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Protective effects of Amaranthus hybridus against aflatoxin B1 and fumonisin B1-induced genotoxicity in H4IIE-luc cells

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Hepatoma Research 2015年第1期1卷 136-146页

作者： Mohamed I.M.Ibrahim Rialet Pieters Sekena H.Abdel-Aziem Anna M.vander Walt Cornelius C.Bezuidenhout John P.Giesy Mosaad A.Abdel-Wahhab food Toxicology and Contaminants Department National Research CenterDokkiCairo 12622Egypt Unit of Environmental Sciences and Management North-West UniversityPrivate Bag X6001Potchefstroom 2520South Africa Cell Biology Department National Research CenterDokkiCairo 12622Egypt Department of Veterinary Biomedical Sciences and Toxicology Centre University of SaskatchewanSaskatoonSaskatchewan S7N 5B4Canada Department of Zoology and Center for Integrative ToxicologyMichigan State UniversityEast LansingMI 48824USA Department of Biology and Chemistry and State Key Laboratory in Marine Pollution City University of Hong KongKowloonHong KongChina School of Biological Sciences University of Hong KongHong KongChina State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210093JiangsuChina Department of Biology Hong Kong Baptist UniversityHong KongChina

Aim:Protective effects of aqueous extract of Amaranthus hybridus against afl atoxin B1(AFB_(1))and/or fumonisin B1(FB_(1))on the H4IIE-luc cell line were determined by use of the methyl thiazol tetrazolium viability assay and disruption of DNA ***:H4IIE-luc cells were incubated with different concentrations of AFB_(1) and/or FB_(1) for 24 and 48 h with or without aqueous extract of ***:AFB_(1) decreased the viability of cells after 24 and 48 h of ***_(50)values for AFB_(1) were 10.5 and 1.8μmol/L for the two periods,*** the 48 h exposure to mycotoxin repeated with a pre-treatment of 20 and 40μg/mL extract of ***,the EC_(50)changed to 3.88 and 7.67μmol/L,respectively.H4IIE-luc cells exposed to FB_(1) for 24 h responded more than those incubated for 48 *** treated with a combination of AFB_(1) and FB_(1) were less viable with a signifi cant decrease in the greater *** mixture of AFB_(1) and FB_(1) resulted in a signifi cant threat to H4IIE-luc as indicated by the absence or appearance of new bands in random amplifi ed polymorphic DNA analysis,which demonstrated damage to *** protective effects were probably due to greater content of total phenolics,carotenoids,β-carotene,folic-,linolenic-,linoleic and palmitic acids,as well as calcium,magnesium,iron,zinc,and selenium observed in the ***:Exposure to 40μg/mL of extract of *** protected cells from damage to DNA by stabilizing DNA.

关键词： Afl atoxin B1 Amaranthus hybridus cytotoxicity DNA fumonisin B1 hepatoma cells methyl thiazol tetrazolium assay

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Aqueous extract of Corchorus olitorius decreases cytotoxicityof aflatoxin B1 and fumonisin B1 in H4IIE-luc cells

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Hepatoma Research 2015年第1期1卷 75-85页

作者： Mohamed I.M.Ibrahim Rialet Pieters Sekena H.Abdel-Aziem Anna M.van der Walt Cornelius C.Bezuidenhout John P.Giesy Mosaad A.Abdel-Wahhab Department of food Toxicology and Contaminants National Research CentreDokkiCairo 12622Egypt Unit of Environmental Sciences and Management North-West UniversityPrivate Bag X6001Potchefstroom 2520South Africa Department of Cell Biology National Research CentreDokkiCairo 12622Egypt Department of Veterinary Biomedical Sciences and Toxicology Centre University of SaskatchewanSaskatoonSaskatchewan S7N 5B4Canada Department of Zoology and Center for Integrative ToxicologyMichigan State UniversityEast LansingMI 48824USA Department of Biology and Chemistry and State Key Laboratory in Marine Pollution City University of Hong KongKowloonHong KongChina School of Biological Sciences University of Hong KongHong KongChina State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210093JiangsuChina Department of Biology Hong Kong Baptist UniversityHong KongChina

