检索结果-南通市图书馆

Analysis of the potential biological value of pyruvate dehydrogenase E1 subunitβin human cancer

World Journal of Gastrointestinal oncology 2024年第1期16卷 144-181页

作者： Yao Rong Song-Hua Liu Ming-Zheng Tang Zhi-Hang Wu Guo-Rong Ma Xiao-Feng Li Hui Cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina key laboratory of molecular diagnostics and precision medicine for surgical oncology in gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC key laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND The pyruvate dehydrogenase E1 subunitβ(PDHB)gene which regulates energy metabolism is located in ***,few studies have elucidated the role and mechanism of PDHB in different *** To comprehensive pan-cancer analysis of PDHB was performed based on bioinformatics approaches to explore its tumor diagnostic and prognostic value and tumor immune relevance in *** vitro experiments were performed to examine the biological regulation of PDHB in liver *** Pan-cancer data related to PDHB were obtained from the Cancer Genome Atlas(TCGA)*** of the gene expression profiles of PDHB was based on TCGA and Genotype Tissue Expression Dataset *** regression analysis and Kaplan-Meier methods were used to assess the correlation between PDHB expression and survival prognosis in cancer *** correlation between PDHB and receiver operating characteristic diagnostic curve,clinicopathological staging,somatic mutation,tumor mutation burden(TMB),microsatellite instability(MSI),DNA methylation,and drug susceptibility in pan-cancer was also *** algorithms were used to analyze the correlation between PDHB and immune cell infiltration and tumor chemotaxis environment,as well as the co-expression analysis of PDHB and immune checkpoint(ICP)*** expression and functional phenotype of PDHB in single tumor cells were studied by single-cell sequencing,and the functional enrichment analysis of PDHB-related genes was *** study also validated the level of mRNA or protein expression of PDHB in several ***,in vitro experiments verified the regulatory effect of PDHB on the proliferation,migration,and invasion of liver *** PDHB was significantly and differently expressed in most *** was significantly associated with prognosis in patients with a wide range of cancers,including kidney renal clear cell carcinoma,kidney renal papillary cell carcinoma,breast invasive carcinom

关键词： Cuprotosis Pyruvate dehydrogenase E1 subunitβ Pan-cancer Prognosis Liver cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comprehensive analysis of the potential pathogenesis of COVID-19 infection and liver cancer

引用

World Journal of Gastrointestinal oncology 2024年第2期16卷 436-457页

作者： Yao Rong Ming-Zheng Tang Song-Hua Liu Xiao-Feng Li Hui Cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina key laboratory of molecular diagnostics and precision medicine for surgical oncology in gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC key laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND A growing number of clinical examples suggest that coronavirus disease 2019(COVID-19)appears to have an impact on the treatment of patients with liver cancer compared to the normal population,and the prevalence of COVID-19 is significantly higher in patients with liver ***,this mechanism of action has not been *** sets for COVID-19(GSE180226)and liver cancer(GSE87630)were obtained from the Gene Expression Omnibus *** identifying the common differentially expressed genes(DEGs)of COVID-19 and liver cancer,functional enrichment analysis,protein-protein interaction network construction and scree-ning and analysis of hub genes were ***,the validation of the differential expression of hub genes in the disease was performed and the regulatory network of transcription factors and hub genes was *** Of 518 common DEGs were obtained by screening for functional *** hub genes including aurora kinase B,cyclin B2,cell division cycle 20,cell division cycle associated 8,nucleolar and spindle associated protein 1,etc.,were further identified from DEGs using the“cytoHubba”*** enrichment analysis of hub genes showed that these hub genes are associated with P53 signalling pathway regulation,cell cycle and other functions,and they may serve as potential molecular markers for COVID-19 and liver ***,we selected 10 of the hub genes for in vitro expression validation in liver cancer *** Our study reveals a common pathogenesis of liver cancer and *** common pathways and key genes may provide new ideas for further mechanistic studies.

