Epithelial-mesenchymal transition in gastroenterological cancer

作     者：Hirohisa Okabe Kosuke Mima Seiya Saito Hiromitsu Hayashi Katsunori Imai Hidetoshi Nitta Daisuke Hashimoto Akira Chikamoto Takatoshi Ishiko Toru Beppu Hideo Baba 

作者机构：Department of Gastroenterological SurgeryGraduate School of Life SciencesKumamoto UniversityKumamoto 860-8556Japan Department of Multidisciplinary Treatment for Gastroenterological CancerKumamoto University HospitalKumamoto 860-8556Japan. 

出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)

年 卷 期：2015年第1卷第1期

页      面：183-189页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Epithelial-mesenchymal transition gastrointestinal cancer microRNA transcription factor 

摘      要：Epithelial-mesenchymal transition(EMT)was first reported as an essential process in embryonic cells and later showed that cancer cells,regardless of the context,exhibited a similar phenomenon that was crucial for tumor *** cells lose their adhesive characteristic capacity which is necessary for their functions but gain a mesenchymal *** change from epithelial to the mesenchymal phenotype of cancer cells makes it difficult to understand the mechanism underlying cancer biology and tumor progression.A number of transcription factors involved in tumor cell EMT and microRNA-regulated EMT have been *** review discussed recent findings and new players in EMT in gastrointestinal *** the molecular mechanisms of tumor progression are sometimes context-dependent,the recent findings of EMT have been reviewed in a context-dependent manner.