Aim:Afl atoxin B1(AFB1)and fumonisin B1(FB1)are important food-borne ***-contamination of foodstuffs with these two mycotoxins is well-known and has been implicated in a possible development of hepatocellular carcinoma in humans living in regions of the world where exposures to these mycotoxins in grain are *** aim of the current study was to evaluate the potential protective effects of an aqueous extract of Cochorus olitorius(***,moroheiya)against cytotoxicity of AFB1 and/or FB1 in H4IIE-luc rat hepatoma cells,using assays to measure cell viability and disruption of DNA *** this transactivation assay was originally developed to specifi cally respond to aryl hydrocarbon agonists,this cell line was used because of its hepatic ***:H4IIE-luc cells were incubated with different concentrations of AFB1 and/or FB1 for 24 and 48 h with or without aqueous extract of ***:Both mycotoxins decreased cell viability and increased DNA *** was more pronounced when cells were exposed simultaneously to AFB1 and ***:Aqueous extract of *** protected cells against cytotoxicity of *** contains a water-soluble,natural chemo-preventative agent for cancer that should be isolated and identifi ed.

关键词： Anticancer cytotoxicity DNA liver moroheiya mycotoxins

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Development of a prediction model to identify undiagnosed chronic obstructive pulmonary disease patients in primary care settings in China

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Chinese Medical Journal 2023年第6期136卷 676-682页

作者： Buyu Zhang Dong Sun Hongtao Niu Fen Dong Jun Lyu Yu Guo Huaidong Du Yalin Chen Junshi Chen Weihua Cao Ting Yang Canqing Yu Zhengming Chen Liming Li on behalf of the China Kadoorie Biobank Collaborative Group Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina–Japan Friendship HospitalBeijing 100029China National Center for Respiratory Medicine and National Clinical Research Center for Respiratory Diseases Beijing 100029China Institute of Respiratory Medicine Chinese Academy of Medical SciencesBeijing 100007China Peking University Center for Public Health and Epidemic Preparedness and Response Beijing 100191China Key Laboratory of Molecular Cardiovascular Sciences(Peking University) Ministry of EducationBeijing 100191China National Center for Cardiovascular Diseases Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China Medical Research Council Population Health Research Unit at the University of Oxford Oxford OX37LFUK Clinical Trial Service Unit and Epidemiological Studies Unit Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK Maiji Center for Disease Control and Prevention TianshuiGansu 741020China China National Center for food Safety Risk Assessment Beijing 100022China 不详

Background:At present,a large number of chronic obstructive pulmonary disease(COPD)patients are undiagnosed in ***,this study aimed to develop a simple prediction model as a screening tool to identify patients at risk for ***:The study was based on the data of 22,943 subjects aged 30 to 79 years and enrolled in the second resurvey of China Kadoorie Biobank during 2012 and 2013 in *** stepwisely selected the predictors using logistic regression *** we tested the model validity through P-P graph,area under the receiver operating characteristic curve(AUROC),ten-fold cross validation and an external validation in a sample of 3492 individuals from the Enjoying Breathing program in ***:The final prediction model involved 14 independent variables,including age,sex,location(urban/rural),region,educational background,smoking status,smoking amount(pack-years),years of exposure to air pollution by cooking fuel,family history of COPD,history of tuberculosis,body mass index,shortness of breath,sputum and *** model showed an area under curve(AUC)of 0.72(95%confidence interval[CI]:0.72-0.73)for detecting undiagnosed COPD patients,with the cutoff of predicted probability of COPD=0.22,presenting a sensitivity of 70.13%and a specificity of 62.25%.The AUROC value for screening undiagnosed patients with clinically significant COPD was 0.68(95%CI:0.66-0.69).Moreover,the ten-fold cross validation reported an AUC of 0.72(95%CI:0.71-0.73),and the external validation presented an AUC of 0.69(95%CI:0.68-0.71).Conclusion:This prediction model can serve as a first-stage screening tool for undiagnosed COPD patients in primary care settings.

