Individual Responses to Creatine Supplementation on Muscular Power is Modulated by Gene Polymorphisms in Military Recruits

作     者：Daniele Mattos Caleb Guedes MSantos Scott CForbes Darren GCandow Douglas Rosa Roberta Giovanini Busnardo Marcos Dornelas Ribeiro Dailson Paulucio Cynthia Chester Marco Machado 

作者机构：Skeletal Muscle Physiology Study GroupUniversidade Iguaçu Campus VR Luiz Carlos Ferreira Tirado148Cidade NovaItaperunaRJ CEP 28300-000Brazil Laboratory of Human Movement StudiesUniversity Fondation of ItaperunaItaperunaRJBrazil Brazilian Army Institute of BiologyRio de JaneiroRJBrazil Biometrics LaboratorySchool of Physical Education and SportsFederal University of Rio de JaneiroRio de JaneiroBrazil Department of Physical Education StudiesFaculty of EducationBrandon UniversityBrandonMBCanada Faculty of Kinesiology and Health StudiesUniversity of ReginaReginaSKCanada Laboratório de Virologia MolecularDepto de GenéticaInstituto de BiologiaUFRJRio de JaneiroBrazil 

出 版 物：《Journal of Science in Sport and Exercise》 (体育运动科学（英文）)

年 卷 期：2023年第5卷第1期

页      面：70-76页

核心收录：

学科分类：0403[教育学-体育学] 040302[教育学-运动人体科学(可授教育学、理学、医学学位)] 04[教育学] 

基　　金：We are very thankful to the subjects who made this study possible and who endured the inconvenience of this investigation 

主　　题：SNP Creatine monohydrate Muscular power MYLK1 gene SPP1 gene 

摘      要：Purpose The aim was to explore five established SNPs(rs1815739,rs1805086,rs2700352,rs28497577,and rs28357094)that are known to modulate skeletal muscle protein kinetics in response to creatine *** A randomized,placebo-controlled,repeated measures design was ***(n=152)were rand-omized divided into one of two groups:CREA(20 g/day creatine monohydrate)or PLAC:(dextrose)for 7 *** were assessed,and participants were classified *** and after supplementation,anthropometrics(height and body mass)and performance measures(vertical jump,countermovement vertical jump,squat jump,abdominal crunches,and maximum push-ups)were *** CREA gained more body mass than PLAC(CREA:Δ0.864±0.06 kg;PLAC:Δ0.154±0.07 kg,P0.001).In the CREA group,the presence of an A allele for the MYLK1 polymorphism was related to changes in countermovement jump height(P=0.027;effect size[d]=0.41)and leg power(P=0.040,effect size[d]=0.18).The total number of abdominal crunches after supplementation was influenced by treatments and SPP1 gene(P=0.041).A higher number of abdominal crunches was associated with the G allele in the CREA group and the TT genotype in the PLAC group(effect size[d]=0.04).Conclusion Collectively,short-term creatine supplementation increased body mass but was unable to alter muscle ***,following creatine supplementation,participants expressing A alleles in the MYLK1 polymorphism had a greater increase in jump height and leg power and participants expressing G alleles in the SPP1 gene had greater improve-ments in abdominal crunch performance.