关键词： COVID-19 Liver cancer Differentially expressed genes Hub genes Pathogenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Present situation of minimally invasive surgical treatment for early gastric cancer

引用

World Journal of Gastrointestinal oncology 2024年第4期16卷 1154-1165页

作者： Chun-Yan Li Yi-Feng Wang Li-Kang Luo Xiao-Jun Yang The First Clinical Medical School Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The First Clinical medicine College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Centre Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina The Second Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Lanzhou University People's Clinical Hospital Lanzhou 730000Gansu ProvinceChina gansu Research Center of Prevention and Control Project for Digestive oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina gansu key laboratory of molecular diagnostics and precision medicine for surgical oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

Minimally invasive surgery is a kind of surgical operation,which is performed by using professional surgical instruments and equipment to inactivate,resect,repair or reconstruct the pathological changes,deformities and wounds in human body through micro-trauma or micro-approach,in order to achieve the goal of treatment,its surgical effect is equivalent to the traditional open surgery,while avoiding the morbidity of conventional surgical *** addition,it also has the advantages of less trauma,less blood loss during operation,less psychological burden and quick recovery on patients,and these minimally invasive techniques provide unique value for the examination and treatment of gastric cancer *** minimally invasive surgical techniques have developed rapidly and offer numerous options for the treatment of early gastric cancer(EGC):endoscopic mucosal resection(EMR),underwater EMR(UEMR),endoscopic submucosal dissection(ESD),endoscopic full-thickness resection(EFTR),endoscopic submu-cosal excavation(ESE),submucosal tunnel endoscopic resection,laparoscopic and endoscopic cooperative surgery(LECS);Among them,EMR,EFTR and LECS technologies have a wide range of applications and different modific-ations have been derived from their respective surgical operations,such as band-assisted EMR(BA-EMR),conven-tional EMR(CEMR),over-the-scope clip-assisted EFTR,no-touch EFTR,the inverted LECS,closed LECS,and so *** new and improved minimally invasive surgeries are more precise,specific and effective in treating different types of EGC.

关键词： Minimally invasive surgery Early gastric cancer Endoscopic mucosal resection Endoscopic full-thickness resection Laparoscopic and endoscopic cooperative surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combining systemic inflammatory response index and albumin fibrinogen ratio to predict early serious complications and prognosis after resectable gastric cancer

引用

World Journal of Gastrointestinal oncology 2024年第3期16卷 732-749页

作者： Jing-Yao Ren Da Wang Li-Hui Zhu Shuo Liu Miao Yu Hui Cai School of Clinical medicine Ningxia Medical UniversityYinchuan 750000Ningxia Hui Autonomous RegionChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina key laboratory of molecular diagnostics and precision medicine for surgical oncology in gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC key laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Medical College of Jiangsu University Jiangsu UniversityZhenjiang 212013Jiangsu ProvinceChina The First Clinical Medical School Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Gastric cancer has a high incidence and fatality rate,and surgery is the preferred course of ***,patient survival rates are still low,and the incidence of major postoperative complications cannot be *** systemic inflammatory response,nutritional level,and coagulation status are key factors affecting the postoperative recovery and prognosis of gastric cancer *** systemic inflammatory response index(SIRI)and the albumin fibrinogen ratio(AFR)are two valuable comprehensive indicators of the severity and prognosis of systemic inflammation in various medical *** To assess the clinical importance and prognostic significance of the SIRI scores and the AFR on early postoperative outcomes in patients undergoing radical gastric cancer *** We conducted a retrospective analysis of the clinicopathological characteristics and relevant laboratory indices of 568 gastric cancer patients from January 2018 to December *** calculated and compared two indicators of inflammation and then examined the diagnostic ability of combined SIRI and AFR values for serious early postoperative *** scored the patients and categorized them into three groups based on their SIRI and AFR *** analysis was used to compare the three groups of patients the prognostic value of various preoperative SIRI-AFR scores for 5-year overall survival(OS)and disease-free survival(DFS).RESULTS SIRI-AFR scores were an independent risk factor for prognosis[OS:P=0.004;hazards ratio(HR)=3.134;DFS:P<0.001;HR=3.543]and had the highest diagnostic power(area under the curve:0.779;95%confidence interval:0.737-0.820)for early serious complications in patients with gastric *** tumor-node-metastasis stage(P=0.001),perioperative transfusion(P=0.044),positive carcinoembryonic antigen(P=0.014)findings,and major postoperative complications(P=0.011)were factors associated with *** Preoperative SIRI and AFR values were s

