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Hepatitis C in Laos： A 7-Year Retrospective Study on 1765 Patients

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Virologica Sinica 2018年第4期33卷 295-303页

作者： Phimpha Paboriboune Thomas Vial Philavanh Sitbounlang Stephane Bertani Christian Trepo Paul Deny Francois-Xavier Babin Nicolas Steenkeste Pascal Pineau Eric Deharo Centre d'Infectiologie Lao-Christophe Merieux 3888 Vientiane Laos UMR 152 PHARMADEV IRD Universite de ToulouseUPS 31062 Toulouse France INSERM U1052 CNRS UMR 5286 Cancer Research Centre of Lyon 69008 Lyon France Universite paris 13 Sorbonne Paris Cite Hopitaux Universitaires Paris Seine Saint Denis 93000 Bobigny France fondation Merieux 69002 Lyon France INSERM U993 Institut Pasteur Unite 'Organisation Nucleaire et Oncogenese' 75015 Paris France

Hepatitis C virus （HCV） is a global health concern, notably in Southeast Asia, and in Laos the presentation of the HCV- induced liver disease is poorly known. Our objective was thus to describe a comprehensive HCV infection pattern in order to guide national health policies. A study on a group of 1765 patients formerly diagnosed by rapid test in health centres was conducted at the Centre of Infectiology Lao Christophe Merieux in Vientiane. The demographic information of patients, their infection status （viral load： VL）, liver function （aminotransferases） and treatments were analysed. Results showed that gender distribution of infected people was balanced; with median ages of 53.8 for men and 51.6 years for women （13-86 years）. The majority of patients （72%） were confirmed positive （VL 〉 50 IU/mL） and 28% of them had high VL （〉 61oglo）. About 23% of patients had level of aminotransferases indicative of liver damage （〉 40 IU/mL）; but less than 20% of patients received treatment. Patients rarely received a second sampling or medical imaging. The survey also showed that cycloferon, pegylated interferon and ribavirin were the drugs prescribed preferentially by the medical staff, without following any international recommendations schemes. In conclusion, we recommend that a population screening policy and better management of patients should be urgently implemented in the country, respecting official guidelines. However, the cost of biological analysis and treatment are significant barriers that must be removed. Public health resolutions should be immediately enforced in the perspective of meeting the WHO HCV elimination deadline by 2030.

关键词： Hepatitis C virus (HCV) HCV incidence Antiviral agents Laos

Converting antimicrobial into targeting peptides reveals key features governing protein import into mitochondria and chloroplasts

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Plant Communications 2023年第4期4卷 99-116页

作者： Oliver D.Caspari Clotilde Garrido Chris OLaw Yves Choquet Francis-Andre´Wollman Ingrid Lafontaine UMR7141(CNRS/Sorbonne Universite´) Institut de Biologie Physico-Chimique13 Rue Pierre et Marie Curie75005 ParisFrance Centre for Microscopy and Cellular Imaging Biology Department Loyola Campus of Concordia University7141 Sherbrooke W.Montre´alQC H4B 1R6Canada Present address:Department of Microbiology Institut Pasteur28 Rue Docteur Roux75015 ParisFrance Present address:UMR7238(CNRS/Sorbonne Universite´) Institut de Biologie Paris-SeineSorbonne Jussieu 7-9 quai Saint Bernard75005 ParisFrance

We asked what peptide features govern targeting to the mitochondria versus the chloroplast,using antimicrobial peptides as a starting *** approach was inspired by the endosymbiotic hypothesis that organelle-targeting peptides derive from antimicrobial amphipathic peptides delivered by the host cell,to which organelle progenitors became *** explore the molecular changes required to convert antimicrobial into targeting peptides,we expressed a set of 13 antimicrobial peptides in Chlamydomonas *** were systematically modified to test distinctive features of mitochondrion-and chloroplast-targeting peptides,and we assessed their targeting potential by following the intracellular localization and maturation of a Venus fluorescent reporter used as a cargo *** targeting can be achieved by some unmodified antimicrobial peptide *** to both organelles is improved by replacing lysines with *** targeting is enabled by the presence of flanking unstructured sequences,additional constraints consistent with chloroplast endosymbiosis having occurred in a cell that already contained *** indeed targeting peptides evolved from antimicrobial peptides,then required modifications imply a temporal evolutionary scenario with an early exchange of cationic residues and a late acquisition of chloroplast-specific motifs.

