A pan-cancer analysis of the biological function and clinical value of BTLA in tumors
作者机构：Graduate SchoolNingxia Medical UniversityYinchuan750004China General Surgery Clinical Medical CenterGansu Provincial HospitalLanzhou730000China Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu ProvinceGansu Provincial HospitalLanzhou730000China NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal TumorGansu Provincial HospitalLanzhou730000China The First Clinical Medical College of Lanzhou UniversityLanzhou730000China
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2023年第47卷第2期
页 面：351-366页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：funded by the Central to guide local scientific and Technological Development(ZYYDDFFZZJ-1) Natural Science Foundation of Gansu Province,China(No.18JR3RA052) Lanzhou Talent Innovation and Entrepreneurship Project Task Contract(No.2016-RC-56) Gansu Da Vinci Robot High-End Diagnosis and Treatment Team Construction Project,and Gansu Provincial Youth Science and Technology Fund Program(20JR10RA415) National Key Research and Development Program(No.2018YFC1311500)
主 题：Pan-cancer BTLA Tumor immunity Clinical value
摘 要：B and T-lymphocyte attenuator(BTLA)plays an immunosuppressive role by inhibiting T-and B-cell *** is associated with a variety of diseases,especially cancer ***,the function of BTLA in various cancers and its clinical prognostic value have still not been comprehensively *** study aimed to identify the relationship between BTLA and cancer from the perspectives of differences in BTLA expression,its clinical value,immune infiltration,and the correlation with immune-related genes in various *** regarding mRNA expression,miRNA expression,lncRNA expression,and clinical data of patients of 33 existing cancers were collected from the TCGA *** miRNA of BTLA and the lncRNA that interacts with the target miRNA were obtained from the StarBase *** on bioinformatics analysis methods,the relationship between various types of cancers and BTLA was thoroughly investigated,and a competing endogenous RNA network of BTLA,target miRNA,and interacting lncRNA was *** Kaplan-Meier(KM)prognostic analysis of BTLA and target miRNA(has-miR-137)in various types of cancers was completed using the KM *** expression varied in different cancers,with statistical significance in nine cancer *** plotter to analyze the overall survival(OS)and regression-free survival prognosis of cancer patients revealed that the BTLA expression was statistically different in the OS of 11 types of cancers out of 21 types of cancers;the OS of 8 type of cancers was also statistically *** analysis of tumor immune genes revealed a positive correlation of BTLA expression with immunosuppressive gene(CTLA4 and PDCD1)*** Set Enrichment Analysis showed that BTLA and its co-expressed genes mainly act through biological processes and pathways,including immune response regulation,cell surface receptor signaling pathway,antigen binding,antigen receptor-mediated signaling pathway,and leukocyte *** has t
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