关键词： Chronic obstructive pulmonary disease Screening Prediction model China Kadoorie Biobank

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FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles

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Fungal Diversity 2020年第2期105卷 I0001-I0016页

作者： Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urm Institute of Ecology and Earth Sciences University of Tartu14A Ravila50411 TartuEstonia Natural History Museum University of Tartu46 Vanemuise Str51003 TartuEstonia Gothenburg Global Biodiversity Centre Box 46140530 GothenburgSweden Department of Biological and Environmental Sciences University of GothenburgGothenburgSweden Department of Soil and Environment Swedish University of Agricultural SciencesBox 701475007 UppsalaSweden Department of Forest Mycology and Plant Pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden Section for Genetics and Evolutionary Biology(EvoGene) Department of BiosciencesUniversity of OsloP.O.Box 1066BlindernNO-0316 OsloNorway University of Hawaiʻi at Mānoa 3190 Maile WaySt.John 102HonoluluHIUSA Department of Biology University of CopenhagenUniversitetsparken 152100 CopenhagenØDenmark Purdue University Northwest WestvilleIN 46391USA Institute of Microbiology Czech Academy of SciencesVidenska 108314220 Praha 4Czech Republic GLOBE Institute University of CopenhagenØster Farimagsgade 5KH7.2.321353 CopenhagenDenmark Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale Mattioli 2510125 TorinoItaly Department of Organismic and Evolutionary Biology and Farlow Library and Herbarium Harvard University22 Divinity AveCambridgeMA 02138USA Blaihofstr.42 72074 TübingenGermany SYNLAB Estonia Veerenni 53aTallinn 11313Estonia Escuela de Tecnología Médica Universidad Santo TomásLos Carreras 753OsornoChile Centro de Genómica y Bioinformática Universidad MayorCamino La Pirámide 5750HuechurabaSantiagoChile Norwegian Institute for Nature Research(NINA) Sognsveien 680855 OsloNorway School of Life Science and technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Evolutionary Biology Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsawul.Zwirki i Wigury 10102-089 WarsawPoland Department of Botany Swedish Museum of

The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental *** the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and ***,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains *** order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis *** the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,*** resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental *** order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS *** the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold.

关键词： Fungal traits Trophic modes Function Guild Bioinformatics High-throughput sequencing Community ecology

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自上而下和自下而上相结合提高大规模生态修复规划的实用性和效率——来自社会生态系统的启示（英文）

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Engineering 2023年第12期 50-58页

作者： Zhaowei Ding Hua Zheng Jun Wang Patrick O'Connor Cong Li Xiaodong Chen Ruonan Li Zhiyun Ouyang State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences College of Resources and Environment University of Chinese Academy of Sciences Key Laboratory of Land Consolidation and Rehabilitation Land Consolidation and Rehabilitation Center Ministry of Natural Resources Centre for Global food and Resources University of Adelaide School of Economics and Finance Xi’an Jiaotong University

Ecological restoration policies and their implementation are influenced by ecological and socioeconomic drivers. Top-down approach-based spatial planning, emphasizing hierarchical control within government structures, and without a comprehensive consideration of social–ecological interactions may result in implementation failure and low efficiency. Although many researchers have indicated the necessity to engage social–ecological interactions between stakeholders in effective planning processes,socioeconomic drivers of ecological restoration on a large scale are difficult to quantify because of data scarcity and knowledge limitations. Here, we established a new ecological restoration planning approach linking a social–ecological system framework to large-scale ecological restoration planning. The new spatial planning approach integrates bottom-up approaches targeting stakeholder interests and provides social considerations for stakeholder behavior analysis. Based on this approach, a meta-analysis is introduced to recognize key socioeconomic and social–ecological factors influencing large-scale ecological restoration implementation, and a stochastic model is constructed to analyze the impact of socioeconomic drivers on the behavior of authorities and participants on a large scale. We used the Yangtze River Basin-based Conversion of Cropland to Forest program(CCFP), one of the largest payments for ecosystem service programs worldwide, to quantify the socioeconomic impacts of large-scale ecological restoration programs. Current CCFP planning without socioeconomic considerations failed to achieve large-scale program goals and showed low investment efficiency, with 19.71% of the implemented area reconverting to cropland after contract expiry. In contrast, spatial matching between planned and actual restoration increased from 61.55% to 81.86% when socioeconomic drivers were included. In addition, compared to that with the current CCFP implementation, the cost effectivenes

