Comprehensive analysis of prognostic value and immunotherapy prospect of brain cytoplasmic RNA1 in hepatocellular carcinoma
作者机构：Gansu General Surgery Clinical Medical CenterGansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Graduate SchoolNingxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu ProvinceGansu Provincial HospitalLanzhou 730000Gansu ProvinceChina The First Clinical Medical CollegeGansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina The First Clinical College of MedicineLanzhou UniversityLanzhou 730000Gansu ProvinceChina Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu ProvinceLanzhou 730000Gansu ProvinceChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal TumorGansu Provincial HospitalLanzhou 730000Gansu ProvinceChina
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2023年第15卷第4期
页 面：644-664页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by the 2021 Central-Guided Local Science and Technology Development Fund,No.ZYYDDFFZZJ-1 Gansu Key Laboratory of Molecular Diagnosis and Precision Treatment of Surgical Tumors,No.18JR2RA033 Key Laboratory of Gastrointestinal Cancer Diagnosis and Treatment of National Health Commission,No.2019PT320005 Key Talent Project of Gansu Province of the Organization Department of Gansu Provincial Party Committee,No.2020RCXM076 Guiding Plan for Scientific and Technological Development of Lanzhou,No.2019-ZD-102
主 题：Brain cytoplasmic RNA1 Immunotherapy Prognostic Biomarker Hepatocellular carcinoma
摘 要：BACKGROUND The expression of brain cytoplasmic RNA1(BCYRN1)is linked to the clinicopathology and prognosis of several types of cancers,among which hepatocellular carcinoma(HCC)is one of the most frequent types of cancer *** To explore the prognostic value and immunotherapeutic potential of BCYRN1 in HCC by bioinformatics and *** Information was obtained from the Cancer Genome Atlas ***,the correlation between BCYRN1 expression and prognosis and clinicopathologic characteristics of HCC patients was *** and multivariate regression analyses were employed to examine the relationship between BCYRN1 and HCC ***,potential functions and pathways were explored by means of enrichment analysis of differentially-expressed *** relationships between BCYRN1 expression and tumor microenvironment,immune cell infiltration,immune checkpoint,drug sensitivity and immunotherapy effect were also ***,three major databases were searched and used to conduct a meta-analysis on the relationship between BCYRN1 expression and patient *** BCYRN1 expression was significantly higher in HCC compared to normal tissues and was linked to a poor prognosis and clinicopathological *** analysis showed that BCYRN1 regulates the extracellular matrix and transmission of signaling molecules,participates in the metabolism of nutrients,such as proteins,and participates in tumor-related ***1 expression was linked to the tumor microenvironment,immune cell infiltration,drug sensitivity and the efficacy of ***,the meta-analysis in this study showed that BCYRN1 overexpression was related to a worse outcome in HCC *** Overexpression of BCYRN1 relates to poor prognosis and may be a potential prognostic factor and immunotherapeutic target in HCC.
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