+)have the same poor prognosis as those with Borrmann IV disease,more attention should be paid to patients with Borrm

关键词： Advanced gastric cancer Borrmann type Vascular invasion Long-term survival

An international expert consensus of management of recurrent hepatocellular carcinoma: a viewpoint

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Hepatobiliary Surgery and Nutrition 2020年第3期9卷 394-396页

作者： Kuniya Tanaka Yuki Takahashi Tetsuji Wakabayashi Department of gastroenterological and General Surgery Showa University Fujigaoka HospitalYokohamaJapan

We read with great interest the article titled "Multidisciplinary management of recurrent and metastatic hepatocellular carcinoma after resection: an international expert consensus" (1) published in Hepato Biliary Sur... 详细信息

关键词： Surgery hepatocellular carcinoma

Self-expanding metal stent placement and pathological alterations among obstructive colorectal cancer cases

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World Journal of Gastrointestinal Endoscopy 2022年第11期14卷 704-717页

作者： Keisuke Kosumi Kosuke Mima Kosuke Kanemitsu Takuya Tajiri Toru Takematsu Yuki Sakamoto Mitsuhiro Inoue Yuji Miyamoto Takao Mizumoto Tatsuo Kubota Nobutomo Miyanari Hideo Baba Department of gastroenterological Surgery Kumamoto UniversityKumamoto 860-8556Japan Department of Surgery National Hospital Organization Kumamoto Medical CenterKumamoto 860-0008Japan Department of gastroenterological Surgery Graduate School of Medical SciencesKumamoto UniversityHonjo 860-8556KumamotoJapan

BACKGROUND Experimental studies suggest that self-expanding metal stents(SEMSs)enhance the aggressive behavior of obstructive colorectal *** influence of SEMS placement on pathological alterations remains to be *** To determine whether SEMS placement is associated with molecular or pathological features of colorectal carcinoma *** Using a nonbiased molecular pathological epidemiology database of patients with obstructive colorectal cancers,we examined the association of SEMS placement with molecular or pathological features,including tumor size,histological type,American Joint Committee on Cancer(AJCC)-pTNM stage,and mutation statuses in colorectal cancer tissues compared with the use of transanal tubes.A multivariable logistic regression model was used to adjust for potential *** SEMS placement was significantly associated with venous invasion(P<0.01),but not with the other features examined,including tumor size,disease stage,mutation status,and lymphatic *** both the univariable and multivariable models with adjustment for potential factors including tumor location,histological type,and AJCC-pT stage,SEMS placement was significantly associated with severe venous invasion(P<0.01).For the outcome category of severe venous invasion,the multivariable odds ratio for SEMS placement relative to transanal tube placement was 19.4(95%confidence interval:5.24–96.2).No significant differences of disease-free survival and overall survival were observed between SEMS and transanal tube *** SEMS placement might be associated with severe venous invasion in colorectal cancer tissue,providing an impetus for further investigations on the pathological alterations by SEMSs in colorectal cancer development.

关键词： Bridge to surgery Colorectal carcinoma Obstruction Stent Venous invasion

Predictive factors for body weight loss and its impact on quality of life following gastrectomy

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World Journal of Gastroenterology 2017年第26期23卷 4823-4830页

作者： Kazuaki Tanabe Masazumi Takahashi Takashi Urushihara Yoichi Nakamura Makoto Yamada Sang-Woong Lee Shinnosuke Tanaka Akira Miki Masami Ikeda Koji Nakada Department of gastroenterological Surgery Hiroshima University Hospital Division of gastroenterological Surgery Yokohama Municipal Citizen’s Hospital Department of gastroenterological Breast and Transplant SurgeryHiroshima Prefectural Hospital Department of Surgery Toho University Ohashi Medical Center Department of Surgery Gifu Municipal Hospital Department of General and Gastroentero-logical Surgery Osaka Medical College Department of gastroenterological Surgery Fukuoka University School of Medicine Department of Surgery Kobe City Medical Center General Hospital Department of Surgery Asama General Hospital Department of Laboratory Medicine the Jikei University School of Medicine

AIM To determine the predictive factors and impact of body weight loss on postgastrectomy quality of life(QOL). METHODS We applied the newly developed integrated questionnaire postgastrectomy syndrome assessment scale-45, which consists of 45 items including those from the Short Form-8 and Gastrointestinal Symptom Rating Scale instruments, in addition to 22 newly selected items. Between July 2009 and December 2010, completed questionnaires were received from 2520 patients with curative resection at 1 year or more after having undergone one of six types of gastrectomy for Stage Ⅰ gastric cancer at one of 52 participating institutions. Of those, we analyzed 1777 eligible questionnaires from patients who underwent total gastrectomy with Roux-en-Y procedure(TGRY) or distal gastrectomy with Billroth-I(DGBI) or Roux-en-Y(DGRY) procedures. RESULTS A total of 393, 475 and 909 patients underwent TGRY, DGRY, and DGBI, respectively. The mean age of patients was 62.1 ± 9.2 years. The mean time interval between surgery and retrieval of the questionnaires was 37.0 ± 26.8 mo. On multiple regression analysis, higher preoperative body mass index, total gastrectomy, and female sex, in that order, were independent predictors of greater body weight loss after gastrectomy. There was a significant difference in the degree of weight loss(P 25 kg/m2). Multiple linear regression analysis identified lower postoperative body mass index, rather than greater body weight loss postoperatively, as a certain factor for worse QOL(P < 0.0001) after gastrectomy, but the influence of both such factors on QOL was relatively small(R2, 0.028-0.080).CONCLUSION While it is certainly important to maintain adequate body weight after gastrectomy, the impact of body weight loss on QOL is unexpectedly small.

关键词：生活的质量 Gastrectomy 重量损失 Postgastrectomy 症候群评价 scale-45