关键词： antimicrobial peptide Chlamydomonas reinhardtii endosymbiotic organellogenesis presequence targeting peptide transit peptide

Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19

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四川生理科学杂志 2021年第1期43卷 122-122页

作者： Aymeric Silvin INSERM U1015 Gustave Roussy Cancer Campus Villejuif 94800 France Université de paris Institut Cochin CNRS UMR8104 INSERM U1016 Paris 75006 France Service d’Hématologie Biologique AP-HP Hôpital Cochin Paris 75014 France Département d’Oncologie Médicale Gustave Roussy Cancer Campus Villejuif 94800 France INSERM U981 Gustave Roussy Cancer Campus Villejuif 94800 France INSERM U1287 Gustave Roussy Cancer Campus Villejuif 94800 France INSERM US23 CNRS UMS 3655 Gustave Roussy Cancer Campus Villejuif 94800 France Service des Urgences AP-HP Hôpital Hôtel-Dieu Paris 75014 France Service de Médecine Intensive et Réanimation AP-HP Hôpital Cochin Paris 75014 France Service de Médecine Interne AP-HP Hôpital Cochin Paris 75014 France Service de Diagnostic Biologique Automatisé AP-HP Hôpital Cochin Paris 75014 France INSERM U1018 Gustave Roussy Cancer Campus Villejuif 94800 France Laboratoire de Virologie AP-HP Hôpital Cochin Paris 75014 France Département de Biologie et Pathologie Gustave Roussy Cancer Campus Villejuif 94800 France Service de Réanimation Médicale Gustave Roussy Cancer Campus Villejuif 94800 France Département d’Hématologie Gustave Roussy Cancer Campus Villejuif 94800 France Singapore Immunology Network (SIgN) Agency for Science Technology and Research (A∗STAR) 8A Biomedical Grove Immunos Building #3–4 Biopolis Singapore 138648 Singapore Institute for Hepatology National Clinical Research Center for Infectious Disease Shenzhen Third People’s Hospital School of Medicine Southern University of Science and Technology Shenzhen 518112 Guangdong Province China Systems Biology Group Department of Computational Biology and USR 3756 Institut Pasteur and CNRS Paris 75015 France Department of Immunology Weizmann Institute of Science Rehovot Israel Département d’Innovation Thérapeutique et d’Essais Précoces (DITEP) Gustave Roussy Cancer Campus Villejuif 94800 France Université paris-saclay Faculté de Médecine Le Kremlin-Bicêtre 94270 France

Blood myeloid cells are known to be dysregulated in coronavirus disease 2019(COVID-19),caused by *** is unknown whether the innate myeloid response differs with disease severity and whether markers of innate immunity discriminate high-risk ***,we performed high-dimensional flow cytometry and single-cell RNA sequencing of COVID-19 patient peripheral blood cells and detected disappearance of non-classical CD14LowCD16High monocytes,accumulation of HLA-DRLow classical monocytes(Human Leukocyte Antigen-DR isotype),and release of massive amounts of calprotectin(S100A8/S100A9)in severe *** CD10LowCD101-CXCR4+/-neutrophils with an immunosuppressive profile accumulated in the blood and lungs,suggesting emergency myelopoiesis.

关键词： S100A9 Blood immunity

Individual Responses to Creatine Supplementation on Muscular Power is Modulated by Gene Polymorphisms in Military Recruits

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Journal of Science in Sport and Exercise 2023年第1期5卷 70-76页

作者： Daniele Mattos Caleb Guedes MSantos Scott CForbes Darren GCandow Douglas Rosa Roberta Giovanini Busnardo Marcos Dornelas Ribeiro Dailson Paulucio Cynthia Chester Marco Machado Skeletal Muscle Physiology Study Group Universidade Iguaçu Campus VR Luiz Carlos Ferreira Tirado148Cidade NovaItaperunaRJ CEP 28300-000Brazil Laboratory of Human Movement Studies University Fondation of ItaperunaItaperunaRJBrazil Brazilian Army Institute of Biology Rio de JaneiroRJBrazil Biometrics Laboratory School of Physical Education and SportsFederal University of Rio de JaneiroRio de JaneiroBrazil Department of Physical Education Studies Faculty of EducationBrandon UniversityBrandonMBCanada Faculty of Kinesiology and Health Studies University of ReginaReginaSKCanada Laboratório de Virologia Molecular Depto de GenéticaInstituto de BiologiaUFRJRio de JaneiroBrazil