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Diagnosis and Treatment Guidelines for Mesenchymal Stem Cell Therapy for Coronavirus Disease 2019(Beijing,2021)

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Infectious Diseases & Immunity 2021年第2期1卷 68-73页

作者： Ruonan Xu Lei Shi Wei-Fen Xie Zhe Xu Fan-Ping Meng Jun-Liang Fu Xin Yuan Lei Huang Ming Shi Yonggang Li Yuanyuan Li Chen Yao Yu Zhang Zhongmin Liu Chenyan Gao Zhaohui Wu Shufang Meng Weidong Han Charlie Xiang Gui-Qiang Wang Taisheng Li Xiaoying Wang Yunxia Sun Zunyou Wu Wenhong Zhang Chunhua Zhao Yu Hu Tao Cheng Yuquan Wei Qi Zhou Fu-Sheng Wang Department of Infectious Diseases Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Department of Gastroenterology Changzheng Hospital of the Second Military Medical UniversityShanghai 200001China Department of Medical Statistics Peking University First HospitalBeijing 100191China National Industrial Base for Stem Cell Engineering Products Tianjin 300384China Department of Cardiac Surgery Shanghai East HospitalTongji UniversityShanghai 310000China Office of Clinical Evaluation of Biological Products Center for Drug EvaluationChina Food and Drug AdministrationBeijing 100053China China Medicinal Biotech Association Beijing 100022China National Cell Collection and Research Center Institute for Biological Product ControlNational Institutes for Food and Drug ControlTiantanXiliDongcheng DistrictBeijing 100050China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003China Department of Infectious Diseases and the Center for Liver Diseases Peking University First HospitalBeijing 100034China Department of Infectious Diseases Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China Radiology Department Peking University First HospitalBeijing 100034China JOINN Laboratories(Beijing) Beijing 100176China Chinese Center for Disease Control and Prevention Beijing 102206China Department of Infectious Diseases Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China CAS Key Laboratory of Microbial Physiological and Metabolic Engineering State Key Laboratory of Microbial ResourcesInstitute of MicrobiologyChinese Academy of SciencesBeijing 100730China Union Hospital Tongji Medical CollegeHuazh

The coronavirus disease 2019(COVID-19)can be caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,and has led to millions of deaths among more than 100 million infected people around the world according to the declaration from World Health *** immune response of both the innate and adaptive immune systems is subsistent on COVID-19 patients,of which the degree are associated with disease severity,lung damage and long term functional *** treatment options have included antiretroviral drugs,anti-inflammatory factors,antibodies,immune checkpoint inhibitors,and convalescent plasma *** recently,mesenchymal stem cell(MSC)therapy has been explored for the management and control of COVID-19,particularly with the aim of preventing or at least mitigating respiratory *** the safety and efficacy of stem cell therapy have been validated in multiple phase I–III clinical trials,to date,no standardized stem cell preparation,administration dosage or interval,product QA/QC testing,storage,transportation,or disposal protocols have been *** present paper proposes a systematic methodology that addresses all the foregoing process steps and evaluation criteria for the efficacious and safe administration of MSCs in the treatment of patients infected with COVID-19.

关键词： COVID-19 Mesenchymal stem cell Treatment

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Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring

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"Environmental Science and Ecotechnology" 2023年第01期 122-130页

作者： Xingwang Ding Ya Wen Xuan Ma Yuepei Zhang Yuting Cheng Zhaofeng Liu Weiyue Hu Yankai Xia State Key Laboratory of Reproductive Medicine Center for Global Health School of Public Health Nanjing Medical University Key Laboratory of Modern Toxicology of Ministry of Education School of Public Health Nanjing Medical University Department of Chronic Non-Communicable Disease Control Wuxi Liangxi District Center for Disease Control and Prevention Department of Nutrition and food Safety School of Public Health Nanjing Medical University

