Changing trends of clinicopathologic features and survival duration after surgery for gastric cancer in Northeast China

作     者：Zhao Zhai Zi-Yu Zhu Xi-Liang Cong Bang-Ling Han Jia-Liang Gao Xin Yin Yu Zhang Sheng-Han Lou Tian-Yi Fang Yi-Min Wang Chun-Feng Li Xue-Feng Yu Yan Ma Ying-Wei Xue 

作者机构：Department of Gastroenterological SurgeryHarbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2020年第12卷第10期

页      面：1119-1132页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Nn10 Program of Harbin Medical University Cancer Hospital China No.Nn10 PY 2017-03 

主　　题：Gastric cancer Clinicopathologic features Survival Time trends Epidemiology Gastrectomy 

摘      要：BACKGROUND Through analyzing the data from a single institution in Northeast China,this study revealed the possible clinicopathologic characteristics that influence the prognosis of patients with gastric cancer(GC).AIM To evaluate the changing trends of clinicopathologic features and survival duration after surgery in patients with GC in Northeast China,which is a highprevalence area of *** The study analyzed the difference in clinicopathologic features and survival duration after surgery of 5887 patients who were histologically diagnosed with GC at the Harbin Medical University Cancer *** study mainly analyzed the data in three periods,2000 to 2004(Phase 1),2005 to 2009(Phase 2),and 2010 to 2014(Phase 3).RESULTS Over time,the postoperative survival rate significantly increased from 2000 to *** the past 15 years,compared with Phases 1 and 2,the tumor size was smaller in Phase 3(P0.001),but the proportion of high-medium differentiated tumors increased(P0.001).The proportion of early GC gradually increased from 3.9%to 14.4%(P0.001).A surprising improvement was observed in the mean number of retrieved lymph nodes,ranging from 11.4 to 27.5(P0.001).The overall 5-year survival rate increased from 24%in Phase 1 to 43.8%in Phase *** multivariate analysis,it was found that age,tumor size,histologic type,tumor-node-metastasis stage,depth of invasion,lymph node metastasis,surgical approach,local infiltration,radical extent,number of retrieved lymph nodes,and age group were independent risk factors that influenced the prognosis of patients with *** The clinical features of GC in Northeast China changed during the observation *** increasing detection of early GC and more standardized surgical treatment effectively prolonged lifetimes.