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Chinese Journal of Chemical Engineering 2024年第4期68卷 165-180页

作者： Xuexiang Fu Xing Tang Yi Xu Xintao Zhou Dengfeng Zhang faculty of Chemical Engineering Kunming University of Science and TechnologyKunming 650500China

In order to comprehend the applicability of microwave irradiation for recovering coalbed methane,it is necessary to evaluate the microwave irradiation-induced alterations in coals with varying levels of *** this work,the carbon molecular sieve combined with KMnO_(4)oxidation was selected to fabricate carbon molecular sieve with diverse oxidation degrees,which can serve as model substances toward ***,the microwave irradiation dependences of pores,functional groups,and highpressure methane adsorption characteristics of model substances were *** results indicated that microwave irradiation causes rearrangement of oxygen-containing functional groups,which could block the micropores with a size of 0.40-0.60 nm in carbon molecular sieve;meanwhile,naphthalene and phenanthrene generated by macro-molecular structure pyrolysis due to microwave irradiation could block the micropores with a size of 0.70-0.90 *** alterations in micropore structure weaken the saturated methane adsorption capacity of oxidized carbon molecular sieve by 2.91%-23.28%,suggesting that microwave irradiation could promote methane ***,the increased mesopores found for oxidized carbon molecular sieve after microwave irradiation could benefit CH4 *** summary,the oxidized carbon molecular sieve can act as model substances toward coals with different ***,microwave irradiation is a promising technology to enhance coalbed methane recovery.

关键词： Microwave irradiation Physicochemical property Coal matrix Adsorption Carbon molecular sieve

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TIP60 acetylation of Bub1 regulates centromeric H2AT120 phosphorylation for faithful chromosome segregation

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science China life sciences 2024年第09期 1957-1969页

作者： Mengjie Sun Biying Yang Guangwei Xin Yao Wang Jia Luo Qing Jiang Chuanmao Zhang The Academy for Cell and life Health Faculty of Life Science and Technology Kunming University of Science and Technology The Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education College of Life Sciences Peking University

Proper function of the centromeres ensures correct attachment of kinetochores to spindle microtubules and faithful chromosome segregation in mitosis. Defects in the integrity and function of centromeres can result in chromosome missegregation and genomic ***1 is essential for the mitotic centromere dynamics, yet the underlying molecular mechanisms remain largely unclear. Here, we demonstrate that TIP60 acetylates Bub1 at K424 and K431 on kinetochores in early mitosis. This acetylation increases the kinase activity of Bub1 to phosphorylate centromeric histone H2A at T120(H2Ap T120), which recruits Aurora B and Shugoshin 1(Sgo1) to regulate centromere integrity, protect centromeric cohesion, and ensure the subsequent faithful chromosome segregation. Expression of the nonacetylated Bub1 mutant reduces its kinase activity, decreases the level of H2Ap T120, and disrupts the recruitment of centromere proteins and chromosome congression, leading to genomic instability of daughter cells. When cells exit mitosis, HDAC1-regulated deacetylation of Bub1 decreases H2Ap T120 levels and thereby promotes the departure of centromeric CPC and Sgo1, ensuring timely centromeres disassembly. Collectively, our results reveal a molecular mechanism by which the acetylation and deacetylation cycle of Bub1 modulates the phosphorylation of H2A at T120 for recruitment of Aurora B and Sgo1 to the centromeres, ensuring faithful chromosome segregation during mitosis.

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Density functional theory study of B- and Si-doped carbons and their adsorption interactions with sulfur compounds

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Carbon Energy 2024年第2期6卷 195-208页

作者： Peng Guo Hong Zhang Shuliang Dong Libao An College of Mechanical Engineering North China University of Science and TechnologyTangshanHebeiChina College of life sciences North China University of Science and TechnologyTangshanHebeiChina

Understanding the adsorption interactions between carbon materials and sulfur compounds has far-reaching impacts,in addition to their well-known important role in energy storage and conversion,such as lithium-ion *** this paper,properties of intrinsic B or Si single-atom doped,and B-Si codoped graphene(GR)and graphdiyne(GDY)were investigated by using density functional theory-based calculations,in which the optimal doping configurations were explored for potential applications in adsorbing sulfur *** showed that both B or Si single-atom doping and B-Si codoping could substantially enhance the electron transport properties of GR and GDY,improving their surface ***,B and Si atoms displayed synergistic effects for the codoped configurations,where B-Si codoped GR/GDY exhibited much better performance in the adsorption of sulfurcontaining chemicals than single-atom doped *** addition,results demonstrated that,after B-Si codoping,the adsorption energy and charge transfer amounts of GDY with sulfur compounds were much larger than those of GR,indicating that B-Si codoped GDY might be a favorable material for more effectively interacting with sulfur reagents.