Pyridaben（PY） is a widely used organochlorine acaricide, which can be detected in the peripheral blood of pregnant women. Available evidence suggests that PY has reproductive toxicity. However, it remains uncertain whether prenatal PY exposure impacts neurobehavioral development in offspring. Here, we administered PY to pregnant mice at a dose of 0.5 and 5 mg kg-1day-1via gavage and observed anxietylike behaviors in PY offspring aged five weeks. We then integrated the metabolome and transcriptome of the offspring's brain to explore the underlying mechanism. Metabolome data indicated that the vitamin B6 metabolism pathway was significantly affected, and the pyridoxal 5'-phosphate（PLP） concentration and the active form of vitamin B6 was significantly reduced. Moreover, the transcriptome data showed that both PLP generation-related Pdxk and anxiety-related Gad1 were significantly ***, there was a decreasing trend in the concentration of GABA in the hippocampal DG ***, we supplemented PLP at a dose of 20 mg kg-1day-1to the PY offspring via intraperitoneal injection at three weeks. We found up-regulated expression of Pdxk and Gad1 and restored anxiety-like behaviors. This study suggests that prenatal exposure to PY can disrupt vitamin B6 metabolism,reduce the concentration of PLP, down-regulate the expression levels of Pdxk and Gad1, inhibit the production of GABA, and ultimately lead to anxiety-like behaviors in offspring.

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Quantitative analysis of Cefpodoxime Proxetil raw material and dry suspension using proton nuclear magnetic resonance

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Asian Journal of Traditional Medicines 2024年第6期19卷 305-320页

作者： Yufei Liu Bin Li Xinyu Tao Dongyang Zhao Xinyu Zhang Yan Wu Wenyi He Chenggen Zhu Xiangju Jin Hongyue Liu Xin Di Ye Tian Yanan Wang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Material MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Division of antibiotics National Institutes for Food and Drug ControlBeijing 100050China School of pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China School of pharmacy Beihua UniversityJilin 132013China

This study established a simple,rapid,and accurate nuclear magnetic resonance(NMR)quantitative method to determine the cefpodoxime proxetil content in raw materials and dry suspensions,and evaluated the *** relative content of cefpodoxime proxetil iso-A and iso-B was also analyzed based on 1H *** this study,an internal standard method was used,with DMSO-d6 as the solvent and maleic acid and 1,3,5-trimethylbenzene as internal standards,to calculate the concentration of the *** analysis was performed using both the traditional quantitative NMR(traditional qNMR)and the quantitative Global Spectral Deconvolution(qGSD)*** linearity range,quantitation limit,precision,robustness,and accuracy of these quantitative analysis methods were *** results indicated that both internal standards and integration methods met the requirements of the“9101 Guidelines for Analytical Method Validation”in the 2020 edition of the Chinese *** to the traditional qNMR,qGSD has unique advantages in accurate quantitative analysis in complex *** using the combined HPLC-SPE-NMR technique,cefpodoxime proxetil iso-A and iso-B were enriched and analyzed,and their NMR data were accurately *** quantitative analysis results were in line with the requirements of the Chinese Pharmacopoeia.

关键词： qNMR qGSD cefpodoxime proxetil uncertainty HPLC-SPE-NMR

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The multi-kingdom microbiome catalog of the chicken gastrointestinal tract

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Biosafety and Health 2024年第2期6卷 101-115页

作者： Yanan Wang Mengqi Qu Yuhai Bi William J.Liu Sufang Ma Bo Wan Yongfei Hu Baoli Zhu Gaiping Zhang George F.Gao International Joint Research Center of National Animal Immunology College of Veterinary MedicineHenan Agricultural UniversityZhengzhou 450046China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Longhu Laboratory Zhengzhou 450046China University of Chinese Academy of Sciences Beijing 100049China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Chicken is an important food animal worldwide and plays an important role in human life by providing meat and *** recent significant advances in gut microbiome studies,a comprehensive study of chicken gut bacterial,archaeal,and viral genomes remains *** this study,we constructed a chicken multi-kingdom microbiome catalog(CMKMC),including 18,201 bacterial,225 archaeal,and 33,411 viral genomes,and annotated over 6,076,006 protein-coding genes by integrating 135 chicken gut metagenomes and publicly available metagenome-assembled genomes(MAGs)from ten *** found that 812 and 240 MAGs in our dataset were putative novel species and genera,respectively,far beyond what was previously *** newly unclassified MAGs were predominant in Phyla Firmicutes_A(n=263),followed by Firmicutes(n=126),Bacteroidota(n=121),and Proteobacteria(n=87).Most of the classified species-level viral oper-ational taxonomic units belong to ***,63.24%of chicken gut viromes are predicted to infect two or more hosts,including complete circular ***,we found that diverse auxiliary metabolic genes and antibiotic resistance genes were carried by ***,our CMKMC provides the largest integrated MAGs and viral genomes from the chicken gut to date,functional insights into the chicken gastrointestinal tract microbiota,and paves the way for microbial interventions for better chicken health and productivity.