Purpose The aim was to explore five established SNPs(rs1815739,rs1805086,rs2700352,rs28497577,and rs28357094)that are known to modulate skeletal muscle protein kinetics in response to creatine *** A randomized,placebo-controlled,repeated measures design was ***(n=152)were rand-omized divided into one of two groups:CREA(20 g/day creatine monohydrate)or PLAC:(dextrose)for 7 *** were assessed,and participants were classified *** and after supplementation,anthropometrics(height and body mass)and performance measures(vertical jump,countermovement vertical jump,squat jump,abdominal crunches,and maximum push-ups)were *** CREA gained more body mass than PLAC(CREA:Δ0.864±0.06 kg;PLAC:Δ0.154±0.07 kg,P<0.001).In the CREA group,the presence of an A allele for the MYLK1 polymorphism was related to changes in countermovement jump height(P=0.027;effect size[d]=0.41)and leg power(P=0.040,effect size[d]=0.18).The total number of abdominal crunches after supplementation was influenced by treatments and SPP1 gene(P=0.041).A higher number of abdominal crunches was associated with the G allele in the CREA group and the TT genotype in the PLAC group(effect size[d]=0.04).Conclusion Collectively,short-term creatine supplementation increased body mass but was unable to alter muscle ***,following creatine supplementation,participants expressing A alleles in the MYLK1 polymorphism had a greater increase in jump height and leg power and participants expressing G alleles in the SPP1 gene had greater improve-ments in abdominal crunch performance.

关键词： SNP Creatine monohydrate Muscular power MYLK1 gene SPP1 gene

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry traces the geographical source of Biomphalaria pfeifferi and Bulinus forskali,involved in schistosomiasis transmission

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Infectious Diseases of Poverty 2024年第1期13卷 98-99页

作者： Papa Mouhamadou Gaye EI Hadj Ibrahima Ndiaye Souleymane Doucoure Doudou Sow Mapenda Gaye Ndiaw Goumballa Carole Cassagne Coralie L'Ollivier Oleg Medianikov Cheikh Sokhna Stephane Ranque Aix-Marseille University IRD AP-HM SSA VITROME Marseille France VITROME International IRD-UCAD Campus Dakar Senegal Hospital-University Institut (IHU) Mediterranée Infection Marseille France Departement of Animal Biology Faculty of Sciences and Techniques UCAD Dakar Senegal Department of Parasitology-Mycology UFR Sciences de la Santé Université Gaston Berger Saint-Louis Senegal

Background Freshwater snails of the genera Bulinus spp.,Biomphalaria spp.,and Oncomelania *** the main intermediate hosts of human and animal *** of these snails has long been based on mor-phological and/or genomic criteria,which have their *** limitations include a lack of precision for the morphological tool and cost and time for the DNA-based ***,Matrix-Assisted Laser Desorp-tion/lonization Time-Of-Flight(MALDI-TOF)mass spectrometry,a new tool used which is routinely in clinical microbi-ology,has emerged in the field of malacology for the identification of freshwater *** study aimed to evaluate the ability of MALDI-TOF MS to identify Biomphalaria pfeifferi and Bulinus forskali snail populations according to their *** This study was conducted on 101 *** and 81 *** snails collected in three distinct geo-graphical areas of Senegal(the North-East,South-East and central part of the country),and supplemented with wild and laboratory *** which had previously been morphologically described were identified by MALDl-TOF MS[identification log score values(LSV)≥1.7],after an initial blind test using the pre-existing *** DNA-based identification,new reference spectra of ***(n=10)and ***(n=5)from the geographical areas were added to the MALDI-TOF spectral *** final blind test against this updated database was per-formed to assess identification at the geographic source *** MALDI-TOF MS correctly identified 92.1%of 101 *** snails and 98.8%of 81 *** *** the final blind test,88%of 166 specimens were correctly identified according to both their species and sampling site,with LSVs ranging from 1.74 to *** geographical source was adequately identified in 90.1%of 91 *** and 85.3%of 75 *** *** Our findings demonstrate that MALDI-TOF MS can identify and differe

关键词： Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry Snail Intermediate host Biomphalaria pfeifferi Bulinus forskali Schistosomiasis Senegal