关键词： Inflammation Albumin fibrinogen ratio Gastric cancer Complications Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Systemic inflammatory response index is a predictor of prognosis in gastric cancer patients: Retrospective cohort and meta-analysis

引用

World Journal of Gastrointestinal Surgery 2024年第2期16卷 382-395页

作者： Jing-Yao Ren Meng Xu Xiang-Dong Niu Shi-Xun Ma Ya-Jun Jiao Da Wang Miao Yu Hui Cai School of Clinical medicine Ningxia Medical UniversityYinchuan 750000Ningxia Hui autonomous regionChina gansu Provincial Hospital Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Medical College of Jiangsu University Jiangsu UniversityZhenjiang 212013Jiangsu ProvinceChina key laboratory of molecular diagnostics and precision medicine for surgical oncology in gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND The systemic inflammatory response index(SIRI)has been demonstrated to make a significant difference in assessing the prognosis of patients with different solid ***,research is needed to ascertain the accuracy and reliability of applying the SIRI to patients who undergo robotic radical gastric cancer *** To validate the applicability of the SIRI in assessing the survival of gastric cancer patients and evaluate the clinical contribution of preoperative SIRI levels to predicting long-term tumor outcomes in patients,who received robotic radical gastric cancer *** Initially,an exhaustive retrieval was performed in the PubMed,the Cochrane Library,EMBASE,Web of Science,and Scopus databases to identify relevant ***,a meta-analysis was executed on 6 cohort studies iden-tifying the value of the SIRI in assessing the survival of gastric cancer ***,the clinical data of 161 patients undergoing robotic radical gastric cancer surgery were retrospectively analyzed to evaluate their clinicopathological characteristics and relevant laboratory *** association between preoperative SIRI levels and 5-year overall survival(OS)and disease-free survival(DFS)was *** The findings demonstrated an extensive connection between SIRI values and the outcome of patients with gastric *** SIRI levels were identified as an independent hazard feature for both OS and DFS among those who received robotic surgery for gastric *** levels in gastric cancer patients were observed to be associated with the presence of comorbidities,T-stage,carcinoembryonic antigen levels,the development of early serious postoperative complications,and the rate of lymph node *** SIRI values are correlated with adverse in the gastric cancer population and have the potential to be utilized in predicting long-term oncological survival in patients who undergo robotic radical gastric canc

关键词： Systemic inflammatory response index Prognosis Gastric cancer Complications Meta-analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A pan-cancer analysis of the biological function and clinical value of BTLA in tumors

引用

BIOCELL 2023年第2期47卷 351-366页

作者： XIANGLAI JIANG JIN HE YONGFENG WANG JIAHUI LIU XIANGYANG LI XIANGUI HE HUI CAI Graduate School Ningxia Medical UniversityYinchuan750004China General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou730000China key laboratory of molecular diagnostics and precision medicine for surgical oncology in gansu Province Gansu Provincial HospitalLanzhou730000China NHC key laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou730000China The First Clinical Medical College of Lanzhou University Lanzhou730000China