关键词： Chicken Microbiome Metagenome assembled genomes Archaeome Virome Antibiotic resistance gene

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Feedstock choice,pyrolysis temperature and type influence biochar characteristics:a comprehensive meta-data analysis review

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Biochar 2020年第4期2卷 421-438页

作者： James A.Ippolito Liqiang Cui Claudia Kammann Nicole Wrage‑Mönnig Jose MEstavillo Teresa Fuertes‑Mendizabal Maria Luz Cayuela Gilbert Sigua Jeff Novak Kurt Spokas Nils Borchard Department of Soil and Crop Sciences Colorado State UniversityFort Collins 80523USA School of Environmental Science and Engineering Yancheng Institute of Technology9 Yingbin AvenueYancheng 224051China Department of Applied Ecology Geisenheim UniversityVon‑Lade‑Straße 165366 GeisenheimGermany Faculty of Agricultural and Environmental Sciences Grassland and Fodder SciencesUniversity of RostockJustus‑von‑Liebig‑Weg 618059 RostockGermany Department of Plant Biology and Ecology University of the Basque Country(UPV/EHU)Apdo.64448080 BilbaoSpain Department of Soil and Water Conservation and Waste Management CEBAS-CSICCampus Universitario de Espinardo30100 MurciaSpain United States Department of Agriculture Agriculture Research ServiceCoastal Plains Research Center2611 West Lucas StreetFlorenceSC 29501USA United States Department of Agriculture Agriculture Research ServiceSoil and Water Management Research UnitUniversity of Minnesota439 Borlaug Hall1991 Buford CircleSt.PaulMN 29501USA Natural Resources Institute Finland(Luke) Latokartanonkaari 900790 HelsinkiFinland

Various studies have established that feedstock choice,pyrolysis temperature,and pyrolysis type influence final biochar physicochemical ***,overarching analyses of pre-biochar creation choices and correlations to biochar characteristics are severely ***,the objective of this work was to help researchers,biochar-stakeholders,and practitioners make more well-informed choices in terms of how these three major parameters influence the final biochar *** approximately 5400 peer-reviewed journal articles and over 50,800 individual data points,herein we elucidate the selections that influence final biochar physical and chemical properties,total nutrient content,and perhaps more importantly tools one can use to predict biochar’s nutrient *** on the large dataset collected,it appears that pyrolysis type(fast or slow)plays a minor role in biochar physico-(inorganic)chemical characteristics;few differences were evident between production *** temperature,however,affects biochar’s longevity,with pyrolysis temperatures>500℃ generally leading to longer-term(i.e.,>1000 years)*** pyrolysis temperatures also led to biochars containing greater overall C and specific surface area(SSA),which could promote soil physico-chemical ***,based on the collected data,it appears that feedstock selection has the largest influence on biochar *** surface area is greatest in wood-based biochars,which in combination with pyrolysis temperature could likely promote greater changes in soil physical characteristics over other feedstock-based ***-and other grass-based biochars appear to have cation exchange capacities greater than other biochars,which in combination with pyrolysis temperature could potentially lead to longer-term changes in soil nutrient *** collected data also suggest that one can reasonably predict the availability of various biochar nutrients(e.g.,N,P

关键词： Biochar Total elemental analysis Plant-available elemental analysis Physico-chemical characteristics·Meta-analysis

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