Soot formation and oxidation during bio-oil gasification:experiments and modeling

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Journal of Energy Chemistry 2013年第5期22卷 701-709页

作者： Younes Chhiti Marine Peyrot Sylvain Salvador LEGI UJF-Grenoble 1/Grenoble-INP/CNRSBP 53Grenoble F-38041 France CEA/DRT/LITEN/DTBH/LTB Laboratoire des Technologies pour la Biomasse 17 rue de Martyrs 38054Grenoble France Ecole des Mines d'Albi-Carmaux Centre RAPSODEE FRE CNRS 3213 Campus Jarlardroute de Teillet 81013Albi France

A model is proposed to describe soot formation and oxidation during bio-oil *** is based on the description of bio-oil heating,devolatilization,reforming of gases and conversion of both char and soot *** chemistry (159 species and 773 reactions) is used in the gas *** production is described by a single reaction based on C2H2species concentration and three heterogeneous soot oxidation *** support the validation of the model,three sets of experiments were carried out in a lab-scale Entrained Flow Reactor (EFR) equipped with soot quantification *** temperature was varied from 1000 to 1400 C and three gaseous atmospheres were considered:default of steam,large excess of steam(H2O/C=8),and the presence of oxygen in the O/C range of 0.075–*** model is shown to accurately describe the evolution of the concentration of the main gas species and to satisfactorily describe the soot concentration under the three atmospheres using a single set of identified kinetic *** to this model the contribution of different mechanisms involved in soot formation and oxidation in various situations can be assessed.

关键词： soot gasification pyrolysis partial oxidation bio-oil

细胞外SQSTM1通过胰岛素受体信号介导小鼠细菌性脓毒症死亡

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中华烧伤杂志 2021年第6期37卷 581-581页

作者：曾茁(译) 彭毅志(审校) Zhou B Liu J Zeng L The Third Affiliated Hospital Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation Guangzhou Medical University Guangzhou China State Key Laboratory of Trauma Burns and Combined Injury Institute of Surgery Research Daping Hospital Army Medical University Chongqing China Department of Pediatrics The Third Xiangya Hospital Central South University Changsha China Laboratory of Emergency Medicine North Shore University Hospital and the Feinstein Institute for Medical Research Manhasset USA Department of Surgery University of Pittsburgh Pittsburgh USA Equipe Labellisée par la Ligue Contre le Cancer Université de Paris Sorbonne Université Institut National de la Santé et de la Recherche Médicale U1138 Centre de Recherche des Cordeliers Paris France Metabolomics and Cell Biology Platforms Gustave Roussy Cancer Campus Villejuif France Pôle de Biologie Hôpital Européen Georges Pompidou Assistance Publique-Hôpitaux de Paris Paris France Suzhou Institute for Systems Medicine Chinese Academy of Sciences Suzhou China Department of Women’s and Children’s Health Karolinska University Hospital Stockholm Sweden Life Sciences Institute and Department of Molecular Cellular and Developmental Biology University of Michigan Ann Arbor USA Department of Surgery UT Southwestern Medical Center Dallas USA

宿主对感染的反应失调导致脓毒症成为全世界ICU最常见的死亡原因。本文研究了脓毒症中SQSTM1/p62——一种自噬受体,其可作为先天性免疫调节剂的作用。作者指出LPS引起gasdermin D依赖性焦亡,使巨噬细胞和单核细胞被动释放SQSTM1;而跨膜... 详细信息

宿主对感染的反应失调导致脓毒症成为全世界ICU最常见的死亡原因。本文研究了脓毒症中SQSTM1/p62——一种自噬受体,其可作为先天性免疫调节剂的作用。作者指出LPS引起gasdermin D依赖性焦亡,使巨噬细胞和单核细胞被动释放SQSTM1;而跨膜蛋白173依赖的TANK结合激酶1激活导致SQSTM1丝氨酸403磷酸化,随后巨噬细胞和单核细胞分泌SQSTM1。此外,细胞外SQSTM1与胰岛素受体结合.