B and T-lymphocyte attenuator(BTLA)plays an immunosuppressive role by inhibiting T-and B-cell *** is associated with a variety of diseases,especially cancer ***,the function of BTLA in various cancers and its clinical prognostic value have still not been comprehensively *** study aimed to identify the relationship between BTLA and cancer from the perspectives of differences in BTLA expression,its clinical value,immune infiltration,and the correlation with immune-related genes in various *** regarding mRNA expression,miRNA expression,lncRNA expression,and clinical data of patients of 33 existing cancers were collected from the TCGA *** miRNA of BTLA and the lncRNA that interacts with the target miRNA were obtained from the StarBase *** on bioinformatics analysis methods,the relationship between various types of cancers and BTLA was thoroughly investigated,and a competing endogenous RNA network of BTLA,target miRNA,and interacting lncRNA was *** Kaplan-Meier(KM)prognostic analysis of BTLA and target miRNA(has-miR-137)in various types of cancers was completed using the KM *** expression varied in different cancers,with statistical significance in nine cancer *** plotter to analyze the overall survival(OS)and regression-free survival prognosis of cancer patients revealed that the BTLA expression was statistically different in the OS of 11 types of cancers out of 21 types of cancers;the OS of 8 type of cancers was also statistically *** analysis of tumor immune genes revealed a positive correlation of BTLA expression with immunosuppressive gene(CTLA4 and PDCD1)*** Set Enrichment Analysis showed that BTLA and its co-expressed genes mainly act through biological processes and pathways,including immune response regulation,cell surface receptor signaling pathway,antigen binding,antigen receptor-mediated signaling pathway,and leukocyte *** has t

关键词： Pan-cancer BTLA Tumor immunity Clinical value

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comprehensive analysis of prognostic value and immunotherapy prospect of brain cytoplasmic RNA1 in hepatocellular carcinoma

引用

World Journal of Gastrointestinal oncology 2023年第4期15卷 644-664页

作者： Xiao-Yong Han Xiong Li Rang-Yin Zhao Hai-Zhong Ma Miao Yu Xiang-Dong Niu Hao-Jie Jin Yong-Feng Wang De-Ming Liu Hui Cai gansu General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Graduate School Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina key laboratory of molecular diagnostics and precision medicine for surgical oncology in gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina The First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina The First Clinical College of medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina key laboratory of Evidence Based medicine and Knowledge Translation of gansu Province Lanzhou 730000Gansu ProvinceChina NHC key laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND The expression of brain cytoplasmic RNA1(BCYRN1)is linked to the clinicopathology and prognosis of several types of cancers,among which hepatocellular carcinoma(HCC)is one of the most frequent types of cancer *** To explore the prognostic value and immunotherapeutic potential of BCYRN1 in HCC by bioinformatics and *** Information was obtained from the Cancer Genome Atlas ***,the correlation between BCYRN1 expression and prognosis and clinicopathologic characteristics of HCC patients was *** and multivariate regression analyses were employed to examine the relationship between BCYRN1 and HCC ***,potential functions and pathways were explored by means of enrichment analysis of differentially-expressed *** relationships between BCYRN1 expression and tumor microenvironment,immune cell infiltration,immune checkpoint,drug sensitivity and immunotherapy effect were also ***,three major databases were searched and used to conduct a meta-analysis on the relationship between BCYRN1 expression and patient *** BCYRN1 expression was significantly higher in HCC compared to normal tissues and was linked to a poor prognosis and clinicopathological *** analysis showed that BCYRN1 regulates the extracellular matrix and transmission of signaling molecules,participates in the metabolism of nutrients,such as proteins,and participates in tumor-related ***1 expression was linked to the tumor microenvironment,immune cell infiltration,drug sensitivity and the efficacy of ***,the meta-analysis in this study showed that BCYRN1 overexpression was related to a worse outcome in HCC *** Overexpression of BCYRN1 relates to poor prognosis and may be a potential prognostic factor and immunotherapeutic target in HCC.