关键词： adsorption density functional theory doping graphdiyne graphene sulfur compounds

Tripartite motif-containing protein 11(TRIM11):a novel weapon against Alzheimer’s disease

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Signal Transduction and Targeted Therapy 2024年第2期9卷 339-340页

作者： Yichu Fu Bi Zhang Jianfeng Liu College of life science and technology Key Laboratory of Molecular Biophysics of MOEHuazhong University of Science and TechnologyWuhanHubei 430074China

In a recent study published in science,Zhang et *** that tripartite motif-containing(TRIM)protein 11(TRIM11)exhibited strong inhibition on tau aggregation,which is a pathological characteristic of tauopathies including Alzheimer’s disease(AD).1 This makes TRIM11 a promising novel target for the treatment of AD and other tauopathies.

关键词： Alzheimer tau TRIM

Super Resolution Fluorescence Microscopy for Cilia Investigation and Ciliopathy Diagnosis

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激光与光电子学进展 2024年

作者： Zhen LIU Yang WU Division of life science The Hong Kong University of Science and Technology

The last two decades have witnessed the invention and development of superresolution microscopy(SRM), which breaks the diffraction limit of light and pushes the resolution of fluorescence microscopy to several nanometers. SRM is now widely applied in biological studies such as resolving subdiffraction structures, molecular mapping, single molecule tracking, probing protein-protein interactions, and observing organelle dynamics. However, its direct application in translational medicine such as disease diagnosis is still preliminary. Despite their small size, cilia play a crucial role as organelles in cell signaling and motility, and defects in cilia lead to ciliopathy. Like other miniature organelles and macromolecular complexes, cilia are ideal for superresolution imaging. In this review, we will 1) introduce cilia and ciliopathy, 2) show how SRM extends our knowledge of cilia, and 3) focus on how SRM improves the diagnosis of motile ciliopathies.

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Integration of multiple flexible electrodes for realtime detection of barrier formation with spatial resolution in a gut-on-chip system

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Microsystems & Nanoengineering 2024年第1期10卷 105-114页

作者： Mara Lucchetti Gabriel Werr Sofia Johansson Laurent Barbe Léa Grandmougin Paul Wilmes Maria Tenje Luxembourg Centre for Systems Biomedicine(LCSB) University of LuxembourgEsch-sur-Alzette L-4362Luxembourg Division of Biomedical Engineering Department of Materials Science and EngineeringScience for Life LaboratoryUppsala University75121 UppsalaSweden Department of life sciences and Medicine Faculty of ScienceTechnology and MedicineUniversity of LuxembourgEsch-sur-Alzette L-4362Luxembourg

In healthy individuals,the intestinal epithelium forms a tight barrier to prevent gut bacteria from reaching blood *** study the effect of probiotics,dietary compounds and drugs on gut barrier formation and disruption,human gut epithelial and bacterial cells can be cocultured in an in vitro model called the human microbial crosstalk(HuMiX)gut-on-a-chip ***,we present the design,fabrication and integration of thin-film electrodes into the HuMiX platform to measure transepithelial electrical resistance(TEER)as a direct readout on barrier tightness in *** various aspects of the HuMiX platform have already been set in their design,such as multiple compressible layers,uneven surfaces and nontransparent materials,a novel fabrication method was developed whereby thin-film metal electrodes were first deposited on flexible substrates and sequentially integrated with the HuMiX system via a transfer-tape ***,to measure localized TEER along the cell culture chamber,we integrated multiple electrodes that were connected to an impedance analyzer via a *** further developed a dynamic normalization method because the active measurement area depends on the measured TEER *** fabrication process and system setup can be applicable to other barrier-on-chip *** a proof-of-concept,we measured the barrier formation of a cancerous Caco-2 cell line in real-time,which was mapped at four spatially separated positions along the HuMiX culture area.

关键词： barrier system multiple

Surface wave inversion with unknown number of soil layers based on a hybrid learning procedure of deep learning and genetic algorithm

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 345-358页

作者： Zan Zhou Thomas Man-Hoi Lok Wan-Huan Zhou Department of Civil and Environmental Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina

Surface wave inversion is a key step in the application of surface waves to soil velocity ***,a common practice for the process of inversion is that the number of soil layers is assumed to be known before using heuristic search algorithms to compute the shear wave velocity profile or the number of soil layers is considered as an optimization ***,an improper selection of the number of layers may lead to an incorrect shear wave velocity *** this study,a deep learning and genetic algorithm hybrid learning procedure is proposed to perform the surface wave inversion without the need to assume the number of soil ***,a deep neural network is adapted to learn from a large number of synthetic dispersion curves for inferring the layer ***,the shear-wave velocity profile is determined by a genetic algorithm with the known layer *** applying this procedure to both simulated and real-world cases,the results indicate that the proposed method is reliable and efficient for surface wave inversion.