关键词：胰岛素受体巨噬细胞免疫调节剂脓毒症 SQS 单核细胞死亡原因跨膜蛋白

The WAK-like protein RFO1 acts as a sensor of the pectin methylation status in Arabidopsis cell walls to modulate root growth and defense

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Molecular Plant 2023年第5期16卷 865-881页

作者： Apolonio I.Huerta Gloria Sancho-Andre´s Juan Carlos Montesinos Javier Silva-Navas Sole`ne Bassard Corinne Pau-Roblot Christopher Kesten Rudolf Schlechter Susanne Dora Temurkhan Ayupov Je´rome Pelloux^ Julia Santiago Clara Sa´nchez-Rodrı´guez ETH Zurich Institute of Molecular Plant Biology(D-BIOL)ZurichSwitzerland University of Lausanne Department of Plant Molecular BiologyLausanneSwitzerland UMRT INRAE 1158 BioEcoAgro–BIOPI Biologie des Plantes et Innovation Universite´de Picardie33 Rue St Leu80039 AmiensFrance Present address:Lonza AG VispVisSwitzerland Present address:Institute of Microbiology Freie Universitat BerlinBerlinGermany Present address:Institute of Molecular and Clinical Ophthalmology-Basel BaselSwitzerland Present address:Centro de Biotecnologı´a y Geno´mica de Plantas Universidad Polite´cnica de Madrid(UPM)–Instituto Nacional de Investigacio´n y Tecnologı´a Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPM28223 Pozuelo de Alarco´nSpain

Most organisms adjust their development according to the environmental *** the majority,this implies the sensing of alterations to cell walls caused by different *** the relevance of this process,few molecular players involved in cell wall sensing are known and ***,we show that the wall-associated kinase-like protein RESISTANCE TO FUSARIUM OXYSPORUM 1(RFO1)is required for plant growth and early defense against Fusarium oxysporum and functions by sensing changes in the pectin methylation levels in the cell *** RFO1 dwell time at the plasma membrane is affected by the pectin methylation status at the cell wall,regulating MITOGEN-ACTIVATED PROTEIN KINASE and gene *** show that the extracellular domain of RFO1 binds de-methylated pectin in vitro,whose distribution in the cell wall is altered during *** *** analyses also indicate that RFO1 is required for the BR-dependent plant growth alteration in response to inhibition of pectin de-methyl-esterase activity at the cell ***,our work demonstrates that RFO1 is a sensor of the pectin methylation status that plays a unique dual role in plant growth and defense against vascular pathogens.

关键词： alterations walls pectin

Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer

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Acta Pharmaceutica Sinica B 2019年第2期9卷 443-454页

作者： Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Department of Biochemistry Institute of Integrative Biology University of Liverpool Division of Molecular Biology and Biochemistry School of Biological Sciences University of Missouri-Kansas City School of Biological Sciences Nanyang Technological University Lee Kong Chian School of Medicine Nanyang Technological University Institute of Molecular and Cell Biology KK Women's and Children Hospital Biochemistry Department School of Biomedical Sciences University of Otago Centre for Biomedical Research (CBMR) University of Algarve Campus de Gambelas Department of Biomedical Sciences and Medicine University of Algarve Algarve Biomedical Center (ABC) University of Algarve Campus de Gambelas Department of Infection Immunity and Cardiovascular Disease University of Sheffield Paul O'Gorman Leukaemia Research Centre Institute of Cancer Sciences University of Glasgow Division of Carcinogenesis The Cancer Institute Japanese Foundation for Cancer Research Department of Pathology and Laboratory Medicine Abramson Family Cancer Research Institute Perelman School of Medicine at the University of Pennsylvania Centre de Recherche en Transplantation et Immunologie (ou CRTI) Inserm Université de Nantes Nantes France Institut de Transplantation Urologie Néphrologie (ou ITUN) CIC bioGUNE CIBERONC Ikerbasque Basque Foundation for Science Biochemistry and Molecular Biology Department University of the Basque Country (UPV/EHU) Institute for Diabetes and Cancer IDC Helmholtz Center Munich Joint Heidelberg-IDC Translational Diabetes Program University Hospital Heidelberg Molecular Metabolic Control Medical Faculty Technical University Munich German Center for Diabetes Research (DZD) Division of Cardiology Department of Medicine Columbia University Irving Medical Center School of Sport and Health Sciences Cardiff Metropolitan Universit

The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases.

关键词： Tribbles Immunology Metabolism Cell biology Kinase inhibitor Tumorigenesis Metastasis TRIB1 TRIB2 TRIB3 Pseudokinase Inflammation Atomic structure Protein quality control Ubiqutin