关键词： Brain cytoplasmic RNA1 Immunotherapy Prognostic Biomarker Hepatocellular carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Giant hemangioma of the caudate lobe of the liver with surgical treatment:A case report

引用

World Journal of Clinical Cases 2021年第21期9卷 5980-5987页

作者： Xin-Xin Wang Bao-Long Dong Biao Wu Shi-Yong Chen Yu He Xiao-Jun Yang Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina gansu University of Chinese medicine The 1st Clinical Medicine CollegeLanzhou 730000Gansu ProvinceChina Peoples Clinical medicine College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina gansu key laboratory of molecular diagnostics and precision medicine for surgical oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina gansu Research Center of Prevention and Control Project for Digestive oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Caudate lobe hemangioma of the liver is relatively *** to the unique anatomical location of the caudate lobe,the caudate lobectomy accounts for only 0.5%to 4%of hepatic resection,which is difficult to operate and takes a long time,and even has many postoperative *** SUMMARY A 34-year-old female presented with a 1 year history of intermittent pain in the right side of the waist without obvious *** laboratory blood tests were within normal *** green 15 min retention was rated 2.9%,and Child-Pugh was rated *** tomography and magnetic resonance imaging diagnosed giant hemangioma of the caudate lobe with hemangioma of left lobe of *** discussion,surgical treatment was performed,which lasted 410 min,with intraoperative bleeding of about 600 mL and postoperative pathological findings of cavernous *** were no obvious postoperative complications,and the patient was discharged 10 d after *** Caudate lobectomy is difficult due to its special anatomical *** the condition of fully exposing the anatomy of the first porta hepatis,the second porta hepatis,the third porta hepatis,the fourth porta hepatis and middle hepatic vein and combining with the Pringle maneuver,caudate lobectomy can be performed in a precise and safe process.

关键词： Caudate lobe hemangioma Caudate lobectomy Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical efficacy of transjugular intrahepatic portosystemic shunt created through left or right branches of the portal vein:A meta-analysis

引用

Journal of Interventional medicine 2021年第4期4卷 190-196页

作者： Shaobo Zhai Qi Cui Fang Dong Shiqi Wen Moubo Si Quan Chen gansu University of Chinese medicine Lanzhou730000People's Republic of China gansu Province People's Hospital Lanzhou730000People's Republic of China key laboratory of molecular diagnostics and precision medicine for surgical oncology in gansu Province Gansu Provincial Hospital Lanzhou730000GansuPeople's Republic of China

Background and aim:Transjugular intrahepatic portosystemic shunt(TIPS)is a technique successfully used to treat portal hypertension and its ***,the choice of the branch,left(L)or right(R),of the portal vein resulting in a better outcome is still under ***,this meta-analysis aims to evaluate which branch has a better curative effect on patients treated with ***:PubMed,EMBASE,Web of science,Cochrane Library databases,Wanfang database and CBM were used for our search in October 2019 and updated in June *** following parameters were used in evaluation:overall mortality,hepatic encephalopathy,shunt dysfunction,variceal rebleeding and rate of postoperative ***:There were seven studies *** sample size was 1940.A lower risk of mortality was observed in TIPS-L-treated patients compared with TIPS-R-treated ones(OR=0.65,95%CI=0.50-0.85,p=0.002).A lower risk of shunt dysfunction was observed in TIPS-L-treated patients compared with TIPS-R-treated ones(OR=0.53,95%CI=0.33-0.87,p=0.01).And the TIPS-L group had a significantly higher hepatic encephalopathy-free rate than the TIPS-R group(OR=0.59,95%CI=0.44-0.78,p=0.0002).However,the rate of rebleeding(OR=0.75,95%CI=0.55-1.03,p=0.07)and incidence of postoperative ascites(OR=1.14,95%CI=0.86-1.51,p=0.38)was not statistically significant between the two ***:Based on the currently available evidence,the technique of TIPS through the left branch of the portal vein can significantly reduce the occurrence of overall postoperative mortality,hepatic encephalopathy and shunt dysfunction.

关键词： Meta-analysis Transjugular intrahepatic portosystemic shunt Portal hypertension Overall mortality Hepatic encephalopathy Shunt dysfunction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：