关键词： surface wave inversion analysis shear-wave velocity profile deep neural network genetic algorithm

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The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Drosophila model of Parkinson’s disease

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Neural Regeneration Research 2024年第5期19卷 1150-1155页

作者： Shuanglong Yi Linfang Wang Margaret S.Ho Shiping Zhang School of life science and technology ShanghaiTech UniversityShanghaiChina College of life sciences University of Chinese Academy of SciencesBeijingChina

Parkinson’s disease is a progressive neurodegenerative disease characterized by motor deficits,dopaminergic neuron loss,and brain accumulation ofα-synuclein aggregates called Lewy *** in protein degradation pathways,such as autophagy,has been demonstrated in neurons as a critical mechanism for eliminating protein aggregates in Parkinson’s ***,it is less well understood how protein aggregates are eliminated in glia,the other cell type in the *** the present study,we show that autophagy-related gene 9(Atg9),the only transmembrane protein in the autophagy machinery,is highly expressed in Drosophila glia from adult *** from immunostaining and live cell imaging analysis reveal that a portion of Atg9 localizes to the trans-Golgi network,autophagosomes,and lysosomes in ***9 is persistently in contact with these *** glial atg9 reduces the number of omegasomes and autophagosomes,and impairs autophagic substrate *** suggests that glial Atg9 participates in the early steps of autophagy,and hence the control of autophagic ***,loss of glial atg9 induces parkinsonian symptoms in Drosophila including progressive loss of dopaminergic neurons,locomotion deficits,and glial *** findings identify a functional role of Atg9 in glial autophagy and establish a potential link between glial autophagy and Parkinson’s *** results may provide new insights on the underlying mechanism of Parkinson’s disease.

关键词： Atg9 autophagy glia Parkinson’s disease

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In situ anchoring in carbon matrix of Bi2O2CO3 as a high-performance anode material for Li-ion batteries

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Rare Metals 2024年第08期43卷 3634-3646页

作者： Pu-Qiang He Jun Guo Hui Huang Zhong-Cheng Guo faculty of Metallurgy and Energy Engineering Kunming University of Science and Technology Research Center of Metallurgical Electrode Materials Engineering technology Kunming Hendera science and technology Co. Ltd.

Bismuth-based anode materials have been regarded as promising Li-ion batteries due to their high theoretical ***,their low conductivity and associated volume expansion inhabited their *** this work,Bi2O2CO3@C composites were successfully synthesized by in situ anchoring of flower-like Bi2O2CO3nanosheets on a carbon-based substrate via *** unique composited structure of Bi2O2-CO3@C leads to a stable specific capacity of 547 mAh·g-1after 100 cycles at a current density of 0.1 A·***,it demonstrates excellent rate capability with a specific capacity of 210 mAh·g-1at 5 A·*** 550 cycles at a current density of 0.5 A·g-1,a high reversible capacity of nearly 400 mAh·g-1was ***,in situ X-ray diffraction measurements clearly demonstrate the conversion between Bi and Li3Bi during alloying/dealloying,confirming the good electrochemical reversibility of the materials for Li *** reaction kinetics of Bi2O2CO3@C were further investigated using galvanostatic intermittent titration ***,Bi2O2-CO3@C exhibited excellent long-term stability,maintaining its high reversible capacity for over 200 cycles at a current density of 0.5 A·g-1in a full cell configuration using Li1.20Mn0.54Ni0.13Co0.13O2as the cathode *** result further underscores its promising potential for lithium-ion *** work may provide inspiration for the design of alloy-type negative electrode materials for high-performance rechargeable batteries.

关键词： Bi 2 O 2 CO 3 Composite materials Anode materials Full batteries

Unimolecular Self-Assembled Hemicyanine-Oleic Acid Conjugate Acts as a Novel Succinate Dehydrogenase Inhibitor to Amplify Photodynamic Therapy and Eliminate Cancer Stem Cells

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Research 2024年第2期6卷 449-461页

作者： Qiang Wang Tian Yang Shiyou Li Chen Xu Chong Wang Yuxuan Xiong Xing Wang Jiangling Wan Xiangliang Yang Zifu Li National Engineering Research Center for Nanomedicine College of Life Science and Technology.Huazhong University of Science and TechnologyWuhan 430074P.R.China Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074P.R.China .3Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medical Huazhong University of Science and TechnologyWuhan 430074P.R.China Hubei Engineering Research Center for Biomaterials and Medical Protective Materials Huazhong University of Science and TechnologyWuhan 430074P.R.China Hubei Bioinformatics and Molecular Imaging Key Laboratory College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074P.R.China

Photodynamic therapy with reactive oxygen species production is a prospective treatment to combat cancer stem cells(CSCs).However,the innate drawbacks,including short lifetime and diffusion distance of reactive oxygen species and hypoxia within solid tumors,have become bottlenecks for clinical applications of photodynamic ***,we develop a mitochondria-targeting hemicyanine-oleic acid conjugate(CyOA),which can self-assemble into supramolecular nanoparticles(NPs)without any exogenous *** is also shown for targeting the mitochondrial complex II protein succinate dehydrogenase to inhibit oxidative phosphorylation and reverse tumor hypoxia,resulting in 50.4-fold higher phototoxicity against breast cancer stem cells(BCSCs)compared to SO_(3)-CyOA NPs that cannot target to *** 4T1 and BCSC tumor models,CyOA NPs achieve higher tumor inhibition and less lung metastasis nodules compared to the clinically used photosensitizer *** study develops a self-assembled small molecule that can serve as both oxidative phosphorylation inhibitor and photosensitizer for eradication of CSCs and treatment of solid tumors.

关键词： cyanine oxidative treatment